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부산시 일개구 지역주민의 위암선별검사 수검 및 반복수검 실태 및 관련요인조사
정인숙,배은숙,천동환,전진호,이화자,박남희 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1
The importance of repeat screening for stomach cancer is well known to decrease deaths from stomach cancer. This study was aimed at assessing practice behaviors and to identify related factors in the aspects of demographic factors, health status and cancer risk recognition, attitude to cancer screening, health behaviors, and inhibiting or facilitating factors to stomach cancer screening in an urban area. Data was collected through self-administered questionnaires from 403 people aged 40 to 69 years from April 23th to May 15th, 2002. Practice behaviors were classified as :"ver"r "ver"and "peat"r "t repeat"rouped based on a recent 5 year screening history. The results were as follows: 1. Among the 403 subjects: "e ever group"as 23.8% and "e repeat group"as 4.0%. The rates of screening were 20.5% for men, 27.8% for those women, and 27.3% for aged 40-49, 24.5% for those aged 50-59, 19.0% for those aged 60-69. The rates of repeat screening were 4.0% for men, 4.1% for women, and 2.9% for those aged 40-49, 6.3% for aged 50-59, 2.5% for those aged 60-69. 2. The main factors associated with adherence to gastric cancer screening were education(post high school vs below : OR=2.44), previous cancer screening(yes vs no : OR=2.61), belief in personal health(no vs yes : OR=2.72), health status(unhealthy vs healthy : OR=3.40), possibility of cancer compared to others(low vs not low : OR=2.56), and regular exercise(yes vs no : OR=2.94). The main factor associated with adherence to gastric cancer repeat screening was other cancer screening (yes vs no : OR=6.33). Consequently, there is a need to change the recognition of the importance and necessity of stomach cancer screening in healthy conditions through health education, and to perform multiple screening tests each visit.
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Quinoline-Based Two-Photon Fluorescent Probe for Nitric Oxide in Live Cells and Tissues
Dong, Xiaohu,Heo, Cheol Ho,Chen, Shiyu,Kim, Hwan Myung,Liu, Zhihong American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.1
<P>A two-photon fluorescent probe (QNO) for nitric oxide is reported. The probe is designed with a photoinduced electron transfer (PeT) mechanism and shows 12-fold fluorescence enhancement toward NO. Adopting a quinoline derivative as the fluorophore, QNO has a large two-photon action cross section value of 52 GM and long-wavelength emission. It also features high selectivity, low cytotoxicity, and pH insensitivity. By utilizing two-photon microscopy (TPM), QNO can detect NO in live cells and live tissues at a depth of 90-180 mu m.</P>
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Generation of Insulin Producing Cells from the Mouse Primary Hepatocytes
( Dong Sik Ham ),( Ji Won Kim ),( Heon Seok Park ),( Chen Lin Sun ),( Seung Hwan Lee ),( Jae Hyoung Cho ),( Jeong Ah Oh ),( Ki Ho Song ),( Ho Young Son ),( Kaneto Hideaki ),( Kun Ho Yoon ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6
Surrogate β-cells derived from available adult stem cells are urgently needed for the treatment of insulindeficient diabetes, and hepatocytes constitute an attractive alternative. Herein, we attempted to generate insulin-producing cells from adult mouse primary hepatocytes (HCs) using triple adenoviruses harboring PDX-1/VP-16, BETA2, and MafA. We noted characteristic changes in the transduced HCs into pancreatic β-cells, including reduced albumin gene and increased insulin, insulin content, and the expression of a variety of pancreatic genes. Glucose tolerance and survival are improved by the renal capsular transplantation. These data demonstrated that the transdifferentiation of HCs into insulin-producing cells could be achieved under both in vitro and in vivo conditions. Further, these data suggest that induction of insulin-producing cells from liver provides a potential cell-replacement therapy for the treatment of patients with diabetes using alternative transplantable cell source.
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Region-Based Object Recognition by Color Segmentation Using a Simplified PCNN
Yuli Chen,Yide Ma,Dong Hwan Kim,Sung-Kee Park IEEE 2015 IEEE transactions on neural networks and learning Vol.26 No.8
<P>In this paper, we propose a region-based object recognition (RBOR) method to identify objects from complex real-world scenes. First, the proposed method performs color image segmentation by a simplified pulse-coupled neural network (SPCNN) for the object model image and test image, and then conducts a region-based matching between them. Hence, we name it as RBOR with SPCNN (SPCNN-RBOR). Hereinto, the values of SPCNN parameters are automatically set by our previously proposed method in terms of each object model. In order to reduce various light intensity effects and take advantage of SPCNN high resolution on low intensities for achieving optimized color segmentation, a transformation integrating normalized Red Green Blue (RGB) with opponent color spaces is introduced. A novel image segmentation strategy is suggested to group the pixels firing synchronously throughout all the transformed channels of an image. Based on the segmentation results, a series of adaptive thresholds, which is adjustable according to the specific object model is employed to remove outlier region blobs, form potential clusters, and refine the clusters in test images. The proposed SPCNN-RBOR method overcomes the drawback of feature-based methods that inevitably includes background information into local invariant feature descriptors when keypoints locate near object boundaries. A large number of experiments have proved that the proposed SPCNN-RBOR method is robust for diverse complex variations, even under partial occlusion and highly cluttered environments. In addition, the SPCNN-RBOR method works well in not only identifying textured objects, but also in less-textured ones, which significantly outperforms the current feature-based methods.</P>
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이기환 ( Ki Hwan Lee ),이동천 ( Dong Chen Lee ),박석호 ( Seok Ho Park ),김일 ( Il Kim ),신상희 ( Sang Hee Shin ) 대한원격탐사학회 2007 대한원격탐사학회지 Vol.23 No.2
This paper introduce a satellite image based blog system built by JeonNam local province. Main goals of this system are as follows: ①Overcome the static aspect of traditional Web-GIS, ②Providing a geoUCC generating platform by combining multimedia technology and GIS in a single web environment, ③Building a two-way Web-GIS through user`s participation, ④Creating a new communicative way between government and citizen by using this system. As a result of the system building, this system enables users to create his/her own UCC(User Created Contents) on high-resolution satellite image and enables users to share his/her own UCC with other system using Web2.0 technology.
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A Science Gateway Cloud With Cost-Adaptive VM Management for Computational Science and Applications
Kim, Seong-Hwan,Kang, Dong-Ki,Kim, Woo-Joong,Chen, Min,Youn, Chan-Hyun IEEE 2017 IEEE systems journal Vol.11 No.1
<P>For the processing of scientific applications in cloud computing, the important challenge is to find an optimized resource scheduling method that guarantees cloud service users' service-level agreement while minimizing the resource management cost. To overcome this problem, in contrast to previous solutions that focus on a few specific applications, we design and implement a unified scientific cloud framework called science gateway cloud, which is a broker between users and providers and is able to process various scientific applications efficiently upon heterogeneous cloud resources. In particular, we design a costadaptive resource management scheme that reduces the resource management cost significantly without any degradation of performance based on the long-term payment plans of cloud resource providers. Furthermore, this system allows us to parallelize divisible scientific applications to improve the processing performance. Through the division policy for workflow scheduling, we show that both deadline assurance and cost minimization can be satisfied concurrently. Finally, we demonstrate that our proposed system significantly outperforms conventional cloud systems through various experimental and simulation results.</P>
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Functional characterization of <i>ObgC</i> in ribosome biogenesis during chloroplast development
Bang, Woo Young,Chen, Ji,Jeong, In Sil,Kim, Sam Woong,Kim, Chul Wook,Jung, Hyun Suk,Lee, Kyoung Hwan,Kweon, Hee‐,Seok,Yoko, Ishizaki,Shiina, Takashi,Bahk, Jeong Dong Blackwell Publishing Ltd 2012 The Plant journal Vol.71 No.1
<P><B>Summary</B></P><P>The Spo0B‐associated GTP‐binding protein (Obg) GTPase, essential for bacterial viability, is also conserved in eukaryotes, but its primary role in eukaryotes remains unknown. Here, our functional characterization of Arabidopsis and rice <I>obgc</I> mutants strongly underlines the evolutionarily conserved role of eukaryotic Obgs in organellar ribosome biogenesis. The mutants exhibited a chlorotic phenotype, caused by retarded chloroplast development. A plastid DNA macroarray revealed a plastid‐encoded RNA polymerase (PEP) deficiency in an <I>obgc</I> mutant, caused by incompleteness of the PEP complex, as its western blot exhibited reduced levels of RpoA protein, a component of PEP. Plastid rRNA profiling indicated that plastid rRNA processing is defective in <I>obgc</I> mutants, probably resulting in impaired ribosome biogenesis and, in turn, in reduced levels of RpoA protein. RNA co‐immunoprecipitation revealed that ObgC specifically co‐precipitates with 23S rRNA <I>in vivo</I>. These findings indicate that ObgC functions primarily in plastid ribosome biogenesis during chloroplast development. Furthermore, complementation analysis can provide new insights into the functional modes of three ObgC domains, including the Obg fold, G domain and OCT.</P>
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