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Effects of Imipramine on A-type K^+ Current in Murine Proximal Colon
Yoon, Hong,Choi, Hyun-Dong,Lee, Jeong-Hoe,Cho, Cheoi-Hee,Kim, Gi-Sig,Shin, Moo-Kyoung,Yeum, Cheol-Ho,Yun, Pyung-Jin,Jun, Jae-Yeoul 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2
목적 : Imipramine은 널리 쓰이는 항우울제로 알려져 있으나 상대적으로 위장관 운동성에 대한 부작용을 빈번히 보이는 바 대장 평활근 세포에서 외향성 칼륨 통로에 대한 imipramine의 효과를 관찰하고 그 조절기전을 알아보고자 하였다. 재료 및 방법 : Collagenase를 사용하여 생쥐 대장 평활근에서 단일세포를 분리한 다음 역상 현미경하에서 세포막전압 고정법(Whole-cell patch clamp)을 시행하였다. Ca2+-의존성 칼륨 전류를 배제하기 위하였다. 결과: 유지전압 80 mV에서 10 mV씩 단계별로 저분극 자극를 주게 되면 자극 초기에 큰 전류가 발생되면서 빠르게 비활성화 되는 전류가 기록되었다. 이 전류는 4-aminopyridine (4-AP) 5 mM를 투여한 경우 억제되어 A-형의 칼륨 전류임을 확인하였으며 tetraethylammonium (TEA) 10 mM 투여시 전류의 후반부가 억제되는 지연 정류성 칼륨 전류임을 확인하였다. Imipramine은 A-형 칼륨 전류를 농도-의존적으로 억제하였다. 이 전류의 halfinactivation은 42.5±2.9 mV를 보였으며 imipramine은 45.1±1.7 mV로서 비활성화 과정에는 아무런 영향을 나타내지 않았다. Recovery time에서도 대조군은 50% 전류가 회복되는 데 있어 23 sec를 보였으며 imipramine은 24 sec로서 통계학상 차이가 없었다. Imipramine에 의한 A-형 칼륨 전류의 억제 현상은 세포내 1 mM guanosine 5-O-(2-thiodiphosphate)(GDPβS)를 첨가한 경우에서도 변화하지 않았다. 또한 protein kinase C 억제제인 chelerythrine이 존재한 경우에서도 변화되지 않았다. 결론 : 이상의 실험결과를 종합해보면 항우울제인 imipramine은 G-단백과 protein kinase C와 무관하게 A-형의 외향성 칼륨 통로를 차단하며 이러한 효과가 위장관 운동성 부작용에 대한 한 기전으로 설명될 수 있으리라 생각된다. To investigate of effects of imipramine, an antidepressant agent, on delayed rectifier K+ currents in murine proximal colonic smooth muscle cells, A-type delayed rectifier K+ currents were recorded from isolated cells using the standard whole-cell configuration. Depolarizing test pulses between -80 mV and +30 mV with 10 mV increment from the holding potential of -80 mV activated voltage-dependent outward K+ currents that peaked within 50 ms followed slow decreasing sustained currents. Early peak currents were inhibited by the application of 4-AP, whereas sustained currents were inhibited by the application of TEA. Bath application of imipramine inhibited the 4-AP sensitive A-type K+ currents, dose-dependently. But, half-inactivation potential and half-recovery time were not changed by imipramine. The imipramine-induced inhibition was not changed when 1 mM guanosine 5-O-(2-thiodiphosphate) (GDPβS) was in the pipette. Also, in the presence of chelerythrine, a protein kinase C inhibitor, imipramine-induced inhibition was not changed. These results suggest that imipramine inhibits A-type delayed rectifier K+ currents by G-protein and protein kinase C- independent manner.
Koh, Yoon-Seok,Jung, Hae-Ok,Park, Mahn-Won,Baek, Joo-Yeoul,Yoon, Sung-Gyu,Kim, Pum-Joon,Ihm, Sang-Hyun,Chang, Kiyuk,Oh, Yong-Seog,Youn, Ho-Joong,Baek, Sang Hong,Chung, Wook-Sung,Seung, Ki-Bae,Kim, Jae Korean Society of Echocardiography 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4
<P>Left ventricular hypertrophy (LVH) has been known as an important predictor of prognosis of cardiovascular disease. Carboxy-terminal propeptide of procollagen type I (PIP) is related with myocardial fibrosis. We sought to analyze the differences in the characteristics of LVH, myocardial fibrosis, and LV functions among hypertension (HBP), diabetes mellitus (DM) and chronic renal failure (CRF).</P>
구경윤(Kyoung Yoon Koo),김원백(Won Baek Kim),박소해(So Hae Park),김민지(Minji Kim),김보람(Bo Ram Kim),황지회(Jihoe Hwang),김민정(Min Jung Kim),손홍주(Hong Joo Son),황대연(Dae Youn Hwang),김동섭(Dong Seob Kim),이충열(Chung Yeoul Lee) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.4
본 연구에서는 천문동 건근의 부위에 따른 항산화 활성을 비교하여 이와 관련된 물질을 탐색하고 동정하였다. 천문동 건근에서 항산화 활성이 높은 부위는 껍질에 해당하고 DPPH radical 소거능, nitrite 소거능, hydroxy radical 소거능 및 ABTS 양이온 소거능과 같은 항산화 활성이 껍질 부위에서 상대적으로 높은 것을 확인할 수 있었으며, 이러한 결과는 껍질에 존재하는 폴리페놀 화합물에 의한 것으로 판단되었다. 껍질에 존재하는 항산화 활성 물질을 HPLC를 이용하여 분리하고 동정한 결과 리그닌의 생합성에 중요한 전구물질인 caffeic acid가 주요 항산화 활성 물질이었으며, 이러한 결과를 토대로 천문동이 지닌 효능을 최대로 사용하기 위해서는 천문동의 건조 후에 껍질을 제거하지 않고 사용하는 것이 바람직한 것으로 생각한다. This study was performed to compare the antioxidative activities of methanol extracts from Asparagus cochinchinensis with whole root (W-AC), flesh (F-AC), and root bark (B-AC). To evaluate the antioxidative properties of their methanol extracts, 1,1-diphenyl-2-picrylhydrazyl radical, nitrite, hydroxyl radical, 2,2"-azino-bis(3-ethylbenz thiazoline-6-sulfonate) radical scavenging activities, and contents of total flavonoid and polyphenol contents were measured. B-AC extract showed the highest antioxidative activity, whereas F-AC extract showed the lowest. For B-AC extract, caffeic acid was isolated by preparative high-performance liquid chromatography and confirmed by liquid chromatography-mass spectrometry and absorption spectroscopy, which showed 1.6% of total polyphenol contents among all methanol extracts.
Seon, Ji-Yun,Yoon, Young Joon,Choi, Jaekyoung,Kim, Hyo Tae,Kim, Chang-Yeoul,Kim, Jong-Hee,Baik, Hong Koo American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.11
<P>A dielectophoretic (DEP) device fabricated by a conventional low temperature co-fired ceramic (LTCC) process, for manipulating micro and nanostructure materials, such as spherical polystyrene microspheres, titanium dioxide (TiO2) nanotubes, and silver (Ag) nanowires, is described. To generate a non-uniform electric field, a castellated electrode configuration was applied to the LTCC-based DEP device using a screen printing method. The actual motions of the micro and nanostructure materials under both a positive and a negative DEP force were observed in detail and the findings compared with numerical simulation data for the electric field distribution. The performance of the LTCC-based DEP device for separating and trapping was evaluated and potential applications are discussed.</P>
Japanese government research grants for Kampo medicine: an overview of 10 years (1997–2017)
Min Kyung Hyun,Hong Yeoul Yoon,Tetsuhiro Yoshino,Min Jung Park 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.4
Background: Japan has its own traditional medicine called Kampo medicine, but it is relatively unknown compared to traditional Chinese medicine. Therefore, this study examined the current status of the research related to Kampo medicine supported by Japanese government research grants (JGRG). Methods: Three databases were searched on October 2019: National Institute of Public Health, Grant-in-Aid for Scientific Research and Japan Agency for Medical Research and Development. The search keywords were Kampo medicine, acupuncture, integrative medicine, oriental medicine, and traditional medicine. The final research that satisfied the inclusion criteria were selected and analyzed. Results: After a comprehensive search of the three databases and removing any duplication research, 2,246 JGRG (985 new proposals) that met the inclusion criteria were selected. The number and amount of JGRG on Kampo medicine have been increasing steadily. The basic research conducted by academic research institutes was mainstream, and the proportion of development research of new Kampo medical technology was low. Most research were non-clinical research and 21 % were clinical research. The largest research institute was the Toyama University and there were many non-clinical, cancer, and Juzentaihoto (Japanese herbal medicine) research. The Japanese government grants were funded relatively evenly without bias to specific fields or institutions. Conclusions: The Japanese government research grants from 1973 to 2017 indicate that research on Kampo medicine which barely had any interest previously, was revived in the 2000s. In particular, it increased sharply in the 2010s, and the research fields were relatively diverse.
( Minji Kim ),( Kim Won-baek ),( Kyoung Yoon Koo ),( Bo Ram Kim ),( Doohyun Kim ),( Seoyoun Lee ),( Hong Joo Son ),( Dae Youn Hwang ),( Dong Seob Kim ),( Chung Yeoul Lee ),( Heeseob Lee ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.4
This study was conducted to evaluate the hyaluronidase (HAase) inhibition activity of Asparagus cochinchinesis (AC) extracts following fermentation by Weissella cibaria through response surface methodology. To optimize the HAase inhibition activity, a central composite design was introduced based on four variables: the concentration of AC extract (X<sub>1</sub>: 1-5%), amount of starter culture (X<sub>2</sub>: 1-5%), pH (X<sub>3</sub>: 4-8), and fermentation time (X<sub>4</sub>: 0-10 days). The experimental data were fitted to quadratic regression equations, the accuracy of the equations was analyzed by ANOVA, and the regression coefficients for the surface quadratic model of HAase inhibition activity in the fermented AC extract were estimated by the F test and the corresponding p values. The HAase inhibition activity indicated that fermentation time was most significant among the parameters within the conditions tested. To validate the model, two different conditions among those generated by the Design Expert program were selected. Under both conditions, predicted and experimental data agreed well. Moreover, the content of protodioscin (a well-known compound related to anti-inflammation activity) was elevated after fermentation of the AC extract at the optimized fermentation condition.
So, Keum Young,Kim, Sang Hun,Sohn, Hong Moon,Choi, Soo Jin,Parajuli, Shankar Prasad,Choi, Seok,Yeum, Cheol Ho,Yoon, Pyung Jin,Jun, Jae Yeoul Springer-Verlag 2009 Molecules and cells Vol.27 No.5
<P>We studied the effect of carbachol on pacemaker currents in cultured interstitial cells of Cajal (ICC) from the mouse small intestine by muscarinic stimulation using a whole cell patch clamp technique and Ca2+-imaging. ICC generated periodic pacemaker potentials in the current-clamp mode and generated spontaneous inward pacemaker currents at a holding potential of-70 mV. Exposure to carbachol depolarized the membrane and produced tonic inward pacemaker currents with a decrease in the frequency and amplitude of the pacemaker currents. The effects of carbachol were blocked by 1-dimethyl-4-diphenylacetoxypiperidinium, a muscarinic M(3) receptor antagonist, but not by methotramine, a muscarinic M(2) receptor antagonist. Intracellular GDP-beta-S suppressed the carbachol-induced effects. Carbachol-induced effects were blocked by external Na+-free solution and by flufenamic acid, a non-selective cation channel blocker, and in the presence of thapsigargin, a Ca2+-ATPase inhibitor in the endoplasmic reticulum. However, carbachol still produced tonic inward pacemaker currents with the removal of external Ca2+. In recording of intracellular Ca2+ concentrations using fluo 3-AM dye, carbachol increased intracellular Ca2+ concentrations with increasing of Ca2+ oscillations. These results suggest that carbachol modulates the pacemaker activity of ICC through the activation of non-selective cation channels via muscarinic M(3) receptors by a G-protein dependent intracellular Ca2+ release mechanism.</P>