양극성장애와 새로운 항경련제의 효과

남범우,서정석,정헌종,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Bipolar disorder, like epilepsy and migraine, is episodic in nature and psychiatric illness requiring lifelong treatment. So, it should not be surprising that anticonvulsants such as carbamazepine and valproate have proven efficacy as mood stabilizers. The newer anticonvulsants such as lamotrigine, gabapentin, topiramate, oxcarbazepine, tiagabine, and zonisamide may also be effective treatments for bipolar disorder. Identifying an anticonvulsant for use in bipolar disorder should take into account not only the pathophysiology of bipolar disorder but also the mechanism of action of the anticonvulsant. Evidence for effectiveness of these novel antiepileptic drugs in treating acute mania and depression as well as in preventing the recurrence of mania and depression is reviewed. In conclusion, although the novel anticonvulsants appear to be clinically useful, more controlled trials are needed to assess the effectiveness in bipolar disorder.

閉塞性 換氣障碍 疾患에 있어서 動脈血가스 分析과 肺換氣機能 檢査에 關한 硏究

金獻男,崔仁善,朴炅玉 全南大醫大 1986 전남의대학술지 Vol.23 No.1

방사선 조사를 받은 흰쥐 신경뇌하수체 관문의 미세구조 : 관문의 새로운 개념설정 Establishment of a New Concept on the Barrier

이헌용,안의태,양남길,고정식,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

신경뇌하수체는 뇌의 일부지만 뇌실둘레기관(circumventricular organ)으로서 전형적인 혈액-뇌관문이 없으므로 혈관 안팎의 물질이동이 자유로운 신경내분비기관이다. 이 실험에서는 심한 방사선 조사시에 혈액-신경뇌하수체관문의 형태적 대응을-연구함으로써, 관문의 특성을 분석했으며, 관문의 구성을 구체적으로 설정하여 이를 개념화 할 것을 제안하였다. 체중 200-250g의 숫흰쥐를 sodium thiopenthal 로 마취시킨 후 Mitsubishi선형가속기로 방사선 조사를 시켰다. 조사조건은 거리 80cm, 조사구역 30 X 30cm, 조사깊이 1.2cm, 조사속도 분당 200 rads로 하여 실험군에 따라 3,000 rads 또는 6,000 rads가 되도록 했다. 조사후 6시간, 2일, 6일후에 각군의 동물을 도살 하여 신경뇌하수체를 떼어냈다. 떼어낸 조직은 1% glutaradehyde- 1% paraformaldehyde액에 1차 고정하고, 1% osmium tetroxide액에 2차 고정하였고, araldine혼합액에 포매된 조직은 절편을 만들어 uranyl acetate와 lead citrate액으로 염색해서 전자현미경으로 관찰하였다. 주로 모세혈관주위공간에서 관문구조를 중심으로 관찰한 결과 3,000 rads 조사군과 6,000 rads조사군 모두가 비슷하게 심한 변화를 보였고, 변화의 정도가 2일군에서 가장 심했으며 6일군에서는 약간 안정되는 모습이었으나 변화의 양상은 모든 실험군을 통해서 비슷하였다. 가장 두드러진 변화는 모세혈관주위공간에서 나타났는데 공간의 확장, 큰포식세포의 증가와 활성화, 신경뇌하수체세포속에 들어 있던 신경종말들의 이탈, 먼지 같은 물질의 증가 등을 들 수 있었다. 특히 큰 포식세포의 변화는 매우 특징적이어서 넓은 세포질관(판상족, lamellipoda)을 형성하여 모세혈관과 신경뇌하수체세포사이를 차단시킬 뿐아니라 왕성한 포식작용으로 공간내의 축삭종말들을 용해시켰다. 큰포식세포의 세포질안에는 과립형질내세망들이 매우 발달하였고, 세포질 영역이 매우 넓어진 것으로 볼 때, 이들이 기동타격대로서 활발히 움직이는 매우 효율적인 관문의 구성성분으로 생각되었다. 특히 신경뇌하수체는 전형적인 혈액-뇌관문이 없으므로 신경내분비기능의 수행에는 유리하나 면역활성물질이나 독성물질등 뇌에 해로운 물질의 왕래를 차단하여 제거하거나, 과다하게 분비된 신경호르몬을 조절하는 일이 중요하다고 볼 때, 큰포식세포가 이같은 역할에 적합한 구성성분이라는 결론을 얻었다. 이 실험에서는 효율성이 높은 관문으로서 혈액-신경뇌하수체관문이 구성성분을 차례로 기재하고 이를 개념화 할 것을 제안한다. 모세혈관과 축삭종말사이에 형성되어 있는 혈액-신경뇌하수체관문이 구성을 차례로 표기하면 다음과 같다 (그림 9,10). 1. 유창모세혈관 내피 2. 모세혈관 내피의 기저판 3. 혈관주위세포와 기저판("이차방어선", 한정된 범위내에서 움직일 수 있다). 4. 큰포식세포, 필요에 따라 판상족(lamellipoda)을 넓게 뻗는다.("삼차방어선", 모세혈관 주위공간 속을 이동해 다니는 "기동타격대") 5. 신경뇌하수체세포의 기저판 6. 신경뇌하수체세포의 세포질돌기(호르몬분비 조절) To study the morphological characteristics of the blood-neurohypophysis barrier system in a severely altered situation, the heads of rats were exposed to heavy X-irradiation. Rats weighing 200-250 g each were anesthetized with sodium thiopenthal, and placed on the table of Mitsubishi linear accelerator ML-4MV. Only heads of rats were placed within the exposure area of 30 cm X 30 cm. Irradiation was processed at the distance of 80 cm, with the speed of 200 rads/min in the radiation depth of 1.2cm. Total doses were 3,000 rads or 6,000 rads according to the animals of the different experimental groups. Rats were sacrificed on 6 hours, 2 days or 6 days following radiations. Tissue blocks of neurohypophyses were fixed in the 1% glutaraldehyde-1% paraformaldehyde solution, and they were refixed in the 1% osmium tetroxide solution. Ultrathin sections were contrasted with uranyl acetate and lead citrate solutions. Electron micrographs exhibited dramatic changes within the perivascular space of neurohypopysis. The perivascular space was greatly enlarged, and it contained many macrophages, floating axonal endings and plentiful flocculent materials. The enlargement was largest in the 2 day-group animals. Many macrophages are activated, and it showed tremendous cytoplasmic lamellipoda. Wide plate of macrophagic cytoplasm usually engulfed the floating axon terminals, and are located between the cappillary and the pituicytes. The situation gave the impression that macrophages prevent, filter and/or retrieve the excessive materials transported between the capillary and the axonal endings. Since the perivascular microenvironment of neurohypophysis is more vulnerable as compared with those brain areas equipped with blood-brain barrier, the functional barrier system by macrophages in the neurohypophysis should have important role. The concept of blood-neurohypophyseal barrier with the following components is proposed. The components of the barrier system from the blood pool to the hormonal pool are 1. Endothelium of fenestrated capillary 2. BAsal lamina of endothelium 3. Pericyte("second line of defense". mobile in a limited area) 4. Macrophage, extending its wide cytoplasmic plate(the lamelipoda) in need("third line of defense". freely movable in the perivascular space, "active surveillance system") 5. Basal lamina of pituicyte 6. Cytoplasmic processes of pituicyte

체외형 자동 제세동기(AED)와 심전도계(ECG)를 위한 통신 프로토콜의 설계 및 사용자 인터페이스 구현

김남훈,권희중,권호열,나학록 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

In this paper, we studied Automated External Defibrillator and Electro- Cardiogram System. Proposed System, CU-EX1, is a PC-based AED/ECG system that manages the data acquired by Paramedic CU-ER1. The system controls the transfer of data from the Paramedic CU-ER1 and the storage of the data in a local host computer. Patient data could be entered as soon as the rescue data is stored in a local computer. The system also displays the data on a local computer and facilitates review of rescue events.

상수도 배수방식의 비교방법

박남식,홍성훈,김한수,황병은 동아대학교 건설기술연구소 2003 硏究報告 Vol.27 No.1

In this study quantitative and systematic methods are proposed to compare alternative water supply pipe networks. The design code gives general guidelines on hydraulics and power requirements. However, the design code lacks detailed approaches. In this study aspects regarding hydraulics, water quality, and power requirements are considered. Various quantitative indices are derived.

골프 웨이트 트레이닝과 비거리의 상관관계분석

허남양,장훈석 용인대학교 국제스포츠과학연구원 체육과학연구소 2008 體育科學硏究論叢 Vol.18 No.1

The purpose of this study was to analysis of the result, Seeks the physical elements which influence to non-distance. The research which sees gives and the man a junior golf players and 7 people professional golf players after criminal record and analyzes the physical VIP whom the which is periodic in the object to execute training, measures to non-distance in method of training reaches most plentifully is first, the pliability, criticism formation, agility and muscular endurance all increase, all appeared with the fact that is the difference which considers statistically. Second, non-distance and pliability (r=.458), criticism formation (r=.119) and agility (r=.717) the interrelation does not consider statistically not to be, only the muscular endurance VIP non-distance and appeared with the fact that is the interrelation (r=.872) which is static (+) considers statistically (p=.011). Three, in the physical VIP appeared with the fact that only the resultant muscular endurance VIP who executes the phased (stepwise) regression analysis affects in non-distance.

도심지 노후 상업 건축물의 리모델링과 재건축 비교 연구

김동훈,임남기 동명정보대학교 2002 건축도시연구소 저널 Vol.1 No.-

It we build new building after demolition of commercial building that is located in the downtown, it will be caused a social and environmental problem as wasting of resources and generating of waste. In this study, I investigated remodeling, this conclusion is given below. 1. As a result of comparing the cost of a construction wiht the term of works, it's represented that reconstruction cost is 2.1 times, construction period 1.4 times unfavorable to requirement and rental value 2.4 is time as much remodeling. So remodeling has an advantage. 2. For repairing and reinforcing timeworn building, we reinforced it as using carbon fiber sheet(girder, slab) and injecting method steel plate bonding method Also, we tried to maintain efficiency of new building as using epoxy to protect concrete crack. 3. In the period of demolition construction, a remodeling is reguired three times as much as a reconstruction, however, in the evacuation cost of one, the former is reguired more moderate price than the latter. The next remodeling in order to show and econmical perception of remodling to the owner of building, we have to consider percedent conditions as follows; the development of projects, and to partially clear up the difficult problem of raising money by developing a suitable organization as the merchandise of construction on the installment If we develop research with enterprise·university·laboratory to exploit material and equipment and to train specialized engineer who will has a capacity to know construct repair and reinforce, it can be attribute to prevail remodeling in new construct market.

바람의 영향을 고려한 제주항의 유동해석

김남형,박지훈 濟州大學校 海洋硏究所 2003 해양과환경연구소 연구논문집 Vol.27 No.-

The effect of wind on the circulation in Jeju harbor was examined using a numerical shallow water model. A finite element for analyzing shallow water flow is presented. The Galerkin method is employed for spatial discretization. Two step explicit finite element scheme is used to discretize the time function. which has advantage in problems treating large numbers of elements and unsteady state. The experiments compare the case considering the effect of wind with the case which do not consider the wind effect. According to wind direction NW winds. velocity of flow vector became slightly stronger in the flow field. The computed results have shown the good adaptability of moving boundary condition and effect of wind. From these studies. it can be concluded that the present method is a useful and effective tool in tidal current analysis.

해안 지역의 지하수 개발가능량

박남식,홍성훈,서경수,김성윤,최뢰 東亞大學校 建設技術硏究所 2006 硏究論文集 Vol.30 No.1

An equation is developed to estimate potential groundwater resources available for development. This equation is useful for planning generally conducted prior to detailed design. The equation is a function of major factors such as aquifer characteristics, saltwater intrusion length, coastalgroundwater discharge and location of proposed pumping wells. Therefore, the equation is quite comprehensive. The equations are derived using well-known analytical solutions. Thus, the basis is scientifically sound. Use of the equation is quite simple since it is an explicit function of variables. A logical method is proposed to assess a radius of influence of a pumping well considering aquifer characteristics and pumping rate. Applications to a hypothetical problem and comparison with results from a more rigorous numerical simulation model indicatethat results obtained from the proposed equation are conservative.

의과대학 인성교육 모델개발을 위한 예비연구

송창훈,임성철,박종,이승일,도남용,박상기,박상화 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1