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Synthesis of Novel 2'-Spirocyclopropanoid 4'-Deoxythreosyl Phosphonic Acid Nucleoside Analogues
Shen, Guang Huan,Hong, Joon Hee Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.3
Efficient synthetic route to novel 2'-spirocyclopropanoid 4'-deoxythreosyl phosphonic acid nucleosides was described from 1,4-dihydroxy-2-butene. Cyclopropane moiety was prepared via ester enolate alkylation using (2-chloroethyl)dimethylsulfonium iodide. Synthesized nucleoside analogues 16, 19, 23 and 26 were tested for anti-HIV activity as well as cytotoxicity. However, none of them showed any anti-HIV activity or cytotoxicity up to 100 ${\mu}M$.
Shen, Guang Huan,Hong, Joon Hee Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
Novel 5'-deoxythreosyl purine phosphonic acid analogues containing a 2'-electropositive moiety such as fluorine atom, were designed and synthesized from commercially available 1,3-dihydroxy acetone. Condensation successfully proceeded from a glycosyl donor 6 under Vorbr$\ddot{u}$ggen conditions and cross-metathesis gave the desired phosphonate analogues 7a, 7b, 17a and 17b. The synthesized nucleoside phosphonic acid analogues 13, 16, 23, 26, 28 were subjected to antiviral screening against HIV-1. The bis(SATE) adenine analogue 28 exhibited significant in vitro activities against HIV-1.
Shen, Guang Huan,Hong, Joon Hee MARCEL DEKKER INC 2014 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol.33 No.1
<P>A very efficient synthetic route to novel 2',2'-difluoro 5'-norcarbocyclic phosphonic acid nucleosides from but-3-en-1-ol 5 is described. The discovery of 2'-fluorinated furanose nucleoside 1 as a potent anti-HIV-1 agent has led to the synthesis and biological evaluation of 2'-modified 5'-norversions of the carbocyclic phosphonate nucleosides. The synthesized nucleoside analogues 18, 19, 23a, 23b, and 24 were tested for anti-HIV activity as well as cytotoxicity. Adenine analogue 19 shows significant anti-HIV-1 activity (EC(50) = 13 μM).</P>
Shen, Guang Huan,Kang, Lien,Kim, Eun-Ae,Lee, Won-Jae,Hong, Joon-Hee Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
The discovery that threosyl phosphonate nucleoside (PMDTA, $EC_{50}=2.53{\mu}M$) is a potent anti-HIV agent has led to the synthesis and biological evaluation of 5'-deoxy versions of threosyl phosphonate nucleosides. In the present study, (E)-3'-phosphonoalkenyl and 3'-phosphonoalkyl nucleoside analogues 13, 16, 20 and 23 were synthesized from acetol and tested for anti-HIV activity and cytotoxicity. The adenine analogue 16 was found to exhibit moderate in vitro anti-HIV-1 activity ($EC_{50}=22.2{\mu}M$).
Guang Huan Shen,Lien Kang,김은애,이원재,홍준희 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
The discovery that threosyl phosphonate nucleoside (PMDTA, EC50 = 2.53 μM) is a potent anti-HIV agent has led to the synthesis and biological evaluation of 5'-deoxy versions of threosyl phosphonate nucleosides. In the present study, (E)-3'-phosphonoalkenyl and 3'-phosphonoalkyl nucleoside analogues 13, 16, 20 and 23 were synthesized from acetol and tested for anti-HIV activity and cytotoxicity. The adenine analogue 16 was found to exhibit moderate in vitro anti-HIV-1 activity (EC50 = 22.2 μM).
Synthesis of Novel 2'-Spirocyclopropanoid 4'-Deoxythreosyl Phosphonic Acid Nucleoside Analogues
Guang Huan Shen,홍준희 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.3
Efficient synthetic route to novel 2'-spirocyclopropanoid 4'-deoxythreosyl phosphonic acid nucleosides was described from 1,4-dihydroxy-2-butene. Cyclopropane moiety was prepared via ester enolate alkylation using (2-chloroethyl)dimethylsulfonium iodide. Synthesized nucleoside analogues 16, 19, 23 and 26 were tested for anti-HIV activity as well as cytotoxicity. However, none of them showed any anti-HIV activity or cytotoxicity up to 100 μM.
Guang Huan Shen,홍준희 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
Novel 5'-deoxythreosyl purine phosphonic acid analogues containing a 2'-electropositive moiety such as fluorine atom, were designed and synthesized from commercially available 1,3-dihydroxy acetone. Condensation successfully proceeded from a glycosyl donor 6 under Vorbrüggen conditions and cross-metathesis gave the desired phosphonate analogues 7a, 7b, 17a and 17b. The synthesized nucleoside phosphonic acid analogues 13, 16, 23, 26, 28 were subjected to antiviral screening against HIV-1. The bis(SATE) adenine analogue 28 exhibited significant in vitro activities against HIV-1.
The Research of Digital Forensics Technologies under Cloud Computing Environment
Huan Ma,Gaofeng Shen,Ming Chen,Jianwei Zhang 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3
As the time of cloud computing comes, Cloud computing is estimated to be one of the most transformative technologies in the history of computing. Cloud organizations, including the providers and customers of cloud services, have yet to establish a well-defined forensic capability. Computer cybercrime has become very prominent forms of crime, but the traditional forensic methods have not met the requirements of the new digital forensics environment. In this paper, upon the use of cloud computing resource sharing, storage distribution and other characteristics and based on the analysis of cloud computing environments difficulties on digital forensics, new digital forensics methods and new digital forensics architecture in the cloud-based platform are proposes to meet rapid forensics needs in the era of cloud computing and to deal with the effectiveness, usefulness, depth issues and real-time and reliability problems.
Shen, Mei-Lin,Xu, Ling,Liu, Bing,Jiao, Huan,Kwon, Young-Uk The Royal Society of Chemistry 2018 Dalton transactions Vol.47 No.25
<P>Compound 1, [Eu(NDC)(H2O)Cl] (H2NDC = 2,6-Naphthalene dicarboxylic acid), with thermosensitive fluorescence was fabricated into composite films with polyether sulfone, and the one with 40% loading of 1 showed highly sensitive and repeatable thermal sensor properties in an alarm device.</P>
TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma
Suqin Shen,Huan Feng,Longjiang Liu,Wei Su,Jiaxue Wu,Long Yu 생화학분자생물학회 2020 BMB Reports Vol.53 No.8
Alpha-fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for Hepatocellular carcinoma (HCC). However, the underlying mechanism of AFP expression in HCC is poorly understood. In this study, we found that TCP10L, a gene specifically expressed in the liver, is down-regulated in HCC and that its expression inversely correlates with AFP expression. Moreover, overexpression of TCP10L suppresses AFP expression whereas knockdown of TCP10L increases AFP expression, suggesting that TCP10L might be a negative regulator of AFP. We found that TCP10L is associated with the AFP promoter and inhibits AFP promoter-driven transcriptional activity. Taken together, these results indicate that TCP10L negatively regulates AFP expression in HCC and that it could be a potential prognostic marker and therapeutic target for HCC.