키토산 미소구체가 약물방출에 미치는 영향

전윤,차월석,권규혁,이동병 조선대학교 생산기술연구소 2000 生産技術硏究 Vol.22 No.1

In this study, we examined about effectives of the drug release by used glutaraldehyde amount and molecular weight varieties of chitosan in DDS. The release experiments of chitosan microspheres containing norfloxacin were operated in the phosphate buffer solutions of pH 7.4 and 37℃, and its results were as follows. In the linearly release time of drug, chitosan microspheres (Mw 190,000) of used glutaraldehyde 1 mL and 2 mL were 45 and 64 days, and chitosan microspheres (Mw 350,000) of used glutaralhyde 1 mL and 2 mL were 60 and 80 days relatively. These results showed more effective drug releases in the increments of molecular weight and glutaraldehyde In short, the formulation allows chitosan microspheres to suppress the burst effect of the drug release mechanism, which led to the controlled release pattern and microspheres

유아 로타바이러스 설사증에 대한 IgY 난황 항체의 효과시험

정동혁, 박효선, 김경미, 정규항, 김강영, 정후길, 윤숭섭, 전호남, 강신영 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

과급 디젤 엔진의 열응력 해석에 대한 컴퓨터 시뮬레이션

천동준,윤준규 慶熙大學校 大學院 院友會 1996 高凰論集 Vol.18 No.-

Recently, high power and high efficiency are required in internal combustion engine. Therefore thermal loading and thermal loading and thermal stress are increased in the components of engine. This study is a thermal stress anlaysis using finite element method to address the issue of designing a low heat loss cylinder to withstand high cycle thermal fatigue. The diesel engine thermodynamic cycle simulation which uses a single zone in combustion chamber to find the heat transfer coefficient and ambient temperature was developed. The CAD data was transferred to model the componets of engine. CAD/CAE technique of engine data, diesel engine cycle simulation, and finite element analysis are unison to access the diesel engine development stage.

관절 내시경술에 의한 퇴행성 슬관절염의 치료

김동헌,장병춘,신규철,이재성 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

The arthroscopic surgery is an increasingly accepted procedure for the treatment of symptomatic arthritic knee. Authors reviewed the operative results of arthroscopic surgery in 35 knee joints of 27 patients from 1993 to 1997. 1. The average age of patients was 64 years old and the primary diagnosis was degenerative osteoarthritis in all patients. 2. Preoperative symptomes and signs were pain(98%), tenderness(85%), swelling(85%), decreased range of motion(71%) and effusion(55%). 3. The operative procedures were irrigation and synovectomy(20%), abrasion arthroplasty(57%), partial menisectomy and abrasion arthroplasty(23%). 4. The symptoms and signs were improved postoperatively: according to Nine point scale, the good results were recorded at postoperative 6 months and follow-up 2 years in nearly all patients. 5. The complications were minimal. Authors concluded that arthroscopic surgery is considered as a reliable method in the treatment of degenerative osteoarthritis of the knee but not as a curable method, needing a long term observation.

코크스 제조 및 사용 공정에서의 코크스오븐 배출물질 연구

이종천,안규동,조광성,이병국 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.2

This study was performed to evaluate the coke oven emissions (COE) and polynuclear aromatic hydrocarbon levels in coke manu- facturing industry, secondary lead smelting industry and glass bottle manufacturing industry. 1. There were no significant difference between the means of personal samples and area samples by the types of industry(p>0.05). The levels of airborne total particulates of the secondary lead smelting industry was the highest(2.30㎎/㎥), and those of the coke manu- facturing industry and glass bottle manufacturing industry were 1.95 ㎎/㎥ and 1.37 ㎎/㎥. The concentration of COE was the highest in the glass bottle manufacturing industry(0.79 ㎎/㎥), and in order of 0.19㎎/㎥ in the coke manufacturing industry and 0.05 ㎎/㎥ in the secondary lead smelting industry. COE/total particulates(%) was highest in the glass bottle manufacturing industry(58.1%) and in order of 10.3% in the coke manufacturing industry and 3.1% in secondary lead smelting industry. There were significant differences in the total particle concentration and Coe by the types of industry(p<0.05) 2. The levels of airborne total particulates was the highest at the smelting process of secondary lead smelting industry(2.30±0.72 ㎎/㎥), and the lowest at the smelting process of glass bottle manufacturing industry (0.99±1.22㎎/㎥) Concentration of COE was the highest at the casting process of glass bottle manufacturing industry (1.09±1.15㎎/㎥), the lowest at the smelting process of secondary lead smelting industry(0.06±0,03 ㎎/㎥). The COE/total particulates(%) was the highest at the casting process of glass bottle manufacturing industry(65.9±20.5%), and the lowest at the smelting process of secondary lead smelting industry(3.1±2.7%). 3. There were positive correlations between level of The airborne total particulates and concentration of COE in COKE manufacturing industry and glass bottle manufacturing industry(p<0.05), but negative correlation in secondary lead smelting industry. 4. The numbers of case and rates that over the Threshold Limit Values(TLVs) were 24 (77.4%)cases in glass bottle manufacture, 14(23.7%) cases in the coke manufacturing industry and no one case in secondary lead smelting industry. Total numbers of case and rates that over TLVs were 38(35.5%) cases. 5. The limit of detection(LOD) for PAH was 10 ㎍/㎖) in standard sample. All PAH levels of the cokes manufacturing industry and the secondary lead smelting industry and the glass bottle manufacturing industry were trace or not to detect.

Potassium Cyanide 중독에 의한 Parkinsonism 1예 보고

이상도,박영춘,이동국,서정규 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Cayanide-induced parkinsonism is very rare. The authors presented a 37 year old man who developed intractable parkinsonian symptoms 5 days later after the recovery of acute cyanide intoxication. Brain CT scan showed bilateral, symmetrical, triangular shaped, non-enhancing, focal low densities in basal ganlia especially putamen and mild ventricular enlargement and cerebella atrophy.

남자 초·중학생의 무산소성 작업능력과 무산소성 파워의 관계

정동식,정덕조,정성태,이병근,전태원,김은혜,이동규,정동춘 師範大學 體育硏究所 1998 서울大學校 體育硏究所論集 Vol.19 No.2

The critical power(CP) is the highest intensity to sustain for a long time without a fatigue. The anaerobic work capacity(AWC) is the highest anaerobic capacity to be provided by anaerobic energy system without the infection of hypoxia. The purpose of this study was to determine the relationship between AWC and AnP and to verify the validity of AWC. The subjects were consisted of 10 elementary and 10 middle school male students(12.8±1.3yrs, 159.3±12.1㎝, 49.4±11.8㎏). The critical power and anaerobic work capacity were calculated by work-time relationship after four cycle ergometry test to fatigue from 1 to 10 minute. The anaerobic power included Margaria-Kalmen test, Sargent jump and Wingate test. The main finding were as follows. The AWC of elementary and middle school students. were 6.47±2.63KJ and 11.10±3.01KJ. The AWC of elementary students was 58.3% of the middle school students's one. The AnP of elementary students were 47.2∼66.5% of the middle school students's one. And there were high correlation between AWC and AnP(0.64∼0.87, P<0.01). This study showed that AWC is useful index on AnP both elementary and middle school students.

1,4-나프토퀴논 유도체의 항균 및 항진균 작용

유충규,류재천,정세영,김동현 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2

In order to evaluate the antimicrobial effect of 2,3-substituted-1.4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1, 4-naphthoquinones and subjected to antibacterial and antifungal activites, in vitro, against Escherichia coli NIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 and Tricophyton mentagrophytes 6085. Among these derivatives 3, 9, 18 and 23 showed the potent antibacterial activities. 18, 23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.

노년의 대퇴골 원위부 골절 시 동시에 시행한 전슬관절 성형술 및 금속판 내고정술 : 8예 보고 Report of Eight Cases

김동헌,장병춘,신규철,양준호 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Supracondylar fracture of the femur can be treated by a wide variety of methods. Although satisfactory results have been achieved with either open and closed treatment, less certain results are obtained for the elderly who have pre-existing osteoarthritis and osteoporosis. Particularly, elderly patients who have preexisting osteoarthritis are at increased risk of posttraumatic arthritis, stiff knee, persistent pain. Primary total knee arthroplasty(TKA) might obviate many of these potential problems and help to return the high-risk patient to an ambulatory functional status immediately. There are few reports about this study. The purpose of this study is to evaluate the results treated by simultaneous internal fixation and TKA for the supracondylar fracture in the elderly who have osteoarthritis of the knee joint. From 1994 to 1998, eight primary TKAs using posterior cruciate sparing PFC knee(Press Fit Condylar, Johnson & Johnson, Raynham, U.S.A) were performed after internal fixation for the supracondylar fracture of the femur with Judet plate or condylar buttress plate by conventional means. Patella was not resurfaced in all knees. According to the M ller classification of the supracondylar fracture of the femur 5 fractures were type A, 2 in type B, 1 in type C. Five patients were female, 3 patients were male. The ages ranged from 66 to 81, with an average of 74 years. Patients were followed for at least 1 year(average 3 years). The mean interval between the injury and operation was 2 weeks(range, 1 week to 4 weeks). Active knee joint exercise was encouraged in a hinge brace under the postoperative pain control. Partial weight bearing was permitted at the postoperative 4 to 6 weeks using crutches. Full weight bearing was allowed after union of the fracture. Fractures were united in all patients and the average duration of bony union was 16 weeks. The average amount of flexion and average flexion contracture for the all patients at the most recent follow-up were 96 degrees (range, 45 to 120 degrees) and 7 degrees (range, zero to 20 degrees), respectively. Using the knee rating score advocated by the American Knee Society, the average postoperative score was 87 for pain and 80 for function. We concluded that simultaneous internal fixation and TKA for supracondylar fracture of the femur in elderly patients who have advanced knee osteoarthritis may provide satisfactory pain relief and function with acceptable morbidity.

지질막의 변위전류측정에 관한 연구

이경섭,전동규,조수영 東新大學校 工業技術硏究所 1996 工業技術硏究 Vol.2 No.-

An electrical technique that allows the reorganization of single mono layers to be probed by measuring the Maxwell-Displacement-Current (MDC) flowing across mono layers was described. The maxwell displacement current was generated from single mono layers with the application of an external stimulus (pressure, light or heat) in the absence of an external electric field. In this paper, We measured the surface pressure, displacement current and the dipole moment of phospholipid mono layers on the water surface with a applied pressure by MDC.