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RISS 인기검색어
- 검색키워드
- 저자 : Guohua Liang (검색결과 5 건)
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Modeling and Optimization Method of Laser Cladding Based on GA-ACO-RFR and GNSGA-II
Guohua He,Yanbin Du,Qiang Liang,Zhijie Zhou,Linsen Shu 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.5
Laser cladding is an environmentally friendly and reliable surface modification technology. The quality characteristics of the coating are directly affected by the process parameters of laser cladding. The reasonable selection of process parameters is essential to obtain high-quality coating. In this study, the single-track 15-5PH alloy coating was fabricated on the surface of 12Cr13 stainless steel. In view of the hybrid Genetic Algorithm and Ant Colony Optimization (GA-ACO) can effectively improve the prediction ability and robustness of Random Forest Regression (RFR), a prediction method of cladding layer quality characteristics based on GA-ACO-RFR was proposed. The fast non-dominated ranking genetic algorithm with elite strategy by introducing the Gaussian distribution crossover operator (GNSGA-II) was used to optimize the process parameters of laser cladding. The results showed that the multi-objective optimization method of laser cladding process parameters proposed in this paper can obtain high-quality laser cladding coating. This work demonstrated the potential of the proposed method in laser cladding process prediction and optimization.
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TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
Guohua Ji,Hongbin Liang,Falin Wang,Nan Wang,Songbin Fu,Xiaobo Cui 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.7
TSPAN12, a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that TSPAN12 could be a novel molecular target for the treatment of OC.
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TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
Ji, Guohua,Liang, Hongbin,Wang, Falin,Wang, Nan,Fu, Songbin,Cui, Xiaobo Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.7
TSPAN12, a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that TSPAN12 could be a novel molecular target for the treatment of OC.
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The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update
Lan Huang,Guohua Liang,Qingyuan Zhang,Wenhui Zhao 한국유방암학회 2020 Journal of breast cancer Vol.23 No.2
As a standard treatment, endocrine therapy has dramatically enhanced the prognosis of patients with estrogen receptor (ER)-positive breast cancer, which accounts for nearly 70% of all breast cancers. Antiestrogen drugs such as tamoxifen and aromatase inhibitors are the standard treatment options for ERα-positive breast cancer. However, acquired antiestrogen resistance is still the leading cause of disease recurrence and progression. Evidence has shown that long noncoding RNAs (lncRNAs) play an essential role in the development of antiestrogen resistance in ER-positive breast cancer and can serve as biomarkers or potential therapeutic targets. This review highlights the role of lncRNAs in the development of antiestrogen resistance in breast cancer.
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Liu Na,Feng Yuchen,Liu Huicheng,Wu Wenliang,Liang Yuxia,Li Pingfei,Wei Zhengping,Wu Min,Tang Zhao-Hui,Han Junyan,Cheng Xiang,Liu Zheng,Laurence Arian,Li Huabin,Zhen Guohua,Yang Xiang-Ping 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3
Purpose Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma. Methods We compared the disease severity between female C57BL/6 wild-type and ATP6V0d2−/− mice in an ovalbumin (OVA)-induced asthma model. We also investigated the association of expression of ATP6V0d2, PU.1 and CCL17 with disease severity among asthmatic patients. Results The expression of ATP6V0d2 in sputum cells of asthmatic patients and in the lungs of OVA-challenged mice was enhanced compared to healthy subjects and their counterparts, respectively. However, ATP6V0d2-deficient mice exaggerated inflammatory cell infiltration as well as enhanced alternative activated macrophage (AAM) polarization and mucus production in an OVA-induced asthma model. Furthermore, we found that Atp6v0d2 promoted lysosomal degradation of Pu.1, which induced AAM polarization and Ccl17 production. Among asthma patients, ATP6V0d2 expression was inversely associated with disease severity, whereas PU.1 and CCL17 expression was positively associated with disease severity. Conclusions Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.
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