http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향
김동희,이규재,최주봉,이영미,윤양숙,김정례,장병수,양용석 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD. 아토피성 피부염은 주로 천식과 비염 등을 동반하는, 주위에서 흔히 볼 수 있는 만성 염증성 피부질환으로 유전학적, 환경적, 면역학적 요인이 복잡하게 연관되어 발병한다. 해수에 포함된 마그네슘염은 피부에 작용하여 피부장벽을 보호하는 것으로 알려지고 그에 대한 면역학적인 연구와 조직학적 연구는 아직 부족한 실정이다. 이번 연구에서는 피부염을 인위적으로 일으키는 hapten 형성물질인 DNCB를 hairless mice에 도포하여 아토피 피부염 동물 모델로 만든 후, 마그네슘이 다량 함유된 해양 미네랄수를 처리한 후 피부장벽에 미치는 영향을 관찰하였다. DNCB로 피부염을 유발한 hairless mice에 해양미네랄수를 국소적으로 도포하였을 때 유의한 피부수분함량이 증가와 경피수분손실의 감소를 확인하였다 (p<0.01). 피부측정에서 피부거칠기(skin roughness, p<0.05)와 스케일생성 (skin scaliness, p<0.01)은 실험군에서 유의한 개선효과를 나타내었으며 조직학적 검사에서도 피부손상지수의 유의한 감소 (p<0.01)와 비만세포와 (p<0.01) 호산구의 감소(p<0.05) 소견을 보였고 또한 혈청 IgE의 감소를 관찰할 수 있었다(p<0.01). 이상과 같이 마그네슘이 다량 함유된 해양 미네랄수 도포는 피부장벽의 손상을 줄이고 피부수분손실을 효과적으로 줄임으로 아토피성 피부염 증상 유발을 억제할수 있음을 확인하였다. 현재까지 아토피성 피부염의 관리를 위하여 세라마이드나 식물성 오일의 보습제가 주로 활용되고 있는 상황에서 부가적인 피부장벽의 보호를 위하여 탈염 해양 미네랄수의 활용이 가능할 것으로 판단되며 장기적으로 아토피 피부염치료의 대체, 혹은 보조적 물질로 활용될 수 있을 것으로 기대된다.
Haolong Xu(Haolong Xu),Fengli Sun(Fengli Sun) 동북아경상학회 2022 동북아경상연구 Vol.3 No.2
Purpose - This paper aims to analyze and provide solutions to the current problems of golf courses and surrounding land in China, guided by the concept of “ecology-production-living” space and using scientific and objective analysis while selecting appropriate indicators. This paper hopes to optimize the utilization value of golf courses and their surrounding space in China and provide a new and feasible basis and method for the rational development and popularization of golf in China based on the country’s actual situation. Design/Methodology/Approach - Combining with domestic and foreign theories and research, this paper analyzed the “ecology-production-life” space problems in golf course and its surrounding area, and draws a series of corresponding conclusions or strategies. Findings - This paper studies the strategic measures for the sustainable development of Chinese golf from the perspective of “ecology-production-life” space are obtained. Research Implications - In terms of the managerial implication of this paper, this study provides a new feasible basis and method for the rational development and popularization of golf in China. It also has certain practical significance for realizing the rural revitalization strategy.
Xu Xu,Jia Song,Ke Wang,YingChun Gu,Feng Luo,XiaoHai Tang,Ping Xie,ZhiYong Qian 한국고분자학회 2013 Macromolecular Research Vol.21 No.8
In this paper, a novel biodegradable and pH/thermo-sensitive hydrogel based on poly(ε-caprolactone),methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide was prepared by UV-initiated free radical polymerization. The hydrogels were characterized by Fourier transforms infrared ray. The thermal responsibility was investigated with the help of differential scanning calorimetry. Swelling behavior in aqueous medium with different pH value was studied in detail. When the pH value of the aqueous medium was increased from 1.2 to 7.2,the swelling ratio of the hydrogels increased accordingly. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior in different aqueous media (pH 1.2 and pH 7.2) was also investigated in detail. The prepared biodegradable pH/thermo-sensitive hydrogel based on poly(ε-caprolactone), methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide hold great promise in the development of a smart drug delivery system.
Inter regional diffusion of policy innovation in China A comparative case study
Xu-Feng Zhu 서울대학교행정대학원 2017 Asian Journal of Political Science Vol.25 No.3
Classic theoretical research on the diffusion of policy innovation is usually based on decentralized democratic regimes. However, in authoritarian centralized countries such as China, questions such as, ‘What are the driving forces and the structural dynamics behind local government policy innovation and inter-regional diffusion?’ and ‘How do the governmental structural factors lead to the different patterns of diffusion of policy innovation across local governments?’ are interesting research topics. The theoretical framework proposed in this study highlights the roles of the contingent vertical and horizontal governmental relations in innovation diffusion. I extract two key properties: vertical mandatory intervention from the central government and horizontal political competition among peer governments. This research uses four models to develop a new typology of the interregional diffusion of policy innovation in China: (1) the enlightenment model, (2) the championship model, (3) the designation model, and (4) the recognition model. A comparative case study is conducted in this research, with four policy cases showing that China has developed diversified mechanisms to encourage local governments to perform policy innovation and inter-regional diffusion.
A Strategy to Protect Al<sub>2</sub>O<sub>3</sub>-based PFC Decomposition Catalyst from Deactivation
Xu, Xiu-Feng,Jeon, Jong Yeol,Choi, Mi Hwa,Kim, Hee Young,Choi, Won Choon,Park, Yong-Ki The Chemical Society of Japan 2005 Chemistry letters Vol.34 No.3
<P>γ-Al<SUB>2</SUB>O<SUB>3</SUB> is one of the most active catalysts for hydrolytic decomposition of PFCs but it has been suffered from deactivation. The main reason for the deactivation was the transformation of catalytically active γ-phase into an inactive α-phase by the HF produced during the decomposition of PFCs. To prohibit the phase transformation, structure modifiers such as ZnAl<SUB>2</SUB>O<SUB>4</SUB> and AlPO<SUB>4</SUB> were strongly required, which resulted in a remarkable catalyst durability.</P>
Feng Xu,Tingting Tao,Qiangwen Chen,Xiangxiang Meng,Jiaping Yan,Jie Chang 한국유전학회 2016 Genes & Genomics Vol.38 No.12
3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) catalyzes the condensation of acetyl-CoA and acetoacetyl- CoA to form 3-hydroxy-3-methylglutaryl-CoA as the first committed enzyme in the mevalonate (MVA) pathway. HMGS plays an important role in the biosynthesis of the sesquiterpene, which is the main constituent of essential oil in Matricaria chamomilla. In this paper, a HMGS gene designated as McHMGS (GenBank Accession No. KU529970) was successfully cloned from M. chamomilla. The full-length cDNA of McHMGS was 1495-bp and contained a 1374-bp open reading frame. It encoded a 458-amino-acid protein with a calculated molecular weight of about 50.7 kDa and isoelectric point of 5.69. Sequence comparison revealed that McHMGS showed extensive homology with HMGSs from other plant species. Phylogenetic tree analysis indicated that McHMGS is clustered with the HMGS of Asteraceae in the dicotyledoneae clade. Further functional complementation of McHMGS in hmgsdeficient mutant yeast strain YSC6274 demonstrated that cloned McHMGS cDNA encodes a functional HMGS and mediates the MVA biosynthesis in yeasts. The tissue expression pattern analysis revealed that McHMGS expression level is highest in the flowers and lowest in the stems. Quantitative real-time PCR analysis showed that the expression of McHMGS was induced by MeJA, and the expression level is highest 24 h after induction. The characterization and expression of McHMGS can help in further studying the role of McHMGS gene in the biosynthesis of sesquiterpene in M. chamomilla.