유제놀에 의한 즉시형 알레르기 반응의 억제

김상현,신태용,김형룡,이영미,이은희,신보경,김윤철,안년형,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1 M/kg. i.p.) at 60 min before and 5.10 min after the compound 48/80 treatment (8 mg/kg.i.p.) were shown the mortality rates as 0.44.4. and 77.8%. respectively. A 60 min before administered group revealed a singificant inhibition of serum his-tamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

토착형 P. vivax에 의한 Malaria 4례

박형렬,이성원,이경미,김태겸,한진영,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

형광검출 역상 액체크로마토그래피에 의한 Histamine의 정량

유희춘,김형룡,김상현,김대기,이영미,김형민,안년형,신태용 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Histamine을 정확하고 신속하게 정량하기 위해 9.Fiuorenylmethyl chloroformate를 형광유도체화제로 하여 역상 HPLC법으로 정량하였다. 히스타민을 형광유도체화할 때 반응액의 pH, 반응시간, 형광유도체화제의 농도 등 최적 반응 조건을 검토하였다. 이 방법으로 히스타민을 분석한 결과 0.1~0.5ug/ml의 농도범위에서 상관계수가 0.922인 양호한 직선성을 나타내었으며 검출한계는 0.01??/ml였다. A rapid and simple method for the determination of histamine by reverse-phase high performance liquid chromatography with fluorescence detection was established. 9-Fluorenylmethyl chloroformate(FMOC) was used as fluorescent derivative reagent. The optimum conditions for the derivatiation such as pH, reaction time and he concentration of FMOC were investigated. Linearity of calibration curve was obtained between 0.1ug/ml/and 0.5ug/ml(r=0.922) and the limit of detection was 0.01ug/ml.

후방 비출혈 환자에서 비내시경하 전기소작술의 치료효과

김재영,이민우,김진국,한창준,남태욱,임채형 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background and Objectives : Epistaxis is a common disease from which approximately 10% of the normal population have suffered in their life. Most bleeding sites of epistaxis are located anteriorly and easily controlled. However posterior epistaxis presents significantly great problems. A number of different treatment modalities are used to control the posterior epistaxis. Although not widely practiced, the nasal endoscopic electrocautery has also been effective. The purpose of this article is to report on the efficacy of nasal endoscopic electrocautery as an alternative and adjuvant to the standard approach for control of posterior epistaxis. Materials and Methods: We conducted retrospective chart review about 19 cases of posterior epistaxis treated from January 1998 to December 1999. Group I patients were managed by nasal packing only and group II patients were managed by nasal packing and endoscopic electrocautery. Results: Hospital days were 5.9 days in the group I and 3.6 days in the group II. The duration of nasal packing was 4.1 days in the group I and 1.8 days in the group II. The results were significant statistically Conclusion: Nasal endoscopic electrocautery was an effective treatment modality for control of posterior epistaxis.

요통환자에 대한 임상적 고찰 : 한·양방 협진병원 내원 환자를 중심으로

김형태,류규수 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

With 160 lumbago patients (85 inpatients and 75 outpatients) who received both Oriental and Western medical treatment from December, 1994 to April, 1995 at the acupuncture section and rehabilitation section of the H Hurb Hospital which is located in Seoul, a clinical study on the realities of lumbago was carried out. Findings from such a study are as follows: 1. It appeared that regarding the distribution of sex, 80 lumbago patients(50%) were male while the same number of lumbago patients were female, thereby presenting a distributional rate of male and female, 1:1 ; regarding the distribution of age groups, from the age group which consists a large number of lumbago patients, they were the age group of 30s 44 lumbago patients(which is 27.5% of total lumbago patients), age group of 60s or more than that, age group of 50s, and age group of 20s ; regarding the distribution of job, from the group which consists a large number of lumbago patients, they were the group of housewives, group of the unemployed(or the aged), group of clerical workers, group of professional job, etc. 2. It appeared that the causes of the attack of lumbago are unknown etiology 56 lumbago patients(35.0%), heavy lifting 39 patients(24.4%), longtime standing 24 patients(15%), sprain 20 patients(12.5%), and accidents and contusion 11 patients(6.9%) in the order from the most case. 3. Regarding the relapse rate among the subjects, it appeared that 106 lumbago patients(66.2%) had more than relapse, and 54 patients(33.8%) were newpatients; and among the patients having more than relapse, the case of 3rd recurrence outnumbered the case of 2nd recurrence. Regarding the distribution other relapse rate according to age groups, it appeared that the most case was in the group of 60s and more than that with 28 patients(26.2%), then the next case in the group of 30s, then the case in the group of 20s, and then the case in the group of 50s. Regarding the distribution of the relapse rate according to job, it appeared that from the most case, there were 28 lumbago patients of housewives(28.0%), 27 patients(24.7%) of theunemployed(an aged population), and 19 patients(17.8%) of clerical workers. 4. Regarding the distribution of the causes of relapse, it appeared that the most case was due to unknown etiology with 43 patients(40.2%), then the next case due to heavy lifting, then due to longtime standing, then due to sprain, and then due to accidents and contusion. Regarding the distribution of the causes of relapse accoriding to age groups, it appeared that the most case was due to unknown etiology which was seen in all the age groups ; in the age group of 30s, due to heavy lifting, then due to longtime standing, and then due to sprain; and in the age group of 60s and more than that, due to heavy lifting, then due to longtime standing, and then due to contusion. Regarding the causes of relapse according to job, it appeared that the most case was due to unknown etiology or no special cause of attack ; in the group of the unemployed(an aged population), due to heavy lifting, and then due to longtime standing in the order from the most case ; in the group of service workers, due to heavy lifting, and then due to contusion ; and in the group of clerical workers, due to heavy lifting, then due to sprain, and then due to longtime standing in the order from the most case. 5. Regarding the results of the combined treatment of Oriental medicine and Western medicine, it appeared that 86 patients(53.8%) were in a superior state, 45 patients(28.1%) in a good, satisfactory state, 15 patients(9.4%) in the evenly improved state, 8 patients(5.1%) in a lightly improved state, and 6 patients(3.8%) in a poorly improved or inferior state, showing a valid rate of 96.2%. 6. Regarding the required period of medical treatment according to the case history of lumbago, it appeared that the acutest patients(82 patients : 51.3%) required 17.5days, the semi-acute(29 patients ; 18.1%) 20.9 days, the acute(10 patients ; 12.5%) 28.1 days, and the chronic(29 patients; 18.1%) 30.5 days(p=0.0874). Regarding the required period medical treatment according to the degree of the pain, 40 patients(25.2%) having an pain in a degree of an even ache required 18.2 days, 87 patients(54.6%) having a severe pain 22.6 days, 26 patients(16.4%) having a very severe pain 27.9 days, and 7 patients(4.6%) having a light pain 29.4 days(p=0.5857). 7. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared that in Western medicine, 57 patients(35.7%) of Accute back pain required 10.1 days, 20 patients(12.4%) of Chronic back pain 24.3% days, 57 patients(37.0%) of HNP 26 days, 19 patients(11.9%) of degenerative spondylosis 26.5 days, 4 patients(2.5%) of Spondyolisthesis 33.3 days, 1 patients(0.6%) of Spinal stenosis 25.5 days(p=0.0108) ; in Oriental medicine, 29 patients(18.2%) of Shensu-zwasum lumbago 31.7% days, 46 patients(28.8%) of Shensu lumbago 25.7 days, 27 patients(16.9%) of Zwasum-yihyul lumbago 20.6 days, 55 patients(34.4%) of Zwasum lumbago 15.5 days, 2 patients(1.3%) of Yihyul lumbago 21 days, and 1 patients(0.6%) of Shi lumbago 2 days(p=0.2762). 8. Regarding the period of medical treatment according to the diagnosed names of lumbago in case of new patients and old patients(or relapsed patients), it appeared that new patients required a period of medical treatment of 18.4 days in general or average for curing lumbago while old patients required a period of 24.1 days in general or average ; this indicates that new patients were cured earlier than old patients. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared in Oriental lumbago, when the diagnosed names was Zwasum lumbago and Yihyul lumbago, the required period of medical treatment was short ; in Western medicine, when the diagnosed name was Acute back pain, the required period of medical treatment was short ; in Western medicine, when Shensu lumbago and Shensu lumbago develop into Chronic back pain and HNP, medical treatment of them required more days ; regarding the period of medical treatment in case of new patients and old patients, new patients required a shorter period than old patients ; in particular, in case of Shensu lumbago in Oriental medicine and Chronic back pain in Western medicine, it was understandable that the required period of medical treatment necessitates more days.

과민성 방광의 개요 및 약물치료

김태형 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.3

원격탐사를 위한 병렬계산 기법

김형중,장태정,김희원,김형수,이정문,장순자 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

원격탐사에 사용되는 편미분방정식을 고속으로 풀기 위한 기법을 프로그래밍하고 성능을 향상시킬 수 있는 방법을 제시했다. 미지수가 30만개 이상되는 복소수(non-Hermitian) 행렬의 해를 구하는 프로그램을 작성했다. 이 프로그램은 C와 PVM에 기반을 두고 있다. 수렴속도를 향상시키기 위해 대각 스케일링을 이용했다. 통신속도의 개선을 위해 데이터 압축 기법을 이용했다. 수렴속도를 측정 제시함으로써 실제 문제 적용에 참고할 수 있다. Network-based computing with cluster of personal computers or workstations recently has become an important and successful technique. Network-based computing enables fast computation and resolves short of storage with computers on the desks. Cluster of inexpensive computers offers them aggregated computing power and storage to challenge very large-scale problems. Iterative solvers are used for the large sparse linear systems. Preconditioners accelerate the rate of convergence of the iterative solvers. However, parallelization accelerate the rate of convergence of the iterative solvers. However, parallelization of preconditioners is far from satisfaction so far. Thus, the simplest diagonal scaling is a good alternative for improved convergence and easy parallelization. In order to reduce communication overhead, a data compression technique is considered. Data communication time can be reduced at the cost of convergence rate. MATLAB simulation result is given in this paper. This method is effective to cluster of computers connected through slow networks.

자궁탈의 임상적 고찰

김동원,노형균,안태규,최상준,송창훈,정혁 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

The purpose of this study was to evaluate clinical aspects of prolape uteri. This clinical and statistical study was attempted to analyze 369 cases of uterine prolapse(328 cases -operated, the other cases - not operated) from Jan. 1994 to Dec. 1998 at the Department of Obstetrics and Gynecology, Chosun University Hospital. The results were as follows. 1. The incidences of uterine prolapse was 0.62% of the total admitted gynecologic patients during the study period. 2. Age distribution at the time of operation showed that 184 cases(25.6%) were 60 to 65 years of age, and 62 cases(18.2%) were 56 to 60 years of age. 3. Age distribution at the time of development of prolapse uteri showed that 134 cases(36.3%) were 21 to 30 years of age, 126 cases(34.1%) were 31 to 40 years of age. 4. 228 cases(61.7%) were those who had suffered from uterine prolapse for more 11 years and the mean durations were 15.6 years. 5. The degree of prolapse uteri showed that 281 cases(76.1%) were 3rd degree and 61 cases(16.5%) were 2nd degree. 6. The parity showed that 297 cases(80.2%) were over 4 times and 2 cases(0.27%) was nullipara. 7. The delivery place was at home in 318 cases(86.1%) and in hospital in 51 cases(13.9%). 8. The main symptoms comprised prolapse in 311 cases(84.2%), urinary frequency in 259 cases(70.1%), and bearing down sensation in 242 cases (65.8%). 9. An operation in 328 cases was carried out of 369 cases of prolapse uteri, 301 cases were treated by the vaginal hysterectomy with either anterior &osterior repair or posterior repair, 23 cases were treated by anterior &osterior repair. 10. The postoperative complications were urinary tract infection in 7 cases(2.1%), urinary retention in 4 cases(1.2%), vaginal vault prolapse in 2 cases(0.6%). 11. The indwelling foley catheter was kept for 7 days in 279 cases and the average postoperative hospitalization was around 9 days. 12. The postoperative pathologic findings were chronic cervicitis in 211 cases(67.8%), squamous metaplasia of the cervical gland in 98 cases(31.5%), adenomyosis in 69 cases, leiomyoma in 47 cases, and dysplasia of cervix, cervical polyp, endometrial polyp were also resulted. In conclusion, clinical features of uterine prolapse were studied. The clinical evaluation of uterine prolapse include age, parity, degree of prolapse, delivery site, age of onset, symptomatology, type of operation, complications, the results of histopathological examinations. Further study is necessary before these aspects can be implicated in the clinical evaluation of uterine prolapse.

금속 결합제를 사용한 Nd-Fe-B 영구자석에 관한 연구

金炯太,金學信 全北大學校 1994 論文集 Vol.38 No.-

Recently there has been a great deal of interests Nd-Fe-B permanent magnet materials because of the broad availability, the low cost of constituents and impressive magnetic properties. Powder metallurgical method is mostly used for fabrication of Nd-Fe-B hard magnets. Nd-Fe-B plastic magnets are fabricated by mixing melt spun magnetic powders with resin. In this study metal powders as a binder are used. MQ powder and Nd-Fe-B alloy powder by mechanical grinding compacted, heat-treated and hot-pressed with additive Zn, Ag-Zn, Al-Cu binders and the magnetic properties on two kinds of permanent magnets were investigated with DC-fluxmeter, SEM and AES. The results obtained in this experiment are as follows; 1. Nd-Fe-B isotropic magnets with mechanical grinding and additive Zn, Ag-Zn, Al-Cu were fabricated, but obtained not above B_r 4.5kG because of no densitification. 2. Nd-Fe-B isotropic magnet which used MQ powder with additive 6wt% Zn and heat-treated at 650℃ for 1 hour is increased to _iH_c 2.7kOe, while Nd-Fe-B magnet with additive 6wt% Ag-Zn at 700℃ for 1 hour is increased _iH_c 5.5kOe. 3. Nd_16Fe_78B_6 isotropic permanent magnet which added Al-Cu 3wt% and hot-pressed at 700℃ is obtained B_r 6.7kG, _iH_c 18.4kOe.

평판과 보의 연성구조물의 진동에너지 전달특성 분석에 관한 연구

김정태,이형택 弘益大學校 科學技術硏究所 1989 科學技術硏究論文集 Vol.9 No.1

The transmission of sound and vibration through structures is of interest in many noise control problems, including architectural acoustics, sound transmission through air craft, spacecraft and ship, and transmission of noise through machinery and engine enclosures. Statistical Energy Analysis provides a simple and accurate method of approaching these problems. In this paper, comparing the measured coupling loss factor of plate-beam with measured coupling loss factor of mass on the junction will be inspected.