심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Quartz 자극에 의한 iNOS 발현의 자가조절

김경아,남혜윤,문제혁,정진숙,임영,정치경 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : Rat2 섬유모세포에서 α-quartz에 의해 유도된 NOS의 조절기전을 알아보기 위하여 본 연구가시도 되었다. 방법 : Rat2 세포에 있어서 α-quartz 자극에 의한 NO와 H₂O₂의 분비 및 iNOS의 발현을 관찰하였고, iNOS 억제제인 L-NIL과 H₂O₂ 억제제인Catalase를 전처리하고 마찬가지로 NO와 H₂O₂분비 그리고 iNOS의 단백발현 정도를 western blot-ting을 이용하여 관찰하였다. 결과 : o-quartz는 Rat2 세포에서 iNOS에 의한NO와 H₂O₂의 분비를 유도하였다. L-NIL은 R3t2세포에서 D-quartz에 의한 H₂O₂의 분비와 iNOS발현을 완전히 억제하였다. Catalase로 전처리 하였을 때 o-quartz로 유도된 iNOS에 의하여 생산증가된 H2Oa가 iNOS를 억제하는 autoinhibitorypathway가 차단되어 결과적으로 H₂O₂의 분비와 iNOS의 발현이 증가하였다. 결론 : Rat2 세포에서 α-quartz에 의하여 유도된iNOS는 H₂O₂의 분비를 촉진하고 이 H₂O₂는 iNOS기능을 조절하는 자가조절기전에 중요한 역할을 하는 것으로 생각된다. Objectives : This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase (NOS) induced by α-quartz in Rat2 fibroblast. Methods : α-quartz-induced nitric Oxide (NO) anti H₂O₂ formation anti α-quarts-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor (L-N6- (1-iminoethyl) lysine hydrochloride, L-NIL) or antioxidant (catalase), we observed NO and H₂O₂ formation and iNOS protein expression in Rat2 fibroblast stimulated with α-quartz. Results : α-quartz stimulated iNOS-induced NO and H₂O₂ formation in Rat2 fibroblast. L-NIL inhibited H₂O₂ formation and iNOS protein expression by α-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOS-induced H₂O₂ therefore H₂O₂ and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with α-quartz Conclusion : α-quartz-induced iNOS Stimulated H₂O₂ formation in Rat2 fibroblast. INOS-induced H₂O₂ by α-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast

초기 유방암 환자에서 피하 유방 절제술후 즉시 유방 재건술에 대한 고찰

오경석,김해진,정재호,설정현 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.5

고등학생의 성 관련 특성, 성 지식에 관한 기초 조사

김혜원,김남순,윤태호,김종숙,홍경자 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Purpose : This preliminary study was done to identify sex related characteristics and sex knowledge of high school students. Methods : 622 high school students participated in the survey living in Gangreung city area. The data collection was done from May 1st to October 31st, 2000 using the self administered questionnaires. Results : The teachers and the peer students had a critical position in high school sex education. Reproductive physiology such as relations with the opposite sex, AIDS, STI, and contraceptions should be intensified in further sex education for high school students. There were sex differences in contraception and permission with sex relationship. And the false belief regarding sex assaults and knowledge deficit in AIDS were discovered. Conclusion : Sex education program development and application are necessary based on the educational needs and attitude evaluation for the sexual health improvement of high school students. In further study, developing the reliable measurement tool and various educational methodologies will be studied which are enough for the include the sex education concepts.

조직공학적 연골생성에 있어서 연골막의 필요성

오경석,김해진,이동준,정재호,최준혁 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.4

일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究

김성삼,홍지우,한현정,최희석,권소희,정해경,김삼태,송용선,이기남 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

〈Objective〉 This study were carried out to study to assess the relationship between job characteristics, general characteristics, health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. 〈Methods〉 We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item self- administered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) 〈Results〉 Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12~4.11), and those of passive group and active group were 2.01(95 0.83~2.76) and 1.80(95 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. 〈Conclusion〉 The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

석회침착을 동반한 위암 1례

김경숙,하해구 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.1

The occurrence of calcification in gastric cancer is extremely rare. Since the first case report by Gruber in 1913, there are about 50 cases in the published literature. (The American Journal of Gastroenterology, 69:481, 1978) The purpose of this paper is to report an additional case of these rare entity with endoscopic observation. This 63 year old, male patient had nausea, vomiting and epigastric hard mass, that is a large apple size, for about 2 months duration. The simple abdomen of this patient showed mottled, stippled, granular, punctuate, sand like and miliary calcifying mass in the upper abdomen. And this was confirmed to mucinous adenocarcinoma of the stomach with upper G-I study, computed tomography, ultrasonography and endoscopic biopsy. The surgery was denied. The fine, sand-like calcifications found in gastric carcinomas appear to be characteristic of a mucus-secreting tumor. It is of interest that the findings permitting correct diagnosis were clearly indicated on a simple film of the abdomen. A few examples which were discorved on pathological examination, but without roentgenographic study, are not considered here.

운동선수의 체중감량 및 운동수행에 따른 혈장 지단백 변화

金乙祥,琴惠卿 단국대학교 1993 論文集 Vol.27 No.-

The purpose of this study was to investigate the relation of exercise and plasma lipoproteins which have the important functions for metabolism and transport of plasma lipids. The subjects of study were twenty male athletes in Korean National College of Physical Education. Their nutrient intakes were surveyed by weighing method, and plasma lipoproteins were determined by eletrophoretic method during the body weight reduction and exercise. And A group was loaded 70-80%, and B group loaded over 85% in maxiam oxygen consumption. The results obtained were as follows ; 1. According to the dietary analysis, in A group, the average intake of energy was 1915.5kcal per day of one man. in B group, was 1922.2kcal. Rates of energy composition were 60.7% in carbohydrate, 16.7% in protein and 22.6% in fats in A group and 61.5% 15.9%, 22.6% respectively, in B group. 2. Before and after body weight reduction, β-lipoproteins(LDL+VLDL) content in plasma of A group and B group were more decreased. And α-lipoprotins(HDL) content in plasma of A group and B group were more increased. 3. In "3rd step", β-lipoproteins content in plasma of A group were more increased in comparison to B group. In "4th step", β-lipoprotein content in plasma of B group were more increased in comparison to A group. 4. After exercise, progressive changes of plasma lipoproteins in each groups, α-lipoprotein content in plasma of A group and B group were more decreased gradually.

종격동 종괴를 의심케한 우대동맥궁 1례

김만우,백학연,정춘해,장경식,홍순표,조건국,김종진 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

Developmental anomalies of the aortic arch, commonly known as vascular rings, are relatively rare congenital vascular anomalies which can compress the trachea and esophagus. One routine chest film of a patient who was checked and hepatoma-diagnosed in Internal Medicine, Chosun University Hospital left the room for doubt of mediastinal mass. But no subjective symptoms for the mass was told by the patient. This is to report our experience of a patient having right side aortic arch with aberrant left subclavian artery, as proved by diagnosis, but none of congenital heart disease. This right side aortic arch with aberrant left subclavian artery is the most frequent type among right aortic arch, the anomaly of which is usually detected from the incidental suspicion for mediastinal mass at routine chest film; because no symptoms are accompanied therewith.

Berberine의 항생제 내성 확색포도구균에 대한 항미생물 효과

김강주,차정단,김해경,유현희,유용욱,이동근 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Antibiotic-resistant Staphylococcus aureus (S. aureus) emerged in many parts of the world and increased complex clinical problems. Therefore, new agents are needed to treat the antibiotic-resistant S. aureus. Some natural products are candidates of new antibiotic substances. Previous reports showed that the extract of Coptidis Rhizoma and Phellodendri Cortex have antimicrobial effects. The main antibacterial substance of Coptidis Rhizoma and Phellodendri Cortex is berberine. In this study, we examined the antimicrobial activity of berberine to antibiotic-resistant S. aureus. We isolated the 13 strains of antibiotic-resistant S. aureus from the oral cavity of healthy children in a preschool, and investigated the antimicrobial activity of berberine. We examined the effects of berberine on the level of resistance to antibiotic-resistant S. aureus. We observed that the invasion of S. aureus into human gingival fibroblasts was blocked by berberine. Berberine inhibited the growth of antibiotic-resistant S. aureus as a dosw dependent maner. Minimum inhibitory concentration (MIC) of berberine against antibiotic-resistant S. aureus was 50∼100㎍/㎖. The inhibition of S. aureus invasion was depended on the concentration of berberine in human gingival fibroblasts. The MIC of ampicillin against antibiotic-resistant S. aureus was 32㎍/㎖. However, the MIC of ampicillin against antibiotic-resistant S. aureus in the presence of 50㎍/㎖ berberine was 1㎍/㎖. These data indicate that the combination with berberine and β-lactam antibiotics resulted in the synergistic reaction. These results suggest that the berberine may have the antimicrobial activities to antibiotic-resistnat S. aureus, and the mechanism may be the inhibition of growth and intracellular invasion, and alteration of antibiotic-resistance level of antibiotic-resistant S. aureus.