21세기 새로운 시대를 준비하는 원광대학교 의과대학의 교육목표 개정과정

이학승,김요식,송윤강,오재민,양연식,정선관 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

교육목적은 대학의 교육이 지향하는 대전제이다. 그러므로 대학교육 목적과 목표가 어떤가에 따라 교육과정과 교육방법이 달라진다. 원광대학교 의과대학의 교육목표는, '지덕겸수'로 요약되는 '과학과 도학을 겸비한 전인교육'의 건학정신과 '학술탐구'와 '덕성함양'의 원광대학교 교육목표와 일치하게 현재까지 유지되었다. 그러나 현행 교육목표의 여러 문제점이 발견되었고, 시대상의 변화에 따라 원광대학교 의과대학에서도 사회적 변화 빛 의료인에 대한 시대적 요구에 걸맞은 의학교육의 목적 및 목표의 재설정 과정을 시작하게 되었다. 그 결과 개정 작업을 통해 새로운 교육목표를 설정하게 되었으며 그 내용은 다음과 같다. 1. 기본진료능력을 지닌 의사를 양성한다. 2. 원불교 교리 이념을 반영한 윤리적, 도덕적인 의사를 양성한다. 3. 평생 학습하는 연구하는 의사 혹은 의과학자를 양성한다. 4. 사회적 책무를 수행하는 리더십을 갖춘 의사를 양성한다. 5. 지역 사회에 공헌하는 봉사정신을 갖춘 의사를 양성한다. Purpose : With the changes to the medical environments and to the medical educational systems, we aimed to evaluate the current mission statement of the School of Medicine, Wonkwang University, and to revise it. Methods : To establish the new goal and mission statement, a Special Committee for the Revision of Medical School Mission and advisory group were organized in 2008. This special committee conducted through five steps of action, which are composed of investigation, education, development, surveillance of various opinions, and announcement. Results : For the development of new goal and mission, the revised, final goal and mission statements decided through the five steps of action. The new mission of Wonkwang University School of Medicine was as follows; 1. Doctor who can diagnose and treat easily 2. Ethical and moral doctor who practice Won Buddhism 3. Doctor or Medical Scholar who studies lifelong study 4. Doctor who has leadership to social responsibility 5. Doctor who goes into service to a local community. Conclusion : The authors expect that the new goal and mission of Wonkwang University School of Medicine would be helpful in giving the guideline on the educational process of medical school and will give the information to reform the medical school system according to the rapidly changing educational environment.

α-디아조 케톤과 올레핀의 광반응

李學沂,曺燦湜,金宇鍾,禹海允 慶北大學校 1990 論文集 Vol.50 No.-

The majority of carbenes add to olefins to give cyclopropanes. In this study, 2-diazo-1,3-indandione, 2-diazo-1-indanone, and 3-diazooxindole were used as carbene precursors. Irradiation of these diazo compounds with trichloroethylene, acrylonitrile, cyclohexene, and cyclooctene was investigated. The addition of carbenes to benzene generally affords norcaradiene or cycloheptatriene or both. Irradiation of 2-diazo-1,3-indandione with benzene gave only cycloheptatriene derivative in 24% yield. But irradiation of 2-diazo-1-indanone with benzene gave norcardiene in equiribrium with cycloheptatriene derivative in 24% yield.

Gitelman씨 증후군 1예

차영학,송명준,신요식,김성민,김영욱,김윤권,김소연,김영중,조민구,이권전 全南大醫大 2001 전남의대학술지 Vol.37 No.3

시뮬레이션을 통한 실리콘 고주파 집적회로를 위한 rectangular spiral 인덕터의 특성조사

윤석출,이연승,김학선 한밭대학교 정보통신전문대학원 2003 정보통신전문대학원 논문집 Vol.1 No.1

본 논문에서는 온 칩 rectangular Spiral 인덕터를 구현할때 인덕터의 크기를 고정하고 권선수를 증가시켜 Q값과 공진주파수의 변화를 보았다. 그리고 인덕터의 도체 구성 물질을 Cu와Al에 대하여 비교하여 Cu가 Al보다 더 높은 Q값을 가짐을 보았다. 또한, 기판과 spiral도체사이의 유전물질이 인덕터의 Q-factor에 어떤 영향을 미치는지를 알아보기 위해 유전물질을 SiO_2와 BCB그리고 Air로 하여 비교 분석하였다. This paper present the effect of number of turns on quality factor and SRF(Self-Resonance Frequency) of on-chip rectangular spiral inductors with a fixed outer dimension. We analyze the inductors using different metals, Copper(Cu) and Aluminum(Al), respectively and demonstrate that Cu inductors have higher quality factors. We also study the impact of various dielectric interface layers of SiO_2, BCB(Benzocyclobutene), and air.

휴대폰용 FBAR Duplexer에 내장되는 위상천이기에 관한 연구

윤석출,송인상,이연승,김학선 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문은 WCDM용 Duplexer의 소형화를 위한 집적화된 1×lmm^(2)이하 크기의 RF Phase Shifter를 설계 하고 제작 평가하였다. 제안된 Phase Shifter는 PCB상에서 긴 마이크로스트립 라인 대신에 실리콘 기판 상에 집중 수동 소자인 high-Q 인덕터와 MIM 커패시터로 구현되었다. 제작된 Phase Shifter를 측정한 결과 삽입손실은 0.37 dB를 얻었고, 입력 VSWR은 15.69 dB를 얻었으며, 위상은 81˚를 얻었다. 크기도 0.8×O.9㎟ 로 제작되어 Phase Shifter의 소형화의 가능성을 보였다. In this paper, we have designed, and evaluated the integrated RF phase shifter to reduce the chip size below 1×1mm^(2) for WCDMA duplexer application. Instead of the large transmission lines on the PCB, the proposed phase shifter was used small-sized lumped elements, such as integrated high-Q inductor and MIM capacitors on silicon substrates. In the measurement results of the fabricated phase shifters, the insertion loss was 0.37dB and input VSWR was 15.68dB, the phase was 81˚. Also, the final chip size was 0.8×0.9㎟, which clearly showed the feasibility of the miniaturized RF LC phase shifter.

Use of the Ion AmpliSeq Cancer Hotspot Panel in clinical molecular pathology laboratories for analysis of solid tumours: With emphasis on validation with relevant single molecular pathology tests and the Oncomine Focus Assay

Lee, Ahwon,Lee, Sung-Hak,Jung, Chan Kwon,Park, Gyungsin,Lee, Kyo Young,Choi, Hyun Joo,Min, Ki Ouk,Kim, Tae Jung,Lee, Eun Jung,Lee, Youn Soo Elsevier 2018 Pathology, research and practice Vol.214 No.5

<P><B>Abstract</B></P> <P>Targeted application of next-generation sequencing (NGS) technology allows detection of specific mutations that can provide treatment opportunities for cancer patients. We evaluated the applicability of the Ion AmpliSeq Cancer Hotspot Panel V2 (CHV2) using formalin-fixed, paraffin-embedded (FFPE) tissue of clinical specimens.</P> <P>Thirty-five FFPE tumour samples with known mutational status were collected from four different hospitals and sequenced with CHV2 using an Ion Chef System and Ion S5 XL system. Out of 35 cases, seven were sequenced with Oncomine focus Assay Panel for comparison. For the limit of detection test, we used an FFPE reference standard, a cell line that included an engineered 50% EGFR T790 M in an RKO cell line background. Coverage analysis results including number of mapped reads, on target percent, mean depth, and uniformity were not different according to hospitals. Sensitivity for mutation detection down to 3% was demonstrated. NGS results showed 100% concordance with the results from single molecular pathology tests Assay in 30 cases with 24 known positive mutations and 14 known negative mutations, and another NGS panel of the Oncomine focus in seven cases.</P> <P>The CHV2 NGS test for solid tumours using Ion chef system and S5 XL system in clinical molecular pathology laboratories for analysis of solid tumours could be routinely used and could replace some single molecular pathology tests after a stringent and thorough validation process.</P>

Comparative proteomic study between tuberous roots of light orange- and purple-fleshed sweetpotato cultivars

Lee, Jeung Joo,Park, Kee Woong,Kwak, Youn-Sig,Ahn, Jae Young,Jung, Young Hak,Lee, Byung-Hyun,Jeong, Jae Cheol,Lee, Haeng-Soon,Kwak, Sang-Soo Elsevier 2012 Plant science Vol.193 No.-

<P><B>Abstract</B></P> <P>This study compares the differences in proteomes expressed in tuberous roots of a light orange-fleshed sweetpotato (<I>Ipomoea batatas</I> (L.) Lam. cultivar Yulmi) and a purple-fleshed sweetpotato cultivar (Shinjami). More than 370 protein spots were reproducibly detected by two-dimensional gel electrophoresis, in which 35 spots were up-regulated (Yulmi vs. Shinjami) or uniquely expressed (only Yulmi or Shinjami) in either of the two cultivars. Of these 35 protein spots, 23 were expressed in Yulmi and 12 were expressed in Shinjami. These protein spots were analyzed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and electrospray ionization tandem mass spectrometry. Fifteen proteins in Yulmi and eight proteins in Shinjami were identified from the up-regulated (Yulmi vs. Shinjami) or uniquely expressed (only Yulmi or Shinjami) proteins, respectively. In Yulmi, α-amylase and isomerase precursor–like protein were uniquely expressed or up-regulated and activities of α-amylase, monodehydroascorbate reductase, and dehydroascorbate reductase were higher than in Shinjami. In Shinjami, peroxidase precursor and aldo–keto reductase were uniquely expressed or up-regulated and peroxidase and aldo–keto reductase activities were higher than in Yulmi. PSG-RGH7 uniquely expressed only in Shinjami and the cultivar was evaluated more resistant than Yulmi against the root-knot nematode, <I>Meloidogyne incognita</I> (Kofold and White, 1919) Chitwood 1949 on the basis of shoot and root growth. Egg mass formation was 14.9-fold less in Shinjami than in Yulmi. These results provide important clues that can provide a foundation for sweetpotato proteomics and lead to the characterization of the physiological function of differentially expressed proteins.</P> <P><B>Highlights</B></P> <P>► Proteomics in tuberous roots of two sweetpotato cultivars were compared. ► Over 370 protein spots were reproducibly detected by 2-dimensional electrophoresis. ► Thirty five spots were differentially expressed in either of the two cultivars. ► This study provides new insights to characterize differentially expressed proteins.</P>

Development and psychometric evaluation of a chronic liver disease-specific quality of life questionnaire

Lee, Eun-Hyun,Cheong, Jae Youn,Cho, Sung Won,Hahm, Ki-Baik,Kim, Hak Yang,Park, Jong-Jae,Lee, Dong Ho,Kim, Seong Kook,Choi, Seok Reyol,Lee, Soo Teik,Moon, Seong Mi Blackwell Publishing Asia 2008 Journal of Gastroenterology and Hepatology Vol.23 No.2

<P>Abstract</P><P>Background and Aims: </P><P>There has been no reliable and valid instrument to measure health-related quality of life for Asian patients with chronic liver disease. The aim of the present study was to develop and evaluate a chronic liver disease-specific quality of life (CLD-QOL) questionnaire for Korean patients with chronic liver disease.</P><P>Methods: </P><P>Content-validated items were evaluated psychometrically in 271 patients with chronic liver disease recruited from seven university hospitals in Korea. The participants were asked to complete a preliminary questionnaire comprising the content-validated items and the Short Form-36 Health Survey. The Child–Pugh classification was used to classify the severity of liver cirrhosis.</P><P>Results: </P><P>Factor analysis extracted a five-factor solution from 27 preliminary items, which were generated by an expert panel and a pilot study, but factor and a multidimensional scaling analysis revealed that four items were not loaded significantly on any factor, suggesting that the four items might be heterogeneous. After deletion of these four items, a multiscaling analysis strongly supported item convergence and discriminant validity. The CLD-QOL was associated significantly with the Child–Pugh classification and the type of patient status (inpatient/outpatient) and was moderately correlated with the subscales of the Short Form-36 Health Survey. The values of Cronbach's alpha for the subscales of the novel CLD-QOL questionnaire were all greater than 0.70.</P><P>Conclusions: </P><P>The novel CLD-QOL questionnaire we developed is an easily applicable tool that exhibits excellent psychometric properties for Korean patients with chronic liver disease. It is recommended for the CLD-QOL to apply for Asian patients with chronic liver disease.</P>

Prognostic significance of syndecan-1 expression in squamous cell carcinoma of the tonsil

Lee, Sung Hak,Choi, Eun Ji,Kim, Min Sik,Park, Jun Wook,Lee, Youn Soo,Kim, Su Young,Kang, Chang Suk Springer-Verlag 2014 International journal of clinical oncology Vol.19 No.2

The Effect of Consistency and Crowding Number on the Formation of Paper Made of Different Pulp Stocks

Hak Lae Lee,Hye Jung Youn,Sang-Gil Lee,Young-Bin Jeong 한국펄프·종이공학회 2007 펄프.종이기술 Vol.39 No.5