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Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells
Farha Arakkaveettil Kabeer,Dhanya Sethumadhavan Rajalekshmi,Mangalam Sivasankaran Nair,Remani Prathapan 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.2
Background: Deoxyelephantopin (DOE) is a natural bioactive sesquiterpene lactone from Elephantopus scaber, a traditionally relevant herb in Chinese and Indian medicine. It has shown promising anticancer effects against a broad spectrum of cancers. Methods: We examined the effect of DOE on growth, autophagy, apoptosis, cell cycle progression, metastasis, and various molecular signaling pathways in cancer cells, and endeavored to decipher the molecular mechanisms underlying its effect. The cytotoxicity of DOE was examined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and colony formation assays. The antimetastatic potential of DOE was identified by wound closure, as well as invasion and migration assays. The expression of mRNAs and proteins related to cytotoxicity in cancer cells induced by DOE was investigated using reverse transcription-polymerase chain reaction, flow cytometry, and Western blot analysis. Results: DOE showed significant cytotoxicity and induced apoptosis in cancer cells. DOE promoted the autophagy of HCT 116 and K562 cells. DOE arrested cell cycle progression in the G2/M phase. DOE treatment caused activation of caspase-8, -9, -3 and -7, reactive oxygen species production, and cleavage of cleavage of poly-ADP-ribose polymerase (PARP), the markers of apoptosis. Moreover, apoptosis induction was associated with mitochondrial permeability and endoplasmic reticulum stress. Treatment of cancer cells with DOE inhibited mitogen-activated protein kinases, nuclear factor-kappa B, phosphatidylinositol 3-kinase (PI3K/Akt), and β-catenin signaling. Furthermore, treatment of DOE increased the expression of p53, phospho-Jun amino-terminal kinases (p-JNK), and p-p38 and decreased the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) and phospho-mammalian target of rapamycin (p-mTOR) in cancer cells. DOE downregulated matrix metalloproteinase (MMP-2) and MMP-9, urokinase-type plasminogen activator (uPA), and urokinase-type plasminogen activator receptor (uPAR) mRNA levels in cancer cells. Conclusion: These findings concluded that DOE may be useful as a chemotherapeutic agent against cancer.
Evaluation of Morus alba leaf extracts after bioconversion for development of anti-diabetic agent
Ive Farha MOONMOON,Jin Hyeok KIM,Tae Jung KIM,Kyung Tae KIM,Young Ho KIM,Cheong Won CHO,Hyung Min KIM,Jong Seong KANG 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
Morus alba has been widely used as herbal medicines and functional foods for its well known bioactivities, such as antitumor, antidiabetic, and antioxidant activities. Recently, many studies have been reported which improved the bioactivities and function of materials using bioconversion technology such as fermentation by microorganisms and enzymes. Therefore, we applied bioconversion method to M. alba to evaluate enhanced bioactivities. The goal of this study was to develop analytical method to evalutate improved bioactivities and to conduct quality control of bio-converted M. alba leaf products. First, liquid-liquid extraction was performed with water and ethyl acetate to achieve best extraction efficiency and to minimize the solvent matrix effects. The water layer was analyzed by HPLC-DAD-ESI-MS on a C18 column (4.6 × 250 mm, 5 ㎛) with 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). Flow rate was set as 0.7 mL/min with gradient condition, detection with 320 nm of UV detector, and in room temperature. As a result, five peaks were increased upon bioconversion of M. alba leaves. Among increased peaks, four peaks were identified by comparison of UV spectra and molecular weight with the literature and MS spectrum aquired by LC-MS. It was identified as trans-caffeic acid, morin 3-O-ß-D-glucopyranoside, moracin M 3’-O-ß-glucopyranoside, and astragalin. These compounds were well known for bioactivities such as anti-diabetes. Therefore, the increased peaks would help to explain the enhanced bioactivities of enzyme processed M. alba leaves. Collectively, these compounds can be a marker candidates for the quality control of enzyme processed M. alba leaf extracts.
05 포스터 발표 : 환경 화학 분야(PC) ; HPLC-UVD를 이용한 근대 중 아족시스트로빈 분석
팔하 ( Waziha Farha ),무스픽 ( Musfiqur Rahman ),카빌 ( Humayun Kabir ),최정희 ( Jeong Heui Choi ),김성우 ( Sung Woo Kim ),임소정 ( So Jeong Im ),정다이 ( Da I Jung ),압두 ( Abd El Aty ),심재한 ( Jae Han Shim ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-
A new method was developed for analysis of Azoxystrobin in chard using HPLC-UVD. Samples were extracted using acetonitrile with salting out and purified usingsolid phase extraction (SPE) procedure. Linearity was excellent with determination coefficient (R2) >0.999. Recovery at 3 different spiking levels were ranged between 83.71-109.45% with relative standard deviation <3. The method was successfully applied to the field samples, which were collected randomly at 0 to 14 days’ post application. The rate of dis-appearance of Azoxystrobin on Chard was described as 1st order kinetics with half-life of 4.95 days.
Efficacy of whip roller setting on physical attributes of denim fabric
Farial Islam Farha,Fahmida Siddiqa,Md. Rashedul Islam 한국의류학회 2017 Fashion and Textiles Vol.4 No.1
Whip roller settings in a weaving machine is one of the vital factor to adjust warp yarn tension properly as well as delivering fault free fabric. The present study was undertaken with an aim to explore the influence of whip roller settings on various physical and mechanical properties of both grey and finished 100% cotton denim fabric in order to select suitable position of whip roller for producing particular (3/1 twill) denim fabric. For this purpose total eight positions of whip roller were selected keeping constant depth with variable height in five cases and constant height with variable depth in three cases. The samples were produced in an air jet loom and some prominence like EPcm, PPcm, areal density, tensile strength, dimensional stability, air permeability, crimp% and skewness were checked. Data analysis of all the results showed that with the ascendance of whip roller, crimp% of warp yarn was decreased whereas crimp% of weft yarn was increased both in grey and finished state. Decreasing the depth of whip roller caused increment of both warp and weft crimp% in both state. Tensile strength in warp way direction was found to increase gradually up to a certain roller height and then decreased whereas air permeability showed reverse trend in both state. Warp density, Weft density as well as areal density was also affected by the alteration in settings of whip roller. Due to reduction of roller depth, warp way tensile strength and lengthwise shrinkage were reduced but air permeability had improved.