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2-置換 Benzimidazole 誘導體에 관한 硏究(I)
馬銀淑 대구효성가톨릭대학교 1986 연구논문집 Vol.33 No.1
In order to investigate the difference of IR and NMR spectra according to substituent group, six 2-substituted benzimidazole derivatives such as 2-ethyl-2-(α-hydroxyethyl)-, 2-acetyl-, 2-benzyl-,2-(α-hydroxybenzyl)-, 2-benzyl BI were synthesized by Phillips method. In the IR spectra, the differences of IR spectra according to substituent group were not found except common properities of benzimidazole compound. In the NMR spectra, as was the substituent group of 2-position changed ?????????????? AA′BB′proton of benzimidazole ring was downfield shift and when benzene was substituted instead of methyl group, the effect of downfield shift was more large.
3β-치환 5-Androstene-17-Carboxamides 합성과 5α-Reductase 저해 활성
조익성(Iksung Jo),마은숙(Eunsook Ma) 大韓藥學會 2010 약학회지 Vol.54 No.6
A series of 3β-substituted 5-androstene-17β-carboxamides were synthesized from analogs of 3β-hydroxy-5-androstene-17β-carboxylic acid (1) with tert-butylamine, N,N-diethylamine and 3-aminopyridine and some compounds were epoxidized with mCPBA. A rat prostate testosterone 5α-reductase inhibitory activity of synthesized compounds was assessed by radioimmunoassay using [1,2,6,7-3H]-testosterone as substrate. All synthesized compounds showed lower activity than finasteride and the N-(3-pyridino)-3β-carboxycarbonyloxy-5-androstene-17β-carboxamide (12) showed weak inhibitory activity (IC50: 2.4×10-7 M).
N,N -(Alkanediyl)bis(phenylacetamide)유도체 합성 및 DNA methyltransferase 저해활성
이소현(Sohyun Lee),마은숙(Eunsook Ma) 대한약학회 2019 약학회지 Vol.63 No.2
DNA methyltransferases (DNMTs) are epigenetic enzymes responsible for gene expression in cancer, therefore their inhibitors have been considered as target for the treatment and prevention of cancer. Psammaplin A (PsA) with dimeric disulfide structure exhibits excellent DNMT inhibitory activity, but there are synthetic limitations in the development of various derivatives. To develop various DNMT inhibitors that are easy to synthesize, N,N -(alkanediyl) bis(phenylacetamide) derivatives 1-16 were synthesized from 3- or 4-substituted phenylacetic acids and α,ω-diaminoalkanes(NH2(CH2)nNH2, n=2-5) and evaluated for the preliminary screening of DNMT inhibitory activity using PsA as an positive control. The DNMT inhibitory activities (21-91%) of all synthesized compounds were lower than that of PsA (>100%) at 200 μM concentration. Among them, N,N -(pentane-1,5-diyl)bis(2-(3-bromophenyl)acetamide) (12) was found to be most active compound with DNMT inhibition of 91%.
Molecular Characterization of the Soybean L-Asparaginase Gene Induced by Low Temperature Stress
조창우,Hye-Jeong Lee,Eunsook Chung,Kyoung Mi Kim,Jee Eun Heo,Jung-In Kim,Jongil Chung,Youzhi Ma,Kiichi Fukui,Dae-Won Lee,Doh-Hoon Kim,Young-Soo Chung,이재헌 한국분자세포생물학회 2007 Molecules and cells Vol.23 No.3
L-asparaginase (EC 3.5.1.1) catalyzes the hydrolysis of the amide group of L-asparagine, releasing aspartate and NH4+. We isolated a low temperature-inducible cDNA sequence encoding L-asparaginase from soybean leaves. The full-length L-asparaginase cDNA, designated GmASP1, contains an open reading frame of 1,258 bp coding for a protein of 326 amino acids. Genomic DNA blotting and fluorescence in situ hybridization showed that the soybean genome has two copies of GmASP1. GmASP1 mRNA was induced by low temperature, ABA and NaCl, but not by heat shock or drought stress. E. coli cells expressing recombinant GmASP1 had 3-fold increased L-asparaginase activity. A possible function of L-asparaginase in the early response to low temperature stress is discussed.
한국·중국 초등교원양성기관 교육과정 내 아동문학교육 관련 교과목 비교 연구
김태호 ( Taeho Kim ),마성은 ( Sungeun Ma ),조은숙 ( Eunsook Cho ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.1
이 논문의 목적은 우리나라 초등교원양성기관 교육과정의 아동문학 및 문학교육 관련 교과목을 분석하는 데 있다. 이를 위해 한국과 문화적 유사성을 지닌 중국 초등교원양성기관의 교육과정을 비교 분석하여 연구하였다. 한국과 중국의 초등교원양성체제 및 교육과정 편성 기준을 탐색하고 양국에서 아동문학교육에 특화된 초등교원양성기관을 선정하여 그 교육과정을 비교하였다. 그 결과 한국의 교육대학교에서 학생들이 아동문학을 학습할 기회는 매우 제한되었다. 중국의 경우, 상대적으로 아동문학교육 관련 교과목이 다수, 체계적으로 편성되어 있었다. 이는 중국의 초등교원양성체제가 다원화되어 있기 때문이다. 중국 초등교원양성기관 교육과정의 장점을 무조건 수용할 필요는 없으나 아동문학교육 특성화된 면모를 검토하여 한국 실정에 적합하게 수용할 필요가 있다. The purpose of this paper is to study how children’s literature education courses are organized in the curriculum of Korean university of education. To do this, the chinese university curriculum with cultural similarities to Korea was compared and studied. First, we explored the standards for organizing university of education curriculums in both countries. In addition, university of education specializing in children’s literature education were selected from both countries and compared the curriculum. As a result, students at university of education in Korea have very limited opportunities to study children’s literature. In China, there were a number of educational courses related to children’s literature and systematically organized. This is because China’s system of nurturing elementary teachers is multiple. Since there are differences in the system for nurturing elementary teachers in both countries, It is not necessary to unconditionally accept the merits of the Chinese elementary school teacher training curriculum, but it is necessary to properly accommodate the Korean elementary school teacher training institutions by reviewing the specialized aspects of children’s literature education.
Androstane-3β-O-sulfonate 및 -sulfamate 유도체 합성과 steroid sulfatase 저해효과
박지현(Ji-Hyun Park),마은숙(Eunsook Ma) 대한약학회 2018 약학회지 Vol.62 No.6
서 론(Introduction) 실험 방법(Experimental Methods) 결과 및 고찰(Results and Discussion) 결 론(Conclusion)
4-치환 androst-4-ene 및 6-치환 androstane 유도체 합성과 및 Aromatase 저해 활성 및 Cytotoxicity
김민우(Min Woo Kim),마은숙(Eunsook Ma) 대한약학회 2020 약학회지 Vol.64 No.6
The development of potent aromatase inhibitors is an important therapeutic strategy for the treatment of breastcancer in postmenopausal women. Synthesized compounds that act as both an aromatase inhibitor and an anti-breastcancer agent are especially effective. In this study, nine 4-substituted androst-4-ene derivatives were synthesized fromdehydroepiandrosterone via Jones oxidation, epoxidation, epoxy ring-opening, and dehydration reactions. Five 6-substitutedandrostane derivatives were synthesized from dehydroepiandrosterone via epoxidation and epoxy ring-opening reactions. Screening assays were used to assess the synthesized compounds for potential inhibitory effects against aromatase; resultsshowed that compared to other compounds, 2 μM of 4-azido-17,17-ethylenedioxyandrost-4-en-3-one (10) had the greatestinhibitory effect (94.70%) against aromatase activity in human placental microsomes. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay was used to analyze the activity of 13 compounds against twohuman breast cancer cell lines (ER+ T47D and ER MDA-MB-231). Compounds 10 and 12 showed strong cytotoxicactivity against MDA-MB-231 (IC50: 25.6 and 32.7 μM, respectively).