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Urushiol Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells
Seaho Kim,So-Hyun Jeong,Mohammad Akbar Hossain1,Min Young Kim,김동환,Jin-Ah Kim,윤정현,나천수,김남득 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
In this study, we investigated the effects of urushiol which was isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), on the proliferation of MCF-7 human breast cancer cells. Forty-eight hour treatment of urushiol inhibited the growth of breast cancer cells and induced cell DNA fragmentation. This urushiol-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly (ADP-ribose) polymerase. Urushiol also caused a marked increase in the level of p21WAF1/CIP1protein in a p53-dependent manner. Based on our data, urushiol can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to confirm this.
Morin Inhibits the Growth of Murine Hepatoma Cells via Cell Cycle Arrest and Induction of Apoptosis
Mi-Na Kim,Eun-Young Ahn,Sang Eun Park,Mohammad Akbar Hossain1,Min Young Kim,문전옥,김남득,윤정현 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.3
Morin (3,5,7,2’,4’-pentahydroxyflavone) is a common dietary flavonoid that exhibits various biological activities, including anti-proliferative, anti-tumor promotion, anti-oxidative, and anti-inflammatory effects. In the present study, we investigated the effects of morin on the cell growth and the viabilities of hepa1c1c7 murine hepatoma cells. Flow cytometric analysis showed that morin-treated cells increased sub-G1 peak accompanied by DNA cleavage and phosphatidylserine externalization, indicating early apoptosis. Flow cytometric analysis also revealed that morin treatment induced G2/M arrest in the cell cycle progression. In addition, morin treatment induced alterations in expression levels of proteins which are linked to cell cycle and apoptosis, such as cyclin B1, Cdc2, Fas, Fas ligand, Bax, Bcl-2, caspase-9,caspase-3, and poly (ADP-ribose) polymerase, in a concentration-dependent manner. Taken together, these results suggest that morin inhibit cell growth and induce cytotoxicity of murine hepatoma cells through G2/M phase arrest and apoptosis.