표고버섯(Lentinus edodes)섭취가 streptozotocin 유발 당뇨 흰쥐의 혈당수준과 에너지원 조성에 미치는 영향

한혜경,임숙자 德成女子大學校 1996 德成女大論文集 Vol.26 No.-

The hypoglycemic effects of Lentinus edodes on streptozotocin(STZ)-induced diabetic rats were investigated. Diabetes mellitus was induced in male Sprague-Dawley rats by injections of STZ into the tail vein at a dose of 45mg/kg. The animals weighing 200-250g were fed either a control diet(AIN-76) or mushroom diets for four weeks. The body weight gain was monitored and the blood levels of glucose and cholesterol were analyzed. The levels of protein, triglyceride and free fatty acid in plasma were determined. The extent of blood glucose decrements in rats fed on Lentinus edodes was greater than that found in the STZ-control group. The plasma protein levels were not influenced, although the plasma cholesterol levels were significantly lowered in rats fed on Lentinus edodes. The levels of plasma triglyceride and free fatty acid were also significantly decreased in Lentinus edodes. The results suggest that Lentinus edodes causes a hypoglycemic effect in diabetic rats and that mushroom intake may be beneficial for the managemant of diabetes mellitus.

자아동일성의 상징적 모티프 William Faulkner의 The Sound and the Fury를 중심으로

韓惠卿 同德女子大學校 1987 同大論叢 Vol.17 No.1

In the Yoknapatawpha novels, William Faulkner dramatizes essentially a deterioration from the past to the present. A tragic sense of loss then always derives from the process of the deterioration. And it has, in fact, something to do with man's self-identity. The Sound and the Fury is initially the degeneration of the Compson family, but it is also, by extension, ultimately the disintegration of modern man who is suffering from the lack of his self. The Compsons, particularly Benjy and Quentin are living in the midst of decay with the glories of the family's past. They are in bondage to the past through a failure of connection with true time. They seem to live with ghosts. They move blindly as if they were shadows. They lose the ability to act in terms of "the actual," and to think in terms of "the possible." It is notable that Faulkner expresses stylistically "i" instead of "I" in the end of Quentin's monologue to show how pervasive is Quentin's fatal lack of identity. Faulkner discovers an ingenious way for representing the images, especially "time," "shadoe," and "death" as metaphors and for giving the unity to the novel's tragic theme. And he manages to keep a dramatic intensity very rarely equalled. Throughout The Sound and the Fury none of these central images exists alone; they are nicely interconnected. These images are essentially signs of something within the Compsons which brings each of them to final ruin. Fundamentally "time" marked by the watch is demonstrated to be indeed the reducto absurdum of all human experience. "Shadow" is but the recorder of the inescapable passage of time. The fact that the changing length of his own shadow makes him nervous proves that Quentin cannot face the passage of time. Consequently "time" and "shadow" combine to remind us "death." After all, "time," "shadow," and "deatj" are the ultimate realities man cannot escape. The title of The Sound and the Fury, which Faulkner derives from Shakespeare's Macbeth, provides a true key to the understanding of the book. Macbeth's words, "It[Life] is a tale/Told by an idiot, full of sound, and fury/Signifying nothing," offer an excellent commentary upon the meaning and the structure of The Sound and the Fury. Exactly the same ideas are stated by Mr. Compson whose cynical and pessimistic remarks open and close the Quentin section, which underlies the whole book. It is therefore Mr. Compson whose values finally prevail in The Sound and the Fury. Persistently casting shadows, the "watch" Mr.Compson gives to Quentin and calls "the mausoleum of all hope and desire" turns out to be just that. Finally, throughout The Sound and the Fury the motifs, "time," "shadow," and "death" deterministically help to reveal nihilism as the meaning of the whole.

PPV 공중합체의 합성 및 발광특성

민혜경,이경민,한동제,박성진,오응주 명지대학교 자연과학연구소 1997 자연과학논문집 Vol.16 No.-

Blue light emitting PPV [poly (p-phenylene vinylene)] copolymers soluble in common organic solvents are synthesized and their structural and light emitting properties are studied. Copolymers show π-π* transition in UV-Vis. spectra and their λmax shift to shorter wavelength compare to that of monomers. The PL and absorption spectrum shows the symmetric vibration modes with muror images which means that copolymers are highly, aligned. The band gap energy of these copolymers are ~3.0 eV. By introducing aliphatic hydrocarbon group into polymer main chain, the stability of copolymers is increased and no significant effects of substituents are observed.

조직기생 선충류 유충에서 분리한 단백 분해 효소의 특성 및 항원성 검토

임한종,주경환,최성아,이혜정,주종윤,정명숙 한국농촌보건회 1997 농촌의학·지역보건 Vol.22 No.1

고본 Ethanol 추출물의 투여가 streptozotocin 유발 당뇨 흰쥐의 혈당 및 글리코겐 함량에 미치는 영향

임숙자,한혜경,최성숙 덕성여자대학교 자연과학연구소 2007 자연과학 논문집 Vol.13 No.-

This study was designed to examine the effects of ethanol (EtOH) extract of Angelicae tenuissimae on glucose and glycogen levels in streptozotocin (STZ) induced diabetic rats. Sprague-Dawley rats were induced diabetes mellitus by STZ injection (45 mg/kg) into the tail vein and were divided into 4 groups: normal, STZ-control, two experimental diabetic groups. EtOH extract of Angelicae tenuissimae were administered orally into the diabetic rats for 14 days. The diet intake and body weight were monitored and plasma levels of glucose, aminotransferase activity and glycogen level in liver and muscle were analyzed. Oral administration of 2.0g/kg b.w. on the EtOH extracts for 14 days resulted in a significant reduction in plasma levels of glucose, activities of ALT and AST. The glycogen levels in liver and muscle of EtOH-2 group were significantly higher than that of STZ-control group. The results show that EtOH extract of Angelicae tenuissimae could be effective to control the STZ-induced diabetic rats.

학교행정가의 리더십과 핵심역량에 대한 인식 연구

조경원,한유경,서경혜,조정아,이지은 이화여자대학교 교육과학연구소 2006 교육과학연구 Vol.37 No.1

21세기 지식정보화 사회는 전통적인 학교교육의 변혁을 요구한다. 이에 학교교육 개혁을 성공적으로 이끌어 나아갈 수 있는 교원의 리더십 특히 학교행정가의 리더십이 절실히 요구되고 있다. 그렇다면 지식정보화 사회에서 요구되는 학교행정가의 리더십이란 무엇이며 어떤 역량을 포함하는가? 본 연구는 학교행정가의 리더십과 핵심역량에 대한 선행연구가 학교 현장과는 유리된 채 이론적, 당위적 수준에 그치고 있다는 문제의식에서 출발하여 학교행정가의 리더십을 구성하는 핵심역량이 무엇인가에 대한 교사, 교감, 교장, 행정실장 및 서무부장의 인식을 파악하고 이들 집단의 인식을 비교 분석하는 데 목적을 두었다. 이를 위해 우선 문헌연구를 통해 리더십에 대한 관점과 개념의 변화를 고찰하였고 변혁적 리더십 관점에 기초하여 학교행정가가 갖추어야 할 핵심역량으로 교육적 리더십, 학교 계획 및 조직, 학교교육과정 편성 및 운영, 학교운영, 인적자원 개발, 학교재정 관리, 교육법 이해 및 집행, 학교교육정책 이해, 학교·학부모 및 지역사회 협력, 정보통신기술 활용과 같은 열 가지 역량을 도출하였다. 문헌연구를 통해 도출된 핵심역량에 대한 학교 현장의 관점을 알아보기 위해 초·중·고등학교 교직원을 대상으로 10대 핵심역량의 중요도와 현재 실행정도에 대해 설문조사를 수행하였다. 설문조사에는 144개 학교의 교직원 1,136명이 참여하였다. The purpose of this study is to investigate the perspectives of teachers, vice-principals, and school staff on school administrators' leadership and core abilities. For this purpose, first, we examined the perspectives and concepts of school administrator's leadership and identified 10 core abilities that constitute the school administrator's leadership. Second, we developed a questionnaire to investigate the perspectives of teachers, vice-principals, and school staff on to what extent the 10 core abilities are important and whether their school administrators actually exert these 10 core abilities. Finally, we conducted a survey research, including teachers, vice-principals, and school staff with various years of experiences in elementary and secondary schools in Korea. The findings show that teachers, vice-principals, principals, and school staff consider the 10 core abilities very important for school administrators. However, they perceive that school administrators, in reality, do not exert the 10 core abilities as much as they think these abilities are important. In particular, teachers rated school administrators' leadership relatively low compared to principals, vice-principals, and school staff. The difference between their perception on the importance and exertion of 10 core abilities indicates the need for programs that promote the development of 10 core abilities for school administrators and consequently support the development of school administrator's leadership.

20대 여성의 정장의류 상표군 선호도와 구매시 평가기준

권수애,장현주,한정혜,조소영,손지희,김선화,안경은 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.2

This study is to analyze the compitition structure and the brand image of the formalwear and the preferance of the brand group among the age of 20's females. The 207 samples of 20's females who live in Cheong-Ju city. The results of this study are followed as: The market competition structre appeared in positioning map have been constituted into four groups of the "Tomboy y'sb","lollol·selly·besti-belly","VOV·o.z.o.c·Joinus",EnC·i.n.v.u". The brand-trasfer of each group may easily be taken place as each compition among these groups was much feeble. By investigating the image of the formalwear brands appeared in positioning map, it may be presented that horizontality dimrnsion is "cute-ellegance image", and verticality dimension is "mannish-feminine image". Group Ⅳ such as EnC·i.n.v.u is brand which are prefered and purechaseed by the age of 20's females, whereas the preferance and puechase of brand such as VOV·o.z.o.c·Joinus.

과체중 성인 여성에 대한 체중조절 프로그램의 효과

강금지,최성숙,한혜경 덕성여자대학교 자연과학연구소 2007 자연과학 논문집 Vol.13 No.-

This study was performed to evaluate the effectiveness of weight control program conducted by public health center in Dobong-gu for overweight women. The subjects of this study consisted of 47 overweight women(BMI≥23) aged 48.5±9.0 years in Dobong-gu, and the educational period was 12 weeks. We evaluated the anthropometric parameters, dietary habits, dietary behaviors of overweight women before and after the nutritional education. Weight, obesity index, BMI of overweight women were significantly decreased after nutritional education, but changes of scores of dietary habits and dietary behaviors were not significant. Their nutritional attitude scores were improved after the nutritional education. These results suggested that the more proper weight control program needed to improve the dietary habits.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes

( Kyoung-moon Han ),( Sun-young Ahn ),( Hyewon Seo ),( Jaesuk Yun ),( Hye Jin Cha ),( Ji-soon Shin ),( Young-hoon Kim ),( Hyungsoo Kim ),( Hye-kyung Park ),( Yong-moon Lee ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3

The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and rifampin on the expression and activities of organic anion-transporting peptide (OATP) and cytochrome P450 (CYP450) 2C9 and CYP3A4 were investigated in vitro. HEK293 cells and primary human hepatocytes overexpressing the target genes were treated with bosentan and various concentrations of rifampin, which decreased the uptake activities of OATP transporters in a dose-dependent manner. In primary human hepatocytes, CYP2C9 and CYP3A4 gene expression and activities decreased upon treatment with 20 μM bosentan+200 μM rifampin. Rifampin also reduced gene expression of OATP1B1, OATP1B3, and OATP2B1 transporter, and inhibited bosentan influx in human hepatocytes at increasing concentrations. These results confirm rifampin- and bosentan-induced interactions between OATP transporters and CYP450.