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- 저자 : He-gao Wu (검색결과 32 건)
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Hydro-mechanical interaction of reinforced concrete lining in hydraulic pressure tunnel
He-Gao Wu,Li Zhou,Kai Su,Ya-Feng Zhou,Xi-Yu Wen 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.6
The reinforced concrete lining of hydraulic pressure tunnels tends to crack under high inner water pressure (IWP), which results in the inner water exosmosis along cracks and involves typical hydro-mechanical interaction. This study aims at the development, validation and application of an indirect-coupled method to simulate the lining cracking process. Based on the concrete damage plasticity (CDP) model, the utility routine GETVRM and the user subroutine USDFLD in the finite element code ABAQUS is employed to calculate and adjust the secondary hydraulic conductivity according to the material damage and the plastic volume strain. The friction-contact method (FCM) is introduced to track the lining-rock interface behavior. Compared with the traditional node-shared method (NSM) model, the FCM model is more feasible to simulate the lining cracking process. The number of cracks and the reinforcement stress can be significantly reduced, which matches well with the observed results in engineering practices. Moreover, the damage evolution of reinforced concrete lining can be effectively slowed down. This numerical method provides an insight into the cracking process of reinforced concrete lining in hydraulic pressure tunnels.
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Pipe-Soil Interaction and Sensitivity Study of Large-Diameter Buried Steel Pipes
He-Gao Wu,Jin-Hong Yu,Chang-Zheng Shi,Zhu Ma 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.3
Large-diameter buried steel pipes (BSPs) have been widely utilized in water diversion and hydropower fields. This paper presents a comprehensive numerical investigation on the interaction between the large-diameter pipe and soil under three typical working conditions, to capture the structural mechanical behaviors of pipe deformation, soil displacement, and soil pressure. Furthermore, a parametric analysis of pipe diameter is conducted, along with the sensitivity study of soil parameters based on the orthogonal test method. The results show that the water weight increases the pipe deformation significantly by 14%, while the high internal water pressure decreases the deformation greatly with the maximum effect of 39%. The pattern of soil pressure at the top of the pipe changes from parabola to double-hump as the pipe diameter varies from 0.5 m to 5.0 m. The pipe deformation and soil pressure keep increasing with the pipe diameter, but the safety margin for prism load decreases gradually. Pipe deformation and soil pressure are very sensitive to the elastic modulus and Poisson's ratio of backfill. Friction coefficients of soil-soil (trench sidewall) and pipe-soil have great influences on the soil pressure, while the bedding material and backfill cohesion have small effects on it.
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Wu, Ying,Gao, He,Li, Huaixing,Tabara, Yasuharu,Nakatochi, Masahiro,Chiu, Yen-Feng,Park, Eun Jung,Wen, Wanqing,Adair, Linda S.,Borja, Judith B.,Cai, Qiuyin,Chang, Yi-Cheng,Chen, Peng,Croteau-Chonka, Da Oxford University Press 2014 Human Molecular Genetics Vol.23 No.4
<P>Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near <I>WDR11-FGFR2</I> (<I>P</I> = 3.0 × 10<SUP>−14</SUP>) and provided suggestive evidence for a locus on chromosome 12 near <I>OR8S1-LALBA</I> (<I>P</I> = 1.2 × 10<SUP>−7</SUP>). Of the adiponectin-associated loci previously described, we confirmed the association at <I>CDH13</I> (<I>P</I> = 6.8 × 10<SUP>−165</SUP>), <I>ADIPOQ</I> (<I>P</I> = 1.8 × 10<SUP>−22</SUP>), <I>PEPD</I> (<I>P</I> = 3.6 × 10<SUP>−12</SUP>), <I>CMIP</I> (<I>P</I> = 2.1 × 10<SUP>−10</SUP>), <I>ZNF664</I> (<I>P</I> = 2.3 × 10<SUP>−7</SUP>) and <I>GPR109A</I> (<I>P</I> = 7.4 × 10<SUP>−6</SUP>). Conditional analysis at <I>ADIPOQ</I> revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (<I>P</I><SUB>initial</SUB> = 0.020; <I>P</I><SUB>conditional</SUB> = 7.0 × 10<SUP>−7</SUP>). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at <I>CMIP</I> and <I>CDH13</I>, and on chromosome 12 at <I>GPR109A</I> and <I>ZNF664</I>. In addition, the newly identified signal near <I>WDR11-FGFR2</I> exhibited evidence of association with triglycerides (<I>P</I> = 3.3 × 10<SUP>−4</SUP>), high density lipoprotein cholesterol (HDL-C, <I>P</I> = 4.9 × 10<SUP>−4</SUP>) and body mass index (BMI)-adjusted waist–hip ratio (<I>P</I> = 9.8 × 10<SUP>−3</SUP>). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms.</P>
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He-chuan Song,Yi-du Zhang,Qiong Wu,Han-jun Gao 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.10
The 3-2-1 constraint principle has been widely applied as the boundary conditions for the finite element method (FEM) to simulate machining deformation of aerospace structure components. However, this principle is inconsistent with the actual contact surface between workpieces and worktables because it provides only three constraint points. These points have rarely been studied in terms of positions and distances. In addition, the applicability of the principle is limited for the workpiece with geometric centers difficult to find or centers without nodes. Therefore, this study proposed a new boundary condition method, low-stiffness spring element constraint method (SECM), drawing on FEM theories and related mechanic theories. With the method proposed this study established the FE model of machining deformation, and then compared the simulation results with both the analytical results and the experimental results of milling and deformation measurements. Good agreement is found between the three results. Finally, this study examined the effect of the three constraint points on simulation of the 3-2-1 principle in terms of point positions and distances. A comparison between SECM and the 3-2-1 principle revealed that SECM is closer to the actual working conditions and more reliable with wider application, which suggests that SECM can replace the 3-2-1 principle as the boundary conditions for the workpiece.
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Cubic time-spline fitting and interpolation for five-axis CNC machining
Wu Qingle,Yuan Chun-Ming,Shen Li-Yong,He Shi-Tao,Gao Xiao-Shan 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.6
In CNC machining, G01 codes are widely used to represent the tool path. Directly interpolating these G01 codes is time-consuming and may cause discontinuities. In this paper, we propose a time-spline curve fitting method that combines tool path fitting and feedrate scheduling into a single step for five-axis CNC machining. The input for this method consists of a three-dimensional linear path of the tool tip in the workpiece coordinate system and two-dimensional tool orientations in the machine coordinate system (MCS). The output is a fitted tool path in the MCS represented by a five-dimensional smooth time-parametric B-spline curve, simply referred to as the time-spline curve. The time-spline curve provides not only position information but also kinematic information, including velocity, acceleration, and jerk for each axis, directly derived from the first, second, and third derivatives of the curve. To meet fitting error constraints and axial kinematic constraints, our objective is to find the time-spline curve that is time-optimal. We formulate the optimization problem as a nonlinear optimization model and design a recursive algorithm to solve it. The resulting time-spline curve demonstrates high accuracy and fully utilizes the machine’s kinematic capabilities. Along the tool path defined by the time-spline curve, exact interpolation points can be straightforwardly obtained according to the interpolation period. Simulations and experimental results indicate that the proposed method yields a time-optimal time-spline curve with the desired precision and kinematic constraints.
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An investigation on the dynamics of domain switching of Bi0.5Na0.5TiO3-based ferroelectric ceramics
Zhipeng Gao,Hang Zhang,Yi Liu,Lingfeng Wu,Jia Yang,Tao Zhang,Haiyan Wang,Xuefeng Chen,Genshui Wang,Hongliang He 한국물리학회 2017 Current Applied Physics Vol.17 No.4
The dynamics of domain switching of Bi0.5Na0.5TiO3-based ferroelectric ceramic was investigated. With the electric field increasing, the domain switch experienced three sections of no domain switch region, creep region and flow region. In the creep region, the domain switch is dominated by the thermally activated domain wall movement. In flow region, the domain wall experience the viscous flow motion. For the BNT-BA-Zn ceramic, the activation energy of creep domain switch is much higher than it in flow region. With temperature increasing, the sensitivity of domain wall motion to the frequency is decreasing. This result demonstrated the domain switch of different ferroelectric materials could be quantitatively analyzed and compared based on the simple polarization - current - electric field data.
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Cloning and analysis of b-amyrin synthase gene in Bupleurum chinense
Ke Gao,Su-rui Wu,Ling Wang,Yan-hong Xu,Jian-he Wei,Chun Sui 한국유전학회 2015 Genes & Genomics Vol.37 No.9
Bupleurum chinense DC. is one of the source plants of a well-known crude drug, Chai hu (Radix Bupleuri), producing triterpenoid saponins (saikosaponins) with a wide-spectrum of pharmacological applications. The biosynthesis of triterpenoid saponins involved with the cyclizing of the precursor 2,3-oxidosqualene to produce the first committed triterpene b-amyrin catalyzed by b-amyrin synthase (b-AS), whereafter diverse of triterpenoid saponins was biosynthesized. In addition, 2,3-oxidosqualene could be catalyzed by cycloartenol synthase directing to the synthesis of phytosterol. b-AS was thus defined as an important branch point between primary and secondary metabolisms, and may play a regulating role in the control of triterpenoid saponins biosynthesis. In this study, the promoter and protein-encoding regions of a b-AS gene (designated bcAS1) were isolated by genome walking and PCR from B. chinense. Several important cis-acting elements for gene regulation were identified within the promoter region including light-responsive, hormoneresponsive and various other stress-related elements. Approximate 0.8 kb fragment on upstream of ATG start codon of bcAS1 was sub-cloned into pAN580 vector to replace the 35S promoter driving the expression of green fluorescent protein (GFP) gene. The promoter activity was detected by transient expression in onion epidermis cells by the expression of GFP. Approximately 6 kb length of bcAS1 gene was cloned, containing 18 exons and 17 introns. Although a dozen of b-AS cDNA was isolated, seldom the promoter and gene of it was reported. This work was a valuable foundation for further studies on the regulatory role of b-AS in biosynthesis of saikosaponins.
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