Modeling of the phase equilibria of aqueous two-phase systems using three-dimensional neural network

Hui-Chao Lv,Da Yong Tian 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.1

A three-dimensional neural network model has been designed for representing the phase equilibrium data related to aqueous two-phase systems. The polyvinyl pyrrolidone/phosphate/water system was selected as the model system to demonstrate the point of interest. The collected experimental data were categorized into two subsets, training and validation sets, not only to find the suitable network configuration but also to prevent the overfitting problem. Meanwhile, the weight comparison method was proposed to optimize the three-dimensional neural net. The results of accuracy comparison indicate that it outperforms the two-dimensional neural network on some details and can further enhance the calculation accuracy of the phase equilibrium data for these investigated aqueous two-phase systems. The development of the neural network in the three-dimensional space should be a research project of concern.

A newly developed tridimensional neural network for prediction of the phase equilibria of six aqueous two-phase systems

Hui-Chao Lv,Yong Zheng 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-

A newly developed tridimensional neural network (TRDNN) has been utilized to represent the phaseequilibria of six polyethylene glycol (PEG)-inorganic salt aqueous two-phase systems (ATPSs).18 data setstotaling 108 experimental data in the temperature range (298.2–318.2 K) were categorized into training,test and validation sets in order to teach the model about the input-output relationships and validate itspredictive ability. The optimal configuration of the model was found to be {5, [3,4,5], 3} and the systemerror for the training process was determined as 0.0055. Results indicate that the TRDNN model hasbetter prediction performance as compared to the two-dimensional model. The standard deviationscorresponding to three data sets for the TRDNN model were 0.0057, 0.0068 and 0.0055, while those forthe two-dimensional model were 0.0065, 0.0078 and 0.0062, respectively. Moreover, it incorporates themolecular weight of polymer, salt type and temperature in one model and can reflect the effects of thesefactors on the phase behavior of these ATPSs correctly.

Correlation of Liquid-Liquid Equilibrium of Four Binary Hydrocarbon-Water Systems, Using an Improved Artificial Neural Network Model

Lv, Hui-Chao,Shen, Yan-Hong Korean Chemical Society 2013 대한화학회지 Vol.57 No.3

A back propagation artificial neural network model with one hidden layer is established to correlate the liquid-liquid equilibrium data of hydrocarbon-water systems. The model has four inputs and two outputs. The network is systematically trained with 48 data points in the range of 283.15 to 405.37K. Statistical analyses show that the optimised neural network model can yield excellent agreement with experimental data(the average absolute deviations equal to 0.037% and 0.0012% for the correlated mole fractions of hydrocarbon in two coexisting liquid phases respectively). The comparison in terms of average absolute deviation between the correlated mole fractions for each binary system and literature results indicates that the artificial neural network model gives far better results. This study also shows that artificial neural network model could be developed for the phase equilibria for a family of hydrocarbon-water binaries.

Enhancement of Anti-tumor Activity of Newcastle Disease Virus by the Synergistic Effect of Cytosine Deaminase

Lv, Zheng,Zhang, Tian-Yuan,Yin, Jie-Chao,Wang, Hui,Sun, Tian,Chen, Li-Qun,Bai, Fu-Liang,Wu, Wei,Ren, Gui-Ping,Li, De-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

This study was conducted to investigate enhancement of anti-tumor effects of the lentogenic Newcastle disease virus Clone30 strain (NDV rClone30) expressing cytosine deaminase (CD) gene against tumor cells and in murine groin tumor-bearing models. Cytotoxic effects of the rClone30-CD/5-FC on the HepG2 cell line were examined by an MTT method. Anti-tumor activity of rClone30-CD/5-FC was examined in H22 tumor-bearing mice. Compared to the rClone30-CD virus treatment alone, NDV rClone30-CD/5-FC at 0.1 and 1 MOIs exerted significant cytotoxic effects (P<0.05) on HepG2 cells. For treatment of H22 tumor-bearing mice, recombinant NDV was injected together with 5-FC given by either intra-tumor injection or tail vein injection. When 5-FC was administered by intra-tumor injection, survival for the rClone30-CD/5-FC-treated mice was 4/6 for 80 days period vs 1/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC and saline alone, respectively. When 5-FC was given by tail vein injection, survival for the rClone30-CD/5-FC-treated mice was 3/6 vs 2/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC or saline alone, respectively. In this study, NDV was used for the first time to deliver the suicide gene for cancer therapy. Incorporation of the CD gene in the lentogenic NDV genome together with 5-FC significantly enhances cell death of HepG2 tumor cells in vitro, decreases tumor volume and increases survival of H22 tumor-bearing mice in vivo.

Fabrication of tubular porous titanium membrane electrode and application in electrochemical membrane reactor for treatment of wastewater

Hui Tong,Chao Yang,Yanqi Lv,Ling Wang,Koucheng Chen,Xingfu Zhou 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.96 No.-

In this study, tubular titanium membrane (TTM) /SnO2-Sb/SnO2-Sb-CeO2 porous anode was fabricatedand used in continuous tubular membrane reactor for electrochemical treatment of dye wastewater. Xraydiffraction (XRD), scanning electron microscopy (SEM) and high-resolution transmission electronmicroscopy (HRTEM) were used to evaluate the morphology and microstructure of the different tubulartitanium membrane. Linear sweep voltammetry (LSV) and accelerated service life test are employed toillustrate the performance of TTM/SnO2-Sb/SnO2-Sb-CeO2 porous membrane electrode. It is found thatTTM/SnO2-Sb/SnO2-Sb-CeO2 active layer on titanium membrane has compact microstructure, high over-potential for oxygen evolution (2.10 V vs saturated calomel electrode). The effects of pore diameter,applied voltage andflow rate on the electro-catalytic property of the tubular porous electrode wereinvestigated. Study shows titanium membrane reactor with an optimized pore diameter of 10 mm has thelowest energy consumption which is important for the practical application of electrochemicaltechnology. The performance of titanium tubular membrane reactor is investigated by treatingmethylene blue (MB) wastewater under the cell voltage of 3.0–4.5 V and theflow rate of 2.5–3.5 L min 1. This continuous titanium membrane electrochemical reactor using solar cell show excellent performancein treating dye wastewater and the further potential application in electrochemical synthesis.

Multiaxial Fatigue Life Prediction Based on High-Cycle Uniaxial Fatigue Test of Steel Pipe Weldments with Welding Defects

Hui Liu,Xiu-wen Lv,Shi-chao Chen,Qiang Zhou,Piao Zhou,Wei-lian Qu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.1

Welding defects are unavoidable for welded structures, which can lead to fatigue damage even under the random wind load with small amplitude. It is therefore necessary to explore the effect of welding defect on the fatigue properties of welded steel pipes. Three groups of welded steel pipe specimens were designed according to welding defect conditions, i.e. specimens without welding defect (Group I), specimens with incomplete fusion (Group II), and specimens with welding porosity (Group III). Uniaxial tension–compression and torsion high-cycle fatigue tests were carried out. S–N curves of uniaxial tension–compression and torsion tests were obtained by cyclic loading with equal stress amplitude. The test results show that the high-cycle fatigue strength of weldments is obviously lower than that of base metal with the same strength under uniaxial tension–compression and torsion loading. In addition, the welding defects result in a decrease in fatigue strength, while the decrease extent by welding porosity is greater than that by incomplete fusion. Finally, because of the inherent multiaxial loading characteristics of welded structures, the high-cycle multiaxial fatigue life of steel pipe weldments was also predicted by using the modified Wöhler curve method based on the uniaxial fatigue test results. It can be found that when the stress amplitude is constant, the fatigue life of welded steel pipe decreases and the modified Wöhler curves move downward more quickly with the increase of damage parameter defined as the ratio of normal stress amplitude to shear stress amplitude on the critical plane, which means that normal stress amplitude will accelerate the cracks growth and result in faster failure of the weld materials.

Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats

Yan-chao Wang,Jin-miao Lu,Hui-zi Jin,Ai-niu Ma,Jin-yang Zhang,Nian Gong,Qi Xiao,Bin Zhu,Ying-fang Lv,Na Yu,Wei-dong Zhang,Yong-xiang Wang 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2

BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (SamdasooTM), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.

Effects of graphite additives in electrolytes on the microstructure and corrosion resistance of Alumina PEO coatings

Guo-Hua Lv,Huan Chen,Wei-Chao Gu,Wen-Ran Feng,Li Li,Er-Wu Niu,Xian-Hui Zhang,Si-Ze Yang 한국물리학회 2009 Current Applied Physics Vol.9 No.3

In the present work, graphite grains of different sizes were added into the electrolyte to prepare ceramic coatings on aluminum by plasma electrolytic oxidation (PEO). Scanning electron microscopy (SEM) coupled with an energy dispersive X-ray analysis system (EDX), Raman spectroscopy and X-ray diffractometer (XRD) were used to characterize the coatings. A three-electrode system was used to evaluate the corrosion performances of the coatings in a 3.5 wt.% NaCl solution. It was found that the morphology and corrosion performance of the coatings were significantly influenced by the size of the graphite grains. Compared with bigger graphite grains, finer ones were involved in the oxidation process and embedded within the ceramic coatings, which made the coatings less porous and more compact. Thus, the corrosion resistance of the coatings with embedded graphite grains was greatly improved. In the present work, graphite grains of different sizes were added into the electrolyte to prepare ceramic coatings on aluminum by plasma electrolytic oxidation (PEO). Scanning electron microscopy (SEM) coupled with an energy dispersive X-ray analysis system (EDX), Raman spectroscopy and X-ray diffractometer (XRD) were used to characterize the coatings. A three-electrode system was used to evaluate the corrosion performances of the coatings in a 3.5 wt.% NaCl solution. It was found that the morphology and corrosion performance of the coatings were significantly influenced by the size of the graphite grains. Compared with bigger graphite grains, finer ones were involved in the oxidation process and embedded within the ceramic coatings, which made the coatings less porous and more compact. Thus, the corrosion resistance of the coatings with embedded graphite grains was greatly improved.

Comorbidity Relationship to Outcome of Radical Cystectomy in Chinese: a Single Institution Study with the ACE-27 Comorbidity Index

Xuan, Zhu,Zhong, Zhao-Hui,Zhang, Xuan-Zhi,Zhang, Lei,Zhao, Xiao-Kun,Lv, Chen,Xu, Ran,Ren, Wei-Gang,Li, Song-Chao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

To determine the relationship between comorbidity and outcome after radical cystectomy in Chinese patients by using the Adult Comorbidity Evaluation (ACE)-27 index. Two-hundred-and-forty-six patients treated with radical cystectomy at the Second Xiangya Hospital of Central South University, Hunan Province, China between 2000 and 2010 were retrospectively analyzed. Medical records were reviewed for age, gender, delayed time of radical cystectomy, urinary diversion type, pelvic lymphadenectomy status, TNM stage, and pathological grade. Comorbidity information was assessed by the ACE-27 index. The outcome measurement was overall survival. Univariate and multivariate Cox proportional hazards regression analyses were used to determine the association between comorbidity and outcome. The study population consisted of 215 (87.40%) males and 31 (12.60%) females with a mean age of $62{\pm}11$ years. Median duration of follow-up was $47{\pm}31$ months. A total of 151 (61.38%) patents died during follow-up. Of those, 118 (47.97%) had at least one comorbidity. According to the ACE-27 scores, 128 (52.03%) patients had no comorbidity, 79 (32.11%) had mild, 33 (13.41%) had moderate, and 6 (2.45%) had severe comorbidities. Multivariate analysis indicated that moderate (p=0.002) and severe (p<0.001) comorbidity was significantly associated with decreased overall survival. In addition, age ${\geq}70$ years (p=0.002), delayed time of radical cystectomy >12 weeks (p=0.044), pelvic lymphadenectomy status (p=0.014), and TNM stage >T3 (p<0.001) were determined to be independent risk factors of overall survival. Increasing severity of comorbidity statistically correlated with decreased overall survival after radical cystectomy.