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Gyu-Tae Yeom,Hae-Geum Park1,Nam-Tae Kim,Sung-Woo Kim,Hyun Kim,Yoon-Jung Do,Young-Sin Kim,Soo-Bong Park,Jae-Hwan Kim,Sang-Rae Cho,Jae-Hyeon Cho,Yeoung-Gyu Ko 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.1
Body condition score (BCS) is a useful management tool for distinguishing differences in nutritional needs of cows in the herd. Although it is not always possible to quantify the nutrient content of the feed supplied to the donor cow, the nutritional status can be determined by the BCS. The objective of this study was to evaluate in vivo embryo production, return to estrous of donor and pregnancy rate of recipients following BCS in Hanwoo superovulation. Sixty nine Hanwoo donor cows were flushed on day 7 of estrus cycle with same FSH and artificial insemination by the same technicians. Embryos were recovered on 7 days after the third insemination by flushing the uterus with Embryo Collection Medium. The results obtained were as follows: No differences were observed in the efficiency of superovulation rates regardless of BCS (≤2.0, 2.5 to 3.0, and ≥3.5). The mean number of total embryos was each 5.20±0.86, 11.56±1.04, and 6.23±1.07. The mean number of transferable embryo from ≤2.0, 2.5 to 3.0, and ≥3.5 of BCS was 2.60±0.87, 7.94±0.89, and 4.75±1.32, respectively (p<0.05). Return to estrous regardless of donor BCS was no difference. The pregnancy rates of recipient were BCS ≤2.0 11.76%, 2.5 to 3.0 40.79%, and ≥3.5 11.11%, following transfer of fresh embryos produced in vivo, respectively. These results indicate that if the Hanwoo with BCS 2.5 to 3.3 are used for donor and recipient, the embryo production and the conception rate will be greater.
Factors and Their Correlation with Injury Severity of Elderly Pedestrian Traffic Accidents
( Tae Gyu Hyun ),( Seok-ran Yeom ),( Sung-wook Park ),( Deasup Lee ),( Hyung Bin Kim ),( Il Jae Wang ),( Byung Gwan Bae ),( Min Keun Song ),( Youngmo Cho ) 대한외상학회 2019 大韓外傷學會誌 Vol.32 No.3
Purpose: No previous study has assessed elderly pedestrian traffic accidents based on a nationwide database. This study aimed to help primary physicians who examine patients in emergency departments to determine and make prompt and accurate treatment decisions. Methods: This study used data from the Emergency Department-based Injury Indepth Surveillance from 2013 to 2017, managed by the Korea Centers for Disease Control and Prevention. Pedestrians aged ≥65 years were included, and using multivariate logistic regression multiple factors were analyzed to determine their relationship with injury severity. Results: Of 227,695 subjects, 6,498 were included, of whom 2,065 (31.8%) were severely injured. There were more female than male patients in all severity groups. Most accidents occurred in the afternoon and on general roads. In the multivariate analysis, the odds ratio (OR) of injury severity for male pedestrians was 1.165 (95% confidence interval: 1.034-1.313, p=0.012). Older age of patients and the use of ambulances were associated with greater injury severity. The accident time affected the degree of injury severity; i.e., compared to dawn, injury severity increased in the morning (OR: 1.246, p=0.047) and decreased at night (OR: 0.678, p<0.001). A significant difference was noted in the correlation between the type of vehicle causing the accident and the accident severity; i.e., motorcycle accidents had lower severity than bicycle accidents (OR: 0.582, p=0.047). Conclusions: Injury severity was correlated with sex, age, transportation to the ED, TA onset time, and type of vehicle. The study results suggest that injury severity may be positively reflected in initial assessments and overall integrated treatments by physicians and in the related policies.
Lim, Tae-Gyu,Jeon, Ae Ji,Yoon, Ji Hye,Song, Dasom,Kim, Jong-Eun,Kwon, Jung Yeon,Kim, Jong Rhan,Kang, Nam Joo,Park, Jun-Seong,Yeom, Myeong Hun,Oh, Deok-Kun,Lim, Yoongho,Lee, Charles C,Lee, Chang Yong,L UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.5
<P>The aim of the present study was to determine the mechanisms through which 20-O-beta-D-glucopyranosy120(S)-protopanaxadiol (20GPPD) promotes the production of hyaluronic acid (HA) in human keratinocytes. 20GPPD is the primary bioactive metabolite of Rb1, a major ginsenoside found in ginseng (Panax ginseng). We sought to elucidate the underlying mechanisms behind the 20GPPD-induced production of HA. We found that 20GPPD induced an increase in HA production by elevating hyaluronan synthase 2 (HAS2) expression in human keratinocytes. The phosphorylation of extracellular signal-regulated kinase (ERK) and Akt was also enhanced by 20GPPD in a dose-dependent manner. The pharmacological inhibition of ERK (using U0126) or Akt (using LY294002) suppressed the 20GPPD-induced expression of HAS2, whereas treatment with an epidermal growth factor receptor (EGFR) inhibitor (AG1478) or an intracellular Ca2+ chelator (BAPTA/AM) did not exert any observable effects. The increased Src phosphorylation was also confirmed following treatment with 20GPPD in the human keratinocytes. Following pre-treatment with the Src inhibitor, PP2, both HA production and HAS2 expression were attenuated. Furthermore, the 20GPPD-enhanced ERK and Akt signaling decreased following treatment with PP2. Taken together, our results suggest that Src kinase plays a critical role in the 20GPPD-induced production of HA by acting as an upstream modulator of ERK and Akt activity in human keratinocytes.</P>
Lim, Tae-Gyu,Kim, Jong-Eun,Lee, Sung-Young,Park, Jun Seong,Yeom, Myung Hun,Chen, Hanyong,Bode, Ann M.,Dong, Zigang,Lee, Ki Won MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.11
<P>Soy isoflavone is an attractive source of functional cosmetic materials with anti-wrinkle, whitening and skin hydration effects. After consumption, the majority of soy isoflavones are converted to their metabolites in the human gastrointestinal tract. To understand the physiological impact of soy isoflavone on the human body, it is necessary to evaluate and address the biological function of its metabolites. In this study, we investigated the effect of 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF), a major metabolite of daidzein, against solar UV (sUV)-induced matrix metalloproteinases (MMPs) in normal human dermal fibroblasts. MMPs play a critical role in the degradation of collagen in skin, thereby accelerating the aging process of skin. The mitogen-activated protein/extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MKK)3/6/p38 and MKK4/c-Jun <I>N</I>-terminal kinases (JNK) signaling pathways are known to modulate MMP-1 function, and their activation by sUV was significantly reduced by 6,7,4'-THIF pretreatment. Our results also indicated that the enzyme activity of protein kinase C (PKC)α, an upstream regulator of MKKs signaling, is suppressed by 6,7,4'-THIF using the<I> in vitro</I> kinase assay. Furthermore, the direct interaction between 6,7,4'-THIF and endogenous PKCα was confirmed using the pull-down assay. Not only sUV-induced MMP-1 expression, but also sUV-induced signaling pathway activation were decreased in PKCα knockdown cells. Overall, we elucidated the inhibitory effect of 6,7,4'-THIF on sUV-induced MMPs and suggest PKCα as its direct molecular target.</P>
UDP 기반의 대용량 VLBI 데이터 전송 프로그램 개발
송민규(Min-Gyu Song),김현구(Hyun-Goo Kim),손봉원(Bong-Won Sohn),위석오(Seog-Oh Wi),강용우(Yong-Woo Kang),염재환(Jae-Hwan Yeom),변도영(Do-Young Byun),한석태(Seog-Tae Han) 한국산업정보학회 2010 한국산업정보학회논문지 Vol.15 No.5
본 논문에서 우리는 대용량 데이터를 보다 효과적으로 전송할 수 있는 프로그램 구현 및 시스템 최적화에 대해 논의하고자 한다. 수백 ~ 수천 km 떨어진 전파망원경을 이용해 천체를 관측하는 VLBI에서 각 관측소는 수 TB에 달하는 대용량 데이터를 상관센터로 전송하여야 한다. 이에 따라 보다 효율적으로 데이터를 전송할 수 있도록 전세계적으로 초고속 네트워크를 활용한 e-VLBI 연구가 활발히 진행되고 있다. 본 논문에서는 이러한 연구 추세에 따라 초고속 네트워크 상에서 Gbps 급의 VLBI 데이터를 효과적으로 전달할 수 있는 프로그램 설계 및 시스템 구축에 대해 기술하였다. 기존의 VTP(VLBI Transport Protocol) 기반 데이터 전송을 넘어 보다 신속한 데이터 전달이 가능하도록 전송 프로그램 설계에 있어 UDP를 적용하였다. 이를 위해 현재 사용되는 VTP 프로그램에 Tsunami-UDP 알고리즘을 이식하여 데이터 전달에 있어 성능을 극대화하였고, 시스템 최적화를 통해 보다 신속하고 안정적으로 KVN 각 사이트 간 데이터 전송이 구현될 수 있도록 하였다. In this paper, we discuss the program implementation and system optimization for the effective transfer of huge amount of data. In VLBI which is observing the celestial bodies by using radio telescope hundreds thousands km apart, it is necessary for each VLBI observatory to transfer up to terabytes of observed data. For this reason, e-VLBI research based on advanced network is being actively carried out for the transfer of data efficiently. Following this trend, in this paper, we discuss design & implementation of system for the high speed Gbps data transfer rates. As a data transfer protocol, we use UDP for designing data transmission program with much higher speeds than currently available via VTP(VLBI Transport Protocol). Tsunami-UDP algorithms is applied to implementing data transfer program so that transmission performance could be maximize, also we make it possible to transfer observed data more fast and reliable through optimization of computer systems in each VLBI statopm.
루프-스타(Loop-Star) 기저 함수와 전제 조건(Preconditioner)을 이용한 모멘트법의 계산 효율 향상에 대한 연구
염재현(Jae-Hyun Yeom),박현규(Hyeon-Gyu Park),이현석(Hyun-Suck Lee),진희철(Huicheol Chin),김효태(Hyo-Tae Kim),김경태(Kyung-Tae Kim) 한국전자파학회 2012 한국전자파학회논문지 Vol.23 No.2
본 논문에서는 전계 적분 방정식 (Electric Field Integral Equation: EFIE)을 사용하는 모멘트 법의 저주파 오차(low frequency breakdown) 문제를 해결하기 위한 방법으로 루프-스타(loop-star) 기저 함수를 사용하였다. 또한, 모멘트 법의 해를 계산하기 위하여 conjugate gradient method(CGM)과 같은 반복법을 적용할 경우 반복 횟수를 줄이기 위한 기법으로 p-Type Multiplicative Schwarz preconditioner(pMUS)를 이용하였다. 헬름홀쯔 정리(Helmholtz theorem)에 기반한 루프-스타(loop-star) 기저 함수와 주파수 정규화 기법을 이용하여 전계 적분 방정식에서 Rao-Wilton-Glisson(RWG) 기저 함수를 사용하였을 때 발생하는 저주파 오차(low frequency instability) 문제를 해결할 수 있다. 하지만, RWG 기저 함수를 비발산(solenoidal) 성분과 비회전성(irroatational) 성분으로 분해함으로써 발생하는 행렬 방정식의 높은 조건 수(condition number)로 인하여 CGM과 같은 반복법을 사용할 경우 해를 계산하기 위하여 많은 반복 횟수가 요구된다. 본 논문에서는 이러한 문제점을 해결하기 위한 방안으로 pMUS 전제 조건 기법을 이용하여 CGM의 반복 횟수를 줄였다. 수치 해석 결과, pMUS와 같은 희소성(sparsity)을 가진 블럭 대각 전제 조건(Block Diagonal Precondtioner: BDP)과 비교하였을 때 pMUS는 BDP보다 빠르게 해를 계산할 수 있다. This paper uses loop-star basis functions to overcome the low frequency breakdown problem in method of moments(MoM) based on electric field integral equation(EFIE). In addition, p-Type Multiplicative Schwarz preconditioner (pMUS) technique is employed to reduce the number of iterations required for the conjugate gradient method(CGM). Low frequency instability with Rao Wilton Glisson(RWG) basis functions in EFIE can be resolved using loop-start basis functions and frequency normalized techniques. However, loop-star basis functions, consisting of irrotational and solenoidal components of RWG basis functions, require a large number of iterations to calculate a solution through iterative methods, such as conjugate gradient method(CGM), due to high condition number. To circumvent this problem, in this paper, the pMUS preconditioner technique is proposed to reduce the number of iterations in CGM. Simulation results show that pMUS preconditioner is much faster than block diagonal preconditioner(BDP) when the sparsity of pMUS is the same as that of BDP.