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Elevated cAMP level attenuates 2-deoxy-D-ribose-induced oxidative damage in pancreatic β-cells
Koh, Gwanpyo,Suh, Kwang Sik,Chon, Suk,Oh, Seungjoon,Woo, Jeong-taek,Kim, Sung-Woon,Kim, Jin-Woo,Kim, Young-Seol KYUNG HEE UNIVERSITY MEDICAL CENTER 2006 고황의학상 수상논문집 Vol.21-22 No.-
Glucose toxicity to pancreatic β-cells is defined as irreversible β-cell damage, including apoptosis, caused by chronic exposure to high glucose levels in type 2 diabetes. Oxidative stress is an important mechanism for glucose toxicity to pancreatic β-cells. Reducing sugars produce reactive oxygen species through autoxidation and protein glycosylation. 2-Deoxy-D-ribose (dRib) is a reducing sugar with high reactivity. We investigated whether cAMP-stimulating agents could protect β-cells from dRib-induced oxidative damage. HIT-T15 cells were cultured with various concentrations of dRib for 24h. We measured cell survival, intracellular cAMP and H_(2)O_(2) levels, and apoptosis. dRib decreased cell survival in a dose-and time-dependent manner and markedly increased intracellular H_(2)O_(2) levels and apoptosis. N-Acetyl-L-cysteine decreased dRib-induced rises in intracellular H_(2)O_(2) and apoptosis to control levels. Forskolin, IBMX, and dbcAMP markedly elevated intracellular cAMP levels and significantly attenuated dRib-induced cytotoxicity and apoptosis, but had no influence on the dRib-induced rise in intracellular H_(2)O_(2) levels, These results demonstrate that dRib produced oxidative stress and apoptosis in pancreatic β-cells and that elevated intracellular cAMP levels reduced dRib-induced damage, independent of reactive oxygen species metabolism.
Suh, Kwang Sik,Koh, Gwanpyo,Park, Cheol Young,Woo, Jeong Taek,Kim, Sung Woon,Kim, Jin Woo,Park, In Kook,Kim, Young Seol WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
The effects of individual soybean isoflavones, genistein (4',5 ,7-trihydroxyisoflavone) and daidzein (4',7-dihydroxyisoflavone), on tumor necrosis factor-α(TNF-α)-induced apoptosis and the production of local factors in osteoblastic cells has been investigated. Soybean isoflavones increased DNA synthesis and the number of viable cells. When cells were treated with TNF-α the number of viable cells dose-dependently decreased. The decrease in cell number caused by TNF-α treatment was due to apoptosis, which was confirmed by TUNEL and cell death ELISA analyses. Soybean isoflavones inhibited apoptosis of osteoblastic cells subjected to TNF-α treatment. MC3T3-El osteoblastic cells secrete interleukin-6(IL-6), interleukin-1β (IL-1β), nitric oxide (NO) and prostaglandin E_(2) (PGE_(2)) constitutively, but at low levels Soybean isoflavones had no effect on the constitutive production of these local factors. When cells were treated with TNF-α (10^(-10)M), the production of IL-6 and PGE_(2), but not that of IL-1β and NO, significantly increased. Treatment with soybean isoflavones (10^(-5)M), in the presence of TNF-α (10^(-10)M), for 48 h inhibited productior, of IL-6 and PGE_(2) suggesting the antiresorptive action of soy phytoestrogen may be mediated by decreases in these local factors. The findings of this study thus suggest that soybean isoflavones may promote the function of osteoblastic cells and play an important role in bone remodeling.
S-423 Plasma aldosterone level and its metabolic implications in patients with type 2 diabetes
( Jeongyeon Won ),( Soyeon Yoo ),( Sang Ah Lee ),( Gwanpyo Koh ),( Dae Ho Lee ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Aldosterone is involved in not only the regulation of blood pressure and renal sodium handling, but also the pathogenesis of insulin resistance, suggesting the clinical relevance of the inhibition of renin-angiotensin-aldosterone system (RAAS) in insulin resistant conditions. To better characterize metabolic implication of RAAS, we measured plasma renin activity (PRA) and aldosterone (PA) level in patient with type 2 diabetes. All other treatments and metabolic evaluations were performed at the discretion of the responsible physicians according to local guidelines. In the present study, we analyzed the data of 628 patients aged 18 or more years. Major exclusion criteria included renal failure, severe hepatic dysfunction, the use of spironolactone, and other severe systemic illnesses. Both PRA and PA were correlated with the circulating levels of serum sodium, apolipoprotein B (ApoB), high sensitivity CRP (hsCRP), and ALT. On a multivariate analysis, PA showed a significant association with ApoB (β=0.580, p=<0.001), ALT (β=0.305, p=0.006), and sodium (β=-0.224, p=0.035) after adjusting for multiple factors. In subgroup analyses according to the type of RAAS inhibition, the association of PA with ApoB and hsCRP was markedly attenuated in patient treated with angiotensin-converting enzyme inhibitor (ACEi) (n=53) compared with that in patients treated with angiotensin receptor blocker (n=187) or with no RAAS inhibitor therapy (n=388). Our results show that aldosterone has important implications for the pathophysiology of type 2 diabetes. Further studies are required to determine whether ACEi therapy is a metabolically better RAAS inhibition in patients with type 2 diabetes.
이상아,Seong Man Lee,So-Yeon Yoo,Young Hwan Kim,Gwanpyo Koh 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.2
Background and Objectives: Autoimmune thyroiditis (AIT) is a form of thyroiditis associated with autoimmune antibodies. Few studies have measured thyroid volume in Asians. This study was undertaken to determine the distribution of thyroid volume and to explore possible correlations between thyroid volume and other factors in a Korean cohort. Materials and Methods: Two hundred eleven patients who underwent 99mTc-pertechnetate thyroid scintigraphy between 2009 and 2011 were recruited and their thyroid volume was measured. AIT was defined as having thyroperoxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) positivity and TRAb negativity, regardless of thyroid function. Results: The mean thyroid volume was 32.1 mL in AIT patients. The distribution of thyroid volume was normal after log transformation. Thyroid volume was larger in patients with both autoantibodies than in patients with only one antibody (p<0.001). The first quartile of patients grouped according to thyroid volume were older (52.1 years, p=0.037) than the patients in other quartile groups. Thyroid volume correlated independently with TPOAb titer, and TgAb titer adjusted for other factors in a multivariate analysis. Conclusion: Thyroid volume in Korean AIT patients had an unimodal distribution and correlated with autoantibody titer.
SUH, Kwang Sik,NAM, Yeon Ho,AHN, Young Min,KIM, Nam Jae,PARK, Cheol Young,KOH, Gwanpyo,OH, Seungjoon,WOO, Jeong Taek,KIM, Sung Woon,KIM, Jin Woo,KIM, Young Seol WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Endothelial cell apoptosis has been postulated as the initial trigger of the progression of progression disease in patients with diabetes mellitus. To investigate the role of Scutellariae radix extract, we examined its effect on the endothelial cell proliferation using the [(3)^H]-thymidine incorporation method. Scutellariae radix extract significantly stimulated endothelial cell proliferation in a dose-dependent manner. We focused on the protective action of Scutellariae radix extract on the endothelial tell apoptosis induced by high glucose concentrations. Determination of endothelial cell apoptosis was performed using DNA gel electrophoresis, terminal deoxynuclotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay, and an ELISA kit. Exposure of vascular endothelial cell to high glucose (16.7mM) for 72h resulted in a significant increase in apoptosis, compared with the normal glucose concentrations (5.5mM). Scutellariae radix extract inhibited high glucose-induced endothelial cell apoptosis. This result suggests that Scutellariae radix extract may contribute to antiapoptotic action against vascular endothelial cells, resulting in a beneficial effect in preventing diabetes-associated microvascular complications.
A Case of Painful Hashimoto Thyroiditis that Mimicked Subacute Thyroiditis
Hye Mi Seo,Miyeon Kim,Jaeseok Bae,Jo-Heon Kim,Jeong Won Lee,이상아,Gwanpyo Koh,Dae Ho Lee 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.1
Hashimoto thyroiditis (HT) is an autoimmune thyroid disorder that usually presents as a diffuse, nontender goiter, whereas subacute thyroiditis (SAT) is an uncommon disease that is characterized by tender thyroid enlargement, transient thyrotoxicosis, and an elevated erythrocyte sedimentation rate (ESR). Very rarely, patients with HT can present with painful, tender goiter or fever, a mimic of SAT. We report a case of painful HT in a 68-year-old woman who presented with pain and tenderness in a chronic goiter. Her ESR was definitely elevated and her thyroid laboratory tests suggested subclinical hypothyroidism of autoimmune origin. 99mTc pertechnetate uptake was markedly decreased. Fine needle aspiration biopsy revealed reactive and polymorphous lymphoid cells and occasional epithelial cells with Hürthle cell changes. Her clinical symptoms showed a dramatic response to glucocorticoid treatment. She became hypothyroid finally and is now on levothyroxine therapy.
Fulminant type 1 diabetes associated with coxachievirus B4: A report of 2 cases
( Jung Re Yu ),( Mi Yeon Kim ),( Jae Geun Lee ),( Seong Joo Ko ),( Sang Ah Lee ),( Gwanpyo Koh ),( Dae Ho Lee ) 대한내과학회 2011 대한내과학회 추계학술발표논문집 Vol.2011 No.1
Recently fulminant type1 diabetes (T1DM) has been identified as a new subtype of idiopathic diabetes. It develops rapidly without any evidence of autoimmunity. Here, we report two cases of patients; each patient presented with abrupt and extreme hyperglycemia and ketoacidosis without an evidence of previous diabetes mellitus. A 74-year-old man presented with a 2-day history of polydipsia. His serum C-peptide level was 0.06 ng/ml and HbA1c level was 6.7%. The serum lipase was elevated. The other 21-year-old man presented with a 2-week history of polydipsia. His serum c-peptide and HbA1c levels were 0.73 ng/ml and 17.6%, respectively. The serum lipase was within normal range in the young patient. In both patients, anti-GAD antibody tests were negative whereas tests for coxsackievirus B4 virus infection were positive. Furthermore, both patients required insulin therapy to control their blood glucose levels at discharges and during the follow-up period.