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( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.
Structural Origin for the Transcriptional Activity of Human p 53
Suk, Jae Eun,Han, Kyou Hoon,Kim, Do Hyung,Choi, Kwan Yong,Choung, Dong Ho,Park, Kyu Hwan,Sung, Young Chul,Chang, Jun,Lee, Si Hyung,Kim, Do Hyung 생화학분자생물학회 2002 BMB Reports Vol.34 No.1
Tanscriptonal activation domains are known to be inherently $quot;unstructured$quot; with no tertiary structure. A recent NMR study, however, has shown that the transactivation domain in human p53 is populated with an amphipathic helix and two nascent turns. This suggests that the presence of such local secondary structures within the overall $quot;unstructured$quot; structural framework is a general feature of acidic transactivation domains. These pre-existing local structures in p53, formed selectively by positional conserved hydrophobic residues that are known to be critical for transcriptional activity, thus appear to constitute the specific structural motifs that regulate recognition of the p53 transactivation domain by target proteins. Here, we report the results of a NMR structural comparison between the native human p53 transactivation domain and an inactive mutant (22L,23W→22R,23S). Results show that the mutant has an identical overall structural topology as the native protein, to the eutent that the amphipathic helix formed by the residues 18T 26L within the native p53 transactivatfng domain is preserved in the double mutant. Therefore, the lack of transcriptional activity in the double mutant should be ascribed to the disruption of the essential hydrophobic contacts between the p53 transactivation domain and target proteins due to the (22L,23W→22R,23S) mutation.
Han, Sang Sub,Kim, Jong Hun,Noh, Chanwoo,Kim, Jung Han,Ji, Eunji,Kwon, Junyoung,Yu, Seung Min,Ko, Tae-Jun,Okogbue, Emmanuel,Oh, Kyu Hwan,Chung, Hee-Suk,Jung, YounJoon,Lee, Gwan-Hyoung,Jung, Yeonwoong American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.14
<P>Two-dimensional (2D) transition-metal dichalcogenides (2D TMDs) in the form of MX<SUB>2</SUB> (M: transition metal, X: chalcogen) exhibit intrinsically anisotropic layered crystallinity wherein their material properties are determined by constituting M and X elements. 2D platinum diselenide (2D PtSe<SUB>2</SUB>) is a relatively unexplored class of 2D TMDs with noble-metal Pt as M, offering distinct advantages over conventional 2D TMDs such as higher carrier mobility and lower growth temperatures. Despite the projected promise, much of its fundamental structural and electrical properties and their interrelation have not been clarified, and so its full technological potential remains mostly unexplored. In this work, we investigate the structural evolution of large-area chemical vapor deposition (CVD)-grown 2D PtSe<SUB>2</SUB> layers of tailored morphology and clarify its influence on resulting electrical properties. Specifically, we unveil the coupled transition of structural-electrical properties in 2D PtSe<SUB>2</SUB> layers grown at a low temperature (i.e., 400 °C). The layer orientation of 2D PtSe<SUB>2</SUB> grown by the CVD selenization of seed Pt films exhibits horizontal-to-vertical transition with increasing Pt thickness. While vertically aligned 2D PtSe<SUB>2</SUB> layers present metallic transports, field-effect-transistor gate responses were observed with thin horizontally aligned 2D PtSe<SUB>2</SUB> layers prepared with Pt of small thickness. Density functional theory calculation identifies the electronic structures of 2D PtSe<SUB>2</SUB> layers undergoing the transition of horizontal-to-vertical layer orientation, further confirming the presence of this uniquely coupled structural-electrical transition. The advantage of low-temperature growth was further demonstrated by directly growing 2D PtSe<SUB>2</SUB> layers of controlled orientation on polyimide polymeric substrates and fabricating their Kirigami structures, further strengthening the application potential of this material. Discussions on the growth mechanism behind the horizontal-to-vertical 2D layer transition are also presented.</P> [FIG OMISSION]</BR>
Sung, Daeho,Jung, Chulho,Cho, Byeong-Gwan,Jo, Wonhyuk,Han, Hee-Sung,Lee, Ki-Suk,Bhat, Vinayak,Farmer, Barry,De Long, L. E.,Lee, Ki Bong,Keavney, D. J.,Lee, Dong Ryeol,Song, Changyong The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.27
<P>Unraveling nanoscale spin structures has long been an important activity addressing various scientific interests, that are also readily adaptable to technological applications. This has invigorated the development of versatile nanoprobes suitable for imaging specimens under native conditions. Here we have demonstrated the resonant coherent diffraction of an artificial quasicrystal magnet with circularly polarized X-rays. The nanoscale magnetic structure was revealed from X-ray speckle patterns by comparing with micromagnetic simulations, as a step toward understanding the intricate relationship between the chemical and spin structures in an aperiodic quasicrystal lattice. Femtosecond X-ray pulses from free electron lasers are expected to immediately extend the current work to nanoscale structure investigations of ultrafast spin dynamics, surpassing the present spatio-temporal resolution.</P>
Han, Sang-Wook,Choi, Min-Seon,Lee, Suk-Ha,Hwang, Duk-Ju,Hwang, Byung-Kook,Heu, Sung-Gi The Korean Society of Plant Pathology 2007 Plant Pathology Journal Vol.23 No.3
Typical susceptible symptoms of the bacterial pustule disease caused by Xanthomonas axonopodis pv. glycines are pustule and chlorotic haloes that usually occur in leaves of Glycine max plants. The soybean genotype 'PI96188' showed an atypical response to all tested races X. axonopodis pv. glycines, accompanied with necrosis without chlorotic haloes on the underside of the necrotic symptoms. X. axonopodis pv. glycines 8ra grew to levels from 10 to 100 fold lower on PI96188 than on susceptible cultivar Jinjoo1, but 10-fold higher than on the resistant cultivar CNS. The chlorophyll content in PI96188 leaves remained unchanged until 12 days after bacterial infection. Ultrastructural observation showed that the infected leaf cells of PI96188 had intact normal chloroplasts compared to those of the susceptible cultivar Jinjoo1. Chloroplast degradation or the absence of chloroplasts in cells of the infected tissues was observed in Jinjoo1. Senescence-related ACS7 gene was significantly induced in PI96188 compared to those in Jinjoo1 at 2 days after inoculation. While photosynthesis-related rbcS gene showed the dramatic change in Jinjoo1, this gene was constitutively expressed in PI96188. However, expression of the defense-related genes, such as peroxidase and isoflavone synthase in the infected PI96188 leaves was similar to that in Jinjoo1. Together, these results suggest that the novel necrotic symptom in PI96188 is a kind of resistant response different from a typical hypersensitive response in the resistant genotypes.
Han, Gill Sang,Lee, Sangwook,Yu, Eun Sang,Park, Sung Pyo,Cho, In Sun,Jung, Hyun Suk Electrochemical Society 2016 Journal of the Electrochemical Society Vol.163 No.6
<P>We report an epitaxial growth of anatase TiO2 nanorods array (ANRs) on a niobium-doped TiO2 (NTO)/SrTiO3 (STO) single crystal substrate and its impact on charge transport and collection properties for photoelectrochemical (PEC) water splitting. The NTO film (similar to 6 at.% of Nb) with a thickness of similar to 250 nm, was initially deposited as a transparent conducting electrode on a STO single crystal substrate by pulsed laser deposition. Subsequently, the anatase TiO2 nanorods array, with an average length of similar to 200 nm, was grown on the NTO/STO substrate by a two-step hydrothermal method. Epitaxial relationship between the TiO2 nanorods and the substrate was investigated by X-ray diffraction and transmission electron microscopic analysis. From impedance spectroscopy measurements, we found that the resistance of the ANRs is much lower than that of anatase TiO2 nanoparticle-based films, which originates from the single crystalline nature of the ANRs and lower interfacial resistance due to epitaxial growth. For PEC water splitting, the lower bulk and interfacial resistance of the ANRs facilitates better charge transport and collection, thereby improving the photocurrent density and rate of hydrogen evolution. (C) 2016 The Electrochemical Society. All rights reserved.</P>
Han, Chang-Suk,Jin, Sung-Yooun,Kwon, Hyuk-Ku Materials Research Society of Korea 2020 한국재료학회지 Vol.30 No.2
Titanium aluminides have attracted special interest as light-weight/high-temperature materials for structural applications. The major problem limiting practical use of these compounds is their poor ductility and formability. The powder metallurgy processing route has been an attractive alternative for such materials. A mixture of Ti and Al elemental powders was fabricated to a mechanical alloying process. The processed powder was hot pressed in a vacuum, and a fully densified compact with ultra-fine grain structure consisting of Ti<sub>3</sub>Al intermetallic compound was obtained. During the compressive deformation of the compact at 1173 K, typical dynamic recrystallization (DR), which introduces a certain extent of grain refinement, was observed. The compact had high density and consisted of an ultra-fine equiaxial grain structure. Average grain diameter was 1.5 ㎛. Typical TEM micrographs depicting the internal structure of the specimen deformed to 0.09 true strain are provided, in which it can be seen that many small recrystallized grains having no apparent dislocation structure are generated at grain boundaries where well-developed dislocations with high density are observed in the neighboring grains. The compact showed a large m-value such as 0.44 at 1173 K. Moreover, the grain structure remained equiaxed during deformation at this temperature. Therefore, the compressive deformation of the compact was presumed to progress by superplastic flow, primarily controlled by DR.