http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Human Postural Control against External Force Perturbation Applied to the High-back
Kim, Ji-Won,Kim, Chul-Seung,Lee, Jae-Ho,Kwon, Yu-Rie,Eom, Gwang-Moon,Tak, Gye-Rae,Hong, Jung-Hwa 한국정밀공학회 2009 International Journal of Precision Engineering and Vol.10 No.4
Many studies have reported postural control against support surface translation. However, postural control mechanism against external force perturbation is not clear. Therefore, in this study we investigated the postural recovery against external force ($1{\sim}4Kg$) applied to the high-back in health young male subjects ($24{\pm}4$ years). Kinematic data and center of pressure of the reaction to an unexpected perturbation were analyzed. Experimental results showed that the hill-lifting strategy with ankle plantar flexion and knee hyperextension was used in all subjects, regardless of the force magnitude. Specifically, maximum ankle plantar flexion and hip flexion increased with the perturbation force magnitude, the heel vertical excursion and anterior COP excursion. The results of this study show that theposturalcontrol strategy for the external force perturbation is quite different from that for surface translation and needs further investigation.
Kim, Shi Hyoung,Park, Jae Gwang,Lee, Jongsung,Yang, Woo Seok,Park, Gye Won,Kim, Han Gyung,Yi, Young-Su,Baek, Kwang-Soo,Sung, Nak Yoon,Hossen, Muhammad Jahangir,Lee, Mi-nam,Kim, Jong-Hoon,Cho, Jae Youl Hindawi Publishing Corporation 2015 MEDIATORS OF INFLAMMATION Vol.2015 No.-
<P>Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated macrophages. In particular, molecular targets for KF action were identified by using biochemical and molecular biological analyses. KF suppressed the release of nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of inflammatory genes encoding inducible NO synthase (iNOS), TNF-<I>α</I>, and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages. KF reduced NF-<I>κ</I>B (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity. Interestingly, it was found that Src, Syk, IRAK1, and IRAK4 responsible for NF-<I>κ</I>B and AP-1 activation were identified as the direct molecular targets of KF by kinase enzyme assays and by measuring their phosphorylation patterns. KF was revealed to have <I>in vitro</I> and <I>in vivo</I> anti-inflammatory activity by the direct suppression of Src, Syk, IRAK1, and IRAK4, involved in the activation of NF-<I>κ</I>B and AP-1.</P>
보행 속도와 보행로 경사에 따른 대퇴상부와 발목상부에서의 가속도의 변화
권유리 ( Yu Ri Kwon ),김지원 ( Ji Won Kim ),강동원 ( Dong Won Kang ),탁계래 ( Gye Rae Tack ),엄광문 ( Gwang Moon Eom ) 한국운동역학회 2010 한국운동역학회지 Vol.20 No.2
The purpose of this study was to investigate the effect of gait speed and walkway slope on the body acceleration, for the future validation of using an accelerometer in the estimation of energy consumption. Ten young healthy subjects with accelerometers on the upper thigh and ankle walked on a treadmill at 9 conditions(three speeds × three slopes) for 5 minutes. Acceleration signals of four directions, i.e. anterior-posterior(AP), medio-lateral(ML), superior-inferior(SI) and vector sum(VS) directions, of each sensor were measured, and root means squared(RMS) values of them were used as analysis variables. As statistical analysis, repeated measure two-way ANOVA was performed for RMS accelerations at each attachment sites, with slope and velocity as independent factors. At both the upper thigh and ankle, RMS acceleration of all directions were affected by gait velocities(p<.001) showing greater accelerations for higher velocities. Contrary to expectations, no slope effect existed in RMS accelerations at hip. Moreover, RMS acceleraion at ankle decreased with slope in SI and VS directions(p<.01). These results suggests that RMS acceleration cannot reflect the change in physical activity due to the change in walkway slope.
호스피스 케어가 말기암환자 가족들의 죽음에 대한 인식 변화에 미치는 영향
계광원,김재송,원주희,이성옥,이채영,조성훈,박윤미,윤영미,이명숙,주선미,Gye Gwang-Won,Kim Jae-Song,Won Ju-Hui,Lee Seong-Ok,Lee Chae-Yeong,Jo Seong-Hun,Park Yun-Mi,Yun Yeong-Mi,Lee Myeong-Suk,Ju Seon-Mi 한국호스피스협회 2005 호스피스 학술지 Vol.5 No.2
The objective of this research is to provide the basic material for effective hospice care by analyzing the recognition of families who have terminally ill patients over death. To do so, this research is designed to investigate the general tendency toward death and changes after hospice care. To analyse the initial status of the recognition about the death, questionnaires were provided to the families of the terminally ill patients who were taken hospice care from June 1st, 2005 to September 10th, 2005 at Saemmul Hospice. The same questionnaires were distributed to research some changes of the recognition of the death after 3 weeks. As the Data Analysis Methodology, SPSS v.10.0 statistics program were utilized. The summary of this research is as follows. First, by gender, it is analyzed that women have more fear than men in terms of incompetence sense after death. By religion, Christians have less fear than other religious people in terms of fear toward after death and general sense of death. Second, those who experienced deaths of close family members, relatives, friends for the past 3 years have more fear toward the moment of death than those who did not experience it. Third, statistically valid difference was found in terms of fear toward the moment of death, fear toward incompetence, fear toward after death, and fear toward death before and after the hospice care was taken. Based on the result of this research, terminally ill patients' families facing death have shown significant differences on fear and incompetence before and after hospice care was offered. It is necessary that the hospice care should be settled more professionally by expanding the opportunities of hospice care and institutionalizing the system. In addition, hospice activities which are focused on providing hope after death and facing death with dignity and peace should be expanded increasingly as the family members who experienced deaths showed higher degree of fear and powerlessness and Christians have less fear toward death with the help of biblical influence. It is also required that hospice care specialized in recognizing the importance of terminal cancer patients and their families at the same time.
다양한 보행속도와 경사각에 대한 보행수 검출을 위한 필터링 조건과 역치의 결정
권유리,김지원,이재호,탁계래,엄광문,Kwon, Yu-Ri,Kim, Ji-Won,Lee, Jae-Ho,Tack, Gye-Rae,Eom, Gwang-Moon 대한의용생체공학회 2009 의공학회지 Vol.30 No.6
The purpose of this study is to determine optimal filtering condition and threshold for the detection of gait-cycles for various walkway slopes as well as gait velocities. Ten young healthy subjects with accelerometer system on thigh and ankle walked on a treadmill at 9 conditions (three speeds and three slopes) for 5 minutes. Two direction signals, i.e. anterior-posterior (AP) and superior-inferior (SI) directions, of each sensor (four sensor orientations) were used to detect specific events of gait cycle. Variation of the threshold (from -1G to 1G) and lowpass cutoff frequency (fc) were applied to the event detection and their performance was evaluated according to the error index (EI), which was defined as the combination of the accuracy and false positive rate. Optimal fc and threshold were determined for each slope in terms of the EI. The optimal fc, threshold and their corresponding EI depended much on the walkway slope so that their coefficients of variation (CV) ranged 19~120%. When all data for 3 slopes were used in the identification of optimal conditions for each sensor, the best error indices for all sensor orientations were comparable ranging 1.43~1.76%, but the optimal fc and threshold depended much on the sensor position. The result indicates that the gait-cycle detection robust to walkway slope is possible by threshold method with well-defined filtering condition and threshold.
Han, Eun Hee,Hwang, Yong Pil,Kim, Hyung Gyun,Choi, Jai Ho,Park, Bong Hwan,Song, Gye Yong,Lee, Gye Won,Jeong, Tae Cheon,Jeong, Hye Gwang Wiley (Blackwell Publishing) 2011 British journal of pharmacology Vol.164 No.6
<P>BACKGROUND AND PURPOSE Capsaicin, a constituent of peppers, has been linked to the suppression of tumorigenesis and carcinogenesis. The influence of capsaicin on cytochrome P450 (CYP) 1A1, which is involved in metabolism of carcinogens, and the underlying mechanisms remain unclear. Here, we examined the effect of capsaicin on CYP1A1 expression in mouse hepatoma cells. EXPERIMENTAL APPROACH Murine hepatoma Hepa-1c1c7 cells were incubated with capsaicin and/or 3-methylcholanthrene (3-MC). Effects of capsaicin on CYP1A1 levels were determined by analysing mRNA expression, transcription activity and protein expression. Regulation of CYP1A1 was investigated by determining transcriptional factor expression, activation and binding activity with cotreatment with target signal antagonists. KEY RESULTS Capsaicin alone slightly induced CYP1A1 activity, mRNA expression, protein level and promoter activity. Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin. Additionally, capsaicin significantly inhibited 3-MC-induced CYP1A1 mRNA and protein level and xenobiotic response element-luciferase activity. Capsaicin also inhibited 3-MC-induced AhR transactivation and nuclear localization of AhRs. Moreover, capsaicin increased Ca2+/calmodulin (CaM)-dependent protein kinase (CaMK) and CCAAT/ enhancer-binding protein beta (C/EBP beta) activation, downstream of TRPV1 receptors. Capsaicin-induced C/EBP beta activation inhibited induction of CYP1A1 mRNA and protein by 3-MC. CONCLUSIONS AND IMPLICATIONS Capsaicin alone weakly induced CYP1A1 expression, and 3-MC-induced CYP1A1 levels were suppressed by capsaicin. Activation of C/EBP beta and inhibition of 3-MC-induced AhR transactivation by capsaicin contributed to the suppression of CYP1A1 expression. Capsaicin has a potential chemopreventive effect through inhibiting induction of CYP1A1 by poly aryl hydrocarbons.</P>