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Bioactive Metabolites from the Fruits of Psoralea corylifolia.
Won, Tae Hyung,Song, Inn-Hye,Kim, Kuk-Hwa,Yang, Woo-Young,Lee, Sang Kook,Oh, Dong-Chan,Oh, Won-Keun,Oh, Ki-Bong,Shin, Jongheon American Society of Pharmacognosy ; American Chemi 2015 Journal of natural products Vol.78 No.4
<P>Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).</P>
( Hye Jung Park ),( Kyung Hee Park ),( Jae Hyun Lee ),( Jung Won Park ),( Chein Soo Hong ),( Kyu Rang Kim ),( Mae Ja Han ),( Hosoeng Choe ),( Jae Won Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The amount of airborne pollen is considered to be related to sensitization rates. The sensitization rates to tree pollen significantly increased and those to grass and weed pollen decreased over the last 30 years in South Korea. We evaluated short term changes of sensitization rates and the correlation with pollen counts. Methods: We assessed the number of pollen grains collected in Seoul. Tree pollen of the 15 species, weed pollen of the 8 species and grass were studied from January 1, 2007 to December 31, 2013. We retrospectively reviewed the results of 4,442 skinprick tests (SPTs) to 33 common inhalant allergens conducted in the Severance Hospital allergy clinics in Seoul from January 1, 2008 to December 31, 2013. Results: The pollen counts of tree, especially pine and corylus, and grass significantly decreased, as years go by. SPT results showed that the skin reactivity to grass significantly increased from 6.9% in 2008 to 14.0% in 2013. The sensitization rates to tree and weed pollen had no changes. In the details, the sensitization rates to Walnut, Popular, Bermuda, Timothy and Dandelion significantly increased. There was significant correlation between rate of change in pollen counts and sensitization rates to oak and hop J (Humulus japonicus). However, the others showed no correlation. Conclusions: Decrease tendency of pollen counts was observed in Seoul, over the seven years. Some species showed significant correlation between pollen counts and sensitization rates over the six years.
( Hye Yun Park ),( Byeong Ho Jeong ),( Won Jung Koh ),( Eun Kyung Kim ),( Seong Yong Lim ),( Ji Hyun Lee ),( Yeon Mok Oh ),( Sang Do Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Adiponectin and leptin regulate metabolic and in ammatory systems reciprocally. In COPD, leptin was associated with BODE index and adiponectin was proved as a biomarker associated with radiologic-assessed emphysema. However, there are limited data of adiponectin/leptin ratio on longitudinal association of lung function and emphysema. The objective of this study is to investigate the predictable role of adiponectin/leptin ratio on the COPD progression. Methods: Two hundred five COPD subjects in this study were taken from Korean Obstructive Lung Disease (KOLD) cohort. The subjects extracted from the KOLD cohort met all of the following criteria (1) diagnosed with COPD, i.e., postbronchodilator FEV1/ FVC < 0.7 and more than 10 pack-years of smoking history as well as no or minimal abnormality on chest radiographs; (2) with follow-up of at least 3 years; (3) with blood sample at enrollment and (4) with pulmonary function test and chest CT scan results during follow-up period. Results: Plasma adiponectin concentration were positively related to initial computed tomography-determined % emphysema (coeffi cient, 11.699; 95% CI, 2.739 20.660; Adjusted P = 0.011), while plasma leptin concentration had a significant inverse correlation with initial FEV1 (adjusted coeffi cient, -0.187; 95% CI, -0.369 -0.005; Adjusted P = 0.044). Unexpectedly, increased plasma ratio of adiponectin to leptin was signifi cantly associated with reduced rate of progression of % emphysema over 3 years (adjusted coeffi cient, -1.464; 95% CI, -2.664 -0.264; Adjusted P = 0.017), while plasma ratio of adiponectin to leptin had no relationship with FEV1 decline over 3 years. Conclusions: The directionality of association between plasma adiponectin and tomography- determined % emphysema is uncertain, however, the inverse relationship between plasma adiponectin/leptin ratio and change of % emphysema might suggest a protective role of adiponectin to development of emphysema.
Oh-Hyun Lee,김영대,김중선,Nak-Hoon Son,박희남,정보영,Cheol Woong Yu,Hyun-Jong Lee,Woong Chol Kang,Eun-Seok Shin,Rak-kyeong Choi,Do-Sun Lim,Yo Han Jung,Hye-Yeon Choi,Kyung-Yul Lee,Bang-Hoon Cho,Sang Won Han,Joong 대한심장학회 2021 Korean Circulation Journal Vol.51 No.7
Background and Objectives: Prior studies have shown that stroke patients treated with percutaneous left atrial appendage occlusion (LAAO) for non-valvular atrial fibrillation (NVAF) experience better outcomes than similar patients treated with warfarin. We investigated the impact of percutaneous left atrial appendage closure on post-stroke neurological outcomes in NVAF patients, compared with non-vitamin K antagonist oral anticoagulant (NOAC) therapy. Methods: Medical records for 1,427 patients in multiple registries and for 1,792 consecutive patients at 6 Korean hospitals were reviewed with respect to LAAO or NOAC treatment. Stroke severity in patients who experienced ischemic stroke or transient ischemic attack after either treatment was assessed with modified Rankin Scale (mRS) scoring at hospital discharge and at 3 and 12 months post-stroke. Results: mRS scores were significantly lower in LAAO patients at 3 (p<0.01) and 12 months (p<0.01) post-stroke, despite no significant differences in scores before the ischemic cerebrovascular event (p=0.22). The occurrences of disabling ischemic stroke in the LAAO and NOAC groups were 36.7% and 44.2% at discharge (p=0.47), 23.3% and 44.2% at 3 months post-stroke (p=0.04), and 13.3% and 43.0% at 12 months post-stroke (p=0.01), respectively. Recovery rates for disabling ischemic stroke at discharge to 12 months post-stroke were significantly higher for LAAO patients (50.0%) than for NOAC patients (5.6%) (p<0.01). Conclusions: Percutaneous LAAO was associated with more favorable neurological outcomes after ischemic cerebrovascular event than NOAC treatment.
Case of Cap Polyposis with Good Response of Steroid Therapy
( Hye Young Lee ),( Hang Lak Lee ),( Kang Nyeong Lee ),( Dae Won Jun ),( Oh Young Lee ),( Ho Soon Choi ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Introduction: Cap polyposis is rare, characterized by fibrinopurulent exudates covering the surface of the polyp on colonoscopic examination. Themost commonly involved sites are the sigmoid colon and rectum. An effective treatment has not been established yet. We described case of cap polyposiswith good response of steroid therapy. Case: A 43-year-old woman was admitted for bloody diarrhea for 2 months. She had experienced abdominal pain and diarrhea 6 months ago. On admission, the patient’s vital signs were within normal limit. There were no abnormal laboratories or physical findings. Enhanced abdominal computed tomography scan showed was nonspecific finding. Colonoscopy was performed and there were multiple erythematous polyps with caps of purulent exudates in sigmoid colon and rectum. Histopathologic evaluation revealed inflammatory polyp and exudates of the mucosal surface. Following steroid therapy(predinisolone 30 mg/day for 2 weeks, 25 mg/day for 2 weeks, 20 mg/day for 3 months), symptoms improved. And we performed a follow up colonoscopy after three months. It showed healed colon mucosa with some scar changes. Conclusions: We should consider cap polyposis if multiple colon polyps with caps of exudates. And steroid therapy is an effective treatment in patients with cap polyposis.
Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
( Hye Jeong Kim ),( Yoon Young Cho ),( Sun Wook Kim ),( Tae Hyuk Kim ),( Hye Won Jang ),( Soo-youn Lee ),( Suk-joo Choi ),( Cheong-rae Roh ),( Jong-hwa Kim ),( Jae Hoon Chung ),( Soo-young Oh ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. Methods: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies. Serum thyroid stimulating hormone (TSH) and free thyroxine were measured using an immunoradiometric assay. Urine iodine concentration was measured using inductively coupled plasma-mass spectrometry in 275 women. Reference ranges of thyroid hormones were determined according to the guidelines of the National Academy of Clinical Biochemistry. Pregnancy and perinatal outcomes were compared according to maternal thyroid function. Results: The reference ranges of serum TSH were 0.03 to 4.24 mIU/L in the first trimester, 0.13 to 4.84 mIU/L in the second trimester, and 0.30 to 5.57 mIU/L in the third trimester. Pregnancy and perinatal outcomes did not vary in mothers with subtle changes in thyroid function. Conclusions: Trimester-specific thyroid hormone reference intervals in Korean pregnant women differ from those of other countries with different iodine nutrition status and ethnicity. The establishment of population-based, reliable trimester-specific reference intervals is critical for the interpretation of thyroid function in pregnant women to avoid unnecessary tests and treatments.
( Hye Ree Park ),( Ji Hee Jung ),( Dong Geon Lee ),( Kyung Jae Lee ),( Jee Hye Oh ),( Eu Jin Lee ),( Song Hee Park ),( Yang Won Lee ),( Seongju Lee ),( Hoon Kang ),( Jung Eun Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Malassezia species are associated with several common dermatologic conditions including pityriasis versicolor, seborrheic dermatitis, folliculitis, and atopic dermatitis and dandruff. However, its causal role remains to be established. Objectives: We intended to explore the role of inflammasome activation in human keratinocytes in response to three different Malassezia species. Methods: We compared the different activation patterns of inflammasomes and the expression of proinflammatory cytokines and antimicrobial peptides by three different Malassezia species―M. restricta, M. globosa, and M. sympodialis―in human keratinocytes. Results: We found that different Malassezia species, especially M. restricta, and M. globosa could induce nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin-domain-containing protein (NLRP)3- apoptosis-associated speck-like protein containing CARD (ASC) inflammasome activation and subsequent interleukin (IL)-1β secretion in human keratinocytes. Malassezia species variably induced thymic stromal lymphopoietin, β -defensin 2, and LL-37. IL-6 mRNA and IL-22 protein significantly increased in the M. sympodialis-treated group, and CCL17 and CCL27 mRNA were increased in response to M. globosa-treated keratinocytes. Conclusion: Our data show that various species of Malassezia promote variable inflammatory responses in keratinocytes by activating NLRP3 inflammasomes, pro-inflammatory cytokines and chemokines, and antimicrobial peptides.