http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
( Sun-uk Bak ),( Suji Kim ),( Hae-jun Hwang ),( Jung-a Yun ),( Wan-sung Kim ),( Moo-ho Won ),( Ji-yoon Kim ),( Kwon-soo Ha ),( Young-guen Kwon ),( Young-myeong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2
Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKLinduced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect. CORM-2 also inhibited RANKLinduced osteoclastogenesis and osteoclastic resorption activity in marrow-derived macrophages. Treatment with hemin, a HO-1 inducer, strongly inhibited RANKL-induced osteoclastogenesis in wild-type macrophages, but was ineffective in HO-1<sup>+/- </sup>cells. CORM-2 reduced RANKL-induced NFATc1 expression by inhibiting IKK-dependent NF-κB activation and reactive oxygen species production. These results suggest that CO potently inhibits RANKL-induced osteoclastogenesis by inhibiting redox-sensitive NF-κB-mediated NFATc1 expression. Our findings indicate that HO-1/CO can act as an antiresorption agent and reduce bone loss by blocking osteoclast differentiation. [BMB Reports 2017; 50(2): 103-108]
Tae-Hoon Kim,Ji-Yoon Kim,Jieun Bae,Young-Mi Kim,Moo-Ho Won,Kwon-Soo Ha,Young-Guen Kwon,Young-Myeong Kim 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.2
Background: Korean Red ginseng extract (KRGE) has beneficial effects on the cardiovascular system by improving endothelial cell function. However, its pharmacological effect on endothelial cell senescence has not been clearly elucidated. Therefore, we examined the effect and molecular mechanism of KRGE on the senescence of human umbilical vein endothelial cells (HUVECs). Methods: HUVECs were grown in normal or KRGE-supplemented medium. Furthermore, they were transfected with heme oxygenase-1 (HO-1) gene or treated with its inhibitor, a NF-κB inhibitor, and a miR-155-5p mimic or inhibitor. Senescence-associated characteristics of endothelial cells were determined by biochemical and immunohistochemical analyses. Results: Treatment of HUVECs with KRGE resulted in delayed onset and progression of senescence-associated characteristics, such as increased lysosomal acidic β-galactosidase and decreased telomerase activity, angiogenic dysfunction, and abnormal cell morphology. KRGE preserved the levels of anti-senescent factors, such as eNOS-derived NO, MnSOD, and cyclins D and A: however, it decreased the levels of senescence-promoting factors, such as ROS, activated NF-κB, endothelial cell inflammation, and p21 expression. The beneficial effects of KRGE were due to the induction of HO-1 and the inhibition of NF-κB-dependent biogenesis of miR-155-5p that led to the downregulation of eNOS. Moreover, treatment with inhibitors of HO-1, NF-κB, and miR-155-5p abolished the anti-senescence effects of KRGE. Conclusion: KRGE delayed or prevented HUVEC senescence through a signaling cascade involving the induction of HO-1, the inhibition of NF-κB-dependent miR-155-5p biogenesis, and the maintenance of the eNOS/NO axis activity, suggesting that it may protect against vascular diseases associated with endothelial senescence.
Choi, Seunghwan,Kim, Joohwan,Kim, Ji-Hee,Lee, Dong-Keon,Park, Wonjin,Park, Minsik,Kim, Suji,Hwang, Jong Yun,Won, Moo-Ho,Choi, Yoon Kyung,Ryoo, Sungwoo,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Young-Myeong Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.11
<P>Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human endothelial cells stimulated with TNF-α. Here, we found that the CO-releasing compound CORM-2 prevented TNF-α-mediated decreases in eNOS expression and NO/cGMP production, without affecting eNOS promoter activity, by maintaining the functional activity of the <I>eNOS</I> mRNA 3′-untranslated region. By contrast, CORM-2 inhibited MIR155HG expression and miR-155-5p biogenesis in TNF-α-stimulated endothelial cells, resulting in recovery of the 3′-UTR activity of <I>eNOS</I> mRNA, a target of miR-155-5p. The beneficial effect of CORM-2 was blocked by an NF-κB inhibitor, a miR-155-5p mimic, a HO-1 inhibitor and siRNA against HO-1, indicating that CO rescues TNF-α-induced eNOS downregulation through NF-κB-responsive miR-155-5p expression via HO-1 induction; similar protective effects of ectopic HO-1 expression and bilirubin were observed in endothelial cells treated with TNF-α. Moreover, heme degradation products, except iron and <I>N</I>-acetylcysteine prevented H<SUB>2</SUB>O<SUB>2</SUB>-mediated miR-155-5p biogenesis and eNOS downregulation. These data demonstrate that CO prevents TNF-α-mediated eNOS downregulation by inhibiting redox-sensitive miR-155-5p biogenesis through a positive forward circuit between CO and HO-1 induction. This circuit may play an important preventive role in inflammatory endothelial dysfunction associated with human vascular diseases.</P>
New-onset Asthma After COVID-19 Infection: A Nationwide Population-based Cohort Study
( Bo-guen Kim ),( Hyun Lee ),( Sang Woo Yeom ),( Cho Yun Jeong ),( Dong Won Park ),( Tai Sun Park ),( Ji-yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Jong Seung Kim ),( Sang-heon 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
윤동현(Yoon, Dong-Hyun),남원호(Nam, Won-Ho),전민기(Jeon, Min-Gi),안현욱(An, Hyun-Uk),유도근(Yoo, Do-Guen),박무종(Park, Moojong) 한국방재학회 2022 한국방재학회논문집 Vol.22 No.2
최근 전 지구적인 기후변화 및 기상이변으로 지구온난화 심화, 이산화탄소 농도 증가, 전 지구적 기온 상승 등 기상 현상이 심화되고 있다. 기후변화는 자연재해 발생빈도를 증가시키며, 최근 전세계적으로 장기간 지속되는 가뭄 발생에도 영향을 미치고 있다. 미국 캘리포니아의 경우 2006년부터 2016년까지 극심한 가뭄이 지속되어 메가가뭄(Mega drought)을 경험하였으며, 호주는 2001년부터 2009년까지 밀레니엄가뭄(Millenium drought), 아프리카 대륙 중북부는 2005년부터 2018년까지 지속되는 장기 가뭄을 겪고 있다. 메가 가뭄의 경우 단기간 발생했던 기존 가뭄과 달리 장기간 수자원 고갈 상황이 지속되는 현상으로, 사회, 경제적으로 대비하기 어려운 막대한 피해를 발생시킨다. 우리나라는 장기 가뭄에 대한 대응책이 부재한 상황으로, 장기 가뭄 발생시 대응책을 마련하기 위해 지역에 따른 가뭄 대응역량 평가가 선행되어야 한다. 본 연구에서는 지역별 수자원 부족량 기반의 가뭄 대응역량 평가를 위하여 용수별(생활용수, 공업용수, 농업용수) 수요량 및 공급량 자료와 지자체별 가뭄대비 시스템, 가뭄훈련 등을 포함하는 복원력 분석을 활용하였다. 가뭄 발생 및 심도 파악을 위한 가뭄지수 값을 위해지표로, 수요량 및 공급량 자료를 기반으로 한 수자원 부족량을 취약지표로, 복원력(회복력) 결과를 경감지표로 활용하여 지자체의 가뭄 대응 역량을 분석하였다. 본 연구의 결과는 지역별 가뭄 대응역량 평가를 통해 향후 중장기적인 가뭄 분석 및 대책 수립 등에 활용될 수 있을 것으로 판단된다. Due to global climate change and weather fluctuations, weather phenomena such as global warming and increasing carbon dioxide concentration are intensifying. Climate change increases the frequency of natural disasters and has been affecting the occurrence of drought. In recent years, severe drought has been occurring all over the world. California in the United States experienced a mega drought from 2006 to 2016, Australia experienced a millennium drought from 2001 to 2009, and the Central and Northern African continent suffered a mega drought from 2005 to 2018. With regard to extreme drought events, depletion of water resources has continued for a long time, causing enormous damage that is difficult to restore socially and economically. Drought response strategy for South Korea has focused on drought recovery and emergency measures for drought damage. To respond to severe drought events, it is necessary to evaluate regional drought response capacity and drought preparedness. In this study, long-term water resource comprehensive plan, water management yearbook, and water statistics were used to evaluate drought response capabilities according to region, including resilience analysis such as local economy, drought preparation system, and drought training. The water resource shortage of each local government was calculated based on water demand and supply data, and drought response capability of the local government was analyzed by combining it with resilience analysis for drought. The results of this study can be used for long-term drought preparedness and establishment of countermeasures in the future through the evaluation of drought response capacity according to region.
허윤(Yoon Hur),문한규(Han Kyu Moon),양웅석(Ung Suk Yang),김성은(Seong Eun Kim),백대근(Dae Geun Baek),도창호(Chang Ho Do),송근암(Guen Am Song),유방현(Band Hyun Liu) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A Hepatocellular Carcinoma (HCC) is considered a highly malignant tumor with a poor prognosis. It is usually not resectable and there is no other effective treatment. The current study was undertaken to evaluate the survival time of patients wit.h hepatocellular carcinoma and to find clinical and biologic criteria. A total of 106 patients with HCC seen during the last 3 >ears were analyzed retrospectively for survival in relation to prognostic factors, treatment and disease stage. The results obtained were summarized as follow; 1) HCC vas found frequently in men, and male and female ratio vas 2.5:1. The average age was 55 years in both sex. 2) A prognostic study hased on 91 untreated patients was undertaken. The median survival times according to age, sex, performance status, positive serologic determination of hepatitis B, alcohol intake, alpha-fetoprotein, transaminase, BUN, creatinine values at the time of cliagnosis were statistically not significant. Whereas in all series of patients, bilirubin, tumor size, ascites, serum albumin values were statistically significant. A new staging scheme based on above factors was used. Clearly, thc prognosis depended on clisease stage. The midian survival of stage I patients who receivecl no specific treatment ivas 4.1 months and stage II patients was 1.8 M, and stage III patients svas 0.9 M (p<0.001). 3) The median survival of 91 patients who received no specific treatment was 2.1 M, however 2.3 M for the group of patients(8) placed on systemic chemotherapy, and 9.9 M of the group of patients(7) for hepatic resection. 1) The major causes of death were hepatic failure; 37%(40/106), gastrointestinal bleeding; 28 % (30/106), cachexia; 14% (14/106), respiratory failuire due to lung metastasis; 8% (8/106), intraperitoneal rupture; 3%(3/106). Unclear; 11% (11/106).