Ought-to L2 Self and Its Influence on L2 Motivation and Demotivation: A Case of College English Majors

Eunbi Kwon 한국영어교육학회 2023 ENGLISH TEACHING(영어교육) Vol.78 No.4

This paper investigates L2 motivation and demotivation of college English majors in a Korean junior college. The participants’ L2 (de)motivation was explored by the oughtto L2 self, an element of the L2 motivational self system. Data were collected from two rounds of interviews with 59 and 31 students in all four years and analyzed qualitatively. The sources of the ought-to L2 self varied; however, it was a matter of how the participants recognized others’ expectations and pressure (i.e., manageable or beyond control). It was also relevant to how they comprehended and internalized these external influences for their L2 learning and (de)motivation. The findings indicate that the oughtto L2 self could be a contributing factor in sustaining L2 motivation and exerting effort. Finally, this paper calls for more needs to ensure and promote personalized and meaningful L2 learning for college English major students.

Paracrine influence of human perivascular cells on the proliferation of adenocarcinoma alveolar epithelial cells

Eunbi Kim,Sunghun Na,Borim An,Se-Ran Yang,Woo Jin Kim,Kwon-Soo Ha,Eun-Taek Han,Won Sun Park,Chang-Min Lee,Ji Yoon Lee,Seung-Joon Lee,Seok-Ho Hong 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2

Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-1α and K562)<i> in vitro</i> using Transwell^Ⓡ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-1α and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.

2,3,4-Trihydroxybenzophenone ameliorates Aβ-induced cytotoxicity by inhibiting formation and disassembling aggregates of Aβ in vitro

Eunbi Cho,Huiyoung Kwon,Jieun Jeon,Wan-Seob Cho,Jong Hyun Cho,Dong Hyun Kim 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.1

Paracrine influence of human perivascular cells on the proliferation of adenocarcinoma alveolar epithelial cells

Kim, Eunbi,Na, Sunghun,An, Borim,Yang, Se-Ran,Kim, Woo Jin,Ha, Kwon-Soo,Han, Eun-Taek,Park, Won Sun,Lee, Chang-Min,Lee, Ji Yoon,Lee, Seung-Joon,Hong, Seok-Ho The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2

Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-$1{\alpha}$ and K562) in vitro using $Transwell^{(R)}$ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-$1{\alpha}$ and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.

DUK101 improves cognitive functions through the dendrite elongation of immature neuron in hippocampal dentate gyrus

Huiyoung Kwon,Eunbi Cho,Jieun Jeon,Jong Hyun Cho,Wan-Seob Cho,Dong Hyun Kim 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.1

A Review of Recent Evidence from Meal-Based Diet Interventions and Clinical Biomarkers for Improvement of Glucose Regulation

Yeseung Jeong,Eunbi Lee,Yoon Jung Park,Yangha Kim,Oran Kwon,Yuri Kim 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.1

In recent decades, the prevalence of diabetes has rapidly increased worldwide. Medical nutrition therapy has been identified as a major therapeutic support for diabetic patients, while preventive strategies in prediabetic or high-risk individuals have mainly focused on supplementation with bioactive compounds. Recently, meal-based interventions have been investigated as novel and safe long-term strategies for improving glucose regulation. However, evaluation of meal-based interventions is difficult since it requires analysis of sensitive markers. Biomarkers can also be used to identify individuals at risk for diabetes, which is important for disease prevention. In this review, we summarize current evidence from meal-based intervention studies conducted with the aim of improving glucose homeostasis in individuals at risk of diabetes using clinical biomarkers currently used to assess diabetic risk. Very low-calorie diets have significantly improved glucose regulation in obese adults and in adults with type 2 diabetes mellitus. In particular, changing the ratios of macronutrients through calorie restriction reduces fasting glucose level and hemoglobin A1c levels in patients with diabetes mellitus. However, this effect is limited in both obese and healthy adults. To date, multiple glucose-related markers have been identified as clinical biomarkers of diabetes. Additional clinical biomarkers include cholesterol levels, hematological markers, and inflammatory markers. Taken together, the evidence presented in this review may help for selection of clinical biomarkers for meal-based preventive approaches for non- or pre-diabetic individuals to prevent onset of diabetes.

Probabilistic Modeling of Fish Growth in Smart Aquaculture Systems

( Jongwon Kim ),( Eunbi Park ),( Sungyoon Cho ),( Kiwon Kwon ),( Young Myoung Ko ) 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.8

We propose a probabilistic fish growth model for smart aquaculture systems equipped with IoT sensors that monitor the ecological environment. As IoT sensors permeate into smart aquaculture systems, environmental data such as oxygen level and temperature are collected frequently and automatically. However, there still exists data on fish weight, tank allocation, and other factors that are collected less frequently and manually by human workers due to technological limitations. Unlike sensor data, human-collected data are hard to obtain and are prone to poor quality due to missing data and reading errors. In a situation where different types of data are mixed, it becomes challenging to develop an effective fish growth model. This study explores the unique characteristics of such a combined environmental and weight dataset. To address these characteristics, we develop a preprocessing method and a probabilistic fish growth model using mixed data sampling (MIDAS) and overlapping mixtures of Gaussian processes (OMGP). We modify the OMGP to be applicable to prediction by setting a proper prior distribution that utilizes the characteristic that the ratio of fish groups does not significantly change as they grow. We conduct a numerical study using the eel dataset collected from a real smart aquaculture system, which reveals the promising performance of our model.

결명자 에탄올 추출물이 알코올로 유도로 유도한 기억 장애에 미치는 영향

권희영(Huiyoung Kwon),조은비(Eunbi Cho),전지은(Jieun Jeon),이영춘(Young Choon Lee),김동현(Dong Hyun Kim) 한국생명과학회 2019 생명과학회지 Vol.29 No.5

최근 알코올 소비량이 증가함에 따라 과량의 에탄올을 섭취하는 경우 또한 늘어나고 있다. 이런 과도한 에탄올 섭취는 γ-aminobutyric acid (GABA) 수용체의 활성화와 glutamate 수용체의 활성 억제를 통해 신경계를 교란시켜 단기 기억 형성을 방해 한다. 알코올에 의한 인지기능의 저하는 알코올성 black out을 유도할 수 있으며, 반복될 경우 알코올성 치매로 이어질 수 있기 때문에 black out을 예방하는 치료제의 개발이 필요하다. 따라서 본 연구자는 해당 연구를 통하여 Cassia obtusifolia seeds 에탄올 추출물(COE)이 가진 black out 예방제로써의 가능성을 평가하였다. 본 연구에서는 에탄올에 의해 유도된 기억 장애에 대한 COE의 효과를 확인하였다. 실험 동물의 기억력을 측정하기 위하여 수동 회피 실험과 Y자 미로 실험을 수행하였고, 마우스 해마 절편을 사용하여 에탄올이 기억의 형성과 관련하여 장기 강화(long term potentiation; LTP)에 어떠한 영향을 끼치는지 전기생리학을 통해 확인하였다. 또한 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 수용체 길항제인 NBQX (50 μM)를 사용하여 에탄올에 의한 인지기능 장애와 관련이 있다고 알려진 N-Methyl-D-aspartate (NMDA) 매개 field 흥분성 시냅스 후 전위를 측정하였다. 결과적으로, COE는 에탄올에 의한 기억력의 손상을 방지하였고, 해마 절편에서 에탄올에 의해 감소된 LTP와 NMDA 매개 흥분성 시냅스 후 전위를 대조군과 비슷한 수준까지 회복시켰다. Heavy drinking disrupts the nervous system by activation of GABA receptors and inhibition of glutamate receptors, thereby preventing short-term memory formation. Degradation of cognition by alcohol induces blackouts, and it can lead to alcoholic dementia if repeated. Therefore, drugs need to be developed to prevent alcohol-induced blackout. In this study, we confirmed the effect of an ethanol extract of Cassia obtusifolia seeds (COE) on alcohol-induced memory impairment. The effects of COE and ethanol on cognitive functions mice were examined using the passive avoidance and Y-maze tests. The manner in which alcohol affects long-term potentiation (LTP) in relation to the learning and memory was confirmed by electrophysiology performed on mouse hippocampal slices. We also measured N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory synapses (fEPSPs), which have a known association with cognitive impairment caused by ethanol. Ethanol caused memory impairments in passive avoidance and Y-maze tests. COE prevented these ethanol-induced memory impairments in these tests. Ethanol also blocked LTP induction in the mouse hippocampus, and COE prevented this ethanol-induced LTP deficit. Ethanol decreased NMDA receptor-mediated fEPSPs in the mouse hippocampus, and this decrease was prevented by COE. These results suggest that COE might be useful in preventing alcohol-induced neurological dysfunctions, including blackouts.

The enhancing effect of Aubang Gahl Soo on the hippocampal synaptic plasticity and memory through enhancing cholinergic system in mice

Lee, Jihye,Kwon, Huiyoung,Yu, Jimin,Cho, Eunbi,Jeon, Jieun,Lee, Seungheon,Ryu, Jong Hoon,Lee, Young Choon,Kim, Dong Hyun,Jung, Ji Wook Elsevier 2018 Journal of Ethnopharmacology Vol.224 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>Aubang Gahl Soo (AGS) is a Korean traditional drink manufactured from medicinal plants and fruits using sugar or honey. Although traditional old book stated its effects on body, there is no scientific evidence yet. Therefore, in the present study, we tested AGS on brain functions.</P> <P><B>Aim of this study</B></P> <P>In this study, we tried to uncover the effect of on brain functions. To do this we examined the action of AGS on the hippocampal synaptic function and memory in mice.</P> <P><B>Materials and methods</B></P> <P>To examine the effect of AGS on synaptic plasticity, we observed input-output curves (I/O curve), paired-pulse facilitation (PPF), and long-term potentiation (LTP) using mouse hippocampal slices. Moreover, to investigate the functional relevance of the effect of AGS on synaptic plasticity, we conducted passive avoidance, Y-maze and Morris water maze tests. To examine relevant mechanism, acetylcholinesterase (AChE) activity and acetylcholine (ACh) level assay were also conducted.</P> <P><B>Results</B></P> <P>In the basal synaptic transmission study, we found that AGS did not affect I/O curves and PPF. However, AGS facilitated hippocampal LTP in a concentration-dependent manner. Moreover, AGS blocked AChE activity (IC<SUB>50</SUB> = 485 μg/ml). Moreover, ACh level was increased by AGS (100 μg/ml) treatment. Along with this, facilitating effect of AGS on hippocampal LTP also blocked by scopolamine, a muscarinic acetylcholine receptor antagonist. Moreover, AGS also ameliorated memory impairments induced by scopolamine in passive avoidance, Y-maze, and Morris water maze tests.</P> <P><B>Conclusions</B></P> <P>These results suggest that AGS facilitates hippocampal LTP through activating cholinergic system and ameliorates cholinergic dysfunction-induced memory deficit.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

유사 HAL 함수 탐색을 통한 펌웨어 퍼징 기법

정세연(Seyeon Jeong),황은비(Eunbi Hwang),조영필(Yeongpil Cho),권태경(Taekyoung Kwon) 한국정보보호학회 2022 정보보호학회논문지 Vol.32 No.6