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- 저자 : Hongzhen Zhang (검색결과 4 건)
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Hongzhen Zhang,Ronghua Xu,Zuowen Yin,Jun Yu,Ning Liang,Geng Qian 한국고분자학회 2022 Macromolecular Research Vol.30 No.1
Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drugloaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.
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Yang Wang,Victoria Nisenblat,Liyuan Tao,XinYu Zhang,Hongzhen Li,Caihong Ma 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3
Objective: To evaluate the effectiveness of oral contraceptive pill (OCP) as therapy for endometrial hyperplasia (EH) without atypia in reproductive-aged women compared with oral progestin. Methods: A retrospective cohort study was carried out in our reproductive center. Consecutive patients diagnosed with infertility and non-atypical EH identified through electronic database who met inclusion criteria (n=309). Patients were assigned to two treatment groups: OCP (n=216) and oral progestin (n=93); clinical and reproductive outcomes were recorded. Results: Reversal of EH to normal endometrium, clinical pregnancy, live birth and miscarriage rate. Women in OCP group were younger, had higher prevalence of Polycystic Ovary Syndrome and other uterine pathology and longer duration of infertility than women in progestin group. Reversal of EH was observed in 93.52% women on OCP and in 86.02% women on progestin (p=0.032; adjusted odds ratio [aOR]= 2.35; 95% confidence interval [CI]=1.06-5.21) after the initial course of treatment for 2 to 6 months. Cyclic OCP (n=184) resulted in better response to treatment compared to continuous OCP (n=32) (95.11% vs. 84.38%; p=0.039; aOR =3.60; 95% CI =1.12-11.55). Clinical pregnancy rate in OCP group was marginally higher than progestin group (87/208, 41.83% vs. 27/90, 30.00%; p=0.054). Miscarriage (25.29% vs. 29.63%; p=0.654) and live birth rate (31.25% vs. 21.11%; p=0.074) were comparable between the groups. Conclusion: For the first time we demonstrate that OCP is an effective therapy for nonatypical EH and is associated with higher remission rate compared with oral progestin. Reproductive outcomes are reassuring and comparable between the two groups.
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Banpu Ruan,Zhenyu Gao,Juan Zhao,Bin Zhang,Anpeng Zhang,Kai Hong,Shenglong Yang,Hongzhen Jiang,Chaolei Liu,Guang Chen,Youlin Peng,Guojun Dong,Longbiao Guo,Zhengjin Xu,Qian Qian 한국식물학회 2017 Journal of Plant Biology Vol.60 No.4
Leaf color-related mutants are important materialsto study the chlorophyll biosynthesis and chloroplastdevelopment. Here, we isolated and characterized a thermosensitiveyellow-green leaf mutant, ygl, through mutagenizedJaponica rice cultivar Zhonghua11 by EMS. The mutantshowed yellow-green leaves only at the seedling stage. Genetic and molecular analyses uncovered that YGL encodean Mg2+-chelatase ChlD subunit, which was a new allele ofChl1/YGL7. Quantitative PCR and GUS staining showedthat the YGL transcripts expressed in all tested organs andsubcellular localization detected YGL protein in the chloroplasts. The mutant displayed yellow-green leaves at 20°C andnormal green leaves at 34°C during the seedling stage. Transcript level of YGL in the ygl mutant was significantlyreduced at 20°C, and increased at 34°C compared with thewild-type plant. Furthermore, the expression of chlorophyllbiosynthesis and chloroplast development related genes wereinfluenced by the mutation of YGL at different temperature. These findings suggested that the YGL gene not only play akey role in chlorophyll biosynthesis, but is affected attranscript level by temperature in rice.
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An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
Zhao Qianwen,Shao Tinghui,Zhu Yuwen,Zong Gengjie,Zhang Junjie,Tang Shifan,Lin Yanshan,Ma Hongzhen,Jiang Zhifan,Xu Yong,Wu Xiaoyan,Zhang Tao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Myofibroblasts, characterized by the expression of the matricellular protein periostin (Postn), mediate the profibrogenic response during tissue repair and remodeling. Previous studies have demonstrated that systemic deficiency in myocardin-related transcription factor A (MRTF-A) attenuates renal fibrosis in mice. In the present study, we investigated the myofibroblast-specific role of MRTF-A in renal fibrosis and the underlying mechanism. We report that myofibroblast-specific deletion of MRTF-A, achieved through crossbreeding Mrtfa-flox mice with Postn-CreERT2 mice, led to amelioration of renal fibrosis. RNA-seq identified zinc finger E-Box binding homeobox 1 (Zeb1) as a downstream target of MRTF-A in renal fibroblasts. MRTF-A interacts with TEA domain transcription factor 1 (TEAD1) to bind to the Zeb1 promoter and activate Zeb1 transcription. Zeb1 knockdown retarded the fibroblast–myofibroblast transition (FMyT) in vitro and dampened renal fibrosis in mice. Transcriptomic assays showed that Zeb1 might contribute to FMyT by repressing the transcription of interferon regulatory factor 9 (IRF9). IRF9 knockdown overcame the effect of Zeb1 depletion and promoted FMyT, whereas IRF9 overexpression antagonized TGF-β-induced FMyT. In conclusion, our data unveil a novel MRTF-A–Zeb1–IRF9 axis that can potentially contribute to fibroblast–myofibroblast transition and renal fibrosis. Screening for small-molecule compounds that target this axis may yield therapeutic options for the mollification of renal fibrosis.
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