http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ahn, Eu-Ree,Cho, Hui-Kyung,Pai, Hyun-Sook Springer-Verlag [etc.] 2013 Planta Vol.237 No.4
<P>The forkhead-associated (FHA) domain is involved in protein-protein interaction by recognizing a phosphothreonine epitope on target proteins. In this study, we investigated in planta functions of the Arabidopsis FHA domain 2. AtFHA2 was mainly localized in the nucleus. Arabidopsis fha2 null mutants grew normally during the vegetative stage, but had severely reduced fertility during reproductive stage. The reduced fertility was mainly caused by defective stamen filament elongation, while female flower parts of the mutants were fertile. Additionally, the mutants had fewer stamens than the wild type and the vegetative organs of the mutants, such as cotyledons and leaves, had increased ploidy. These results suggest that AtFHA2 may play a role in a signaling pathway for the control of plant organ development.</P>
Molecular Characterization of NLP Function in Nicotiana benthamiana
Eu-Ree Ahn,Sujon Sarowar,전영,배현숙 한국식물학회 2011 Journal of Plant Biology Vol.54 No.3
In this study, we investigated the cellular functions of nuclear localizing protein (NLP) in Nicotiana benthamiana. The GFP fusion protein of Arabidopsis NLP is mostly targeted to the nucleus and cytosol, but it infrequently targets only the nucleus. Silencing of NLP using virus-induced gene silencing caused growth retardation and abnormal leaf development in N. benthamiana. At the cellular level,downregulation of NLP expression increased the size of pavement cells and stomata in the leaf tissues. NLP suppression also increased endoreduplication in leaf cells,suggesting a role of NLP in the endocycle. NLP transcript levels in leaves were significantly increased in response to infection with the nonhost pathogens. NLP deficiency attenuated HR cell death against nonhost pathogens and in response to gene-for-gene interaction. These findings suggest that NLP plays a role in plant development and plant defense responses against pathogens.
Molecular Characterization of NLP Function in Nicotiana benthamiana
Ahn, Eu-Ree,Sarowar, Sujon,Jeon, Young,Pai, Hyun-Sook 한국식물학회 2011 Journal of Plant Biology Vol.54 No.3
In this study, we investigated the cellular functions of nuclear localizing protein (NLP) in Nicotiana benthamiana. The GFP fusion protein of Arabidopsis NLP is mostly targeted to the nucleus and cytosol, but it infrequently targets only the nucleus. Silencing of NLP using virus-induced gene silencing caused growth retardation and abnormal leaf development in N. benthamiana. At the cellular level, downregulation of NLP expression increased the size of pavement cells and stomata in the leaf tissues. NLP suppression also increased endoreduplication in leaf cells, suggesting a role of NLP in the endocycle. NLP transcript levels in leaves were significantly increased in response to infection with the nonhost pathogens. NLP deficiency attenuated HR cell death against nonhost pathogens and in response to gene-for-gene interaction. These findings suggest that NLP plays a role in plant development and plant defense responses against pathogens.
Enhanced sensitivity of CpG island search and primer design based on predicted CpG island position
Park, Hyun-Chul,Ahn, Eu-Ree,Jung, Ju Yeon,Park, Ji-Hye,Lee, Jee Won,Lim, Si-Keun,Kim, Won Elsevier 2018 FORENSIC SCIENCE INTERNATIONAL GENETICS Vol.34 No.-
<P><B>Abstract</B></P> <P>DNA methylation has important biological roles, such as gene expression regulation, as well as practical applications in forensics, such as in body fluid identification and age estimation. DNA methylation often occurs in the CpG site, and methylation within the CpG islands affects various cellular functions and is related to tissue-specific identification. Several programs have been developed to identify CpG islands; however, the size, location, and number of predicted CpG islands are not identical due to different search algorithms. In addition, they only provide structural information for predicted CpG islands without experimental information, such as primer design. We developed an analysis pipeline package, CpGPNP, to integrate CpG island prediction and primer design. CpGPNP predicts CpG islands more accurately and sensitively than other programs, and designs primers easily based on the predicted CpG island locations. The primer design function included standard, bisulfite, and methylation-specific PCR to identify the methylation of particular CpG sites. In this study, we performed CpG island prediction on all chromosomes and compared CpG island search performance of CpGPNP with other CpG island prediction programs. In addition, we compared the position of primers designed for a specific region within the predicted CpG island using other bisulfite PCR primer programs. The primers designed by CpGPNP were used to experimentally verify the amplification of the target region of markers for body fluid identification and age estimation. CpGPNP is freely available at http://forensicdna.kr/cpgpnp/.</P>
Park Hyun-Chul,Ahn Eu-Ree,Shin Sang-Cheul 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background Allele frequency using short tandem repeats (STRs) is used to calculate likelihood ratio for database match, to interpret DNA mixture and to estimate ethnic groups in forensic genetics. In Korea, three population studies for 23 STR loci have been conducted with diferent sample size for forensic purposes. Objective We performed comparative analysis to determine how the diference of sample size afects the allele frequency and allele variation within same ethnic population (i.e. Korean). Furthermore, this study was conducted to check how the sampling group and multiplex kit also afect allele variation such as rare alleles and population specifc alleles. Methods To compare allele variation, we used allele frequencies of three population data published from three Korean forensic research groups. Allele frequencies were calculated using diferent sample sizes and multiplex kits: 526, 1000, and 2000 individuals, respectively. Results The results showed the diferent distribution of allele frequencies in some loci. There was also a diference in the number of rare alleles observed by the sample size and sampling bias. In particular, an allele of 9.1 in the D2S441 locus was not observed in population study with 526 individuals due to multiplex kits. Conclusion Because the allele frequencies play an important role in forensic genetics, even if the samples are derived from the same population, it is important to consider the efects of sample size, sampling bias, and selection of multiplex kits in population studies.
DNA 데이터베이스의 좌위 확장에 의한 해결 사례 보고
정주연(Jung, Ju Yeon),류가희(Ryu, Ga Hee),김주영(Kim, Joo Young),안으리(Ahn, Eu Ree),문서현(Moon, Seo Hyun),강필원(Kang, Pil Won),최동호(Choi, Dong Ho) 경찰대학 경찰학연구편집위원회 2020 경찰학연구 Vol.20 No.4
2010년 7월 제정된 「디엔에이신원확인정보의 이용 및 보호에 관한 법률」에 의해 구속피의자, 수형인 및 사건현장에서 확보된 DNA 신원확인정보 관리 목적의 데이터베이스가 구축되었다. 미국 FBI(Federal Bureau of Investigation)의 CODIS(Combined DNA Index System) 중심 좌위(Core loci)가 확장됨에 따라 대한민국의 DNA 데이터베이스 좌위도 2018년부터 13개에서 20개로 확장되었다. 본 논문에서는 2018년 1년간 의뢰된 구속피의자 DNA 프로필이 좌위 확장에 의해 DNA 데이터베이스 수록 기준에 도달한 현장증거물과 일치함으로써 사건 해결에 기여한 사례를 보고하고자 한다. 2018년 1년간 수록된 구속피의자 4,947건 중에 28건이 이러한 경우에 해당하였고, 이와 일치된 현장증거물의 약 86%가 미량(Low Copy Number, LCN) 시료인 접촉증거물로부터 검출된 것으로 분석되었다. 지속적으로 접촉증거물의 의뢰가 증가함에 따라 좌위 확장에 의한 해결 사례가 증가할 것으로 판단되었으며, 혼합된 DNA 프로필로부터 1인의 DNA 프로필 분리 가능성도 증가됨으로써 성범죄 등의 강력범죄 해결에도 도움이 될 것으로 사료되었다. Under the ‘Act on the Use and Protection of DNA Identification Information’ enacted in July 2010, a DNA identification database was constructed for the purpose of managing DNA information obtained from detained suspects (arrestees), prisoners, and crime scenes. As the Federal Bureau of Investigation (FBI) Combined DNA Index System (CODIS) core loci has expanded, the Korea DNA identification database loci have also expanded, from 13 to 20 in 2018. Here, we report the information that contributed to case resolution by matching arrestees to the DNA profile obtained from crime scene evidence, and the criteria was reached by loci expansion. Of the 4,947 arrestees whose DNA was uploaded in 2018, 28 cases were included. In addition, we found that approximately 86% of the crime scene evidence that corresponded to these cases were extracted from touched-evidence, which are low copy number (LCN) samples. As the number of requests for touched-evidence continues to increase, the number of cases that are resolved by loci expansion are expected to increase steadily as well. Furthermore, as the possibility of separating a single DNA profile from a mixture also increases, loci expansion will have additional utility in resolving violent crimes, including sex crimes, as well.