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최민호,이계복,조규원,박진영,김경수,송정석,한종현 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
The purpose of this study is to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) of Cortex Acanthopanacis in rats, and to determine the effect of Cortex Acanthopanacis on phenylephrine (PE) induced contraction of isolated rat thoracic aorts. The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure transducer (Grass, USA) in anesthetized adult Sprague-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. Contractile force was measured with force displacement transducer under 1.5 g loading tension. The result of this experiment was as following; 1. Cortex Acanthopanacis did not effect the changes of rCBF and blood pressure significantly. 2. Contractions evoked by phenylephrine were decreased significantly by Cortex Acanthopanacis 3. L-NNA, ODQ, atropine and indomethacin significantly altered the relaxation of Cortex Acanthopanacis. 4. Propranolol did not change the relaxation of Cortex Acanthopanacis. These results indicate that Cortex Acanthopanacis did not change the rCBF and BP, but Cortex Acanthopanacis can relax PE induced contraction of isolated rat thoracic aorta and that this increasing contraction related to endothelium and various mechanism.
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그림책을 활용한 반편견 교육활동이 유아의 장애 수용 인식 및 태도에 미치는 영향
원계선,최일선 국립특수교육원 2004 특수교육연구 Vol.11 No.2
본 연구의 목적은 그림책을 활용한 반편견 교육프로그램이 만 5세 유아의 장애에 대한 인식 및 태도에 미치는 효과를 밝히는 데 있다. 본 연구의 대상은 이천 시 소재 유치원의 만 5세 일반 유아 50명으로, 실험 집단 유아 25명에게는 그림책을 활용한 반편견 교육활동을, 통제집단 유아 25명에게는 정규 유아교육활동을 시행하였다. 연구결과, 두 집단 유아들 간에 장애인에 대한 상호작용의도, 인식 및 수용태도에 있어서 유의한 차이가 있는 것으로 나타났다. 이는 장애와 관련된 그림책을 선정하여 반편견 교육활동을 시행한 것이 일반 유아들의 장애에 대한 인식과 태도에 긍정적인 영향을 끼친다는 점을 시사한다. This study investigates the effects of the anti-bias program using literature on children's intentions, recognitions and attitudes toward children with disabilities. In this study, the subjects were 50 children without disabilities 5 years old kindergarten children. They were placed to an experimental or a control group, with 25 children in each other. While normal regular program was provided for the control group, the anti-bias program through literature was applied to the experimental group for 4 weeks. Significant differences were showed between the pre and post-test scores in intentions, recognitions and attitudes toward the disabled. This results indicates that the anti-bias program using literature affects positive influences to children's intentions, recognitions and attitudes toward children with disabilities.
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강계원,김대연,이영훈,강봉석,박정현,최병호 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-
AC powder electroluminescence(EL) device consists of seven layers : PET substrate, transparent electrode, phosphor layer, dielectric layer, two layer metal electrodes and protective layer. Etch layer needs to control to improve electrical and optical properties. Both phosphor and dielectric layer among them is more important to increase its properties. For long-time reliability, proper choices of passivation and sealing material are essential. In this paper, influence of phosphor and dielectric layer thickness on EL performance is studied. Type of cellulos is selected as a sealing material to avoid moisture. To add two type of plasticizer to resin improves flexibility and passivation of EL devices. Through this experiments, technologies of fabrication low-cost thick film EL device can be established.
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각질 형성 세포에서 TNF-ɑ로 유도된 염증 반응에 대한 흑삼 추출물의 항염증 효과
최원영(Won Yeoung Choi),이계원(Gye Won Lee),권득상(Deuk Sang Kwon),신현중(Hyun Joong Shin),조영호(Young Ho Cho) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.10
본 연구에서는 85°C에서 9번 증숙한 흑삼 추출물의 총 폴리페놀 함량 및 항산화 활성을 측정하고, TNF-α 유도 피부 각질 형성 세포에서 항염증 효과와 LPS로 유도된 대식세포에서 NO 생성 억제능을 확인하였다. 그 결과 총 폴리페놀 함량은 증숙 전에 비해 증숙 후에 약 2.5배 증가하는 것으로 나타났다. 흑삼 추출물의 항산화 활성을 DPPH, ABTS, superoxide anion 라디칼 소거 활성 및 환원력으로 평가한 결과 증숙 후 흑삼 추출물이 증숙 전에 비해 항산화 활성이 높아지는 것으로 나타났다. Mouse 대식세포인 Raw 264.7 세포에 LPS를 처리한 후 NO 생성량을 확인한 결과 증숙 후 흑삼 추출물의 경우 LPS 단독 처리군에 비해 NO 생성량을 농도 의존적으로 감소시켰다(P<0.001). NO 생성량 감소에 따라 TNF-α로 자극된 피부 각질 형성 세포에서 친염증성 사이토카인인 IL-6, IL-1β 및 IL-8의 mRNA 발현량을 확인한 결과, 흑삼 추출물의 농도 50과 100 μg/mL에서 IL-6의 mRNA 발현을 TNF-α 처리군 대비 약 20% 감소시켰으며 IL-1β와 IL-8의 발현은 농도 의존적으로 감소시키는 것으로 나타났다. 흑삼 추출물이 친염증성 사이토카인의 유전자 발현을 감소시키는 것으로 나타났기 때문에 흑삼 추출물의 항염증 작용을 규명하기 위하여 염증신호전달에 관여하는 전사인자인 NF-κB와 염증 반응을 유도하는 단백질 중 하나인 iNOS와 COX-2 발현에 미치는 영향을 측정하였다. 그 결과 흑삼 추출물 처리 시 TNF-α 처리에 의해 증가된 NF-κB의 인산화와 염증 반응매개물질인 iNOS 및 COX-2의 발현을 유의적으로 감소시키는 것으로 확인되었다(P< 0.001). 이러한 흑삼 추출물의 항염증 효과는 NF-κB의 인산화 억제를 통해 염증 매개 분자의 발현을 감소시켜 친염증성 사이토카인의 생성을 억제하여 나타나는 것으로 확인되었다. 따라서 흑삼 추출물은 피부 염증 개선을 위한 관련 제품의 소재로 활용이 가능할 것으로 기대된다. We evaluated the antioxidant activity and anti-inflammatory effects of black ginseng manufactured by a steaming process in a cell-based inflammatory model. Free radical (DPPH, ABTS, superoxide anion) scavenging activity, reducing power, and total polyphenol content in the extracts of ginseng and black ginseng were investigated. The total polyphenol content of the black ginseng extract was 38.83±1.01 mg/g, which was 2.5 times higher than that of the ginseng extract. Also, the black ginseng extract showed higher free radical scavenging activity than the ginseng extract. The anti-inflammatory effect on lipopolysaccharide (LPS, 50 ng/mL)-induced inflammatory reactions in RAW 264.7 cells demonstrated that treatment with black ginseng extract decreased nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production in a dose-dependent manner (P<0.001). The quantitative RT-PCR result indicated that the black ginseng extract markedly reduced the expression of pro-inflammatory cytokines (interleukin (IL)-6, IL-1β, and IL-8) mRNA in tumor necrosis factor (TNF)-α-treated human keratinocytes. Furthermore, the reduced mRNA expression was associated with the downregulation of iNOS, cyclooxygenase (COX)-2, and nuclear factor (NF)-κB activity. These results suggest that black ginseng extract exhibits anti-inflammatory effects by the downregulation of NF-κB and the consequent suppression of inflammatory mediators (iNOS and COX-2) in TNF-α-induced human keratinocytes and suppression of NO production in LPS-induced murine macrophages. Taken together, these results indicate that black ginseng extract could be a valuable anti-inflammatory agent in products used to treat skin inflammation.
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Choi, Jung Woo,Kim, Gye Won,Shin, Ki Ryong,Yoo, Bongyoung,Shin, Dong Hyuk ELSEVIER SCIENCE 2017 Journal of Alloys and Compounds Vol.726 No.-
<P><B>Abstract</B></P> <P>This work was carried out to elucidate the mechanism underlying the formation of zirconium and titanium oxide mixed layers on titanium substrates via plasma electrolytic oxidation (PEO) and plasma-enhanced electrophoresis. A series of constant high anodic currents were applied to KOH-based electrolytes containing ZrO<SUB>2</SUB> nanoparticles with four different concentrations of K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB>. Scanning electron microscopy observations indicated that the coating layer formed in the electrolyte without K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB> was underdeveloped owing to the absence of phosphate ions, which act as a complexing agent for uniform coating growth. Compositional analyses using X-ray diffraction and X-ray photoelectron spectroscopy revealed that the coating layer formed in the electrolyte with 0.015 M K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB> consisted predominately of ZrO<SUB>2</SUB>, whereas increasing amounts of additional Zr compounds, such as ZrTiO<SUB>4</SUB>, and Zr–P compounds were found in the coating layers formed in the electrolytes with 0.03 and 0.045 M K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB>. The formation of such compounds could be mainly attributed to electrochemical reactions between ZrO<SUB>2</SUB> and other components in the electrolytes owing to the high electrical energy of microarcs. Consequently, excessive phosphate ions in the electrolytes with 0.03 and 0.045 M K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB> act as reactants for the formation of Zr–P compounds rather than complexing agents for the growth of the oxide layer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The mixture of Zr and Ti oxide on Ti was synthesized via PEO and electrophoresis. </LI> <LI> The PO<SUB>4</SUB> ions with K<SUB>4</SUB>P<SUB>2</SUB>O<SUB>7</SUB> act as reactants for formation of Zr–P compounds. </LI> <LI> The oxide formed by reactions between ZrO<SUB>2</SUB> and other components with microarcs. </LI> </UL> </P>
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