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아토피피부염 소아의 피부집락균 중 Staphylococcus aureus의 빈도와 항생제 감수성에 관한 연구
황윤하 ( Yoonha Hwang ),강준석 ( Joon Seok Kang ),김병국 ( Byoung Kuk Kim ),김성원 ( Sung Won Kim ) 대한천식알레르기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.1
Purpose: Staphylococcus aureus colonization exacerbates atopic dermatitis. Local or systemic antibiotics can increase difficulty in controlling skin colonization and the possibility of methicillin-resistant S. aureus (MRSA). Choosing appropriate antibiotics has become more challenging. We investigated the frequency of S. aureus and MRSA colonization and susceptibility to antimicrobial agents. Methods: We collected and cultivated the skin colonization samples of atopic dermatitis children less than 20 years old from June 2006 to May 2016, and tested the antibiotic sensitivity. We also checked the severity of atopic dermatitis by SCORing Atopic Dermatitis (SCORAD) index and analyzed. Results: Out of 2,355 subjects, 1,935 (82.2%) had S. aureus and 762 (39.4%) had MRSA. The frequency of MRSA increased from 13.3% in 2006 to 26.6% in 2007, 18.4% in 2008, 27.1% in 2009, 38.3% in 2010, 42.6% in 2011, 42.4% in 2012, 48.3% in 2013, 44.5% in 2014, 38.1% in 2015, and 37.5% in 2016. Mupirocin resistance started with 0% in 2009, and gradually increased annually to 13.7% in 2010, 14.7% in 2011, 25.4% in 2012, 35.2% in 2013, 34.9% in 2014, 39.8% in 2015, and 35.6% in 2016. The mupirocin resistant group has a higher SCORAD index than the other groups (P<0.05). Conclusion: MRSA frequency and mupirocin resistance tended to increase annually. We should choose the methods of managing bacterial colonization in atopic dermatitis carefully in order to prevent antibiotic resistance. (Allergy Asthma Respir Dis 2017:5:21-26)
Bird-Egg syndrome diagnosed by ImmunoCap ISAC
( Jaeeun Chung ),( David Lee ),( Yoonha Hwang ) 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.3
Adult-onset egg allergy is rare compared to child-onset egg allergy, and the component-resolved diagnosis test is effective in evaluating food allergy. We herein report a 24-year-old woman with late-onset egg-yolk allergy diagnosed as bird-egg syndrome. The prolonged exposure to pet parrots' dander or dropping through the respiratory system caused sensitization to the Gal d 5 component and resulted in a cross-reaction to egg yolk. Since the patient was suspected of the syndrome by her history, the skin prick test, ISAC ImmunoCAP, and serum ImmunoCAP test were performed. By confirming Gal d 5 component by ISAC ImmunoCAP, the patient was diagnosed with the syndrome. In patients with newly adult-onset food allergy, the clinician must identify the environmental conditions which can cause cross-sensitization and perform the causative component test. (Allergy Asthma Respir Dis 2023;11:161-163)
Oh, Bae Jun,Jin, Sang-Man,Hwang, Yoonha,Choi, Jin Myung,Lee, Han-Sin,Kim, Gyuri,Kim, Geunsoo,Park, Hyo Jun,Kim, Pilhan,Kim, Sung Joo,Kim, Jae Hyeon American Diabetes Association 2018 Diabetes Vol.67 No.3
<P>Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31(+) CD14(+) CD34(+) monocyte subset via three dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the efficacy of BM-spheroids could be demonstrated in clinically relevant intraportal islet transplantation models without increasing the risk of portal thrombosis. The thrombogenic potential of intraportally infused BM-spheroids was compared with that of mesenchymal stem cells (MSCs) and MSC-derived spheroids (MSC-spheroids). The angiogenic efficacy and persistence in portal sinusoids of BM-spheroids were examined in rodent syngeneic and primate allogeneic intraportal islet transplantation models. In contrast to MSCs and MSC-spheroids, intraportal infusion of BM-spheroids did not evoke portal thrombosis. BM-spheroids had robust angiogenetic capacity in both the rodent and primate intraportal islet transplantation models and improved post-transplant glycemic outcomes. MRI and intravital microscopy findings revealed the persistence of intraportally infused BM-spheroids in portal sinusoids. Intraportal cotransplantation of allogeneic islets with autologous BM-spheroids in nonhuman primates further confirmed the clinical feasibility of this approach. In conclusion, cotransplantation of BM-spheroids enhances intraportal islet transplantation outcome without portal thrombosis in mice and nonhuman primates. Generating BM-spheroids by 3D culture prevented the rapid migration and disappearance of intraportally infused therapeutic cells.</P>
장애인의 사회적 자본이 취업 및 구직기간에 미치는 영향
도화정(Do Hwajeong),조유진(Jo Yujin),황윤하(Hwang Yoonha) 한국장애인고용공단 고용개발원 2023 장애와 고용 Vol.33 No.2
연구목적: 본 연구는 장애인이 보유한 사회적 자본이 취업 및 구직기간에 미치는 영향을 분석하는 데 목적이 있다. 연구방법: 장애인고용패널 2차 웨이브 2차 조사부터 6차 조사까지 자료를 사용하여 2017년 기준 만 15-64세 장애인 미취업자 869명을 대상으로 취업여부 및 구직기간과 영향요인을 살펴보기 위해 Cox 회귀분석을 실시하였다. 연구결과: 사회적 자본 중 친구 네트워크, 공식적 네트워크, 사회참여가 장애인이 미취업 상태에서 이탈해 취업할 가능성을 유의하게 높이는 것으로 나타났다. 통제변수 중에서는 연령, 학력이 취업 가능성에 부적으로 유의한 영향을 미쳤고, 장애유형 중 지체장애에 비해 지체 외 신체외부장애와 시각장애가 정적으로 유의한 영향을 미치는 것으로 나타났다. 결론: 이와 같은 연구결과를 바탕으로 장애인이 구직기간을 단축하고 일자리에 성공적으로 진입하기 위해 활발한 사회활동을 통한 네트워크 확대 및 국가 일자리 사업 참여를 위한 다방면의 지원책이 필요함을 제언하였다. Purpose: The purpose of this study is to analyze the impact of social capital of people with disabilities on their employment and job search duration. Method: Cox regression analysis was conducted using the data from the 2nd to 6th year of the 2nd wave Panel Survey of Employment for the Disabled(PSED) to examine the impact of social capital on employment status and job search duration. Results: The results of analysis revealed that friendship network, formal network, and social participation significantly increased the likelihood that people with disabilities would become employed. Conclusion: Based on the results, we recommended that people with disabilities need multifaceted support measures to expand their networks through social activities and participation in national employment projects in order to shorten their job search duration and help them successfully enter employment.
Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury
Park, Inwon,Kim, Mingyo,Choe, Kibaek,Song, Eunjoo,Seo, Howon,Hwang, Yoonha,Ahn, Jinhyo,Lee, Seung-Hyo,Lee, Jae Hyuk,Jo, You Hwan,Kim, Kyuseok,Koh, Gou Young,Kim, Pilhan European Respiratory Society 2019 The European respiratory journal Vol.53 No.3
<▼1><P>The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by disturbances in the pulmonary microcirculation is poorly understood. This study aimed to investigate how the pulmonary microcirculation is distorted in sepsis-induced acute lung injury (ALI) and reveal the underlying cellular pathophysiologic mechanism.</P><P>Using a custom-made intravital lung microscopic imaging system in a murine model of sepsis-induced ALI, we achieved direct real-time visualisation of the pulmonary microcirculation and circulating cells <I>in vivo</I>. We derived the functional capillary ratio (FCR) as a quantitative parameter for assessing the fraction of functional microvasculature in the pulmonary microcirculation and dead space.</P><P>We identified that the FCR rapidly decreases in the early stage of sepsis-induced ALI. The intravital imaging revealed that this decrease resulted from the generation of dead space, which was induced by prolonged neutrophil entrapment within the capillaries. We further showed that the neutrophils had an extended sequestration time and an arrest-like dynamic behaviour, both of which triggered neutrophil aggregates inside the capillaries and arterioles. Finally, we found that Mac-1 (CD11b/CD18) was upregulated in the sequestered neutrophils and that a Mac-1 inhibitor restored the FCR and improved hypoxaemia.</P><P>Using the intravital lung imaging system, we observed that Mac-1-upregulated neutrophil aggregates led to the generation of dead space in the pulmonary microcirculation that was recovered by a Mac-1 inhibitor in sepsis-induced ALI.</P></▼1><▼2><P><B>Neutrophils induce dead space in the pulmonary microcirculation in sepsis-induced ALI, recovered by a Mac-1 inhibitor</B>http://ow.ly/vUzO30nbUyU</P></▼2>
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park, Dae-Young,Lee, Junyeop,Park, Intae,Choi, Dongwon,Lee, Sunju,Song, Sukhyun,Hwang, Yoonha,Hong, Ki Yong,Nakaoka, Yoshikazu,Makinen, Taija,Kim, Pilhan,Alitalo, Kari,Hong, Young-Kwon,Koh, Gou Young American Society for Clinical Investigation 2014 The Journal of clinical investigation Vol.124 No.9
<P>Schlemm's canal (SC) is a specialized vascular structure in the eye that functions to drain aqueous humor from the intraocular chamber into systemic circulation. Dysfunction of SC has been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to elevated ocular pressure, a factor for glaucoma development in humans. Here, using lymphatic and blood vasculature reporter mice, we determined that SC, which originates from blood vessels during the postnatal period, acquires lymphatic identity through upregulation of prospero homeobox protein 1 (PROX1), the master regulator of lymphatic development. SC expressed lymphatic valve markers FOXC2 and integrin α9 and exhibited continuous vascular endothelial-cadherin (VE-cadherin) junctions and basement membrane, similar to collecting lymphatics. SC notably lacked luminal valves and expression of the lymphatic endothelial cell markers podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1). Using an ocular puncture model, we determined that reduced AHO altered the fate of SC both during development and under pathologic conditions; however, alteration of VEGF-C/VEGFR3 signaling did not modulate SC integrity and identity. Intriguingly, PROX1 expression levels linearly correlated with SC functionality. For example, PROX1 expression was reduced or undetectable under pathogenic conditions and in deteriorated SCs. Collectively, our data indicate that PROX1 is an accurate and reliable biosensor of SC integrity and identity.</P>