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Treatment Modality of Prostatic Abscess according to Size: A Retrospective Study
Gwon Kyeong Lee,Kyoung Ha Jang,Woo Seop Seong,Byeong Jin Kang,Kyung Hwan Kim,Hong Koo Ha 대한요로생식기감염학회 2022 Urogenital Tract Infection Vol.17 No.3
Purpose: This study aimed to determine the treatment modality for prostatic abscesses according to size. Materials and Methods: Twenty-five patients diagnosed with prostatic abscesses were retrospectively reviewed. All patients were treated with intravenous empirical and appropriate antibiotics according to culture results. They were grouped according to the size of the prostate abscess based on computed tomography results (group A, with prostate abscess ≤2 cm, n=10; group B, with prostate abscess size >2 cm, n=15), and their treatment modality and outcomes were compared. Results: The prostatic abscess sizes were 1.31±0.37 and 3.49±1.06 cm for groups A and B, respectively. Prostate-specific antigen, prostatic volume, and comorbidity were not significantly different (p>0.05), whereas pelvic pain was significantly different (p=0.028). There was no difference in the microorganisms isolated from urine and blood culture, empirical antibiotics, and broad-spectrum antibiotics between the two groups (p>0.05). More patients in group B underwent transurethral abscess deroofing than those in group A (p=0.040). Patients in group B had a more extended hospitalization period and intravenous antibiotics duration than those in group A (p=0.024 and p=0.013, respectively). Group B had more cases of septic shock, intensive care unit admission, and mortality events than group A (p=0.024, p=0.001, and p=0.061, respectively). However, prostatic abscess recurrence and urological chronic complication did not significantly differ (p>0.05). Conclusions: Appropriate use of antibiotics is crucial. This study shows that the treatment of patients with prostatic abscess >2 cm is more difficult, but transurethral abscess deroofing can lower mortality, prostatic abscess recurrence, and urological chronic complications.
The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis
Jung, Gwon-Soo,Kim, Mi-Kyung,Choe, Mi Sun,Lee, Kyeong-Min,Kim, Hye-Soon,Park, Young Joo,Choi, Hueng-Sik,Lee, Ki-Up,Park, Keun-Gyu,Lee, In-Kyu American Society of Nephrology 2009 Journal of the American Society of Nephrology Vol.20 No.10
<P>The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by stimulating the generation and inhibiting the removal of matrix proteins. The small heterodimer partner (SHP) represses PAI-1 expression in the liver by inhibiting TGF-beta signaling, but whether SHP inhibits renal fibrosis is unknown. Here, unilateral ureteral obstruction (UUO) markedly increased the expression of PAI-1, type I collagen, and fibronectin but decreased SHP gene expression. Moreover, in kidneys of SHP-/- mice, the expression of PAI-1, type I collagen, fibronectin and alpha-smooth muscle actin (alpha-SMA) were higher compared with those in kidneys of wild-type mice. In addition, loss of SHP accelerated renal fibrosis after UUO. Adenovirus-mediated overexpression of SHP in cultured rat mesangial cells and renal tubular epithelial cells inhibited TGF-beta-stimulated expression of PAI-1, type I collagen, and fibronectin. SHP inhibited TGF-beta- and Smad3-stimulated PAI-1 promoter activities as well as TGF-beta-stimulated binding of Smad3 to its consensus response element on the PAI-1 promoter. Similarly, in vivo, adenovirus-mediated overexpression of SHP in the kidney inhibited the expression of UUO-induced PAI-1, type I collagen, fibronectin, and alpha-SMA. In summary, SHP attenuates renal fibrosis in obstructive nephropathy, making its pathway a possible therapeutic target for chronic kidney disease.</P>
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Gwon, Gwang Hyeon,Jo, Aera,Baek, Kyuwon,Jin, Kyeong Sik,Fu, Yaoyao,Lee, Jong-Bong,Kim, Youngchang,Cho, Yunje Published for the European Molecular Biology Organ 2014 The EMBO journal Vol.33 No.9
<P>The Mus81-Eme1 complex is a structure-selective endonuclease with a critical role in the resolution of recombination intermediates during DNA repair after interstrand cross-links, replication fork collapse, or double-strand breaks. To explain the molecular basis of 3' flap substrate recognition and cleavage mechanism by Mus81-Eme1, we determined crystal structures of human Mus81-Eme1 bound to various flap DNA substrates. Mus81-Eme1 undergoes gross substrate-induced conformational changes that reveal two key features: (i) a hydrophobic wedge of Mus81 that separates pre- and post-nick duplex DNA and (ii) a '5' end binding pocket' that hosts the 5' nicked end of post-nick DNA. These features are crucial for comprehensive protein-DNA interaction, sharp bending of the 3' flap DNA substrate, and incision strand placement at the active site. While Mus81-Eme1 unexpectedly shares several common features with members of the 5' flap nuclease family, the combined structural, biochemical, and biophysical analyses explain why Mus81-Eme1 preferentially cleaves 3' flap DNA substrates with 5' nicked ends.</P>
무선 센서 네트웍을 이용한 콘크리트 유동성능 평가장치 설계
이보희(Lee, Bol-Hee),경정규(Kyeong, Jeong-Kyu),최연왕(Choi, Yung-Wang),정재권(Jeong, Jae-Gwon) 한국전기전자학회 2010 전기전자학회논문지 Vol.14 No.3
고유동 콘크리트 유동성능 평가장치는 슬럼프 플로 500 mm 도달속도와 플로우 유동의 데이터를 종합하여 KS F 2594 기준을 측정하기 위한 장비이다. 그러나 기존의 KS F 2594 측정 방법은 시험은 시험자와 감독자의 관점에 따라 점도에 대한 데이터가 매우 불규칙하여, 실무에서는 작은 수치 차이로 인하여 많은 의견 충돌이 발생하는 문제점이 있다. 따라서 본 논문 에서는 기존의 이러한 문제점을 개선한 형태의 기구부의 메카니즘 설계와, 아울러 기구부를 구동하는 전자회로를 제시 하였다. 아울러 설계된 장치와 사용자간의 인터페이스를 위한 알고리즘과 무선센서 네트웍을 사용한 데이터 전송 방식에 대하여 다루었다. 제시된 방법은 실제 실험을 통해 검증하여 그 유용성을 보였다. The high flowability performance evaluation device for the concrete is the device which was designed to compensate from the incorrect data detection of the viscosimetry examination of the existing concrete. As for the existing concrete viscosimetry method, the measuring data for a viscosity are very irregular by the point of view of an experimenter and a supervisor, Therefore there were some problems to have many different opinions by a small numerical value difference according to the job characteristic. In this paper, we suggested some mechanism to compensate the problem and some driving electronics including the related algorithm, and the communication structure with wireless sensor network between the devices and users are also presented. The effectiveness of the suggested method was verified with a real experiment.
One-stepdiffusion으로 형성된 선택적 에미터 결정질 실리콘 태양전지에 관한 연구
정경택(Jeong, Kyeong-Taek),양오봉(Yang, O-Bon),유권종(Yu, Gwon-Jong),이정철(Lee, Jeong-Chul),송희은(Song, Hee-eun) 한국태양에너지학회 2011 한국태양에너지학회 학술대회논문집 Vol.2011 No.11
Recent studies in crystalline silicon solar cell fabrication have been focused on high efficiency and low cost. However, the rising of the cost results in additional processes to approach high efficiency. The fabrication process also becomes complicated with additional technologies. In thispaper, we studied the selective emitter formation with phosphorous paste to improve the conversion efficiency. Selective emitter formations like two-step diffusion or etch-back method require at least one more step compared in the conventional line since heavily and lightly doped area was needed to form separately.However,one-step diffusion process is the method diffusing heavily and lightly doped area at the same time only with additional screen-printing step. This study lays the foundation for the simple way to form the selective emitter.