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Recombinant canstatin inhibits angiopoietin‐1‐induced angiogenesis and lymphangiogenesis
Hwang‐,Bo, Jeon,Yoo, Ki Hyun,Park, Jong‐,Hwa,Jeong, Han‐,Sin,Chung, In Sik Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.2
<P><B>Abstract</B></P><P>We describe the effect of recombinant canstatin, the NC1 domain of the α2 chain of Type IV collagen, on suppression of angiogenesis and lymphangiogenesis both <I>in vitro</I> and <I>in vivo</I>. Recombinant canstatin produced from stably transformed <I>Drosophila</I> S2 cells reduced the expression of angiopoietin‐1 in hypoxia mimetic agent, CoCl<SUB>2</SUB>‐treated CT‐26 cells. Recombinant canstatin inhibited proliferation, tube formation and migration of human angiopoietin‐1 (rhAngpt‐1)‐treated human umbilical vein endothelial cells (HUVEC) and lymphatic endothelial cells (LEC). Recombinant canstatin suppressed the expression of Tie‐2 and vascular endothelial growth factor‐3 (VEGFR‐3) transcripts in rhAngpt‐1‐treated HUVEC and LEC, respectively. The inhibitory effect of recombinant canstatin on tumor growth was also investigated using a heterotopic CT‐26 colon carcinoma animal (BALB/c mice) model. Recombinant canstatin reduced the final volume and weight of tumors, and blood and lymphatic vessel densities of tumors, which were evaluated by CD‐31 and LYVE‐1 immunostaining. Immunohistochemical analysis showed that recombinant canstatin dramatically reduced the expression of angiopoietin‐1 in CT‐26 colon carcinoma‐induced tumor, but not the expression of VEGF‐C. Tie‐2 and VEGFR‐3 expressions were also reduced in recombinant canstatin‐treated tumors. These results indicate that recombinant canstatin has anti‐tumoral activities against CT‐26 colon carcinoma cells. Recombinant canstatin reduces the expression of angiopoietin‐1 in hypoxia‐induced CT‐26 cells and inhibits the angiogenic and lymphangiogenic signaling induced by angiopoietin‐1. Recombinant canstatin probably inhibits angiogenesis and lymphangiogenesis <I>via</I> suppression of the integrin‐dependent FAK signaling induced by angiopoietin‐1/Tie‐2 and/or VEGFR‐3.</P>
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a-TN-LCD의 전기광학특성에 표면액정배향이 미치는 영향
황율연,이창훈,서대식,이보호 崇實大學校 生産技術硏究所 1996 論文集 Vol.26 No.2
The characteristics of the response time and the viewing angle on twisted nematic(TN)-liquid crystal display(LCD) and amorphous (a)-TN-LCD without rubbing were investigated. To measure the Tansmission-Voltage, response time, and viewing angle characteristics, we prepared three kinds of LC cells and then studied the surface liquid crystal alignment effect. It was found that the response time on a-TN-LCD was fast compared to the TN-LCD, and the weak anchoring strength was attributed to the fast response time on a-TN-LCD. Also, we obtained the wide viewing angle characteristics on-a-LCD. We suggest that the liquid crystal alignment effect on LCD device is very important for electro-optical characteristics.
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황성욱,전보경,김찬훈,서정민,최금찬 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1
It is important to know the impacts of acid rain because of soil acidification, reduced biological productivity. Many researchers were interested in regional acid problems, and former research were focued in short-term trends of acid rain. It is not easy to evaluate acid rain problems because of many parameters relating to meteorological factors, which are wind, temperature, humidity and other factors. Rainfall sampling for this study was done from September 1933 to December 2000 in Dong-A University, Busan. All Samples were collected in separately to early fraction and succeeding fraction. Also, the samples were measured for pH, and EC, cations and anions were analysed by ion Chromatography.
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黃保根 대구대학교 인문과학연구소 1986 人文科學硏究 Vol.4 No.-
A structural description of passive constructions in Old English is the primary purpose of this paper. In other words, it can fairy be said to be the preliminary stage for further studies on syntactic changes in English, since diachrony must be studied on the basis of patterned synchronic data. The structural description of passives in Old English, unlike that in Modern English, is not an easy task. Major obstacles are: passives in OE have few corresponding actives, and the analysis performed only on literature-written language-not on spoken one. However, the following can be classified, as the three major patterns of OE passive constructions, by the analysis of them in Anglo-Saxon Chronicles, Alfred’s Pastoral Care, and several primary OE texts available: 1. NP hatan NP beon/wesan NP 2. NP{ weorpan }+PP (Prep) {AP} (Prep+NP) beon/wesan 3. NP weorpan +PP NP (Prep +NP) Except for the Tppe 1, the passive auxiliaries used in OE are beon, wesan and weorpan, and their semantic functions are different in the early OE period. Later they came to be used interchangibly as the original meaning of weorpan disappeared. The identification of the semantic functions of prepositions in agentive adjuncts is grueling. The reason is the agentive adjuncts can be viewed as ‘principle agents’, ‘medium’, ‘means’, ‘cause’, ‘reason’, or ‘instrumentality’according to modern interpretation. The preposition used before agent NPs in Oe are : at, by/be, fram/from, mid, of, purh, etc.
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황보승 호남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.7 No.-
본 논문에서는 현재까지 광원의 주류를 이루고 있는 형광등에 의한 불필요한 전력소모를 억제하고 전기요금을 절약하기 위한 최적의 형광등 교체주기 표시에 대한 연구를 수행하였다. 이를 위하여 본 연구에서는 시간경과에 따른 형광등 노화에 의한 소모전력의 증가와 그에 따른 경제성을 분석하였으며, 이를 바탕으로 최적의 교환시기가 되면 자동으로 적색 LED가 소등(또는 점등)되는 장치를 설계 및 개발하였다. 또한 P-spice를 통한 회로 해석과 실험을 통하여 개발된 장치의 정상적인 동작을 확인하였다. In this paper, in order to restrict the power consumption and save electric charges due to the fluorescent lamp which is still main lighting source, we have carried out the studies on the indicating the optimal replacement time of it. For these purposes, we have evaluated the increment of power consumption of the fluorescent lamp and its economical efficiency due to degradation according to elapsed time. On the basis of the evaluation, we have designed and developed the system that turned off(or on) the red LED at the optimal replacement time. We also verified correct operations of the developed system through the circuit simulation by P-spice and experiments.
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펄스정전응력법을 이용한 고분자 재료에서 공간전하분표 측정에 대한 이론적 고찰
황보승 호남대학교 산업기술연구소 1998 산업기술연구논문집 Vol.6 No.-
본 논문에서는 최근 국 ·내외적으로 활발하게 연구되고 있는 고체 고분자 재료 내의 공간전하 측정법과 관련하여, 공간전하의 비파괴 측정법 중의 하나인 펄스정전응력법(PEA 법)에 대한 이론적 고찰을 수행하였다. 또한, 두꺼운 압전소자를 이용해서 PEA 법의 공간분해능을 향상시킬 수 있는 새로운 방법을 제안하였다. In this paper, we have evaluated theoretically the PEA method which is one of the most popular methods for the nondestructive measurement of space charge distribution in polymers. On the basis of this theoretical evaluation, we also suggest a new measuring method that uses a thick piexo-material for improving the space resolution of PEA method.
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