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Lee, Sun Haeng,Kwak, Sung Chul,Kim, Dong Kwan,Park, Sang Woug,Kim, Hyun Soo,Kim, Young-Sik,Lee, Donghun,Lee, Ju Won,Lee, Chang Gon,Lee, Hae Kyung,Cho, Sung-Min,Shin, Yu Jeong,Lee, Jin Yong,Kim, Hocheo Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 <I>μ</I>g/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only), or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary.</P>
Lee, Donghun,Lee, Sung Hyun,Lee, Yoon Hee,Song, Jungbin,Kim, Hocheol Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>Astragalus extract mixture HT042 is a standardized ingredient of health functional food approved by Korean FDA with a claim of “height growth of children.” HT042 stimulates bone growth rate and increases local IGF-1 expression in growth plate of rats which can be considered as direct stimulation of GH and its paracrine/autocrine actions. However, it remains unclear whether HT042 stimulates circulatory IGF-1 which also plays a major role to stimulate bone growth. To determine the effects on circulatory IGF-1, IGF-1 and IGFBP-3 expressions and phosphorylation of JAK2/STAT5 were evaluated in the liver after 10 days of HT042 administration. HT042 upregulated liver IGF-1 and IGFBP-3 mRNA expression, IGF-1 protein expression, and phosphorylation of JAK2/STAT5. HT042 also increased bone growth rate and proliferative zonal height in growth plate. In conclusion, HT042 stimulates bone growth rate via increment of proliferative rate by upregulation of liver IGF-1 and IGFBP-3 mRNA followed by IGF-1 protein expression through phosphorylation of JAK2/STAT5, which can be regarded as normal functioning of GH-dependent endocrine pathway. </P>
이중선체 내의 용접작업을 위한 자율주행 형 메커니즘 개발 및 응용
이동훈(Donghun Lee),이성철(Sungcheul Lee),구남국(Namkuk Ku),하솔(Sol Ha),김종원(Jongwon Kim),이규열(Kyu-Yeul Lee),김태완(Taewan Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
The welding is very difficult and dangerous for manual welders. Especially double hull structure has very hazardous environment, so shipbuilding industry demands the autonomous system instead of manual welders. This paper describes design of a totally new designed mobile robot, called ‘Rail Runner’, for welding in a double hull structure. Due to the welding work involved in the assembly procedure of a double hull structure, this research addressed both the mechanical and control systems of the robot. The mechanical system of this robot is composed of six axes manipulator for welding function and six axes mobile platform for traveling in the double hull structure. This robot is able to autonomously travel and weld a U-shaped part in a double hull structure. The ‘Rail Runner’ can elevate the efficiency of the welding process against manual welders and the international competitiveness of the shipbuilding industry.
( Jong-hoon Lee ),( Donghun Shin ),( Bitnara Lee ),( Hyundong Lee ),( Inhyung Lee ),( Do-won Jeong ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.5
Eighty-five Enterococcus faecalis isolates collected from animals (40 isolates), meju (a Korean fermented soybean product; 27 isolates), humans (10 isolates), and various environmental samples (8 isolates) were subjected to multilocus sequence typing (MLST) to identify genetic differences between samples of different origins. MLST analysis resulted in 44 sequence types (STs), and the eBURST algorithm clustered the STs into 21 clonal complexes (CCs) and 17 singletons. The predominant STs, ST695 (21.1%, 18/85) and ST694 (9.4%, 8/85), were singletons, and only contained isolates originating from meju. None of the STs in the current study belonged to CC2 or CC9, which comprise clinical isolates with high levels of antibiotic resistance. The E. faecalis isolates showed the highest rates of resistance to tetracycline (32.9%), followed by erythromycin (9.4%) and vancomycin (2.4%). All isolates from meju were sensitive to these three antibiotics. Hence, MLST uncovered genetic diversity within E. faecalis, and clustering of the STs using eBURST revealed a correlation between the genotypes and origins of the isolates.
An Antenna Tracking Profile Design for Communication with a Ground station
Donghun Lee,Kyung-Min Lee,Mohammed Irfan Rashed,Hyochoong Bang 한국항공우주학회 2013 International Journal of Aeronautical and Space Sc Vol.14 No.3
In order to communicate with a ground station, the tracking profile design problem for a directional antenna system is considered. Because the motions of the gimbal angles in the antenna system affect the image quality, the main object is to minimize the motion of the gimbal angles during the satellite’s imaging phase. For this goal, parameter optimization problems in the imaging and maneuver phases are formulated separately in the body-frame, and solved sequentially. Also, several mechanical constraints, such as the limitation of the gimbal angle and rate, are considered in the problems. The tracking profiles of the gimbal angles in the maneuver phases are designed with N-th order polynomials, to continuously connect the tracking profiles between two imaging phases. The results confirm that if the vector trace of the desired antenna-pointing vector is within the antenna’s beam-width angle, motions of the gimbal angles are not required in the corresponding imaging phase. Also, through numerical examples, it is shown that motion of the gimbal angles in the imaging phase can be minimized by the proposed design process.
과학로켓 3호(KSR-3) 자력계 데이터 분석을 통한 로켓비행자세 연구
이은석,장민환,이동훈,김성수,황승현,이선민 경희대학교 자연과학종합연구원 2003 자연과학논문집 Vol.9 No.1
2002년 11월에 발사된 KSR-3 과학 로켓에 탑재된 자력계의 데이터 처리 결과에 대해 논한다. KSR-3 과학 로켓에는 로켓의 비행 자세 정보 획득을 위한 Fluxgate 자력계인 AIM (Attitude Information Magnetometer)과 지구 자기장 섭동 측정용 Search-coil 자력계인 SIM (Scientific Investigation Magnetometer)인 2종류의 자력계가 탑재되었었다. KSR-3 과학 로켓의 발사부터 비행종료까지 총 비행시간 2314초 동안 AIM과 SIM에서 각 축별 데이터를 성공적으로 획득하였다. 먼저 AIM은 획득된 데이터를 수치계산법 및 자체 개발한 MFD_View 변환 프로그램, Spline 보정법을 이용하여 데이터를 분석하였고, 자체 개발한 비행정보 획득 프로그램을 이용하여 시간에 따른 로켓의 비행상태를 확인 중에 있다. 차후 로켓의 좌표값을 이용해 지구 자기장의 여러 성분값 및 데이터 처리 결과들을 비교 분석하여 자력계가 차후 발사되는 로켓의 자세제어에 적합한지 알아볼 예정이다. SIM은 지구 자기장 섭동 현상 관측 및 로켓의 이벤트에 대한 정보를 확인하였다. SIM 데이터는 로켓의 최고 고도가 427㎞밖에 안되어 지구 자기장 섭동 현상을 관측하지 못했으나 로켓의 시간대별 이벤트 현상을 확인할 수 있었다. We describe the result of the two onboard magnetometers of KARI(Korea Aerospace Research Institute)'s sounding rocket. KSR-3, which was launched in November 2002. The KSR-3 magnetometers consist of the fluxgate magnetometer, AIM(Attitude Information Magnetometer) for acquiring the rocket flight attitude information and the search-coil magnetometer, SIM(Scientific Investigation Magnetometer) for the observation of the Earth's magnetic field fluctuations. We acquired 3-axis data of the KSR-3 magnetometer AIM and SIM for 231.4 seconds flight time of science rocket AIM data was analyzed using numerical method, the MFD_View conversion program that we develop independently and Spline method. And we studied the rocket flight attitude information using flight information acquisition program that we developed. The resulting dc magnetic vector field was compared with the IGRF(International Geomagnetic Reference Field). Although SIM could not observe the Earths magnetic field fluctuation, it confirmed the various events of rocket.
Psychological, family, and social factors linked with juvenile theft in Korea
Lee, DongHun,Han, Yoonsun,Park, ManSik,Roh, SeakZoon SAGE Publications 2015 SCHOOL PSYCHOLOGY INTERNATIONAL Vol.36 No.6
<P>The absence of an approach which encompasses several micro-systems in Korea may leave important factors of youth risk behaviors undetected. Thus, an examination of a broad set of ecological factors within the micro-system--including individual characteristics as well as immediate family, peer, and school environments surrounding the youth--that is associated with juvenile theft is warranted. The current study analyzes a rare dataset of 176 youth who were arrested for theft and a matching non-theft sample of 180 youth. Stepwise logistic regression analysis was used to examine variables related to theft engagement. Higher levels of depression was associated with greater odds of theft behavior when examining psychological factors only. Maternal positive parenting behaviors in the family model and school adjustment in the social model were significantly linked with decreased odds of theft engagement. These results may have important implications for providing counseling and educational services to adolescents arrested for theft. Findings encourage expanding the scope of the currently individual-focused program to consideration of family and school contexts that may be crucial for serving youth with theft experience.</P>
Gimbal-Angle Vectors of the Nonredundant CMG Cluster
Donghun Lee,Hyo-ChoongBang 한국항공우주학회 2018 International Journal of Aeronautical and Space Sc Vol.19 No.2
This paper deals with the method using the preferred gimbal angles of a control moment gyro (CMG) cluster for controlling spacecraft attitude. To apply the method to the nonredundant CMG cluster, analytical gimbal-angle solutions for the zero angular momentum state are derived, and the gimbal-angle vectors for the nonzero angular momentum states are studied by a numerical method. It will be shown that the number of the gimbal-angle vectors is determined from the given skew angle and the angular momentum state of the CMG cluster. Through numerical examples, it is shown that the method using the preferred gimbal-angle is an efficient approach to avoid internal singularities for the nonredundant CMG cluster.