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RISS 인기검색어
- 검색키워드
- 저자 : En-Shi Jiang (검색결과 6 건)
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En-Shi Jiang,최유경,임범순,박영석,정신혜 대한치과재료학회 2022 대한치과재료학회지 Vol.49 No.4
This study aimed to analyze the eluted components of syringe-type bis-acryl composites and to evaluate the effect of removingthe oxygen-inhibited layer on cytotoxicity. Four different bis-acryl provisional composite materials-Protemp 4 (PT), Structur2 SC (ST), Luxatemp Automix Plus (LT), and Hexa-Temp (HT)-were evaluated. Gas chromatography/mass spectrometry wasused to analyze the composite eluate after 24 h of immersion in methanol. An agar overlay test and a live/dead assay wereperformed on the polymerized disc-shaped specimens after 24 h. To evaluate the effect of removing the oxygen-inhibitedlayer, samples were prepared with a surface oxygen-inhibited layer. The surface oxygen-inhibited layer of the disc-shapedspecimens was removed with alcohol only (subgroup A) or with polishing and alcohol (subgroup PA), and their cytotoxicitieswere compared with those of “as received” (subgroup N) specimens using the WST-1 assay. Statistical significance was assessedusing analyses of variance, followed by Bonferroni multiple comparison tests (α=0.05). Different components were detectedby gas chromatography/mass spectrometry analysis among the groups. The agar overlay assay confirmed severe cytotoxicityin HT, LT, and ST groups, whereas PT showed moderate cytotoxicity. The effect of removing the oxygen-inhibited layer oncell viability was significantly higher in PA than in N in all composite groups. In HT and ST, the cell viability was significantlyhigher in PA than in A. Syringe-type bis-acryl composites for provisional restorations may elute various components into theoral cavity, which may cause cytotoxicity in adjacent structures. The cytotoxicity of the materials is reduced by the removalof the oxygen-inhibited layer.
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Shi-Lei Cao,En Chen,Qi-Zhi Zhang,Xin-Guo Jiang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 mPa·s and caproic acid content of 1.31± 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly (1.1oC at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.
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Cao, Shi-Lei,Chen, En,Zhang, Qi-Zhi,Jiang, Xin-Guo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 $mPa{\cdot}s$ and caproic acid content of $1.31{\pm}$ 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly ($1.1^{\circ}C$ at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.
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Jie Cui,Quan Jiang,Shaojun Liu,Xiating Feng,Youliang Zhang,Ying-en Shi 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.3
The strength of a rock cut by non-persistent open joint set is controlled by complex interactions of the joint network and intact rock bridges. An extensive series of uniaxial numerical tests of the particle models are carried out under different joint fabrics and rock compression-tension strength ratios. The test results show joint dip angle is the main factor controlling the overall anisotropic strength characteristics. With joint dip angle increasing, the main failure modes successively appear as splitting failure, block rotation failure, step-path failure, planar failure, and splitting failure. Accordingly, the strength generally shows a trend of decreasing first and then increasing, and the joint dip angle corresponding to the minimum strength is biased towards 0°, usually at 15° − 30°. The damage of rock bridges is mainly controlled by tensile failure, except in planar failure mode. Joint spacing has an impact on the local anisotropic strength characteristics. The joint spacing and persistence ratio jointly control the degree of penetration difficulty of the rock bridges. The compression-tension strength ratio of intact rock uniformly affects the absolute magnitude of the jointed rock strength and does not affect its anisotropic characteristics. Based on the weakening mechanism, an empirical strength formula is established to realize the practical equivalent characterization of the anisotropic weakening degrees of the non-persistent open joint set on the rock strength.
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Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population
Chen, Guang-Lie,Hou, Gai-Ling,Sun, Fei,Jiang, Hong-Li,Xue, Jin-Feng,Li, Xiu-Shen,Xu, En-Hui,Gao, Wei-Shi,Cao, Jian-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous cell carcinomas (ESCCs) in a Mongolian population. Methods: Two non-synonymous single nucleotide polymorphisms in the coding region of STK15, rs2273535 (Phe31Ile) and rs1047972 (Val57Ile) were assessed in 380 ESCC patients and 380 healthy controls. We also detected STK15 mRNA expression in 39 esophageal squamous cell carcinomas and corresponding adjacent tissues by real time PCR. Results: rs2273535 showed a significant association with ESCC in our Mongolian population (rs227353, P allele = 0.0447, OR (95%CI) = 1.259 (1.005~1.578)). Real time PCR analysis of ESCC tissues showed that expression of STK15 mRNA in cancer tissues was higher than in normal tissues (p = 0.013). Conclusions: Our study showed that functional SNPs in the STK15 gene are associated with ESCC in a Mongolian population and up-regulation of STK15 mRNAoccurs in ESCC tumors compared adjacent normal tissues. STK15 may thus have an important role in the prognosis of ESCC and be a potential therapeutic target.
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