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Dinesh Babu,박수영,김영휘,양홍철,김정애,Dinesh Thapa,이종숙,김아라 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
An aqueous extract of Cornus kousa Burg. leaves (ACK) that contained high amount of polyphenols showed significant antioxidant activity against diphenylpicrylhydrazyl (DPPH) radicals and TNF-α-generated reactive oxygen species. ACK at concentrations of 10 and 50 μg/mL significantly inhibited TNF- α-induced adhesion of U937 pre-monocytic cells to HT-29 colon epithelial cells in a concentrationdependent manner. The reduced adhesion by ACK correlated with the suppressed expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8, the major inflammatory bowel disease (IBD)-associated chemokines. Moreover, ACK significantly suppressed TNF-α-induced translocation of redox-sensitive nuclear factor (NF)-κB as well as degradation of cytosolic I-κBα. The effective concentrations of ACK were much lower than that of 5-aminosalicylic acid (3.06 mg/mL), which is an active metabolite of sulfasalazine, a well-known drug used in the treatment of IBD. The results indicate that ACK may provide a potential benefit for the prevention and treatment of inflammatory diseases such as IBD.
Babu, Dinesh,Lee, Jong-Suk,Park, Su-Young,Thapa, Dinesh,Choi, Mi-Kyoung,Kim, Ah-Ra,Park, Young-Joon,Kim, Jung-Ae 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
Oxidative stress and the activation of nuclear factor (NF)-${\kappa}B$ play crucial roles in the pathogenesis of inflammatory bowel disease (IBD). In the present study, we examined the effects of the ethanol extract of Platycarya strobilacea Sieb. stem (EPS) on TNF-$\alpha$-induced monocyte adhesion to HT29 human colon epithelial cells, an initial step of colon inflammation. EPS contained high amount of polyphenols ($0.241{\pm}0.017\;mg$ of catechin equivalent/g of extract) and showed substantial DPPH radical scavenging activity. In addition, EPS significantly suppressed TNF-$\alpha$-induced reactive oxygen species (ROS) increase. Moreover, TNF-$\alpha$-induced monocyte adhesion to HT29 colon epithelial cells was significantly suppressed by EPS in a concentrationdependent manner. The reduced adhesion by EPS was correlated with suppressed expression of MCP-1 and IL-8, the major chemokines in IBD. EPS also prevented the TNF-$\alpha$-induced nuclear translocation of NF-${\kappa}B$, one of the redox-sensitive transcription factors, in a concentration-dependent manner. Taken together, our results suggest that the anti-oxidant components of EPS prevent TNF-$\alpha$-induced NF-${\kappa}B$ activation, chemokine induction, and monocyte adhesion at the site of intestinal inflammation.
Synthesis and Characterization of Eggshell-Derived Hydroxyapatite Bioceramics
Dinesh K. Patel,김혜빈,임기택 한국농업기계학회 2019 바이오시스템공학 Vol.44 No.2
Several methods are frequently used to make high-value-added biomaterials from waste biomass for various biomedical applications. Hydroxyapatite (HA), a type of bio-ceramic material, has received considerable attention for use in bone tissue and implanted medical devices owing to its physiochemical properties and excellent biocompatibility. It can be synthesized from calcium- and phosphorous-containing precursor moieties such as calcium oxide and tricalcium phosphate (TCP). In this study, we synthesized an HA bio-ceramic from bio-waste eggshells via a reaction between calcium oxide and TCP, followed by heat treatment. The synthesized HAwas characterized through scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy. The material exhibited no significant cytotoxicity even at a higher concentration, indicating high biocompatibility. Our study provides an effective way of converting low-cost bio-waste eggshells into a value-added biomaterial for tissue-engineering applications.
Lifting Idempotents and Projective Covers
Dinesh Khurana ...et al KYUNGPOOK UNIVERSITY 2001 Kyungpook mathematical journal Vol.41 No.2
A necessary and sufficient condition is given so that direct summands of a module, with projective cover, have projective covers. We characterize the rings over which direct summands of cyclic (respectively finitely generated) modules, with projective covers, have projective covers. Some sufficient conditions are given so that direct summands of arbitrary modules, with projective covers, have projective covers. Let L be a left ideal of a ring R. It is said that idempotents lift modulo L in R if for every X ∈ R with x² - x ∈ L there exists an idempotent e in R such that e - x ∈ L. It is proved that if idempotents lift modulo the Jacobson radical of a ring, then idempotents also lift modulo every one sided ideal contained in the Jacobson radical. Let I be an ideal of a ring R. We prove that if idempotents lift in R modulo every left ideal contained in I then, idempotents also lift in R modulo every right ideal contained in I. On taking I = R we get that left exchange rings are right exchange.
( Dinesh D,Jayasena ),( Hewa W. Cyril ),( Cheorun Jo ) 한국동물자원과학회 ( 구 한국축산학회 ) 2012 한국축산학회지 Vol.54 No.3
The objective of this study was to assess the external and internal quality traits of eggs in wholesale egg market in Colombo, Sri Lanka and the effect of storage period in egg quality traits in the same market after receiving the eggs. First, a total of 482 fresh eggs were randomly collected from the above market and external egg quality traits were determined and recorded according to the definitions given in the Specification for Chicken Egg SLS 959:1992. After that, a total of 288 fresh eggs were randomly collected and various external and internal egg quality traits were measured and recorded according to the standard procedures over a storage period of 1, 3 and 5d after receiving the fresh eggs to the wholesale market. Information about the shops was also collected using a pretested questionnaire. Using the recorded data, shape index, Haugh unit, albumen index and yolk index were calculated for each egg. Average weight, width, length and shape index of the eggs in the sample was 59.96g, 4.33cm, 5.78 cm and 75.03, respectively. Average shape index value was much closer to the standard value of 74. From the total sample 80.5% eggs had a normal and sound shape. However only 60.37% of the eggs are in the desirable quality range specified in SLS 959:1992, when the overall shell quality of the sample is considered based on shell cleanliness, defects and shape. The results of the current study indicated that eggs had significant(p<0.05) deterioration of all internal quality parameters tested with increasing storage time. However the effect was not significant(p>0.05) between the storage periods of 3 and 5 d after receiving eggs except for yolk color and yolk height. Desirable category of eggs had reduced and rejections had increased with the storage period. Main problems associated with the particular market were less space availability, higher percentages of dirty eggs, unavailability of proper packaging materials, no standard packaging system for eggs, and not implementing a standard grading system for eggs. Therefore the results of this study suggest that proper egg handling and storage conditions such as low temperature storage may be implemented to increase the proportion of desirable quality eggs in the above market.