http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Individual and common inhibitors of coronavirus and picornavirus main proteases
Kuo, Chih-Jung,Liu, Hun-Ge,Lo, Yueh-Kuei,Seong, Churl-Min,Lee, Kee-In,Jung, Young-Sik,Liang, Po-Huang Elsevier 2009 FEBS letters Vol.583 No.3
<P><B>Abstract</B></P><P>Picornaviruses (PV) and coronaviruses (CoV) are positive-stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS-CoV 3CL<SUP>pro</SUP> with IC<SUB>50</SUB> of low μM. Interestingly, one of them equally inhibited both 3C<SUP>pro</SUP> and 3CL<SUP>pro</SUP> from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti-viral agents against PV and CoV.</P>
Synthesis and Evaluation of Benzoquinolinone Derivatives as SARS-CoV 3CL Protease Inhibitors
Ahn, Tae-Young,Kuo, Chih-Jung,Liu, Hun-Ge,Ha, Deok-Chan,Liang, Po-Huang,Jung, Young-Sik Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.1
For the discovery of new antivirals against Severe Acute Respiratory Syndrome-coronavirus (SARS-CoV), we prepared and evaluated several benzoquinoline compounds as its 3C-like protease (3CLpro) inhibitors. Based on the computer modeling study that each of the two rigid benzoquinolinone and N-phenoltetrazole moieties of the compound 1 is bound to the S1 and S2 sites, respectively, of the SARS protease by forming H-bonds and hydrophobic interactions, we designed and synthesized alkylated benzoquinolines at both the sites of the hydroxyl groups. We found that the compound 2a showed five times higher inhibiting activity against the 3CLpro compared to the compound 1.
Synthesis and Evaluation of Benzoquinolinone Derivatives as SARS-CoV 3CL Protease Inhibitors
Tae-Young Ahn,Chih-Jung Kuo,Hun-Ge Liu,하덕찬,Po-Huang Liang,Young-Sik Jung 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.1
For the discovery of new antivirals against Severe Acute Respiratory Syndrome-coronavirus (SARS-CoV), we prepared and evaluated several benzoquinoline compounds as its 3C-like protease (3CLpro) inhibitors. Based on the computer modeling study that each of the two rigid benzoquinolinone and N-phenoltetrazole moieties of the compound 1 is bound to the S1 and S2 sites, respectively, of the SARS protease by forming H-bonds and hydrophobic interactions, we designed and synthesized alkylated benzoquinolines at both the sites of the hydroxyl groups. We found that the compound 2a showed five times higher inhibiting activity against the 3CLpro compared to the compound 1.