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Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites
Eunkyo Park,Gyoung Deuck Kim,Min-Sun Go,Dodan Kwon,In-Kyung Jung,Joong Hyuck Auh,Jung-Hyun Kim 대한지역사회영양학회 2017 Nutrition Research and Practice Vol.11 No.4
BACKGROUND/OBJECTIVES: Nelumbo leaves have been used in traditional medicine to treat bleeding, gastritis, hemorrhoids, and halitosis. However, their mechanisms have not been elucidated. MATERIALS/METHODS: The present study prepared two Nelumbo leaf extracts (NLEs) using water or 50% ethanol. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and nitric oxide (NO) and prostaglandin E₂ (PGE₂) productions were assessed. To determine the anti-inflammatory mechanism of NLEs, we measured nuclear factor-κB (NF-κB) activity. Major metabolites of NLEs were also analyzed and quantified. RESULTS: NLEs effectively reduced the expression and productions of pro-inflammatory mediators such as IL-1β, IL-6, TNF-α, PGE₂ and NO. NLEs also reduced NF-κB activity by inhibiting inhibitor of NF-κB phosphorylation. Both extracts contained catechin and quercetin, bioactive compounds of NLEs. CONCLUSIONS: In this study, we showed that NLEs could be used to inhibit NF-κB-mediated inflammatory responses. In addition, our data support the idea that NLEs can ameliorate disease conditions involving chronic inflammation.
신지영,박은교,신정은,하은희 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.2
Objectives: The accumulated evidence shows that adult disease may have origins during the fetal period and maternal environmental exposure may affect fetus and infant health. To assess the environmental health of fetus and infants and examine women’s concerns about environmental health, we designed and conducted an environmental health survey in reproductive-aged women in 2011. Methods: A stratified multi-stage design was adopted for our survey, and 1,000 reproductive- aged women aged 25 to 39 years participated. The participants were asked to complete an electronic questionnaire using the computer-assisted web interviewing method. All the participants were married woman, and 80% had experienced pregnancy before completing the survey. Results: In the study, 86.3% of the participants responded that they are worried about the environmental problems that may affect the fetus and infant. The participants responded that they were most worried about global warming and climate change (36.2%), electromagnetic waves (31.4%), and endocrine disrupting chemicals (25.1%). Moreover, participants responded that environmental problem can cause children’s allergic disease, such as atopic dermatitis, metabolic syndrome and growth development. Conclusion: We found reproductive-aged women have high awareness of children’s environmental health. We also recommended that additional surveys on mother and child environmental health be conducted to make a health policy for women, fetus and infant.
Effects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean men
Ji Eun Lee,Eunkyo Park,Jung eun Lee,Joong Hyuck Auh,Hyung-Kyoon Choi,Jaehwi Lee,SooMuk Cho,Jung-Hyun Kim 한국영양학회 2011 Nutrition Research and Practice Vol.5 No.5
Korean raspberry, Rubus coreanus Miquel (RCM), contains high concentrations of phenolic compounds, which prevent oxidative stress. To determine the effect of RCM on antioxidant capacity in humans, we assessed in vivo lipid oxidation and antioxidant enzyme activities from plasma in 15 healthy men. The subjects ingested 30 g of freeze-dried RCM daily for 4 weeks. Blood was taken at baseline and at the end of the study to determine blood lipid profiles, fasting plasma glucose, liver function, lipid peroxidation, and antioxidant enzyme activities. RCM supplementation had no effect on blood lipid or fasting plasma glucose concentrations but decreased alkaline phosphatase activity. RCM supplementation increased glutathione peroxidase activities (P<0.05) but had no effect on lipid peroxidation. These results suggest that short-term RCM supplementation may offer health benefits by enhancing antioxidant capacity in a healthy population.
Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase
Jung Eun Lee,Soo-Muk Cho,Eunkyo Park,Seung Min Lee,Yuri Kim,Joong Hyuck Auh,Hyung-Kyoon Choi,Sohee Lim,Sung Chul Lee,Jung-Hyun Kim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.5
BACKGROUND/OBJECTIVES: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this study, we examine the anti-inflammatory effects of RCM and their possible mechanisms using RAW 264.7 cells. MATERIALS/METHODS: Unripe RCM ethanol extract (UE), unripe RCM water extract (UH), ripe RCM ethanol extract (RE), and ripe RCM water extract (RH) were prepared. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (iNOS, COX-2, TNF-α, IL-1β, and IL-6) and NO and PGE2 productions were assessed. To determine the anti-inflammatory mechanism of RCM, we measured NF-κB and MAPK activities. RESULTS: UE and UH treatment significantly reduced NF-κB activation and JNK and p38 phosphorylation and reduced transcriptional activities decreased iNOS, COX-2, and pro-inflammatory cytokines expressions, and NO and PGE2 productions. RE and RH treatments reduced IL-1β and IL-6 expressions through suppressions of JNK and p38 phosphorylation. CONCLUSIONS: In this study, we showed that RCM had anti-inflammatory effects by suppression of pro-inflammatory mediator expressions. Especially, unripe RCM showed strong anti-inflammatory effects through suppression of NF-κB and MAPK activation. These findings suggest that unripe RCM might be used as a potential functional material to reduce chronic inflammatory responses.
Kim, Sujung,Kim, Eunah,Lee, Yeon Ui,Ko, Eunkyo,Park, Hyeong-Ho,Wu, Jeong Weon,Kim, Dong-Wook Springer US 2017 Nanoscale research letters Vol.12 No.1
<P>We investigated the influence of metal coating on the optical characteristics of Si nanopillar (NP) arrays with and without thin metal layers coated on the sample surface. The reflection dips of the metal-coated arrays were much broader and more pronounced than those of the bare arrays. The coated metal layers consisted of two parts—the metal disks on the Si NP top and the holey metal backreflectors on the Si substrate. The Mie-like geometrical resonance in the NPs, the localized surface plasmons in the metal disks, and the propagation of surface plasmon polariton along the backreflector/substrate interface could contribute to the reflection spectra. Finite-difference time-domain simulation results showed that the interplay of the plasmonic effects and the geometric resonance gave rise to significantly enhanced light confinement and consequent local absorption in the metal-Si hybrid nanostructures.</P>
일개 항공기 정비시설의 화학물질 노출의 정성 및 정량 노출평가
백기욱 ( Baek Kiook ),김민석 ( Kim Minseok ),박해동 ( Jang Konghwa ),장공화 ( Park Haedong ),정은교 ( Chung Eunkyo ) 국군의무사령부 2019 대한군진의학학술지 Vol.50 No.1
Objectives; To evaluate exposure of chemicals, especially organic solvent, of aircraft maintenance facility in Korean army. Methods; We sampled bulk sample of solvent and air sample from maintenece facility workplace; cleaning and painting process. Air sampling was done by area sampling and personal sampling method. Analysis of sampling was done by gas chromatography/ mass spectrometry. Results; Benzene, heptane, toluene, ethylbenzene, xylene were detected among cleaning process. Comparison of TLV limit value, benzene was detected at a level of 22% of time weighted average level. Toluene, ethylbenzene, xylene were detected among painting process. Conclusions; We detected several organic solvents which is not enlisted on material safety data sheet. Carcinogenic or reproductive toxic agents were detected. Although the level was lower than exposure limit, safetly and health issues of workers should be concerned.
Antibody Responses One Year after Mild SARS-CoV-2 Infection
Choe Pyoeng Gyun,Kim Kye-Hyung,Kang Chang Kyung,Suh Hyeon Jeong,Kang EunKyo,Lee Sun Young,Kim Nam Joong,Yi Jongyoun,Park Wan Beom,Oh Myoung-don 대한의학회 2021 Journal of Korean medical science Vol.36 No.21
Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.