Study on Preparation and Properties of PAI Materials Containing Trifluoromethyl in Side Chain

Haiyang Yang,Duxin Li,Jun Yang,Jin Wang,Shunchang Gan,Kaikai Cao,Yufeng Liu 한국고분자학회 2021 Macromolecular Research Vol.29 No.10

Polyamide-imide (PAI) materials with good heat resistance, excellent friction, wear properties, and low water absorption were prepared by acyl chloride process with diamine monomer containing trifluoromethyl in the side chain. The results showed that PAI prepared from 2,2'-bis(trifluoromethyl)-[1,1'-biphenyl]- 4,4'-diamine without flexible hinge group had the best heat resistance, with T g as high as 302.6℃ and T d5% as 490.1℃. With the increase of the proportion of flexible hinge groups in diamine monomer, the thermal properties of PAI materials would decrease. The wear mechanism of PAI prepared from 2,2'-bis(trifluoromethyl)- [1,1'-biphenyl]-4,4'-diamine was mainly adhesive wear. With the increase of the proportion of flexible hinge groups in diamine monomer, the wear mechanism would change from abrasive wear, slight adhesive wear to severe adhesive wear. The friction coefficient and wear loss of PAI prepared by 1,4-bis(4-amino-2-trifluoromethylphenoxy) benzene were the smallest, which were 0.4706 and 3.5, respectively. PAI synthesized by diamine monomer containing trifluoromethyl had low water absorption and high water contact angle. With the increasing flexibility of monomer containing trifluoromethyl diamine, the elongation at break and tensile strength of the material increased gradually.

LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer

Yang, Haiyang,Peng, Minqi,Li, Yanjiao,Zhu, Renjie,Li, Xiang,Qian, Zhengjiang The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.4

Purpose: Long noncoding RNA 00703 (LINC00703) was found originating from a region downstream of Kruppel-like factor 6 (KLF6) gene, having 2 binding sites for miR-181a. Since KLF6 has been reported as a target of miR-181a in gastric cancer (GC), this study aims to investigate whether LINC00703 regulates the miR-181a/KLF6 axis and plays a functional role in GC pathogenesis. Materials and Methods: GC tissues, cell lines, and nude mice were included in this study. RNA binding protein immunoprecipitation (RIP) and pull-down assays were used to evaluate interaction between LINC00703 and miR-181a. Quantitative real-time polymerase chain reaction and western blot were applied for analysis of gene expression at the transcriptional and protein levels. A nude xenograft mouse model was used to determine LINC00703 function in vivo. Results: We revealed that LINC00703 competitively interacts with miR-181a to regulate KLF6. Overexpression of LINC00703 inhibited cell proliferation, migration/invasion, but promoted apoptosis in vitro, and arrested tumor growth in vivo. LINC00703 expression was found to be decreased in GC tissues, which was positively correlated with KLF6, but negatively with the miR-181a levels. Conclusions: LINC00703 may have an anti-cancer function via modulation of the miR-181a/KLF6 axis. This study also provides a new potential diagnostic marker and therapeutic target for GC treatment.

The Implications of Private Higher Education in Europe and America for Private Higher Education in Henan

NIU Yitong(Yitong NIU),WANG Haiyang(Haiyang WANG),YANG Yuqing(Yuqing YANG) ACADEMIC FRONTIERS PUBLISHING GROUP(AFP) 2024 Journal of Sinological Studies(JSS) Vol.1 No.1

A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission

( Haiyang Wang ),( Xiaojing Zhao ),( Xiufang Cui ),( Meifeng Wang ),( Chunhua Jiao ),( Jiajia Li ),( Yan Yang ),( Yi Li ),( Hongjie Zhang ) 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4

Background/Aims Some inflammatory bowel disease (IBD) patients in remission suffer from irritable bowel syndrome (IBS)-like symptoms (IBD-IBS). The pathogenesis has not yet been elucidated. The study aim is to evaluate relationships among quality of life (QOL), psychological status, and visceral sensitivity, and explore the formation mechanism of IBD-IBS. Methods Forty-seven patients with Crohn’s disease in remission, 24 ulcerative colitis in remission, 26 IBS, and 20 healthy controls were included in the study. The abdominal pain, QOL, anxiety, and depression were evaluated through questionnaires. Visceral sensitivity was measured by rectal balloon distension. The serum levels of 5-hydroxytryptamine (5-HT) and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay. The expressions of tryptase, 5-HT, NGF, and related receptors in colonic tissues were detected by immunohistochemistry and western blot. Results Prevalence of IBS-like symptoms in Crohn’s disease and ulcerative colitis patients in clinical remission was 29.8% and 50.0%, respectively. The QOL was lower, the anxiety/depression scores were higher in IBD-IBS patients than those without IBS-like symptoms. Additionally, patients with IBD-IBS existed visceral hypersensitivity. Besides, abdominal pain was associated with poor QOL, visceral hypersensitivity, anxiety, and depression in IBD-IBS patients. The number of mast cells (MCs) and expressions of 5-HT, NGF, and related receptors were higher in IBD-IBS patients than those with no such symptoms. The serum levels of 5-HT and NGF positively correlated with abdominal pain and visceral hypersensitivity. Conclusion IBD-IBS patients may have low QOL and psychological abnormalities, as wells as visceral hypersensitivity which may be related to increased 5-HT and NGF levels released from activated mast cells. (J Neurogastroenterol Motil 2021;27:612-625)

Improvement of FK506 Production by Selection of 4-Aminobutyric Acid-tolerant Mutant and Optimization of its Fermentation Using Response Surface Methodology

Yang, Tianyi,Li, Jiaojiao,Li, Liangzhi,Zhang, Haiyang,Ma, Jing,Chen, Zhi,Hu, Cuiying,Ju, Xin,Fu, Jiaolong 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6

Tacrolimus (FK506), a 23-membered polyketide macrolide with immunosuppressant activity, can be produced by Streptomyces tsukubaensis. We studied a variety of mutant strains of S. tsukubaensis for the microbial production of FK506. The best strain (CZ-19) was obtained from the parent strain LLZ-1 by nitrosoguanidine mutation and 4-Aminobutyric acid (FK506 precursor structure analogs) adaption. In the shake-flask experiments, titer of FK506 by CZ-19 was 532.44 mg/L, increased by 65.13% compared to that of the parent strain. Through single factor experiments and response surface methodology, we further optimized the medium for improved FK506 production by CZ-19 in shake flask culture. The optimal medium for enhanced FK506 production was as follows: 17.19 g/L corn starch, 21.78 g/L glucose, 8.06 g/L peptone, and 18.98 mg/L 4-aminobutyric acid. The predicted FK506 titer was 906.49 mg/L, and the experimental data confirmed the validity of the model. The present study demonstrates that S. tsukubaensis CZ-19 is a promising strain for industrial production of FK506.

A Reflective Heterogeneous Service Coordination Middleware Based On Mobile Agents in Wireless Environments

Haiyang Hu,Hua Hu,Yi Zhuang,Lianghuai Yang 보안공학연구지원센터 2008 International Journal of Software Engineering and Vol.2 No.4

Software services distributed in open wireless environments are implemented using different middleware types and advertised using different discovery protocols. Client application needs to adopt a flexible approach to discover and bind these services. Compared with other related work, this paper presents a new reflective coordination middleware based on mobile agent. It dynamically adapts both its binding and discovery protocol to allow interoperation with heterogeneous services by uploading different functional components. By dynamically creating subagents at run time, it can interoperate with multiple services in parallel. As a result, the client burden is released, and the efficiency of the coordination process is enhanced.

Activating Endogenous Neurogenesis for Spinal Cord Injury Repair: Recent Advances and Future Prospects

Haiyang Yu,Shangbin Yang,Haotao Li,Rongjie Wu,Biqin Lai,Qiujian Zheng 대한척추신경외과학회 2023 Neurospine Vol.20 No.1

After spinal cord injury (SCI), endogenous neural stem cells are activated and migrate to the injury site where they differentiate into astrocytes, but they rarely differentiate into neurons. It is difficult for brain-derived information to be transmitted through the injury site after SCI because of the lack of neurons that can relay neural information through the injury site, and the functional recovery of adult mammals is difficult to achieve. The development of bioactive materials, tissue engineering, stem cell therapy, and physiotherapy has provided new strategies for the treatment of SCI and shown broad application prospects, such as promoting endogenous neurogenesis after SCI. In this review, we focus on novel approaches including tissue engineering, stem cell technology, and physiotherapy to promote endogenous neurogenesis and their therapeutic effects on SCI. Moreover, we explore the mechanisms and challenges of endogenous neurogenesis for the repair of SCI.

Transcriptome analysis reveals critical genes and key pathways involved in early phyllotaxy development in maize

Yang Zhao,Xiaojian Peng,Wenbo Chai,Yingquan Tan,Qing Dong,Haiyang Jiang,Beijiu Cheng 한국유전학회 2017 Genes & Genomics Vol.39 No.1

Integrated networks of gene expression, hormonal signaling and metabolite sensing regulate phyllotaxy pattern development. In this study, we characterized differentially expressed genes (DEGs) between maize plants with alternate and opposite phyllotaxies. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that 2432 DEGs were involved in biological processes, molecular functions, cellular components and many pathways. Importantly, we identified 19 DEGs related to plant hormone signal transduction. Additionally, we identified four main alternative splicing types: skipped exons, retained introns, alternative 50-splice sites, and alternative 30-splice sites, which exhibited different characteristics in the alternate and opposite phyllotaxy libraries. The reliability of the sequencing data was verified through using quantitative real-time reverse transcription PCR analysis of the 19 genes: 15 were validated to play a role in phytohormone signal transduction pathways. Taken together, our data provide new insight into the mechanisms of phyllotaxy pattern development, and will increase our understanding of how relative changes in gene expression determine alternate/opposite phyllotaxy in maize.

Rational design of porous NiCo2S4 nanotubes for hybrid supercapacitor

Wang Haiyang,Liang Miaomiao,He Zemin,Guo Zhun,Zhao Yang,Li Kexuan,Song Wenqi,Zhang Yongming,Zhang Xin,Zhao Yuzhen,Miao Zongcheng 한국물리학회 2022 Current Applied Physics Vol.35 No.-

The nanotube-consisted flower-like NiCo2S4 is successfully fabricated by a novel two-step hydrothermal technique. X-ray diffraction (XRD) identifies the spinel structure, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) imply the flower-like morphology of the synthesized NiCo2S4. The electrochemical behaviors are studied by cyclic voltammetry and galvanostatic charge-discharge measurements. The NiCo2S4 nanotubes demonstrate enhanced pseudocapacitive performance of 429.5 C g− 1 at current density of 0.5 A g− 1 . The NiCo2S4//AC device delivers high energy density of 37.69 Wh kg− 1 , maximum power density of 4000.6 W kg− 1 and satisfied cycle property of 96% capacitance retention after over 7000 cycles. The results show that the NiCo2S4 nanotubes are promising electrode material for high performance supercapacitor applications.

Online probabilistic forecasting method for trapezoidal photovoltaic stream data

Yu, Haiyang,Chen, Chunyi,Yang, Huamin The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.11

For the probabilistic forecasting of photovoltaic generation, the design of a feasible online predictive framework is a challenging problem. To deal with this issue, an ensemble dynamic OS-ELM based on quantile estimation has been proposed. Considering inherent intermittent and random variations of the photovoltaic sequence, the weights of the forecasting model are updated according to the loss suffered. At the same time, the accommodative feature threshold can be calculated on the basis of increasing characteristics space, which builds the optimal network architecture for point forecast. A two-dimensional kernel density estimation algorithm based on a fuzzy inference method is exploited. This method breaks through the assumptive limit of error distribution. The changeable parameters help the model to be suitable for power fluctuations. Both the arriving data sample and the increasing feature space are tackled. Numerical experiments are conducted on two practical applications for solar power systems. The results show that the proposed algorithm not only has lower generalization error, but also provides higher confidence coefficient.