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Gajendiran, Mani,Jo, Heejung,Kim, Kyobum,Balasubramanian, Sengottuvelan Dove Medical Press 2019 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.14 No.-
<P><B>Background</B></P><P>Surface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells.</P><P><B>Methods</B></P><P>AuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. After synthesis of polymer-AuNPs, the freely available hydroxyl and carboxylate groups of CPEG, MAP, and TAP were used to attach a cancer cell-targeting agent, FA, via a 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxy succinimide coupling reaction to obtain FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanocon-jugates, respectively. The 5-fluorouracil (5FU) was attached to π back-bonded carbonyl oxygens of the nanoconjugates, and the in vitro drug release profile was studied by high pressure liquid chromatography. Biocompatibility profiles of the FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanoconjugates were investigated using adult human dermal fibroblasts. Anti-breast cancer activity of 5FU-loaded nanoconjugates was investigated using MCF-7 breast cancer cells.</P><P><B>Results</B></P><P>X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses confirmed that AuNPs attached to CPEG, MAP, or TAP via the formation of π back bonding between AuNPs and the ester carbonyl group. The π back-bonded nanoconjugates exhibited sustained release of 5FU up to 27 days. FA-MAP-AuNPs exhibited an IC<SUB>50</SUB> at 5 µg/mL, while FA-CPEG-AuNPs and FA-TAP-AuNPs showed the IC<SUB>50</SUB> at 100 µg/mL toward MCF-7 cancer cells.</P><P><B>Conclusion</B></P><P>The developed polymer π back-bonded multifunctional gold nanoconjugates could be used as a potential drug delivery system for targeting MCF-7 cancer cells.</P>
Mani Gajendiran,Sungjun Kim,Heejung Jo,Kyobum Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-
A new poly (3-arginylamino propylene succinate-b-polypropylene glycol) (PAPS-PPG) diblock copolymerwas synthesized by one-pot ring opening polymerization (ROP) technique. 1H NMR spectral techniquewas used to determine arginine conjugation efficiency and molecular weight offinal polycations by using4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA) as an internal standard. The PAAPS-PPG polycation was electrostatically complexed with heparin (HEP) at an isoelectric point to obtainPAAPS-PPG/HEP coacervate microparticles (Coa MPs). The PAAPS-PPG/HEP Coa MPs exhibit acid induceddissociation at pH 5, but PAAPS/HEP Coa MPs without PPG block do not show acid induced dissociation. The PPG block in PAAPS-PPG/HEP Coa MPs increased 20 folds of cell attachment efficiency on humanmesenchymal stem cells (hMSCs). The PAAPS-PPG/HEP Coa MPs could effectively encapsulate siRNA andexhibit more than 95% cell viability up to 200 mg/mL. Hence, the pH responsive PAAPS-PPG/HEP Coa MPsplatform with enhanced stem cell attachment ability wouldfind potential application in gene delivery.
Conductive biomaterials for tissue engineering applications
Gajendiran, Mani,Choi, Jonghoon,Kim, Se-Jeong,Kim, Keongsoo,Shin, Heungsoo,Koo, Hyung-Jun,Kim, Kyobum THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2017 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.51 No.-
<P><B>Abstract</B></P> <P>Conductive biomaterials with a suitable biocompatibility have been utilized to fabricate <I>in vitro</I> platforms for differentiation of progenitor cell population as well as implantable tissue engineering scaffolds. This review evaluates biocompatibility of various conductive biomaterials and relevant fabrication techniques including coating, incorporation into composites, and functionalization with biological moieties. In addition, recent developments in tissue engineering applications using various conductive biomaterials are discussed in detail. Therefore, this overview could provide fundamental knowledge for engineering strategies in regulation of stem cell differentiation, maintenance of phenotypic characteristics, and design of functional implantable scaffolds for better regenerative medicines.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P> <P>Recent literatures for the conducting materials applied in various tissue engineering such as neural, cardiac and bone tissue engineering and for biosensor applications have been reviewed.</P>
In vitro controlled release of tuberculosis drugs by amphiphilic branched copolymer nanoparticles
Mani Gajendiran,조희정,김효범,Sengottuvelan Balasubramanian 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-
Poly(lactic-co-glycolic acid) (PLGA)-poly ethylene glycol (PEG) based amphiphilic branched copolymernanoparticles (NPs) have been developed for controlled release of tuberculosis (TB) drugs which includerifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ). The drug loading efficiency and the percentagedrug content of polymer NPs increase by increasing the amount of PEG content in polymer NPs. Thebranched PLGA-PEG based copolymer NPs exhibit initial burst release followed by sustained release ofRIF for 840 h, INH for 72 h, and PYZ for 720 h. The branched citrate-PEG-PLGA copolymer NPs can act aspotential drug carriers when compared to their linear analogues.
Conductive biomaterials for tissue engineering applications
MANI GAJENDIRAN,최종훈,김세정,김경수,신흥수,구형준,김교범 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.51 No.-
Conductive biomaterials with a suitable biocompatibility have been utilized to fabricate in vitro platformsfor differentiation of progenitor cell population as well as implantable tissue engineering scaffolds. Thisreview evaluates biocompatibility of various conductive biomaterials and relevant fabrication techniquesincluding coating, incorporation into composites, and functionalization with biological moieties. Inaddition, recent developments in tissue engineering applications using various conductive biomaterialsare discussed in detail. Therefore, this overview could provide fundamental knowledge for engineeringstrategies in regulation of stem cell differentiation, maintenance of phenotypic characteristics, anddesign of functional implantable scaffolds for better regenerative medicines.