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Hyebin Lee,Hee Chul Park,Won Park,Doo Ho Choi,Young-Il Kim,Young Suk Park,Joon Oh Park,Ho-Kyung Chun,Woo-Yong Lee,Hee Cheol Kim,Seong Hyeon Yun,Yong Beom Cho,Yoon Ah Park 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.3
Purpose: Although anemia is considered to be a contributor to intra-tumoral hypoxia and tumor resistance to ionizing radiation in cancer patients, the impact of pretreatment anemia on local control after neoadjuvant concurrent chemoradiotherapy (NACRT) and surgery for rectal cancer remains unclear. Materials and Methods: We reviewed the records of 247 patients with locally advanced rectal cancer who were treated with NACRT followed by curative-intent surgery. Results: The patients with anemia before NACRT (36.0%, 89/247) achieved less pathologic complete response (pCR) than those without anemia (p = 0.012). The patients with pretreatment anemia had worse 3-year local control than those without pretreatment anemia (86.0% vs. 95.7%, p = 0.005). Multivariate analysis showed that pretreatment anemia (p = 0.035), pathologic tumor and nodal stage (p = 0.020 and 0.032, respectively) were independently significant factors for local control. Conclusion: Pretreatment anemia had negative impacts on pCR and local control among patients who underwent NACRT and surgery for rectal cancer. Strategies maintaining hemoglobin level within normal range could potentially be used to improve local control in rectal cancer patients.
Lee, Hyebin,Kim, Kwangsoo,Woo, Jongmin,Park, Joonho,Kim, Hyeyoon,Lee, Kyung Eun,Kim, Hyeyeon,Kim, Youngsoo,Moon, Kyung Chul,Kim, Ji Young,Park, In Ae,Shim, Bo Bae,Moon, Ji Hye,Han, Dohyun,Ryu, Han Suk American Society for Biochemistry and Molecular Bi 2018 Molecular and Cellular Proteomics Vol.17 No.9
<P>Cytological examination of urine is the most widely used noninvasive pathologic screen for bladder urothelial carcinoma (BLCA); however, inadequate diagnostic accuracy remains a major challenge. We performed mass spectrometry-based proteomic analysis of urine samples of ten patients with BLCA and ten paired patients with benign urothelial lesion (BUL) to identify ancillary proteomic markers for use in liquid-based cytology (LBC). A total of 4,839 proteins were identified and 112 proteins were confirmed as expressed at significantly different levels between the two groups. We also performed an independent proteomic profiling of tumor tissue samples where we identified 7,916 proteins of which 758 were differentially expressed. Cross-platform comparisons of these data with comparative mRNA expression profiles from The Cancer Genome Atlas identified four putative candidate proteins, AHNAK, EPPK1, MYH14 and OLFM4. To determine their immunocytochemical expression levels in LBC, we examined protein expression data from The Human Protein Atlas and in-house FFPE samples. We further investigated the expression of the four candidate proteins in urine cytology samples from two independent validation cohorts. These analyses revealed AHNAK as a unique intracellular protein differing in immunohistochemical expression and subcellular localization between tumor and non-tumor cells. In conclusion, this study identified a new biomarker, AHNAK, applicable to discrimination between BLCA and BUL by LBC. To our knowledge, the present study provides the first identification of a clinical biomarker for LBC based on in-depth proteomics.</P>
Subjective Experience on Virtual Reality-Assisted Mental Health Promotion Program
Hyebin Ko,Hyun Ju Lim,Jeonghyun Park,Kyungwon Kim,Hwagyu Suh,Byung Dae Lee,Young Min Lee,Eunsoo Moon,Du-Ri Kim,Jong-Hwan Park,Myung-Jun Shin,Yean-Hwa Lee 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.4
Objective Mental health promotion programs using virtual reality (VR) technology have been developed in various forms. This study aimed to investigate the subjective experience of a VR-assisted mental health promotion program for the community population, which was provided in the form of VR experience on a bus to increase accessibility.Methods Ninety-six people participated in this study. The relationship between the subjective experience and mental health states such as depression, anxiety, perceived stress, and quality of life was explored. The subjective experience on depression and stress before and after VR program treatment was compared using the Wilcoxon signed-rank test. The satisfaction with the VR-assisted mental health promotion program was examined after using the VR program.Results The VR-assisted mental health promotion program on a bus significantly improved subjective symptoms such as depression (p=0.036) and perceived stress (p=0.010) among all the participants. Among the high-risk group, this VR program significantly relieved subjective depressive feeling score (p=0.033), and subjective stressful feeling score (p=0.035). In contrast, there were no significant changes in subjective depressive feelings (p=0.182) and subjective stressful feelings (p=0.058) among the healthy group. Seventy-two percent of the participants reported a high level of satisfaction, scoring 80 points or more.Conclusion The findings of this study suggest that the VR-assisted mental health promotion program may effectively improve the subjective depressive and stressful feelings. The use of VR programs on buses to increase of accessibility for the community could be a useful approach for promoting mental health among the population.
Hyebin Hwang,Seyoung Lee,Kyung-won Park,Eun-bee Lee,Tae-Young Kang,Jong-pil Seo,Hyohoon Jeong 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.2
A seven-month pregnant four-year-old Thoroughbred mare with colic weighing 600 kg was referred to the Jeju National University Equine Hospital. A physical examination and ultrasound suggested epiploic foramen entrapment. The patient underwent ileum resection and end-to-side jejunocecostomy. After surgery, the horse showed a consistent pain when introduced to feeding. A repeat laparotomy was performed to enlarge the stoma size with side-to-side jejunocecostomy. The repeat laparotomy was successful, and the mare gave birth uneventfully. This report describes a case of small intestinal epiploic foramen entrapment and the clinical outcomes of the 2 consecutive laparotomies a Thoroughbred mare in late gestation.
Lee, Hyebin,Park, Hee Chul,Park, Won,Choi, Doo Ho,Kim, Young-Il,Park, Young Suk,Park, Joon Oh,Chun, Ho-Kyung,Lee, Woo-Yong,Kim, Hee Cheol,Yun, Seong Hyeon,Cho, Yong Beom,Park, Yoon Ah The Korean Society for Radiation Oncology 2012 Radiation Oncology Journal Vol.30 No.3
Purpose: Although anemia is considered to be a contributor to intra-tumoral hypoxia and tumor resistance to ionizing radiation in cancer patients, the impact of pretreatment anemia on local control after neoadjuvant concurrent chemoradiotherapy (NACRT) and surgery for rectal cancer remains unclear. Materials and Methods: We reviewed the records of 247 patients with locally advanced rectal cancer who were treated with NACRT followed by curative-intent surgery. Results: The patients with anemia before NACRT (36.0%, 89/247) achieved less pathologic complete response (pCR) than those without anemia (p = 0.012). The patients with pretreatment anemia had worse 3-year local control than those without pretreatment anemia (86.0% vs. 95.7%, p = 0.005). Multivariate analysis showed that pretreatment anemia (p = 0.035), pathologic tumor and nodal stage (p = 0.020 and 0.032, respectively) were independently significant factors for local control. Conclusion: Pretreatment anemia had negative impacts on pCR and local control among patients who underwent NACRT and surgery for rectal cancer. Strategies maintaining hemoglobin level within normal range could potentially be used to improve local control in rectal cancer patients.
Lee, Eonju,Kim, Tae Gyu,Park, Hee Chul,Yu, Jeong Il,Lim, Do Hoon,Nam, Heerim,Lee, Hyebin,Lee, Joon Hyeok The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.3
Purpose: To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT). Materials and Methods: This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4 fractions for group A lesions (n = 15) and 50 Gy in 10 fractions for group B lesions (n = 21). Results: The median follow-up period was 7 months (range, 2 to 16 months). Seven patients developed grade 1 or 2 gastrointestinal toxicity, and one developed grade 2 leucopenia. Compression fractures occurred in association with 25% of the lesions, with a median time to fracture of 2 months. Pain relief occurred in 92.3% and 68.4% of group A and B lesions, respectively. Radiologic response (complete and partial response) occurred in 80.0% and 61.9% of group A and B lesions, respectively. The estimated 1-year spinal-tumor progression-free survival rate was 78.5%. The median overall survival period and 1-year overall survival rate were 9 months (range, 2 to 16 months) and 25.7%, respectively. Conclusion: SBRT for spinal metastases from HCC is well tolerated and effective at providing pain relief and radiologic response. Because compression fractures develop at a high rate following SBRT for spinal metastases from primary HCC, careful follow up of the patient is required.
부유식 풍력-파력발전 플랫폼과 탑재된 파력발전기와의 단방향 연성 운동 해석
이혜빈(Hyebin Lee),배윤혁(Yoon Hyeok Bae),조일형(Il-Hyoung Cho) 한국해양공학회 2016 韓國海洋工學會誌 Vol.30 No.2
In this study, a six degree-of-freedom motion analysis of a wind-wave hybrid platform equipped with numerous wave energy converters (WECs) was carried out. To examine the effect of the WECs on the platform, an analysis of one-way coupling was carried out, which only considered the power take-off (PTO) damping of the static WECs on the platform. The equation of motion of a floating platform with mooring lines in the time domain was established, and the responses of the one-way coupled platform were then compared with the case of a platform without any coupling effects from the WECs. The hydrodynamic coefficients and wave exciting forces were obtained from the 3D diffraction/radiation pre-processor code WAMIT based on the boundary element method. Then, an analysis of the dynamic responses of the floating platform with or without the WEC effect in the time domain was carried out. All of the dynamics of a floating platform with multiple wind turbines were obtained by coupling FAST and CHARM3D in the time domain, which was further extended to include additional coupled dynamics for multiple turbines. The analysis showed that the PTO damping effect on platform motions was negligible, but coupled effects between multiple WECs and the platform may differentiate the heave, roll, and pitch platform motions from the one without any effects induced by WECs.