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L. B. Zhao,N. Lin,X. Q. Han,C. Ma,Z. Y. Wang,Y. H. He 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.8
The efects of tungsten carbide addition on the microstructure, mechanical properties and corrosion resistance of Ti(C,N)-based cermets prepared by the sinter-HIP method are investigated through scanning electron microscope, X-ray difraction,electron back scattered difraction, mechanical test and electrochemical method. The results show that the appropriate WCaddition has an important infuence on promoting the formation of core-rim microstructure of cermet, increasing the wettability of ceramic phase and binder phase, and improving the mechanical properties. Ti(C,N)-based cermet with 5 wt% WCaddition has the highest hardness of 92.4 HRA and excellent wear resistance. However, excessive WC addition causes theappearance of slight white core phase containing plenty of W and Ti element in microstructure, which increases the fracturetoughness, and reduces the hardness and wear resistance of cermet. Additionally, the electrochemical result shows that theaddition of 5 wt% WC in cermet has the optimal corrosion resistance in 1 mol/L hydrochloric acid solution.
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.
Nano-Layer Structure of Silicon-on-Insulator Materials
X Wang,x Wang,J Chen,L. L. Tian,M Chen,P He,X. H. Liu,Y. M. Dong,Z. L. Liu 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.III
Silicon-on-insulator (SOI) has been recognized as a promising semiconductor starting material for ICs where high speed and low power consumption are desirable, in addition to its unique applications in radiation-hardened circuits. In the present paper, three novel SOI nano-layer structures have been demonstrated. ULTRA-THIN SOI has been fabricated by separation by implantation of oxygen (SIMOX) technique at low oxygen ion energy of 45 keV and implantation dosage of 1.8´1017/cm2. The formed SOI layer is uniform with thickness of only 60 nm. This layer is of crystalline quality, and the interface between this layer and the buried oxide layer is very sharp. PATTERNED SOI nano-structure is illustrated by source and drain on insulator (DSOI) MOSFETs. The DSOI structure has been formed by selective oxygen ion implantation in SIMOX process. With the patterned SOI technology, the floating-body effect and self-heating effect, which occur in the conventional SOI devices, are significantly suppressed. In order to improve the total-dose irradiation hardness of SOI devices, SILICON ON INSULATING MULTILAYERS (SOIM) nano-structure is proposed. The buried insulating multilayers, which are composed of SiO$_x$ and SiN$_y$ layers, have been realized by implantation of nitride and oxygen ions into silicon in turn at different ion energies, followed by two steps of high temperature annealing process, respectively. Electric property investigation shows that the hardness to the total-dose irradiation of SOIM is remarkably superior to those of the conventional SIMOX SOI and the Bond-and-Etch-Back SOI.
He, X.,Bonaparte, N.,Kim, S.,Acharya, B.,Lee, J.Y.,Chi, L.,Lee, H.J.,Paik, Y.K.,Moon, P.G.,Baek, M.C.,Lee, E.K.,Kim, J.H.,Kim, I.S.,Lee, B.H. Elsevier Science Publishers 2012 Journal of controlled release Vol.162 No.3
Chemotherapy-induced apoptosis of tumor cells enhances the antigen presentation and sensitizes tumor cells to T cell-mediated cytotoxicity. Here we harnessed the apoptosis of tumor cells as a homing signal for the delivery of T cells to tumor. Jurkat T cells were anchored with ApoPep-1, an apoptosis-targeted peptide ligand, using the biocompatible anchor for membrane (BAM), an oleyl acid derivative. The ApoPep-1-BAM conjugate was efficiently anchored to cell membrane, while little anchoring was obtained with ApoPep-1 alone. The retention period of the ApoPep-1-BAM conjugate on cell membrane was approximately 80 and 40min in the absence and presence of serum, respectively. ApoPep-1 was resistant to degradation in serum until 2h. The apoptosis-targeted T cells that were anchored with the ApoPep-1-BAM preferentially bound to apoptotic tumor cells over living cells. When intravenously injected into tumor-bearing mice, the number of apoptosis-targeted T cells and in vivo fluorescence signals by the homing of the cells to doxorubicin-treated tumor were higher than those of untargeted T cells. Accumulation of apoptosis-targeted T cells at other organs such as liver was not detected. These results suggest that the chemotherapy-induced apoptosis and subsequent enhancement of T cell delivery to tumor by the membrane anchoring of the apoptosis-targeted peptide could be a novel strategy for cancer immunotherapy.
SYNTHESIS OF POLYBENZONITRILE WITH ULTRAFAST OPTICAL KERR EFFECT
Zhao, X.Y,Xu, Q,He, Y.K,Chen, H.Y,Wang, C.F,Ai, X.C,Xia, Z.J,Zou, Y.H 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.3
Plasma polymerization of benzonitrile was carried out with RF glow discharge system. The polymer was characterized by FT-IR, UV-VIS, and Elemental Analysis. the molecular weitht was determined by vapor pressure osmometer. for the first time the nonresonant optical Kerr effect(OKE) of plasma polymerized benzonitrile was measured, and a power law dependence of ${\gamma}_{1111}$ on average polymerization degree was discussed. An ultrafast response was also observed.
Hu, X -T,Zhang, F -B,Fan, Y -C,Shu, X -S,Wong, A H Y,Zhou, W,Shi, Q -L,Tang, H -M,Fu, L,Guan, X -Y,Rha, S Y,Tao, Q,He, C Macmillan Publishers Limited 2009 Oncogene Vol.28 No.26
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. We found that PLCD1 was expressed in all normal adult tissues but low or silenced in 84% (16/19) gastric cancer cell lines, well correlated with its CpG island (CGI) methylation status. Methylation was further detected in 62% (61/98) gastric primary tumors, but none of normal gastric mucosa tissues. PLCD1 methylation was significantly correlated with tumor high stage. Detailed methylation analysis of 37 CpG sites at the PLCD1 CGI by bisulfite genomic sequencing confirmed its methylation. PLCD1 silencing could be reversed by pharmacological demethylation with 5-aza-2′-deoxycytidine, indicating a direct epigenetic silencing. Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.Oncogene (2009) 28, 2466–2475; doi:10.1038/onc.2009.92; published online 18 May 2009
An improved particles model for stress sensitivity in low-permeability sandstones
S. H. Gai,H. Q. Liu,S. L. He,G. Lei,S. Y. Mo,X. Huang,Y. Yang,X. Chen 한국자원공학회 2016 Geosystem engineering Vol.19 No.2
Stress-dependent permeability and porosity of porous media is very important for the development of oil reservoirs, especially in low-permeability reservoirs. Porous structure can change in response to an increase in the effective stress to induce the decline of permeability and porosity, which ultimately affects the fluid flow property. In this study, a capillary module, considering the arrangement and the deformation of particles, has been established to express the stress sensitivity of porous media based on the particle packing model. The predictions of variation of permeability by the proposed model have been validated by comparing with the experimental data. The predictions by the current model show the same variation trend with the experimental data and are consistent with the compression experiments. The proposed variation of permeability with the increase in effective stress depends on the factors such as the arrangement of particles (contact angle), the deformation of particles (elastic module and Poisson’s ratio) and effective stress. The effects of these parameters on variation of permeability are discussed in detail.
FATE AND METABOLISM OF NITROGEN IN GOATS FED <sup>15</sup>N-LABELLED RICE STRAW
Xing, T.X.,He, D.Y.,He, L.H.,Zhou, W.J.,Liao, X.L.,Chen, H.P. Asian Australasian Association of Animal Productio 1992 Animal Bioscience Vol.5 No.4
Three goats were fed with $^{15}N$-labelled rice straw to study the characteristics of digestion, assimilation, metabolism and excretion of C and N compounds from rice straw. It was shown that the amount of $^{15}N$ assimilated into the bodies of the two slaughtered goats accounted for 38.5 and 23.6% of the total amount of $^{15}N$ ingestion in the experimental diet by each goat. The $^{15}N$ excreted via the feces and urine for the three goats accounted for 34.8, 33.2 and 33.9% of the total amount of $^{15}N$ ingested in the feed of the 3 goats. The recoveries of $^{15}N$ from the two slaughtered goats were 73.3 and 57.5%, with the corresponding rates of $^{15}N$ loss 26.7 and 42.5% respectively. The amino acids digestibilities were 68.7 and 54.0%, while the digestibilities of carbohydrates were 74.8 and 67.7% respectively for goats 1 and 3.