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( Golam Mezbah Uddin ),( Chul Young Kim ),( Dong Hwa Chung ),( Kyung-a Kim ),( Sang Hoon Jung ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.5
Caesalpinia sappan is a well-distributed plant that is cultivated in Southeast Asia, Africa, and the Americas. C. sappan has been used in Asian folk medicine and its extract has been shown to have pharmacological effects. Two homoisoflavonoids, sappanol and brazilin, were isolated from C. sappan by using centrifugal partition chromatography (CPC), and tested for protective effects against retinal cell death. The isolated homoisoflavonoids produced approximately 20-fold inhibition of N-retinylidene-N-retinyl-ethanolamine (A2E) photooxidation in a dose-dependent manner. Of the 2 compounds, brazilin showed better inhibition (197.93 ∂ 1.59 UM of IC50). Cell viability tests and PI/Hoechst 33342 double staining method indicated that compared to the negative control, sappanol significantly attenuated H2O2-induced retinal death. The compounds significantly blunted the up-regulation of intracellular reactive oxygen species (ROS), and sappanol inhibited lipid peroxidation in a concentration-dependent manner. Thus, both compounds represent potential antioxidant treatments for retinal diseases. [BMB Reports 2015; 48(5): 289-294]
Golam Mezbah Uddin,Hee Ju Lee,Je-Seung Jeon,정동화,Chul Young Kim 한국생약학회 2011 Natural Product Sciences Vol.17 No.3
High-performance liquid chromatography coupled to an online ABTS+-based assay (online HPLC-ABTS+) system was used to determine the principal antioxidants in Cudrania tricuspidata fruits. Six prenylated isoflavonoids (1 - 6) were isolated from C. tricuspidata fruits according to the online HPLC-ABTS+ system. The structures of isolated compounds, alpiniumisoflavone (1), 6,8-diprenylorobol (2), 6,8-diprenylgenistein (3), pomiferin (4), 4'-methylalpiniumisoflavone (5), and osajin (6) were identified by their retention time, UV spectra, ESI-MS, and NMR data. Among these compounds, 6,8-diprenylorobol (2) and pomiferin (4) reduced A2E photooxidation in a dose dependent manner.
김정화,오수연,한상배,Golam Mezbah Uddin,김철영,이재권 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Dendrobium nobile belongs to the Orchidaceaefamily and is one of the medicinal herbs used in traditionalChinese medicine as a therapeutic agent for gastrointestinaland cardiovascular diseases. In this study, we separatedthree phenanthrenes (ephemeranthol A (EA), 1,5,7-trimethoxyphenanthren-2-ol (TP), dehydroorchinol (DO))from D. nobile, and compared their anti-inflammatoryactivities. TP is a new phenanthrene compound and itsstructure was determined from 1H, 13C NMR and HR-ESIMSdata. To analyze the anti-inflammatory activities of thephenanthrenes, Raw 264.7 cells were used, since they areimmature-macrophages and easily matured by LPS stimulation. EA and DO showed anti-inflammatory activities inthe activated Raw 264.7 cells. That is, we showed that EAis a potent inhibitor of the production of nitric oxide andpro-inflammatory cytokines. The inhibitory activities ofphenanthrenes were found to be caused by blockage of NFjBactivation and the phosphorylation of MAP kinases inthe macrophages. These results are expected to serve as aguide for future studies on the ability of phenanthrenes toinhibit acute and chronic inflammatory diseases.