P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

HPGe 검출기에 의한 지각방사선의 핵분광학적 연구

전재식,채하석,진응국,이철영,조혁,하정우 충남대학교 기초과학연구소 1992 연구논문집 Vol.12 No.-

고순도 Ge(HPGe) 검출장치를 사용한 현장측정을 통하여 지각방사선에 대한 핵분광학적 연구를 수행하였는바 지각방사선장의 핵분광학적 특성차이를 규명하기 위하여 지면의 자연방사성 핵종분포가 대표적 전형인 충남대학교 캠퍼스내 미경작 개활지 잔디밭과, 우라늄 함량이 높은 곳으로 알려진 괴산군 덕평리 지역 등 특이한 두 지역을 측정지점으로 선택하였다. 환산선량의 비교확인을 위하여 HPGe 분광측정은 3″ø×3″원통형 NaI(T1) 섬광검출기에 의한 분광측정과 동시에 수행하였으며 본 연구에 사용된 HPGe 검출기에 대한 스펙트럼-선량율 환산인자 G(E)는 감마선속이 검출기 축에 수직 입사하는 것으로 가정하고 Monte Carlo 방법으로 씨뮬레이션한 감응스펙트럼들을 사용하여 산출하였다. 이 G(E)를 사용하여 산출된 선량율(D˙_Ge)은, 이미 기준기급 전리함과의 비교 교정을 통하여 스펙트럼-선량 환산체계가 확립된 바 있는 NaI(T1) 검출기로 구한 선량율(D˙_NaI)과 만족스러운 일치를 보였으며 D˙_Ge와 D˙_NaI 사이의 상관계수는 +0.9988, 회귀 방정식의 기울기는 1.001을 나타내었다. 측정한 스펙트럼에서는 미미한 크기의 ^137Cs 감마선 피크가 확인되었으나 1960년대에 수행되었던 대기권 핵실험의 영향이나 Chernobyl 원전사고의 영향은 관측되지 않았다. Study of terrestrial gamma-rays was carried out by means of in-situ spectrometry using high purity germanium (HPGe) detector system. Two distinguishable fields of measurements, namely, uncultivated flat lawns in CNU campus where the distribution of natural radionuclides in the ground in known to be quite typical and well-known uranium rich area of Dukpyung-ri in Gwoesan-kun were selected in order to specify the difference in spectrometric characteristics of the fields. In-situ HPGe spectromety was accompanied by scintillation spectrometry with 3″ø×3″cylindrical NaI(T1) detector for comparative confirmation of derived dose rates from the spectra measured. Spectrum-dose rate conversion operator, G(E), of our particular HPGe detector was calculated using response spectra simulated by Monte Carlo method with an assumption of gamma-ray beams incident vertically to the detector axis. Resultant dose rates (D˙_Ge) showed satisfactory agreement with those obtained by NaI(T1) spectrometry and corresponding G(E) operation (D˙_NaI) of which system has been well-established through intercalibration with a reference ion chamber. Correlation coefficient and the slope of regression equation between D˙_Ge and D˙_NaI came out to be +0.9988 and 1.001, respectively. Though traceable height of ^137Cs gamma-ray peak was identified on the field spectrum, ground contamination of fission products released from atmospheric nuclear test performed in 1960s and possibly from Chernobyl accident was not observed as of today.

마이크로 팩토리 물류이송용 평면모터

이창우,송준엽,하태호,정영상 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

The micro factory of size is so small that consuming power is reduced and also manufacturing line could be easily reconfigurable. The micro factory is required automation to satisfy high productivity. It is one of the big problems to convey goods, In case of automated reconfigurable micro factory. Planar motor that can perform linear motion in XY direction is one of solution that solves this problem. But conventional planar motor using a magnetic force has a disadvantage that planar motor base is permanent magnet. In this paper we consider new type of a planar motor based on principle of ultrasonic waves using PZT.

Tocopherol 投與가 家兎의 增體 및 飼料利用性에 미치는 影響

林鍾佑,尹昌鉉,河正基,朴琦緖 진주농과대학 1970 진주농과대학 연구논문집 Vol.- No.9

本 試驗은 Tocopherol이 家兎의 增體 및 飼料利用性에 미치는 影響을 究明하기 위해 雌兎 20頭, 雄兎20頭 計 40頭를 8週間 試驗하였던바 다음과 같은 結果를 얻었다. 1. 日當 增體量에 있어서는 處理區間에 1% 水準의 有意性이 認定되었으며 T₂區가 14.68g, T₁區가 13.17g로서 對照區보다 優秀하였으나 T₃區는 對照區보다 좋지 않았다. 2. 飼料攝取量에 있어서는 處理區間과 性別間에 1%水準의 高度의 有意性이 認定되었고 T₂區, T₁區가 對照區보다 飼料攝取量이 많았으나 T₃區는 對照區보다 不良했다. 3. 飼料利用率에 있어서는 處理區에 있어서 別다른 差가 認定되지 않았다. This experiment was conducted to study the effects of Tocopherol on gain weight, feed consumption and feed conversion of growing rabbits. Twenty male and twenty female rabbits of Japanese white breed used for 8 weeks. The results obtained from this study may be summarized as follows: 1. There was found a highly significant difference(P<0.01) for daily gain weight between treatments. T₂lot with 14.68g and T₂lot with 13.17g had higher daily gain weight than its of control lot. But T₃lot had lower daily gain weight than its of control lot. 2. In feed consumption there were highly significant differences (P<0.01) between treatments and sex. T₂lot and T₁lot had more feed intake than its of control lot. But T₃lot had lower feed intake than its of control lot. 3. The difference in feed conversion was found insignificant between treatments.

종골 골절 치료에 있어서의 전산화 단층 촬영의 유용성

김학준,하권익,윤정로,심재익,김택선,김영배,이우승,최재혁 대한골절학회 2003 대한골절학회지 Vol.16 No.4

Dipping법에 의한 천연고무 라텍스 필름의 표면개질 특성

이영우,박준하 충주대 산업과학기술연구소 1999 産業科學論文集 Vol.7 No.2

The vulcanized NR film was prepared with mixing natural rubber latex(NRL) with various additives by dipping process. The optimum conditions such as the mature time and swelling degree were investigated. NR-t-PST films were prepared to decrease stickiness by modifying surface of NR film with NR/PST(I, II) solution, In order to identify the slip properties of NR-t-PST(I, II) films kinetic and static friction coefficients were investigated. Their kinetic and static friction coefficients were decreased with increasing blending ratio of PST(I, II) but that of NR-t-PST(I) were lower than NR-t-PST(II). NR-t-PST films were prepared with various solid contents. In the case of NR-t-PST(I) kinetic and static friction coefficients were 0.2, 0.18 respectively at 10% solid content. Although coefficients of NR-t-PST(II) were also lowest at 10% solid content, they were higher than those of NR-t-PST(I).

매크로/마이크로 레벨 볼트 결합 구조물에서의 실험적/해석적 방법을 통한 시스템 특성 비교

김봉석,이성민,이문구,이수훈,Jun Ni,송준엽,이창우,하태호 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

As the micro technology and miniaturization of a structure and component in the last couple of decades have been concretely realized, the understanding of structural and dynamic characteristics and prediction of dynamic behavior are indispensable to the miniaturized structures and micro machines. This paper shows the effect of dynamic characteristics in bolt-jointed structures by comparing natural frequencies and mode shapes between macro and micro-scale beams through experimental modal analysis and finite element analysis with a1 8 test models by materials, by size, and by joining condition; that is, SS41 and A16061-T651, micro and macro, and monolithic beam and bolt-jointed beam.

입원한 정신분열병 환자의 가족에 대한 가족교육 단기 프로그램의 효과

이부영,신민섭,하규섭,권준수,손정우 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

정신분열병 환자의 가족은 많은 심리적 스트레스와 부담감을 지니고 생활하게 된다. 또한 환자와 그 가족 사이에 마찰이 생겨 결국 환자의 예후에 좋지 않은 영향을 끼치기도 한다. 이런 것들을 해결하기 위한 여러 정신과적 중재방법들 중 정신교육적 가족치료의 일환으로서 가족 교육 단기 프로그램의 유용성이 점점 부각되고 있다. 이에 우선 가족 교육 연구진을 구성하고 교육자료를 준비한 뒤, 1995년 9월 2일부터 입원한 정신분열병 환자의 가족을 대상으로 가족교육을 시행하였으며 교육적·후에 설문지 평가를 하였다. 이때 평가한 것은 일상생활에서의 가족의 전반적인 불안, 환자와 연관된 걱정, 환자에 대한 가족의 거부감, 정신분열병에 대한 전반적 지식 등이다(N=20). 또 대조군은 1996년 1월부터 5월까지 서울대학병원 신경정신과 폐쇄병동에 입원한 정신분열병 환자 가족을 대상으로 하였으며, 같은 종류의 설문지로 사전·사후평가를 하였다(N=10). 결과는 다음과 같다. 1) 교육군과 대조군의 사전평가 점수를 각 설문지별로 비교하였는데, 불안 설문지, 지식 설문지의 점수에서는 두 군간의 차이가 발견되지 않았으나, 거부감 설문지의 점수는 교육군에서 대조군보다 통계적으로 유의하게 높았다(F=9.50, df=1.28, p<0.01). 2) 교육군과 대조군 각 군 내에서 사전·사후평가 점수를 비교하였을 때, 교육군에서는 지식 설문지에서 사후평가 점수가 사전평가 점수보다 유의하게 높았으며(t=5.43, df=19, p<0.01), 걱정 설문지와 거부감 설문지에서는 사후평가 점수가 사전평가 점수보다 유의하게 낮았다(걱정 설문지의 t=-3.03, df=19, p<0.01 ; 거부감 설문지의 t=-2.34 df=19, p<0.05). 그러나 교육군에서 불안 설문지의 점수에서는 별다른 차이가 나타나지 않았다. 한편 대조군에서도 지식 설문지에서 사후평가 점수가 사전평가 점수보다 유의하게 높았지만 (t=1.86, df=19, p<0.05), 교육군에 비해서 그 차이는 경미하였다. 3) 각 설문지의 사전·사후평가 점수의 차이의 상관관계를 측정한 결과 교육군에서는 우선 불안 점수의 차(r=-0.56, p<0.01)와 걱정 점수의 차(r=-0.57, p<0.01)가 지식 점수의 차와 유의한 부적 상관관계를 보였으며, 불안 점수의 차와 걱정 점수의 차 사이에는 유의한 정적 상관관계(r=0.55, p<0.01)가 보였다. 대조군에서는 걱정 점수의 차와 지식 점수의 차 사이에 유의한 부적 상관관계가 존재하였다(r=-0.60, p<0.05). 4) 각 설문지의 사전·사후평가 점수의 차와 사회인구학적 특성 사이의 상관관계를 조사한 결과 교육군에서는 불안 점수의 차와 환자의 유병기간(r=0.39, p<0.05), 불안 점수의 차와 참가 가족의 교육 수준(rs=0.43, p<0.05), 걱정 점수의 차와 환자의 유병기간(r=0.45, p<0.05), 걱정 점수의 차와 참가 가족의 교육 수준(rs=0.49, p<0.05) 사이에 통계적으로 유의한 정적 상관관계가 존재하였으며, 대조군에서는 걱정 점수의 차와 참가 가족의 나이 사이에 정적 상관관계(r=0.64, p<0.05)를, 그리고 걱정 점수의 차와 참가 가족의 교육 수준 사이에 부적 상관관계가 존재하였다(rs=-0.74, p<0.01). Objects : The purpose of this study was to investigate the effectiveness of the brief program of family education in helping families of inpatients with schizophrenia. Methods : The education group consisted of twenty people who were families of inpatients with schizophrenia and who attended the brief program of family education. Ten people who were families of inpatients with schizophrenia and who didn't attend the brief program of family education comprised the comparison group. Four self=report questionnaires assessing global anxiety(Anxiety Questionnaire), worry related to patient(Worry Questionnaire), rejection feeling to patient(Rejection Questionnaire), and knowledge about schizophrenia(Knowledge Questionnaire) were administered to the education group and to the comparison group, twice at the pre-test and post-test. Results : 1) In the education group, scores of Knowledge Questionnaire(t=5.43, df=19, p<0.01) at the post-test were significantly higher than those at the pre-test. Scores of Worry Questionnaire(t=-3.03, df=19, p<0.01) and Rejection Questionnaire t=-2.34 df=19, p<0.05) at the post-test were significantly lower than those at the pre-test. In comparison group, scores of Knowledge Questionnaire were significantly higher at the post-test compared to those at the pre-test(t=1.86, df=19, p<0.05). However, the change in comparison group was not as divergent as in the education group. 2) Differences between the pre-test scores and the post-test scores in each questionnaire were sought. In the education group, significant negative correlation existed between calculated differences of Knowledge Questionnaire and Anxiety Questionnaire(r=-0.56, p<0.01), between Knowledge Questionnaire and Worry Questionnaire(r=-0.57, p<0.01), and significant positive correlation existed between Anxiety Questionnaire and Worry Questionnaire(r=0.55, p<0.01). In the comparison group, significant negative correlation existed between Knowledge Questionnaire and Worry Questionnaire(r=-0.60, p<0.05). 3) The author also assessed the relationship between calculated differences of the pre-test scores from the post-test scores in each questionnaire and demographic characteristics. In the education group, significant positive correlation existed between calculated difference of Anxiety Questionnaire nd duration of illness(r=0.39, p<0.05), between Anxiety Questionnaire and educational level of family(rs=0.43, p<0.05), between Worry Questionnaire and duration of illness(r=0.49, p<0.05) and between Worry Questionnaire and educational level of family(rs=0.45, p<0.05). In control group, significant positive correlation existed between Worry Questionnaire and age of family(r=0.64, p<0.05) and significant negative correlation existed between Worry Questionnaire and educational level of family(rs=-0.74, p<0.01). Conclusion : The brief program of family education was effective in increasing knowledge about schizophrenia, decreasing of worry related to the patients and rejection feeling about the patients in families of inpatienis with schizophrenia.

가상공간의 가공 공정과 상태 구현에 관한 연구

이수훈,김봉석,홍민성,김종민,JUN NI,박상호,송준엽,이창우,하태호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper presents virtual machining system in order to realize turning process in virtual space. A reliable virtual turning process simulation was developed based on the surface shaping system which is capable of considering geometric model, thermal error model, and vibration model. Accuracy of surface shape resulting from proposed machining simulator was verified experimentally. This paper also developed the watchdog agent that continuously assessed, diagnosed, and predicted performance of products and machines in machining. The Watchdog agent extracted feature signal using time-frequency analysis among various signals from multi-sensor and evaluated machining condition using performance confidence value.