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남은우,사카마키 히로유키,조은주,조혜전 고신대학교 보건과학연구소 2002 보건과학연구소보 Vol.12 No.-
This research is based on the drastically increased occurrence and death rate of diabetes recorded within the past ten years and the analysis of the Korean government's Diabetes Mellitus Management system in Korea in handling this alarming problem. The information used for this analysis is based on documents and statistics from the Ministry of Health and Welfare Statistics(2001, 2002) and also, health insurance statistics and documents from the National Health Insurance Corporation, 2001. The analysis of Health Plan 2010 will also be a key issue discussed in this paper. The Korean government's Diabetes Mellitus Management Plan's aim of increasing the life and healthy life expectancy while decreasing the medical costs at the same time is considered as a vital link in the government's Chronic Disease Management Plan. The main aim is to decrease the death rate, due to diabetes, from 22.6 people in 2000 to 19.0 by the year 2010. Health Plan 2010 plans to increase the role of public health centers. It also plans to form a system that will be used as a device in decreasing chronic diseases such as high blood pressure, diabetes and increasing general health by using the strategies of Health Plan 2010 against diabetes -to increase the government's role in public health. Korea's death rate, due to diabetes, is 2.2 times higher than that of Japan. Korea's being 22.6% compared to that of Japan which is only 10.1%. From now on our concerns should be directed in education and manpower. We need to have more specialized personnel who can be responsible for the nutrition, exercise, prevention and care of the public. Education is the fundamental basis for the control of Diabetes and is known throughout the world as the most cost-effective treatment. From this point on, the Government should concentrate on educating the people on the importance of healthy life styles. To do this it needs to provide the necessary funds needed in Health promotion and health education, and also to provide for professional personnel(eg. health educator).
김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
Hye Myoung Jang(장혜명),Joo Hyun Kim(김주현),Garam Park(박가람),Ji Hye Lee(이지혜),Hye Young Park(박혜영),Seun Eui Kim(김선의),Myoung Hoon Lee(이명훈),Yun Dong Choi(최윤동),Gwang Joo Jeon(전광주) 한국약용작물학회 2021 한국약용작물학회 학술대회논문집 Vol.2021 No.1
Background : Agarwood has been widely used in many different areas including oriental medicines, aroma therapy, cosmetics, health supplement products and etc. There are more than 20 Aquiralia species which were officially registered as Agarwoods. Most commonly used among them are Aquilaria malaccensis, Aquilaria crassna and Aquilaria sinensis. Agarwoods are massively growing in Southeast Asian countries. For Agarwoods used as medicinal purposes, they are well known for their effects on anticancer, diabetes and respiratory diseases. However, their effects on dementia related diseases have been limitedly reported regarding Alzhermer’s and Parkinson’s. The objective of our study was to see the inhibition effects of Agarwood on plaque formation of beta-amyloid and tau-protein which are, to date, the most significant factors associated with the dementia. Methods and Results : For treatment in the experiment, Aquilaria crassna was extracted by 70% EtOH and was orally administered daily to ICR mice for 6 weeks. The mice used in our research were divided into 2 different groups; (1) High-fat diet control and (2) High-fat diet. with Agarwood extracts. The western blot analysis was made for the expression of beta-amyloid and tau-protein as markers for dementia associated diseases. We have found the group (2) has less expressed beta-amyloid and tau-protein compared to the group (1). As was reported in other study, obesity, causes the increased expression of beta-amyloid and tau-protein, which leads to potential cause of dementia. The group (2) treated with Agarwood showed less expression of beta-amyloid and tau-protein than the control group. Conclusion : From the result of our study, Agarwood could be a potential remedy and preventative medicine for dementia related diseases. Agarwood also needs to be fractioned to screen and test major single compounds for the effectiveness of the dementia associated diseases.
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau
Joo, Yuyoung,Schumacher, Benjamin,Landrieu, Isabelle,Bartel, Maria,Smet-Nocca, Caroline,Jang, Ahram,Choi, Hee Soon,Jeon, Noo Li,Chang, Keun-A,Kim, Hye-Sun,Ottmann, Christian,Suh, Yoo-Hun The Federation of American Societies for Experimen 2015 The FASEB Journal Vol.29 No.10
<P>14-3-3 proteins act as adapters that exert their function by interacting with their various protein partners. 14-3-3 proteins have been implicated in a variety of human diseases including neurodegenerative diseases. 14-3-3 proteins have recently been reported to be abundant in the neurofibrillary tangles (NFTs) observed inside the neurons of brains affected by Alzheimer’s disease (AD). These NFTs are mainly constituted of phosphorylated Tau protein, a microtubule-associated protein known to bind 14-3-3. Despite this indication of 14-3-3 protein involvement in the AD pathogenesis, the role of 14-3-3 in the Tauopathy remains to be clarified. In the present study, we shed light on the role of 14-3-3 proteins in the molecular pathways leading to Tauopathies. Overexpression of the 14-3-3σ isoform resulted in a disruption of the tubulin cytoskeleton and prevented neuritic outgrowth in neurons. NMR studies validated the phosphorylated residues pSer214 and pSer324 in Tau as the 2 primary sites for 14-3-3 binding, with the crystal structure of 14-3-3σ in complex with Tau-pSer214 and Tau-pSer324 revealing the molecular details of the interaction. These data suggest a rationale for a possible pharmacologic intervention of the Tau/14-3-3 interaction.—Joo, Y., Schumacher, B., Landrieu, I., Bartel, M., Smet-Nocca, C., Jang, A., Choi, H. S., Jeon, N. L., Chang, K.-A., Kim, H.-S., Ottmann, C., Suh, Y.-H. Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.</P>
류마티스관절염에 동반된 만성 골수성 백혈병 환자에서 Imatinib Mesylate 효과 보고 1예
전혜경 ( Hye Kyung Jeon ),박영은 ( Young Eun Park ),김성일 ( Sung Il Kim ),박성후 ( Seong Hu Park ),백승훈 ( Seung Hoon Baek ),이정욱 ( Joung Wook Lee ),하동우 ( Dong Woo Ha ),이혜원 ( Hye Won Lee ),정주섭 ( Joo Seop Chung ),이승 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2
Rheumatoid arthritis is associated with an increased risk of hematological malignancy as a result of the RA itself or its treatment. We report here on an unusual case of a 55-year-old female with long-standing rheumatoid arthritis and who was treated with low dose methotrexate and hydrochloroquine. She was diagnosed with chronic myelogenous leukemia that manifested with severe thrombocytosis and basophilia, and this was treated with imatinib mesylate. After 6 months, she achieved a complete cytogenetic response of the CML and a complete resolution of all the RA symptoms without DMARDs.
청소년 인기 웹툰에 나타나는 외모지상주의 현상에 대한 연구
전주혜(Jeon, Joo Hye),신명환(Shin, Myoung Hwan) 한국출판학회 2019 한국출판학연구 Vol.45 No.2
본 연구는 청소년들에게 인기 있는 웹툰에서의 외모 관련 묘사가 청소년의 외모에 대한 인식과 가치관에 영향을 미칠 수 있다는 문제의식을 갖고 청소년 인기 웹툰에서 ‘외모’가 어떻게 묘사되는지 내용분석을 통해 살펴보았다. 연구는 외모의 정도(우월/열등)에 따라 ‘사회적 유용성’과 ‘사회적 차별’이 어떠한 형태로 나타나는지 분석하였다. 연구결과 외모가 우월한 경우 외모가 열등한 경우에 비교해 ‘사회적 유용성’이 높게 나타났으며, 연인관계에서 ‘사회적 유용성’이 가장 높게 나타났다. 반면 외모가 열등한 경우, 외모가 우월한 경우에 비교해 ‘사회적 차별’이 높게 나타났으며, 대인관계에서 ‘사회적 차별’이 가장 높게 나타났다. This study examines how appearance is depicted in popular youth webtoons being conscious of the fact that the images related to appearance in the webtoons, can affect the perception and values of the appearance of youth s who watch them. Particularly, it analyzs social usability and social discrimination appear according to the degree of appearance (superiority / inferiority). The results show that Social usefulness was higher than that of inferiority , Social usefulness was also the highest in lover relationships. On the other hand, when the appearance was inferior, social discrimination was higher than appearance , and social discrimination was the highest in interpersonal relations.
The etiology of potential small-bowel bleeding depending on patient’s age and gender
Song, Joo Hye,Hong, Sung Noh,Kyung Chang, Dong,Ran Jeon, Seong,Kim, Jin-Oh,Kim, Jinsu,Lee, Bo-In,Choi, Myung-Gyu,Kim, Kyeong Ok,Yang, Dong-Hoon,Song, Hyun Joo,Hyuk Do, Jae,Jeong Lim, Yun,Shim, Ki-Nam SAGE Publications 2018 United European gastroenterology journal Vol.6 No.8
<B>Background</B><P> Whether the etiology of potential small-bowel bleeding depends on the age and gender of the patient is not yet fully understood. </P><B>Methods</B><P> A total of 1953 patients who underwent video capsule endoscopy (VCE) to evaluate potential small-bowel bleeding and were registered in the Capsule Endoscopy Nationwide Database Registry from 2003 to 2014 were eligible for this study. VCE findings and the etiology of small-bowel bleeding were analyzed by age and gender. </P><B>Results</B><P> The diagnostic yield of VCE was 48.4% (95% CI: 46.2%-50.6%) and the diagnosis rate of etiology of potential small-bowel bleeding was 61.4% (95% CI: 59.2%-63.6%). The etiology of potential small-bowel bleeding depends on the age and gender of the patient. Crohn's disease and small-bowel diverticular diseases were more prevalent etiology of potential small-bowel bleeding in the young adults group (@@<@@ 40 years) whereas angiodysplasia was revealed to be a most common etiology in elderly group (≥ 60 years), reaching statistical significance ( p@@<@@0.00152) by Bonferroni correction. </P><B>Conclusions</B><P> The etiology of potential small-bowel bleeding depends on the age of the patient. Thus, an individualized lesion-specific diagnostic approach based on age might be needed for patients with potential small-bowel bleeding. </P>