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Application of magnetic nanoparticle for controlled tissue assembly and tissue engineering
Lee, Eunjee A.,Yim, Hyungu,Heo, Jiseung,Kim, Hwan,Jung, Giyoung,Hwang, Nathaniel S. 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Magnetic nanoparticles have been subjected to extensive studies in the past few decades owing to their promising potentials in biomedical applications. The versatile intrinsic properties of magnetic nanoparticles enable their use in many biomedical applications. Recently, magnetic nanoparticles were utilized to control the cell's function. In addition, intracellular delivery of magnetic nanoparticles allowed cell's positioning by appropriate use of magnetic field and created cellular cluster. Furthermore, magnetic nanoparticles have been utilized to assemble more complex tissue structures than those that are achieved by conventional scaffold-based tissue engineering strategies. This review addresses recent work in the use magnetic nanoparticle for controlled tissue assembly and complex tissue formation.
Song, Joohyun,Lee, Eunjee A.,Cha, Seungwoo,Kim, Insun,Choi, Yonghoon,Hwang, Nathaniel S. Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.1
To engineer tissue-like structures, cells are required to organize themselves into three-dimensional networks that mimic the native tissue micro-architecture. Here, we present agarose-based multi-well platform incorporated with electrical stimulation to build skeletal muscle-like tissues in a facile and highly reproducible fashion. Electrical stimulation of C2C12 cells encapsulated in collagen/matrigel hydrogels facilitated the formation 3D muscle tissues. Consequently, we confirmed the transcriptional upregulations of myogenic related genes in the electrical stimulation group compared to non-stimulated control group in our multi-well 3D culture platform. Given the robust fabrication, engineered muscle tissues in multi-well platform may find their use in high-throughput biological studies drug screenings.
Song, Joohyun,Lee, Eunjee A.,Cha, Seungwoo,Kim, Insun,Choi, Yonghoon,Hwang, Nathaniel S. Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.1
To engineer tissue-like structures, cells are required to organize themselves into three-dimensional networks that mimic the native tissue micro-architecture. Here, we present agarose-based multi-well platform incorporated with electrical stimulation to build skeletal muscle-like tissues in a facile and highly reproducible fashion. Electrical stimulation of C2C12 cells encapsulated in collagen/matrigel hydrogels facilitated the formation 3D muscle tissues. Consequently, we confirmed the transcriptional upregulations of myogenic related genes in the electrical stimulation group compared to non-stimulated control group in our multi-well 3D culture platform. Given the robust fabrication, engineered muscle tissues in multi-well platform may find their use in high-throughput biological studies drug screenings.
Chondroitin Sulfate-Based Biomineralizing Surface Hydrogels for Bone Tissue Engineering
Kim, Hwan D.,Lee, Eunjee A.,An, Young-Hyeon,Kim, Seunghyun L.,Lee, Seunghun S.,Yu, Seung Jung,Jang, Hae Lin,Nam, Ki Tae,Im, Sung Gap,Hwang, Nathaniel S. American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.26
<P>Chondroitin sulfate (CS) is the major component of glycosaminoglycan in :connective tissue. In this study, we fabricated methacrylated PEGDA/CS-based hydrogels with varying CS concentration (0, 1, 5, and 10%) and investigated them as biomineralizing three-dimensional scaffolds for charged ion binding and depositions. Due to its negative charge from the sulfate group, CS exhibited an osteogenically favorable microenvironment by binding charged ions such as calcium and phosphate. Particularly, ion binding and distribution within negatively charged hydrogel was dependent on CS concentration. Furthermore, CS dependent biomineralizing microenvironment induced osteogenic differentiation of human tonsil-derived mesenchymal stem cells in vitro. Finally, when we transplanted PEGDA/CS-based hydrogel into a critical sized cranial defect model for 8 weeks, 10% CS hydrogel induced effective bone formation with highest bone mineral density. This PEGDA/CS-based biomineralizing hydrogel platform can be utilized for in situ bone formation in addition to being an investigational tool for in vivo bone mineralization and resorption mechanisms.</P>