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골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구
정영신,변향민,신지영,김정목,정형민,오유경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4
To design gene delivery systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several cultrure conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells and marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 and CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression chemokine receptors generally decreased in most chemokine receptors with the cultivation of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher lever of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased level of receptor-mediated gene delivery into stromal stem cells.
정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.
난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 : 1예 보고 A case Report
조향정,민부기,문형배 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1
저자들은 우측 난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 본 예는 수술 후 상부 소화기 내시경검사, 대장 내시경 검사 및 복부와 골반에 대한 전산단층촬영을 시행하였으나 특이 소견은 없었고 현재 6개월정도 추적 관찰중이다. The most common malignant change in cystic teratoma is squamous cell carcinoma, followed by carcinoid tumor and adenocarcinoma. Ovarian carcinoid tumor can be seen in the ovary as a metastasis of a tumor located in the gastrointestinal tract or elsewhere, as a component of adult cystic teratoma, or as a primary pure neoplasm of the ovary. The prognosis in primary carcinoid tumors (whether pure or as a component of cystic teratoma) is very good, whereas metastatic carcinoids have a poor outcome. We report a case of a primary carcinoid tumor arising in a mature cystic teratoma of the ovary that developed in a 38-year-old woman with a brief review of literature.
김태우,고동희,김민기,유승원,류향우,한정희,정순희 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2
배경: 주물공장 근로자에서 발생한 석면폐증의 작업 관련성을 평가하고 그 증례를 보고하고자 한다. 증례: 30년간 주물공장에서 근무한 환자로 인후통, 기침, 노란 가래가 있어 검사한 결과 결핵이 의심되어 치료 하였으며, 치료 중 석면폐증으로 진단되었다. 작업 관련성 평가를 위해 실시한 폐 조직의 조직학적 검사에서 1 cm^(2)당 3개의 석면소체가 발견되었고, 투과전자현미경으로 분석한 석면 함유량은 23.26x10^(6) fibers/g이었다. 결론: 작업환경조사, 폐 조직의 석면 분석 등을 통해 작업 관련성이 높다고 판단하였다. Background: Foundry workers are known to be exposed to silica and have an increased risk of Silicosis. There are also reports that state these foundry workers were associated with asbestos-related change in the X-ray results of the lungs. This report discusses a case of localized asbestosis developed in a foundry worker who worked in 12 Korean foundries. Case report: A 49-year-o1d man who worked at molding and melting for 30 years, Presented with sore throat, cough and yellow sputum for 1 month. From physical and clinical examination, Pulmonary tuberculosis was highly suspicious; therefore, he was medicated for 6 months. After tuberculosis medication, the radiological finding was reactivation of tuberculosis, and an asbestos body was detected at a trans-bronchial lung biopsy. During an operation, operators found multiple palpable masses and bullae 10calized in the right upper lobe (RUL) and performed right upper lobectomy and right middle lobe wedge resection. Using hematoxylin-eosin stain and iron stain, we could detect asbestos bodies by light microscopy. We analyzed the asbestos fiber burden in dry lung tissue by transmission electron microscopy with energy dispersive X-ray spectrometer (TEM-EDX). The fiber type was chrysotile and the fiber burden was 23.26 x 10^(6) fiber/g dry lung. Discussion: This case study of a foundry worker with localized asbestosis is uncommon in Korea. We found an occupational relationship between the foundry worker and localized asbestosis through various investigative techniques such as measurements taken at his working environment, clinical, radiological and pathological examination of the foundry worker and mineralogical examination of the asbestos fiber.
Traveling Baseball Players’ Problem in Korea
Hyang Min Jeong,김상우,Younguk Choi,Aaram J. Kim,Jonghyoun Eun,김범준 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.3
We study the so-called traveling tournament problem (TTP) to find an optimal tournament schedule. Differently from the original TTP, in which the total travel distance of all the participants is the objective function to minimize, we instead seek to maximize the fairness of the round robin tournament schedule of the Korean Baseball League. The standard deviation of the travel distances of teams is defined as the energy function, and the Metropolis Monte-Carlo method combined with the simulated annealing technique is applied to find the ground-state configuration. The resulting tournament schedule is found to satisfy all the constraint rules set by the Korean Baseball Organization, but with drastically increased fairness in traveling distances.
Hyang-Im Baek,Su-Young Jung,Ki-Chan Ha,Hye-Mi Kim,Eun-Kyung Choi,Su-Jin Jung,Eun-Ock Park,Sang-Wook Shin,Min-Gul Kim,Seok-Kweon Yun,Dae Young Kwon,Hye Jeong Yang,Min-Jeong Kim,Hee-Joo Kang,Jin-Hee Kim 한국식품연구원 2015 Journal of Ethnic Foods Vol.2 No.2
Background: Studies in animals have demonstrated the antiallergenic properties of Chongkukjang (CKJ), a traditional Korean food made by fermentation of soybean with Bacillus subtilis. CKJ might therefore be used as an ingredient in a functional food designed to suppress allergies. The purpose of this study was to investigate the effect of CKJ on histamine-induced skin wheal response in healthy participants. Methods: A randomized, double-blind, placebo-controlled trial was conducted. Sixty participants (48 women and 12 men) were randomly assigned to one of two groups: One group received 35 g CKJ daily for 12 weeks, and the other received a placebo at the same dosing frequency. A skin prick test with histamine (10 mg/mL) was conducted on the ventral forearm 10 cm from the elbow, and assessed 15 minutes later. Outcomes included measurement of efficacy [skin wheal response, immunoglobulin E (IgE), histamine, interferon-gamma, interleukin-4, eosinophil, and eosinophil cationic protein (ECP)], and safety (adverse events, laboratory test results, electrocardiogram, anthropometric values, and vital signs). Results: Fifty-five participants (28 in the CKJ group and 27 in the placebo group) completed the study. After 12 weeks of supplementation, participants in the CKJ group showed a significant reduction in histamine-induced skin wheal areas compared with placebo group (p < 0.05). At 12 weeks, the CKJ group showed a significant improvement in percentage change from baseline in histamine-induced wheal area, compared with the placebo group (p < 0.05). CKJ did not influence blood levels of IgE, histamine, interferon-gamma, interleukin-4, eosinophil, or ECP. Conclusion: Oral administration of CKJ for 12 weeks resulted in a reduction of the skin wheal response to histamine, with no apparent adverse effects. Trial registration: ClinicalTrials.gov: NCT01402141.
P183 Assessment of quality of life in patients with nail diseases in Korea
( Min-young Yang ),( Kyung-min Lim ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Nail diseases have considerable emotional impact and may limit activity by impairing functionality of both fingers and toes Objectives: To assess the influences of nails diseases on quality of life (QOL) in Koreans Methods: 135 patients with nail diseases completed an questionnaire on QOL (Dermatology Quality of Life Index, DLQI). The subjects were classified into subgroups according to sex, age, number of nails involved, nail area affected, duration of nail disease, specific diseases (e.g. onychomycosis, psoriatic nail and etc.) and groups of diseases (e.g. traumatic, infectious, and etc.). Statistical analysis was carried out using T-test, ANOVA analysis to compare the values between subgroups Results: Comparison between various disease groups showed a statistically significant higher impact for traumatic, infectious, inflammatory and structural diseases and a lower impact for pigmentary diseases. QOL was statistically significantly more affected in patients having multiple involved nails, women, widely affected nail area, longer duration of diseases and in people aged 60-79 years. There was no statistically significant difference on QOL impact between patients having only fingernails or toenails involved Conclusion: Even though published literature tends to focus on the impact of nail psoriasis and onychomycosis on QOL, other nail diseases induced similar frustration to patients. Dystrophic appearance of the nails has a significant influences on patients irrespective of diseases