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비글개에서 l-muscone의 급성독성 및 아급성독성시험 연구
유아선,권오경,성하정,곽형일,방명주,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of l-muscone, a major active ingredient of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dosage of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of l-muscone, 0.2㎎/㎏/day(low dosage group), 2 ㎎/㎏/day(middle dosage group), or 20 ㎎/㎏day(high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korean Food and Drug Administration(1996.4.16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ on oral route for both male and females. In animals administered with l-muscone, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, eye examination, hematology, serum chemistry, organ weight and other findings. No histolopathological lesions were observed in both control and treatment groups. Above data strongly suggest that l-muscone in beagle dogs is considered to be safe.
임병선,이점숙,조승원,양효식,김명화,곽애경 木浦大學校 沿岸環境硏究所 1995 沿岸環境硏究 Vol.12 No.1
The nutrient removal-capacity of four major dominant species distributed in Namchang-chon polluted with livestock wastewater and Samhyang-chon polluted with industrial and domestic wastewater were investigated. Water qualities and soil properties of three polluted sites were a quite different in concentration of nitrogen, SS and Ga. Dominant species in livestock wasetewater were Persicaria thunbergii, Zizania latiforia, Phragmites communis and Oenanthe japanica, those in industrial and domestic were Phragmites communis. Changes of NO₃-N, NH₄-N and P concentrations of culture solution are high in cultivor of Zizania latiforia and Oenanthe japanica. All four species removed NO₃-N most effectively. In experiment used directely polluted water from three areas ; all species from livestock wasetewater uptaked NO₃-N effectively. Phragmites communis from domestic, and Persicaria thunbergii and Oenanthe japanica from industrial and domestic wasetewater removed NH₄-N effectively. All species cultured in industrial waserewater removed P well, and Phragmites communis and Persicaria thunbergii cultured in domestic wastewater removed it moderately.
Kwak, Jae-Hwan,Won, Sun-Woo,Kim, Tae-Jeong,Roh, Eun-Mi-Ri,Kang, Han-Young,Lee, Hyo-Won,Jung, Jae-Kyung,Hwang, Bang-Yeon,Kim, Young-Soo,Cho, Jung-Sook,Lee, Hee-Soon 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
A series of chroman-2-carboxylic acid N-(substituted)phenylamides (2a-s, 3a-j) were synthesized. Their ability to inhibit nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) activity was evaluated in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells and their antioxidant activity was examined. $NF-{\kappa}B$ inhibition by chroman compounds was not related to their antioxidant activity. Compounds with -H,$-NO_2$ monosubstituents and $-OCH_3,\;-CF_3$ disubstituents on the phenyl ring were poor inhibitors of $NF-{\kappa}B$ activity. Compounds with $-CH_3,\;-CF_3,\;-CI$ monosubstituents or -CI, $-CH_3$ disubstituents exhibited moderate to good $NF-{\kappa}B$ activity inhibition $(IC_{50}:\;18.2-95.8\;{\mu}M)$. The most active $NF-{\kappa}B$ inhibitor, 2s, contained a 4-CI $(IC_{50}:\;18.2\;{\mu}M)$ substituent on the phenyl ring and was slightly more potent than the compound KL-1156 (1) $(IC_{50}:\;43.9\;{\mu}M)$.
A Study on the Processing Standard of REALGAR
Kwak, Hwa-Sun,Byun, Young-Ho,Lee, Soo-Chan,Lee, Hyo-Jeong,Park, Seong-Cheol,Kim, Hye-Sung,Kwon, Dong-Yeul 대한한약학회 2010 Journal of oriental pharmacy Vol.3 No.1
While herbal medicine including mineral herbal medicine mostly provides microelements to the human body thanks to abundant metallic elements, its harmfulness has been raised due to elements of heavy metals. Harmfulness of mineral herbal medicine needs to be analyzed quantitatively as well as qualitatively so that specificity of herbal medicine including mineral herbal medicine can be reflected. Consequently, the following aims should be set up to mineral herbal medicine, REALGAR, standard processing of REALGAR and the standards of processed drugs should be secured. On the basis of the results of this study, the reasonable measures to develop the processing method and the test method for heavy metals were presented. Such measures are expected to give the following results. First, consumers may take food and medicine without anxiety, and food and medicine may be effectively managed, and the national service may be improved, and also safety against heavy metals may be publicized. Second, as the principal ingredients and microelements of mineral herbal medicine are qualitatively analyzed, such results are expected to contribute to the advance of national analytics for herbal medicine.
( Hyo Jin Lee ),( Jaeyoung Cho ),( Nakwon Kwak ),( Sun Mi Choi ),( Jinwoo Lee ),( Chang-hoon Lee ),( Young Sik Park ),( Sang-min Lee ),( Chul-gyu Yoo ),( Young Whan Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: In general populations, short and long duration of sleep negatively affect health-related quality of life (HRQOL). However, the association of sleep duration with HRQOL in patients with chronic kidney disease (CKD) remains uncertain. Methods: In this cross-sectional study, data from 1,659 adult participants with CKD enrolled in the 2007- 2015 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. CKD was defined by estimated glomerular filtration rate < 60 ml/min/1.73m2, using the CKD Epidemiology Collaboration creatinine equation. Participants were categorized into three groups according to self-reported sleep duration < 6 (short sleeper), 6-8, and > 8 hours (long sleeper). HRQOL was measured with the European Quality of Life-5 Dimensions (EQ-5D) index. Results: In multiple linear regression, short and long sleep duration were associated with lower EQ- 5D index (β= -0.030; 95% confidence interval [CI], -0.050 to -0.009 for short sleepers; β= -0.033 ; 95% CI, -0.061 to -0.005 for long sleepers). The adjusted EQ-5D index was 0.814 (95% CI, 0.796 to 0.831) for short sleepers, 0.849 (95% CI, 0.838 to 0.859) for 6 to 8-hour sleepers, 0.809 (95% CI, 0.783 to 0.835) for long sleepers (P < 0.001). In subgroup analysis, there was a statistically significant interaction between sleep duration and depression (P for interaction = 0.047). Short and long sleep duration were not associated lower HRQOL in patients with CKD and depression (P = 0.668 and P = 0.068, respectively) whereas its associations were significant in those without depression. Conclusions: In patients with CKD, both short and long sleep duration were associated with poor HRQOL. However, sleep duration was not associated with self-reported HRQOL in patients with CKD and depression.
Nonlinear dynamic analysis of RC frames using cyclic moment-curvature relation
Kwak, Hyo-Gyoung,Kim, Sun-Pil,Kim, Ji-Eun Techno-Press 2004 Structural Engineering and Mechanics, An Int'l Jou Vol.17 No.3
Nonlinear dynamic analysis of a reinforced concrete (RC) frame under earthquake loading is performed in this paper on the basis of a hysteretic moment-curvature relation. Unlike previous analytical moment-curvature relations which take into account the flexural deformation only with the perfect-bond assumption, by introducing an equivalent flexural stiffness, the proposed relation considers the rigid-body-motion due to anchorage slip at the fixed end, which accounts for more than 50% of the total deformation. The advantage of the proposed relation, compared with both the layered section approach and the multi-component model, may be the ease of its application to a complex structure composed of many elements and on the reduction in calculation time and memory space. Describing the structural response more exactly becomes possible through the use of curved unloading and reloading branches inferred from the stress-strain relation of steel and consideration of the pinching effect caused by axial force. Finally, the applicability of the proposed model to the nonlinear dynamic analysis of RC structures is established through correlation studies between analytical and experimental results.