소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례

이은희,임동희,임형은,유기환,원남희,홍영숙,이주원,Lee, Eun-Hee,Lim, Dong-Hee,Yim, Hyung-Eun,Yoo, Kee-Hwan,Won, Nam-Hee,Hong, Young-Sook,Lee, Joo-Won 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1

Infection of Epstein-Barr virus(EBV) gives rise to a broad spectrum of clinical manifestations in children. Although renal involvement is rare, diverse renal manifestations are known from hematuria to acute renal failure. Secondary membranous nephropathy(MN) associated with systemic EBV infection is an uncommon renal pathology and only two cases have been reported. We are adding another case of MN associated with EBV infection in a child. An 8-year-old girl was admitted for renal biopsy. She had been followed up for microscopic hematuria and intermittent proteinuria for 5 months. There had been no specific findings in serology and radiology. Tonsil biopsy had been done due to exudative tonsillar hypertrophy and enlarged multiple cervical lymph nodes. And it showed EBV-associated lymphoproliferative findings. Serologic tests for EBV showed positive evidence of recent infection; viral capsid antigen(VCA) IgM was borderline positive, VCA IgG and early antigen IgG were positive, and EB nuclear antigen IgG was negative. In Situ Hybridization of tonsil for EBV mRNA was positive. Because her proteinuria and hematuria were aggravated at that time(protein 3 +, RBC >60/HPF), renal biopsy was done. Renal biopsy showed the findings of MN, characterized by thickened capillary walls with epimembranous spikes on light microscopy and subepithelial, mesangial and subendothelial electron dense deposits on electron microscopy. On immunofluorescence microscopy, IgG, C1q, kappa and lambda chains were positive. After steroid administration, proteinuria and hematuria resolved gradually within 6 months. 막성 신병증은 성인에 비해 소아에서는 드문 신병증으로 감염, 자가면역, 종양에 의한 이차성 신병증이 알려져 있다. 그 중에서도 엡스타인-바 바이러스 감염과의 관련은 잘 알려지지 않아, 최근 1개 보고에서 면역기능이 저하된 2례를 소개한 바 있을 뿐이다. 이에 저자들은 면역기능이 정상으로 보이는 소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례를 경험하였기에 보고하는 바이다.

논문편 : 소비자 정보의 내용별 요구도와 관련변수들간의 인과모형 분석

이은희,이기춘 ( Eun Hee Lee,Kee Choon Rhee ) 대한가정학회 1997 Family and Environment Research Vol.35 No.5

일부지역 여성건강간호센터 설립 및 여성건강관리 프로그램을 위한 기초조사

이은희,최상순,소애영,Lee, Eun-Hee,Choi, Sang-Soon,So, Ae-Young 한국여성건강간호학회 1999 여성건강간호학회지 Vol.5 No.1

The purpose of this paper was to identify the performance of health promoting lifestyles and health perception over 18 years old women living Wonju city so that the results will be based for setting up women's health nursing center. The subjects were 1080 women selected by stratified and purposive sampling. The data were collected by self reporting questionnaire and interview from May to June, 1998. Data were analyzed by SPSS win program. The results were as follows : 1. The range of age was 18-84 years, The proportion according to women's lifecycle was premarital group 20.0%, delivery and rearing group 49.9%, over middle aged-elderly group 29.8%. 2. The mean menarchial age was 15.2 and menopausal age was 48. Mean frequenices of pregnancy is 2.4 and artificical abortion rate is 36.4%. Primary cause of abortion was unwanted babies 42.8%. The practice rate of family planning was 79.4% and permanent sterilization rate was 37.6%. 3. Fatigue was predominated problem in target population. Depression and headache was predominated in premarital group, headache and nervous felling in delivery and rearing group, arthritis and loss of memory in over middle aged-elderly group. 4. Only 13.7% of the target population make some efforts for their health in compare to 85.9% have attention for their health. Perception of unhealthy rate was 9.1% in premarital group, 24.8% in delivery and rearing group, 30.1% in middle aged-elderly group. 5. The average score of the HPLP(Health Promoting Lifestyle Profile) was 2.41. The variable with the highest degree of performance was interpersonal relationship, whereas the one with the lowest degree was the professional health maintenance. The significant difference was found in HPLP according to age, residential area, marital status, educational level, income level. 6. Majority(95.1%) of the target population agreed on necessity for women's health nursing center. Proper location area was presented to women's center and public health center. The priority for health education program was proper diet, family health, stress management, and exercise. In conclusion, we should prepare the education program for women's health according to women's lifecycle, because health perception, HPLP, and education program needed was differentiated in women's lifecycle. Also we suggest that women's health nursing center based community was needed for proper management of women's health.

경남 창녕군 증산리 일대 방사집수정을 활용한 강변 여과수 개발량 평가

이은희,현윤정,이강근,김형수,정재훈,Lee, Eun-Hee,Hyun, Yun-Jung,Lee, Kang-Kun,Kim, Hyoung-Soo,Jeong, Jae-Hoon 한국지하수토양환경학회 2010 지하수토양환경 Vol.15 No.4

Well production by a riverbank filtration facility with multi-radial collector well systems in Jeungsan-ri, Changnyeong gun, Korea was evaluated. In this study, the drawdown at collector wells due to pumping and groundwater inflow rates along the horizontal arms of the collector wells were computed through numerical simulations. Sensitivities of the well production to hydraulic conductivity and well flow coefficient, which represents the resistance to the flow from the aquifer to the horizontal arms, were analyzed. Simulation results showed that, with given proposed pumping rate conditions, the drawdown in the caisson exceeded maximum drawdown constraints in the study site and the adjustment of the pumping rate at each well is needed. The drawdown is affected by the hydraulic conductivity of the main aquifer and the well flow coefficient, which means the profound field investigation of the study site is needed to accurately estimate the efficiency of riverbank filtration through radial collector wells.

사람 융모 성선 자극 호르몬에 의한 복강 대식세로로부터 산화질소의 발생

이은희,신태용,김형민,Lee, Eun-Hee,Shin, Tae-Yong,Kim, Hyung-Min 대한약학회 1997 약학회지 Vol.41 No.3

Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric ox ide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon- ${\gamma}$ (rIFN-${\gamma}$) alone had modest activity. When hCG was used in combination with rIFN-${\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-${\gamma}$. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.

가압성형용 치과도재의 제조와 특성

이은희,최희락,정해용,Lee, Eun-Hee,Choi, Hee-Rak,Jeong, Hae-Yong 한국재료학회 2006 한국재료학회지 Vol.16 No.3

Pressable ceramics have many applications in the field of dental industry because of their excellent esthetic, compressive strength, chemical durability. Despite these attractive characteristics, they have not been widely used since they are very brittle and extremly sensitive to porcelain. In this study, the fabrication of pressable dental porcelain ($SiO_2-Al_2O_3-K_2O-Na_2O$) as a function of contents of $Al_2O_3,\;BaO\;and\;ZrO_2$ were investigated. And then compressive strength, Vickers hardness, density and thermal expansion coefficient (TEC) tests have been carried out to evaluate properties of pressable dental porcelain fabricated. The property of pressable dental porcelain fabricated by adding of 15%$Al_2O_3$ and 2%BaO contents was closely approximated to that of natural tooth.

논문편 : 소비자정보요구와 관련요인 연구

이은희,이기춘 ( Eun Hee Lee,Kee Choon Rhee ) 대한가정학회 1991 Family and Environment Research Vol.29 No.1

신경독성물질에 의한 신경계장애 조기발견을 위한 색각검사의 활용가능성

이은희,최경호,채홍재,백도명,Lee, Eun-Hee,Choi, Kyung-Ho,Chae, Hong-Jae,Paek, Do-Myung 대한예방의학회 2008 예방의학회지 Vol.41 No.6

This paper reviews the published literature that is concerned with color vision impairment from industrial and environmental exposure to neurotoxic substances, and we evaluated whether testing for color vision impairment could be an affordable procedure for assessing these neurotoxic effects. In general, most cases of congenital color vision impairment are red-green, and blue-yellow impairment is extremely rare. However, most of the acquired color vision impairment that is related to age, alcohol or environmental factors is blue-yellow impairment. Therefore, many studies have been performed to identify this relationship between exposure to neurotoxic substances, such as organic solvents and heavy metals, and the prevalence of blue-yellow color vision impairment. The test for color vision impairment is known to be very sensitive to the early signs of nervous system dysfunction and this can be useful for making the early diagnosis of neurotoxic effects from exposure to very low concentrations of toxic substances.

하이퍼써미아 응용을 위한 하이브리드 에어로젤 내 분산된 마그네타이트 나노입자

이은희,좌용호,김창열,Lee, Eun-Hee,Choa, Yong-Ho,Kim, Chang-Yeoul 한국재료학회 2012 한국재료학회지 Vol.22 No.7

Magnetite nanoparticles(NPs) have been the subject of much interest by researchers owing to their potential use as magnetic carriers in drug targeting and as a tumor treatment in cases of hyperthermia. However, magnetite nanoparticles with 10 nm in diameter easily aggregate and thus create large secondary particles. To disperse magnetite nanoparticles, this study proposes the infiltration of magnetite nanoparticles into hybrid silica aerogels. The feasible dispersion of magnetite is necessary to target tumor cells and to treat hyperthermia. Magnetite NPs have been synthesized by coprecipitation, hydrothermal and thermal decomposition methods. In particular, monodisperse magnetite NPs are known to be produced by the thermal decomposition of iron oleate. In this study, we thermally decomposed iron acetylacetonate in the presence of oleic acid, oleylamine and 1,2 hexadecanediol. We also attempted to disperse magnetite NPs within a mesoporous aerogels. Methyltriethoxysilicate(MTEOS)-based hybrid silica aerogels were synthesized by a supercritical drying method. To incorporate the magnetite nanoparticles into the hybrid aerogels, we devised two methods: adding the synthesized aerogel into a magnetite precursor solution followed by nucleation and crystal growth within the pores of the aerogels, and the infiltration of magnetite nanoparticles synthesized beforehand into aerogel matrices by immersing the aerogels in a magnetite nanoparticle colloid solution. An analysis using a vibrating sample magnetometer showed that approximately 20% of the magnetite nanoparticles were well dispersed in the aerogels. The composite samples showed that heating under an inductive magnetic field to a temperature of $45^{\circ}C$ is possible.

Ni 나노 분말을 이용한 안정한 현탁액 제조 및 특성

이은희,이민구,이창규,Lee Eun-Hee,Lee Min-Ku,Rhee Chang-Kyu 한국분말야금학회 2006 한국분말재료학회지 (KPMI) Vol.13 No.2

In this study, the effects of the dispersants, i.e., Hypermer KD-2 and poly(l-vinyl-2-pyrrolidone) (PVP), and their concentration on the dispersion stability of Ni nanoparticles ($10nm{\sim}40nm$) in ethanol were investigated by using a visual inspection, a transmission profile (Turbiscan), and a zeta potential measurement. The transmission profiles measured by Turbiscan showed that the particle size increased over the entire height of the sample for suspensions with both the dispersants without showing any particle coalescence and sedimentation. The visual inspection also confirmed that the Ni suspensions with Hypermer KD-2 and PVP were very stable for more than a year. The zeta potential values varied from positive to negative with increasing the dispersant's concentration. The dispersion stability of the suspensions was not affected by both the dispersant's concentration and the zeta potential values. The observed suspension stability of Ni nanoparticles was attributed to the steric effect for the Hypermer KD-2 and to the bridging effect for the PVP.