http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Elevation of C-Reactive Protein Level is Associated with High-Risk Adenoma
( Hye-jin Ki ),( Hyae Min Lee ),( Jae Myung Cha ),( Jung Won Jeon ),( Hyun Phil Shin ),( Il Hyun Baek ),( Kwang Ro Joo ),( Joung Il Lee ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background: There has been growing evidence supporting the role of inflammation in the pathogenesis of colorectal cancer, recently. However, the associations between serum CRP, a serologic marker of the inflammatory reactions and risk of CRC have been inconsistent, and few studies are known about the association between serum CRP and risk of colorectal adenoma. Thus, we aimed to examine whether risk of colorectal adenoma is associated with serum CRP levels. Methods: A retrospective cross sectional study was performed on a first-time screening colonoscopy performed for asymptomatic subjects, who checked serum CRP level during a routine health check-up, between September 2006 and September 2009in Korea. Serum CRP levels were compared between high- and low-risk adenoma groups, and multivariate regression analysis was performed to determine independent predictors of the high risk adenoma. Results: A total of 3,308 patients were finally enrolled, and patients with high (>0.5 mg/L) serum CRP level was significantly higher in HRAs group than those in LRAs group (8.8% vs. 4.7%, p=0.009). Proportion of subjects with a high-risk adenoma were more frequently included in the high CRP group than low CRPgroup (11.0% vs. 5.9%, p=0.009). Compared with the lowest quartiles of CRP level, the prevalence of high-risk adenoma was 3.5 times higher in highest quartiles (p=0.000). In logistic regression analysis, higher quartiles of CRP was found to be an independent risk factor of high-risk adenomas (odds ratio=1.8, 95% confidence interval=1.3-2.5, p=0.000). Conclusions: Elevated plasma CRP levels are associated with a risk of high-risk colorectal adenoma. These data might be support the hypothesis that inflammation is a risk factor for the development of colorectal neoplasia.
Roles of Islet Toll-Like Receptors in Pig to Mouse Islet Xenotransplantation
Ro, Han,Lee, Eun Won,Hong, Joo Ho,Han, Kyu Hyun,Yeom, Hye-Jung,Kim, Hwa Jung,Kim, Myung-Gyu,Jung, Hye Seung,Oh, Kook-Hwan,Park, Kyong Soo,Ahn, Curie,Yang, Jaeseok SAGE Publications 2013 Cell transplantation Vol.22 No.9
<P>Although innate immunity plays important roles in xenograft rejection, there have been few studies on the role of toll-like receptors (TLRs) in xenotransplantation. Furthermore, most studies focused on the recipient's TLRs. Therefore, we investigated whether TLRs in porcine islets can contribute to islet xenograft rejection. Adult porcine islets were isolated and stimulated by polyinosinic/polycytidylic acid (poly I:C) or lipopolysaccharide (LPS). Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1). Porcine islet supernatants stimulated by TLR agonists induced chemotaxis of human leukocytes. They also induced procoagulant activation (tissue factor and fgl-2). However, TLR stimulation did not influence insulin secretion. When porcine MyD88 was knocked down using shRNA lentivirus, TLR-mediated induction of proinflammatory mediators and procoagulants was attenuated. When LPS was injected to MyD88 or TLR4 knockout mice after porcine islet transplantation, LPS stimulation on donor islets interfered with islet xenograft tolerance induction by anti-CD154 antibodies. Inflammatory cell infiltration and expression of proinflammatory chemokines and cytokines in islet xenografts also increased. In conclusion, TLR activation in porcine islets induced both a proinflammatory and procoagulant response and thereby contributed to xenograft rejection.</P>
Roles of Toll-Like Receptors in Allogeneic Islet Transplantation
Ro, Han,Hong, Juho,Kim, Beom Seok,Lee, Eun Won,Kim, Myung-Gyu,Han, Kyu Hyun,Yeom, Hye-Jung,Lee, Eun Mi,Jeong, Jong Cheol,Oh, Kook-Hwan,Ahn, Curie,Yang, Jaeseok Lippincott Williams Wilkins, Inc. 2012 Transplantation Vol.94 No.10
BACKGROUND: Toll-like receptors (TLRs) are involved in the rejection of solid organ allografts. However, the roles of TLRs in islets are still controversial. We investigated the roles of TLRs in donor islets together with those in recipients in allogeneic islet transplantation. METHODS: To assess the roles of TLRs in either donor islets or recipients, allogeneic islet transplantation was performed using myeloid differentiation factor 88 (MyD88)-knockout (KO), TLR4-KO, or Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-&bgr; (TRIF)-KO mice. RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-&ggr;–inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-&bgr; promoter stimulator-1-KO, and TLR4-KO mice. When islets from MyD88-KO, TLR4-KO, or TRIF-KO C57BL/6 mice were transplanted to BALB/c recipients, graft survival was not better than that of wild-type (WT) islets. However, the survival of the MyD88-KO islet allograft was significantly prolonged when combined with anti-CD40L. In parallel, LPS stimulation in donor islets interfered with anti-CD40L blockade-mediated long-term survival of islet allografts in TLR4-KO recipients. LPS stimulation increased the perigraft infiltration of both T cells and macrophages. Then again, when islets from WT BALB/c mice were transplanted to MyD88-KO, TRIF-KO, or WT C57BL/6 mice, there was no difference in graft survival, although some of the MyD88-KO recipients obtained long-term graft survival. However, anti-CD40L prolonged graft survival significantly in MyD88-KO recipients. The absence of MyD88 in either donors or recipients decreased the perigraft infiltration of inflammatory cells when combined with anti-CD40L. CONCLUSIONS: TLRs in both donor islets and recipients are involved in islet allograft rejection.
한국인 아토피피부염 환자에서 동반된 피부질환에 대한 연구: 다기관 연구
이혜인 ( Hye In Lee ),한태영 ( Tae Young Han ),서성준 ( Seong Jun Seo ),김도원 ( Do Won Kim ),김명남 ( Myeung Nam Kim ),김문범 ( Moon Bum Kim ),김일환 ( Il Hwan Kim ),노영석 ( Young Suck Ro ),박영립 ( Young Lip Park ),박영민 ( You 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Background: Dermatological diseases can occur with atopic dermatitis. Objective: The purpose of this study was to analyze diseases associated with atopic dermatitis in Koreans. Methods: From November, 2007, to May, 2008, 948 patients with atopic dermatitis who visited the department of dermatology at 19 hospitals were evaluated for associated diseases. Results: Of 948 patients, 53.8% (510) had symptoms associated with other dermatological diseases. In order of frequency, diseases associated with atopic dermatitis included acne, hand/foot eczema, seborrheic dermatitis, urticaria, warts, and recurrent herpes simplex. The number of associated diseases did not change significantly with the severity of atopic dermatitis. However, the incidence of hand/foot eczema and eczema herpeticum correlated significantly with the severity of atopic dermatitis. Conclusion: There is a distinct pattern of diseases associated with atopic dermatitis in Koreans. (Korean J Dermatol 2010;48(3):191~197)
신혜원 ( Hye Won Shin ),강명승 ( Myung Seung Kang ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Plasma cell cheilitis is a rare, idiopathic, benign inflammatory disease of lips, characterized by dense plasma cell infiltrates in the upper dermis. It presents as erythematous patches with erosion usually on the lower lip of elderly people. Although, various therapeutic options, including topical steroids, intralesional injection of glucocorticoids, oral nystatin and topical antibiotics have been tried, none of them is promising. A 68-year-old woman presented with a 4-month history of erosive patches with crusts on her lower lip, which was resistant to topical corticosteroids. A histopathologic examination revealed dense inflammatory cell infiltration mainly consisting of plasma cells in the dermis, consistent with plasma cell cheilitis. She was treated with topical pimecrolimus and after 2 weeks of application, the lesion started to get better. After 7 weeks it had almost disappeared. Herein, we present a case of plasma cell cheilitis treated with topical application of pimecrolimus. (Korean J Dermatol 2008;46(8):1061~1064)