Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19

( Hye Hee Cha ),( So Yun Lim ),( Ji-soo Kwon ),( Ji Yeun Kim ),( Seongman Bae ),( Jiwon Jung ),( Sung-han Kim ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.2

Background/Aims: Data comparing the antibody responses of different coronavirus disease 2019 (COVID-19) vaccine platforms according to dose with natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced antibody responses are limited. Methods: Blood samples from adult patients with mild and severe COVID-19 and healthcare workers who received ChAdOx1 nCoV-19 vaccine (2nd dose at 12-week intervals) and BNT162b2 vaccine (2nd dose at 3-week intervals) were collected and compared by immunoglobulin G immune responses to SARS-CoV-2 specific spike protein using an in-house-developed enzyme-linked immunosorbent assay. Results: A total of 53 patients, including 12 and 41 with mild and severe COVID-19, respectively, were analyzed. In addition, a total of 73 healthcare workers, including 37 who received ChAdOx1 nCoV-19 and 36 who received BNT162b2, were enrolled. Antibody responses after the first and second doses of the ChAdOx1 nCoV-19 vaccine or the first dose of the BNT162b2 vaccine were similar to those in convalescent patients with mild COVID-19, but lower than those in convalescent patients with severe COVID-19, respectively. However, after the second dose of the BNT162b2 vaccine, the antibody response was comparable to that in convalescent patients with severe COVID-19. Conclusions: Our data suggest that the second dose of mRNA vaccination may be more beneficial in terms of long-term immunity and prevention of SARS-CoV-2 variant infection than a single dose of COVID-19 vaccination or homologous second challenge ChAdOx1 nCoV-19.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

夫婦의 結婚實在相異性에 대한 事例硏究 : 幼兒期 ·學童期 家族을 중심으로 Case of the Families with Preschoolchildren & Schoolchildren

차명희,박혜인 啓明大學校 生活科學硏究所 1994 科學論集 Vol.20 No.-

This study is intended to identify the dichotomized structure of both sexes in the marriage life of husband and wife. This study used, as a qualitative method, a deep interview on the discrepancy between a dyad about their marriage realities. 20 couples were interviewed by the ethnomethodology. And the main results are as follows. In terms of marriage processes, husbands showed an active tendency while wives a passive one. This seems attributable to the effects of socialization. And in terms of role performance, roles were divided into public and private between dyads in the middle class, while couples together performed public roles in the lower class, but did not do private ones together. Consequently, couples were revealed to sympathize only half of each other's understanding and sympathy, and each of them recognized in a way that marriage realities between a couple are different. However, the origins of these discrepancy are a lot related to a society with the double standard, a structural division of role, and to discriminatory social areas, there should be alternatives for the realities in this respect.

중학생의 역사 드라마 시청이 역사의식에 미치는 영향

장희흥,차경호,구혜진 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.5 No.2

This study is aimed at proposing the specific plans to use history drama lessons through the study on the relations between reality, fascination and involvement that are sub-variables of history drama viewing and middles school students’ historical consciousness, and to raise their historical consciousness by using history drama lessons. In order to accomplish such a goal, the study selected respective 250 middle school students in Daegue and Gumi, Gyeongsangbuk-do as its subjects, and the surveyed and analyzed findings are obtained as follows. First, it is the result obtained by dividing the subjects’ general characteristics. Fascination and involvement among reality, fascination, and involvement that were sub-variables had a difference in the division by sex. Fascination was shown to be higher in female students while involvement was higher in male students. In addition, as to the region, history drama viewing had no difference in middle school students of Daegue and Gyeongsangbuk-do. Historical consciousness was higher in middle school students of Daegue that those of Gyeongsangbuk-do, while regarding the grade there was no difference in history drama viewing and historical consciousness. Second, it was the result regarding how reality, fascination, and involvement that were sub-variables of history dram viewing affected historical consciousness. With regards to types of history dram viewing, fascination, reality, and involvement significantly affected historical consciousness in order. According to the gender, male students’ reality, involvement, and fascination gave a significant effect on historical consciousness while female students’ involvement didn’t affect historical consciousness, and fascination and reality gave an effect on historical consciousness in order. As to the grade, the first graders’ reality, fascination, and involvement were not related to historical consciousness while the second graders’ reality and fascination except for involvement affected in order. Besides, the third graders’ fascination only affected historical consciousness. Regarding the region, fascination and reality of middle school students in Daegu affected historical consciousness in order while fascination, involvement, and reality of middle school students in Gyeongsangbuk-do influenced historical consciousness. Like this, there was a little difference in the gender, grade, and region, but reality, fascination, and involvement that were sub-variables related to history drama viewing affected historical consciousness, and the higher sub-variables related to history drama viewing were, the higher historical consciousness was. Due to the fact that history dramas had a fictional element, there was a discussion on educational efficiency. However, this study verified the fact that history dramas can be educationally used, instead of deciding whether history drams were true or not. Based on the findings of the study, the effective utilization methods of history dramas in history lessons are suggested as follows. First, the study of historical figures using history dramas is possible. Students can understand properties of characters through re-enactment and empathy, and approach various figures that don’t appear in textbooks. Second, they can raise critical view that is able to divide false and fact of history dramas and use it to the fact learning. Third, it is possible to learn historical terms. By learning unfamiliar and difficult historical terms in advance, they can increase interest in history lessons. Fourth, storytelling of historical materials is possible. Students can make their own new interpretation by constructing various historical materials in a way of history dramas. Fifth, they can use a decoration making of history dramas, a visiting of the set, and a clipping of TV screen capture in various manufacturing studies as materials. Sixth, they can have a mock trial and a role-playing lesson regarding behaviors decisions of history drama figures. Seventh, they can study the public life history through history dramas. 이 논문은 중학생의 역사 드라마 시청이 역사의식에 미치는 영향에 대한 것이다. 역사 드라마 시청과 관련된 하위변인인 현실감, 심취도, 관여도는 성별, 학년, 지역에 따른 차이는 있지만, 역사의식에 분명 히 영향을 미치고 있다. 영향력의 크기는 심취도, 현실감, 관여도 순으로 나타났다. 그렇기에 역사 드라 마 시청과 관련한 역사 수업은 중학생의 역사의식 향상에 도움을 줄 수 있을 것으로 보인다. 역사 드라마를 시청하려는 의도와 시청하는 동안의 관여도 정도는 남학생의 경우 역사의식에 유의한 영향을 미쳤지만, 여학생의 경우 유의한 영향을 미치지 않는 것으로 나왔다. 학년별로 결과를 살펴보면 모든 학년에서 관여도는 역사의식에 통계적으로 유의한 영향을 주지 않는 것으로 나타났고, 제일 고학 년인 3학년에서 심취도만이 영향을 주는 것으로 보아 역사 드라마를 시청함에 있어 역사적 사실과 허구를 구별하는 능력이 아래 학년보다 발달하여 현실감의 영향을 덜 받은 것으로 보인다. 역사의식은 대구광역시 중학생이 경상북도 중학생보다 다소 높다. 그리고 실제 사극의 선호도는 퓨전 이나 판타지를 선호하지만 실제 전통사극이 역사의식에 더 높은 영향을 미쳤다. 이것은 현장 교사의 경 험담과 일치한다.

관상정맥동과의 연결이 없는 좌상대정맥의 CT 소견 : 1예 보고 case report

백상현,박재성,이혜경,홍현숙,김대호,조준희,박성진,차장규 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A persistent left superior vena cava (PLSVC) is the most common thoracic venous anomaly. It is a persistent remnant of a vessel that is present as a counterpart of normal right-sided superior vena cava(SVC) in early embryological development but normally disappears later. Its diagnosis can be confirmed by many noninvasive and invasive tests, or it is incidentally diagnosed at insertion into the left subclavian or jugular vein or thoracic surgery. If it is not associated with other congenital cardiac anomalies, it is usually asymptomatic and hemodynamically insignificant. We describe the chest radiograph and CT findings of bilateral SVC with drainage to left superior intercostal vein, hemiazygos, azygos vein and right SVC, and no connection of coronary sinus.

Association of the Folate Metabolism-related Gene Polymorphisms in Spontaneously Aborted Embryos with Abnormal Chromosomal Integrity

Hye Mi Park,Hye Jin Kim,Seung Joo Shin,Sun Hee Cha,Dong Hee Choi,Jung Jae Ko,Do Yeun Oh,Nam Keun Kim 한국유전학회 2007 Genes & Genomics Vol.29 No.3

The major reason for early spontaneous abortion is believed to be chromosomal abnormality. But the genetic etiologies are still largely unknown in aborted embryos with abnormal chromosomal integrity. MTHFR and TS proteins are key enzymes that modulate plasma levels of folate and homocysteine. We studied 25 spontaneously aborted embryos with abnormal chromosomal integrity at <20 weeks of gestational age, 317 adult controls and 100 child controls. Genotypes of MTHFR and TSER genes were analyzed by PCR-RFLP. The statistical analysis was performed by GraphPad Prism 4.0. The AC+CC genotype of MTHFR 1298A>C polymorphism was significantly different between abnormal chromosomal integrity group in spontaneously aborted embryos and child control. The two control groups and case group also exhibited significant differences in the combined MTHFR 1298/TSER genotype. In the present study, we found a relationship between folate metabolism-related gene polymorphisms and risk of spontaneously aborted embryos with abnormal chromosomal integrity in a Korean population.

CCL5 Inhibits Elevation of Blood Pressure and Expression of Hypertensive Mediators in Developing Hypertension State Spontaneously Hypertensive Rats

Hye Young Kim,Hye Ju Cha,Jin Hee Choi,Young Jin Kang,So Young Park,Hee Sun Kim 대한미생물학회 2015 Journal of Bacteriology and Virology Vol.45 No.2

Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats

Cha, Hye Ju,Kim, Hye Young,Kim, Hee Sun Elsevier 2018 Cytokine Vol.110 No.-

<P><B>Abstract</B></P> <P>Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II-induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT<SUB>2</SUB> R) pathway in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). In this study, we investigated the effect of Sulfs on anti-hypertensive effects of CCL5 in SHR VSMCs. CCL5 attenuated Ang II-induced inhibition of sulfatase activity in SHR VSMCs. Inhibition of Ang II-induced 12-lipoxygenase (12-LO) and endothelin-1 (ET-1) expression by CCL5 was reduced in Sulf1 small interfering RNA (siRNA)-transfected SHR VSMCs. In addition, attenuation of Ang II-induced dimethylarginine dimethylaminohydrolase-1 (DDAH-1) inhibition by CCL5 was reduced in Sulf1 siRNA-transfected SHR VSMCs. Downregulation of Sulf2 did not affect inhibitory effects of CCL5 on Ang II-induced 12-LO and ET-1 expression and Ang II-induced inhibition of DDAH-1 expression in SHR VSMCs. Downregulation of Sulf1 abrogated the expression of CCL5-induced AT<SUB>2</SUB> R messenger RNA (mRNA) and synergistic effect of CCL5 on Ang II-induced AT<SUB>2</SUB> R expression in SHR VSMCs. These findings suggest that Sulf1 is a potential up-regulatory factor in anti-hypertensive actions of CCL5 via AT<SUB>2</SUB> R pathway on Ang II-induced hypertensive effects in SHR VSMCs.</P>

Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs

Cha, Hye-Jin,Ko, Moon-Jung,Ahn, Soo-Mi,Ahn, Joon-Ik,Shin, Hee-Jung,Jeong, Ho-Sang,Kim, Hye-Soo,Choi, Sun-Ok,Kim, Eun-Jung The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3

Toxicogenomics has the potential to be used for the regulatory decision making to predict toxicity in developing new drugs. We have identified the classifiers for hepatotoxicity prediction in nonsteroidal anti inflammatory drugs (NSAIDs) through analyzing differential gene expression profiles of hepatotoxic and nonhepatotoxic compounds using HepG2 cell. $100\;{\mu}M$ of 8 hepatotoxic and 8 nonhepatotoxic NSAIDs were treated to HepG2 cell and the analysis of gene expression changes after 24 hallowed a set of genes to be identified differentiating hepatotoxicants from nonhepatotoxicants by statistical method. The hepatotoxicity prediction model was built using the selected 77 genes. These genes and pathways, commonly regulated by hepatotoxicants, may be indicative of the early characterization of hepatotoxicity and possibly predictive of later hepatotoxicity onset. 4 test compounds including hepatotoxic and nonhepatotoxic NSAIDs were used for validating the prediction model and the accuracy was 100%. Given that the specificity and sensitivity showed 100%, these are the most precise classifiers identified until now.

근로자의 직무스트레스가 구강건조감 및 구강증상에 미치는 영향

조혜진 ( Hye Jin Cho ),조민희 ( Min Hee Cho ),조윤지 ( Yoon Ji Jo ),장영은 ( Young Eun Jang ),전은희 ( Eun Hee Jeon ),정복림 ( Bok Lim Jeong ),정윤선 ( Yoon Sun Jeong ),차혜경 ( Hye Kyung Cha ),최영주 ( Young Joo Choi ),한인성 ( I 한국치위생과학회 2012 치위생과학회지 Vol.12 No.6

직무스트레스는 점차 복잡하고 다양화되어 가는 현대사회에서 건강 및 구강건강에 중요한 문제로 대두되고 있다. 본 연구는 2012년 6월 1일부터 6월 20일까지 366명의 근로자를 대상으로 직무스트레스와 구강건조정도를 파악하고 자가 구강증상을 측정하여 직무스트레스 및 구강건조정도와의 관련성을 알아보고자 하였다. 연구결과 다음과 같다. 1. 성별에 따른 직무스트레스 수준 차이 결과 남성은 직무요구, 관계갈등, 직장문화에서 상위 50%에 속해 있었으며, 여성은 관계갈등, 직무 불안정, 직장문화에서 상위 50%에 속해있었다. 2. 직무스트레스 수준에 따른 구강건조감과 자가 구강증상의 차이 결과, 구강건조감은 직장문화에서 유의한 차이를 나타냈다. 구강증상은 직무요구, 관계갈등, 조직체계, 보상부적절, 직무스트레스에서 유의한 차이를 나타냈다. 3. 구강건조감은 직장문화와 양의 상관관계를 나타냈으며, 구강증상은 직무요구, 관계갈등, 직무불안정, 조직체계, 직무스트레스, 구강건조감과 양의 상관관계를 나타냈다. 4. 직장문화, 보상부적절은 구강건조감에 유의한 영향을 주는 것으로 나타났으며, 구강건조감, 직무불안정, 조직체계는 구강증상에 유의한 영향을 주는 것으로 나타났다. 따라서 근로자 개인의 구강건강증진과 기업의 생산성 향상을 위해 직무스트레스의 원인을 정확히 파악하여야 하며, 스트레스로 인한 구강 내 증상을 인지하고 관리함으로써 삶의 질 향상에 큰 영향을 미칠 것이다. Job stress is emerging as one of major issues related to oral health in modern society that has increasingly been complicated and diversified. The purpose of this study was to examine the job stress and dry mouth of workers and their self-diagnosed oral symptoms in an attempt to determine the relationship between job stress and dry mouth. The subjects in this study were 366 workers, and a survey was conducted to June 1 to 20, 2012. Whether there would be any differences in dry mouth and self-diagnosed oral symptoms according to job stress was analyzed, and it`s found that there were significant differences in dry mouth according to organizational climate. And oral symptoms made significant differences to job demand, interpersonal conflicts, organizational system, lack of reward and job stress. There was a positive correlation between dry mouth and organizational climate, and oral symptoms had a significant correlation to job demand, interpersonal conflicts, job insecurity, organizational system, job stress and dry mouth. Organizational climate and lack of reward had a significant impact on dry mouth, and oral symptoms were under the significant influence of dry mouth, job insecurity and organizational system.