http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
강승희,한승희,강해진,Muller M.G.,,Feld M.S. 한국의학물리학회 2001 의학물리 Vol.12 No.1
본 논문의 목적은 조직(Tissue)에서의 광학적 특성(Optical Properties)을 이용한 광학적 생검(Optical Biopsy)방법을 소개하고, 방사선 치료에서 치료 반응 결과를 확인하는데 적당한 도구인가를 확인하고자 한다 본 연구는 구강(Oral Cavity) 내부조직을 샘플로, 건강한 사람 4명과 구강 암환자 4명의 자원을 받았다. 연구실에서 제작한 FastEEM(Excitation Emission Matrix) 장비를 이용하여 생체 내(in vivo)상태에서 측정하였다. 건강한 구강의 정상조직(Normal Tissue)과 병이 있는 구강의 비정상조직에서 기존의 생검과 동시에 새로운 광학적 생검을 하였다. 광학적 생검 결과와 기존의 생검 결과를 비교 확인하고, 암 조직으로 진단 받은 환자들에게 2차 광학적 생검을 실시하였다. 암 조직에 대한 1차 광학적 생검과 2차 측정 결과에 대한 형광스펙트럼을 비교 분석하였고, 자료분석은 Gillenwater가 개발한 337nm에 근거한 진단 알고리즘을 이용하였다. 광학적 생검 방법은 암 조직을 정상조직과 확실하게 구분시키는 장비임을 확인하였다. 건강한 구강조직과 악성 종양 조직의 측정 형광세기를 비교하면 정상조직인 경우 암 조직의 형광세기보다 모든 환자에 대해서 크게 나타났다. 암 조직의 구성이 시간에 따라 변하였을 때(7일) 광학적 생검을 하면 측정된 4명의 환자의 형광의 세기에 변화가 있었다. 7일간 시간이 지난 암 조직이 형광세기가 더 작은 값을 갖는다. 광학적 생검은 조직을 인체에서 분리하지 않는 생체 내, 실시간, 비침습성(noninvasive)생검 방법이다. 본 연구에서는 구강의 정상조직과, 암 조직, 그리고 암 조직의 진화에 따른 구성의 변화를 형광스펙트럼으로 확인하였다. 형광분광법을 이용한 FastEEM장치는 암 조직의 변화를 확인함으로 방사선 치료 후 발생하는 암 조직 구성의 화학적, 생물학적, 형태학적 변화를 실시간으로 정확하게 측정이 가능한 장치임을 확인하였다. The prior purpose of this study is to introduce a optical biopsy and evaluate whether the optical biopsy, real-time, non-invasive technique, is a reliable tool to assess response to radiotherapy Four healthy volunteers, and four patients with inflammatory conditions of the oral cavity participated on the study. was obtained from each person enrolled in the study. Using FastEEM(Ercited Emission Matrix) as a optical biopsy tool, normal and tumor spectra are taken from the normal and the tumor regions. And then second optical biopsy are taken from the tumor regions in 4 patients with time delay at 7days.. Using a diagnostic algorithm, made by Gillenwater based on spectra excited at 337nm The Optical Biopsy turned out to be more suited for tumor diagnostic resulting in significant difference fluorescence spectra. The fluorescence intensity of cancerous tissue showed a higher position. The second fluorescence intensity of optical biopsy of cancerous oral tissue has more smaller than the first result. I conclude that optical biopsy, which technique don't need to remove tissue sample from body, and is a real time , and non-invasive measurement is a reliable tool to access to radiotherapy because FastEEM can do measure the variation of the tissue composition chemical, biological, and morphological after radiotherapy. Based on the fluorescence spectrum are taken from the optical biopsy in normal and tumor spectra as well as tumor spectra after 7days.
Evaluation of an Active Humidification System for Inspired Gas
Nicolás G. Roux,Gustavo A. Plotnikow,Darío S. Villalba,Emiliano Gogniat,Vivivana Feld,Noelia Ribero Vairo,Marisa Sartore,Mauro Bosso,José L. Scapellato,Dante Intile,Fernando Planells,Diego Noval,Pablo 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.1
Objectives. The effectiveness of the active humidification systems (AHS) in patients already weaned from mechanical ventilation and with an artificial airway has not been very well described. The objective of this study was to evaluate the performance of an AHS in chronically tracheostomized and spontaneously breathing patients. Methods. Measurements were quantified at three levels of temperature (Tº) of the AHS: level I, low; level II, middle; and level III, high and at different flow levels (20 to 60 L/minute). Statistical analysis of repeated measurements was performed using analysis of variance and significance was set at a P<0.05. Results. While the lowest temperature setting (level I) did not condition gas to the minimum recommended values for any of the flows that were used, the medium temperature setting (level II) only conditioned gas with flows of 20 and 30 L/minute. Finally, at the highest temperature setting (level III), every flow reached the minimum absolute humidity (AH) recommended of 30 mg/L. Conclusion. According to our results, to obtain appropiate relative humidity, AH and T° of gas one should have a device that maintains water T° at least at 53°C for flows between 20 and 30 L/m, or at T° of 61°C at any flow rate.
High-speed synthetic aperture microscopy for live cell imaging.
Kim, Moonseok,Choi, Youngwoon,Fang-Yen, Christopher,Sung, Yongjin,Dasari, Ramachandra R,Feld, Michael S,Choi, Wonshik Optical Society of America 2011 Optics letters Vol.36 No.2
<P>We present a high-speed synthetic aperture microscopy for quantitative phase imaging of live biological cells. We measure 361 complex amplitude images of an object with various directions of illumination covering an NA of 0.8 in less than one-thirteenth of a second and then combine the images with a phase-referencing method to create a synthesized phase image. Because of the increased depth selectivity, artifacts from diffraction that are typically present in coherent imaging are significantly suppressed, and lateral resolution of phase imaging is improved. We use the instrument to demonstrate high-quality phase imaging of live cells, both static and dynamic, and thickness measurements of a nanoscale cholesterol helical ribbon.</P>
( Mark S. Sulkowski ),( Henry Lik Yuen Chan ),( Jordan J. Feld ),( Kosh Agarwal ),( Christophe Hezode ),( Tarik Asselah ),( Peter J. Ruane ),( Norbert Gruener ),( Armand Abergel ),( Alessandra Mangia 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Background: Velpatasvir (VEL) is a pangenotypic HCV-NS5A inhibitor. This Phase 3 study evaluated treatment with a fixed dose combination of SOF/VEL for 12 weeks in patients with genotype 1, 2, 4, 5, or 6 HCV infection. Methods: Patients with genotype 1, 2, 4, or 6 chronic HCV infection were randomized 5:1 to received SOF/VEL (400 mg /100 mg daily) or placebo for 12 weeks. Patients with genotype 5 infection were enrolled to the SOF/VEL treatment group and patients with genotype 3 were evaluated in a separate study. Results: 740 patients were enrolled at 81 international sites: 60% male, 79% white, 32% treatment-experienced (TE), and 19% compensated- cirrhosis. Of the 624 patients treated with SOF/VEL, the genotype distribution was 53% GT1, 17% GT2, 19% GT4, 6% GT5 and 7 % GT6. Overall SVR12 for SOF/VEL-treated patients was 99.0% and the study met its primary efficacy endpoint. SVR12 rates by HCV genotype are presented in the table. Two of 328 patients (0.6%) with genotype-1 infection had virologic relapse. No patients with genotype 2, 4, 5, or 6, including 48 with cirrhosis, had virologic failure. Four patients did not achieve SVR12 for non-virologic reasons. AEs and laboratory abnormalities were similar in the SOF/VEL-treated patients compared with the 116 placebo-treated patients. One patient discontinued SOF/VEL treatment due to adverse-events. Conclusions: Treatment with the once daily, all-oral, single tablet regimen of SOF/VEL for 12 weeks is well tolerated and results in high SVR12 rates in treatment-naive and treatment-experienced genotype 1, 2, 4, 5, and 6 HCV-infected patients with and without cirrhosis.
Kalashnikov, Maxim,Choi, Wonshik,Hunter, Martin,Yu, Chung-Chieh,Dasari, Ramachandra R.,Feld, Michael S. Optical Society of America 2012 Optics express Vol.20 No.2
<P>We report a method of assessing the contribution of whole cell body and its nucleus to the clinically most relevant backward light scattering. We first construct an experimental system that can measure forward scattering and use the system to precisely extract the optical properties of a specimen such as the refractive index contrast, size distribution, and their density. A system that can simultaneously detect the backscattered light is installed to collect the backscattering for the same specimen. By comparing the measured backscattering spectrum with that estimated from the parameters determined by the forward scattering experiment, the contribution of cell body and nucleus to the backward light scattering is quantitatively assessed. For the HeLa cells in suspension, we found that the cell body contributes less than 10% and cell nucleus on the order of 0.1% to the total backscattering signal. Quantitative determination of the origin of backscattered light may help design a system that aims for detecting particular structure of biological tissues.</P>
Observation of sub-Poisson Photon Statistics in the Cavity-QED Microlaser
Choi, Wonshik,Lee, Jai-Hyung,An, Kyungwon,Fang-Yen, C.,Dasari, R. R.,Feld, M. S. American Physical Society 2006 Physical review letters Vol.96 No.9
<P>We have measured the second-order correlation function of the cavity-QED microlaser output and observed a transition from photon bunching to antibunching with increasing average number of intracavity atoms. The observed correlation times and the transition from super- to sub-Poisson photon statistics can be well described by gain-loss feedback or enhanced-reduced restoring action against fluctuations in photon number in the context of a quantum microlaser theory and a photon rate equation picture. However, the theory predicts a degree of antibunching several times larger than that observed, which may indicate the inadequacy of its treatment of atomic velocity distributions.</P>
Overcoming the Diffraction Limit Using Multiple Light Scattering in a Highly Disordered Medium
Choi, Youngwoon,Yang, Taeseok Daniel,Fang-Yen, Christopher,Kang, Pilsung,Lee, Kyoung Jin,Dasari, Ramachandra R.,Feld, Michael S.,Choi, Wonshik American Physical Society 2011 Physical review letters Vol.107 No.2
Video-rate tomographic phase microscopy.
Fang-Yen, Christopher,Choi, Wonshik,Sung, Yongjin,Holbrow, Charles J,Dasari, Ramachandra R,Feld, Michael S SPIE--the International Society for Optical Engine 2011 JOURNAL OF BIOMEDICAL OPTICS Vol.16 No.1
<P>Tomographic phase microscopy measures the 3-D refractive index distribution of cells and tissues by combining the information from a series of angle-dependent interferometric phase images. In the original device, the frame rate was limited to 0.1 frames per second (fps) by the technique used to acquire phase images, preventing measurements of moving or rapidly changing samples. We describe an improved tomographic phase microscope in which phase images are acquired via a spatial fringe pattern demodulation method, enabling a full tomogram acquisition rate of 30 fps. In addition, in this system the refractive index is calculated by a diffraction tomography algorithm that accounts for the effects of diffraction in the 3-D reconstruction. We use the instrument to quantitatively monitor rapid changes in refractive index within defined subregions of cells due to exposure to acetic acid or changes in medium osmolarity.</P>