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( Dinesh Kumar Patel ),( Kanika Patel ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Plants derived natural products are well known for their contributions to human health. Inflammation and oxidative stress are key parameters for the development of liver disorders and molecule having good antioxidant potential could be used for the treatment of liver damage. Oxidative stress, inflammation and apoptosis cause scar formation in the liver cells, however inflammatory mediators such as IL-1, ICAM-1 and TNFa also play important role in hepatic failure. Antioxidant enzyme such as Catalase, SOD, and GSH-Px are used as indexes to evaluate the level of oxidative stress. Acute infection damages the liver cells and killed healthy tissue and formed scar tissue which is called fibrosis. Methods: Different electronic database have been searched to collect needed information of senegin for their medicinal importance in acute liver inflammation and infection and all the information have been analyzed through statistically. Pharmacological activity of senegin has been also validated through different experimental work. Molecular study has been investigated in the present work through interaction of senegin with ligand to know their mode of action. Molecular docking and dynamic experiments were performed with senegin against nuclear factor kappa B (NF-κB), superoxide dismutase (SOD) and Catalase to know how senegin fit on active site. Results: Data analysis revealed the importance of senegin for the treatment of various form of inflammatory disorders including hepatic disorders. Senegin have been found to have neuroprotective and anti-inflammatory activity which are used for the treatment of Hepatic disorders. Scientific databases analysis has also proved their importance as immunomodulatory, hypoglycemic and anticancer potential in the medicine. Database analysis also demonstrates that senegin could prevent liver damage and therefore play important role in the Hepatic inflammation. In-silico studies showed that senegin exhibited a higher docking score against NF-κB, SOD and Catalase which signified their therapeutic potential and role in the various form of hepatic inflammation and complication. Conclusions: Senegin prevent liver damage through its antioxidants and anti-inflammatory potential. However protective effect of senegin in Hepatic cells could be due to interaction of NF-κB, SOD and Catalase.
Stimuli-Responsive Graphene Nanohybrids for Biomedical Applications
Patel, Dinesh K.,Seo, Yu-Ri,Lim, Ki-Taek Hindawi 2019 Stem cells international Vol.2019 No.-
<P>Stimuli-responsive materials, also known as smart materials, can change their structure and, consequently, original behavior in response to external or internal stimuli. This is due to the change in the interactions between the various functional groups. Graphene, which is a single layer of carbon atoms with a hexagonal morphology and has excellent physiochemical properties with a high surface area, is frequently used in materials science for various applications. Numerous surface functionalizations are possible for the graphene structure with different functional groups, which can be used to alter the properties of native materials. Graphene-based hybrids exhibit significant improvements in their native properties. Since functionalized graphene contains several reactive groups, the behavior of such hybrid materials can be easily tuned by changing the external conditions, which is very useful in biomedical applications. Enhanced cell proliferation and differentiation of stem cells was reported on the surfaces of graphene-based hybrids with negligible cytotoxicity. In addition, pH or light-induced drug delivery with a controlled release rate was observed for such nanohybrids. Besides, notable improvements in antimicrobial activity were observed for nanohybrids, which demonstrated their potential for biomedical applications. This review describes the physiochemical properties of graphene and graphene-based hybrid materials for stimuli-responsive drug delivery, tissue engineering, and antimicrobial applications.</P>
Patel Priya,Singh Shailesh,Patel Arvind Kumar,Kumar Bhupendra,Singh Arvind Kumar,Kumar Dinesh 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
Parthenium hysterophorus L. (Asteraceae) is a toxic weed of agricultural farms, pastures and wastelands with a pan-tropical distribution. The weed causes a reduction in crop production of agricultural fields and severe health problems in humans. The Mexican beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae) is among the most promising candidates for the weed biocontrol. However, no previous study has evaluated assimilation of nutrients in this beetle. In the present study, feeding attributes and assimilation of nutrients by larvae of Z. bicolorata were assessed on the weed. Results revealed that the first larval instars of Z. bicolorata exhibited lowest consumption rates, and accumulated minimum concentrations of glucose, proteins and triglycerides in their body. They showed compensatory feeding, and displayed highest food utilization efficiencies and developmental rates. In contrast, the fourth larval instars exhibited higher food consumption rates and conversion efficiencies, but displayed lowest developmental rates. Accumulation of food reserves was also recorded maximum for the fourth larval instars. Overall, the findings may aid current mass-rearing efforts for Z. bicolorata in laboratories, but field trials are still needed to strengthen the present findings.