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남상욱,송재경,최종호,홍순도,이종학,허광현,박일영 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3
This study was undertaken to review the case series of 216 ectopic pregnancies admitted to the Department of Obstetrics and Gynecology, Pohang Sunrin Hospital from January, 1990 to December, 1991. The incidence of ectopic pregnancy was relatively high, being found to be 1 in 34.4 delivery cases. On the symptomatology, low abdominal pain was encountered in 96.8 percent, amenorrhea in 93.5 percent and vaginal bleeding in 16.2 percent in order. The fallopian tube was the most frequently, being found to be 98.6 percent, followed by the ovary with 0.9 percent and the cervix with 0.5 percent.
Jung, Hun Soon,Erkin, Ozgur Cem,Kwon, Mi Jeong,Kim, Seok Hyung,Jung, Jae In,Oh, Yu‐,Kyoung,Her, Song Wook,Ju, Woong,Choi, Yoon‐,La,Song, Sang Yong,Kim, Joong Kyu,Kim, Young Deug,Shim, Ga Y Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.130 No.8
<P><B>Abstract</B></P><P>Human papillomavirus (HPV) types 16 and 18 are the major etiologic factors in the development of cervical epithelial neoplasia. Our study was designed to validate antiviral short interfering RNA (siRNA) targeting the <I>E6</I> and <I>E7</I> oncogenes as a potential chemosensitizer of cisplatin (<I>cis</I>‐diaminedichloroplatinum II; CDDP) in cervical carcinoma. Specifically, the therapeutic efficacy of combination of CDDP and E6/E7‐specific siRNA was assessed in an <I>in vivo</I> cervical cancer xenograft models. The combination of CDDP and E6/E7‐specific siRNA had greater efficacy than the combination of CDDP and E6‐specific siRNA especially in terms of inducing cellular senescence. Through <I>in vitro</I> and <I>in vivo</I> experiments, the mechanism of synergy between these two treatments was revealed, demonstrating that the combination of E6/E7‐specific siRNA and CDDP therapy was significantly superior to either modality alone. <I>In vitro</I>, long‐term exposure of HeLa cells to the combination of CDDP and E6/E7‐specific siRNA induced apoptosis and cellular senescence. <I>In vivo</I>, E6/E7‐specific siRNA potentiated the antitumor efficacy of CDDP <I>via</I> induction of apoptosis, senescence and antiangiogenesis. Our results suggest that E6/E7‐specific siRNA may be an effective sensitizer of CDDP chemotherapy in cervical cancer.</P>
전장관리체계 전자결재시스템을 위한 역할기반 스토리지 암호화 기법
허경순,이수진,Her, Kyoung-Soon,Lee, Soo-Jin 한국국방경영분석학회 2011 한국국방경영분석학회지 Vol.37 No.1
전장관리체계의 전자결재시스템은 가용성과 신뢰성이 최우선이기 때문에 서버와 스토리지를 가장 신뢰성 있게 구축하지 위해 SAN(Storage Area Network)을 이용하고 있다. 본 논문에서는 전장관리체계 내 전자결재 시스템에서 중요한 군사자료가 저장되는 SAN을 대상으로 보안취약점을 분석하고, 분석된 결과를 바탕으로 가상 공격 시나리오를 작성하여 내부자에 의한 자료 유출이 가능할 수 있음을 실험을 통해 검증한 후, 내부자에 의한 자료 유출 위협을 방지할 수 있는 새로운 개념의 사용자 역할 기반 스토리지 암호화 기법을 제안한다. The most important factors of Electronic approval system of battle management system are availability and reliability. Therefore, the electronic approval system uses a SAN(storage area network) to construct the reliable server and storage. In this paper, we analyze the security vulnerabilities of the SAN storage that stores the critical military information in the electronic approval system of battle management system. Based on the analysis, we verify the possibility of information leakage by the inside attackers through the scenario-based experiment. And we finally propose a new storage encryption algorithm on the basis of user's role that can prevent the leakage of information by the inside attackers.
한국인 성인형 스틸병 환자에서 Interleukin-18 유전자 다형성
허민영 ( Min Young Her ),김숙경 ( Sook Kyoung Kim ),성윤경 ( Yoon Kyoung Sung ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정원태 ( Won Tae Chung ),최정윤 ( Jung Yoon Choe ),장현 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.2
Objective: It has been suggested that overproduction of interleukin -18 (IL-18) may contribute to the pathogenesis of adult onset Still`s disease (AOSD). Recently, positive association between a polymorphism in the IL-18 gene and different diseases like diabetes, sarcoidosis and asthma has been reported. The aim of the present study was to investigate the potential association of two single-nucleotide polymorphisms (SNPs) at position -137 (G/C) and -607 (C/A) in the promoter region of the IL-18 gene with susceptibility and clinical feature of AOSD in the Korean population. Methods: We examined two SNPs of IL-18 in 70 patients with AOSD and 204 healthy control individuals. The genotyping were performed using sequence specific PCR. Haplotypes were analyzed by the estimated haplotype program. The patients with AOSD were subdivided into groups according to disease course: monocyclic systemic, polycyclic systemic, and chronic articular type. Results: As for the -607 genotypes, 13 of the 69 patients had CC genotype (18.8%), 36 the CA type (52.2%) and 20 the AA type (29.0%). AOSD patients had higher frequency of A allele at -607 when compared to controls (OR 1.48, 95% CI 1.00∼2.18, p=0.048). AOSD patients had significantly higher frequency of AA genotypes at -607 when compared to controls (AA vs CA& CC, OR 1.90, 95% CI 1.01∼3.58, p=0.044). As for the -137 genotypes, of the 68 patients, 57 had GG genotype (83.8%), 9 the GC type (13.2%) and 2 (2.9%) had the CC type. No differences were found in allele and genotype frequencies between two groups. The haplotype frequencies of the IL-18 polymorphism were not significantly different between patients with AOSD and controls. The frequency of-137 GG genotype was significantly increased in chronic articular type compared to healthy control and systemic type of AOSD. Conclusion: In IL-18 gene polymorphisms, the A allele and AA genotye at position -607 might be genetic risk factors for the development of AOSD in Korean population. Further investigation in larger groups is required to provide more conclusive evidence regarding the role of the IL-18 gene polymorphism in AOSD.